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Items: 1 to 50 of 857

1.

Muir-Torre Syndrome Appropriate Use Criteria: Effect of Patient Age on Appropriate Use Scores.

Vidal CI, Sutton A, Armbrect EA, Lee JB, Litzner BR, Hurley MY, Alam M, Duncan LM, Elston DM, Emanuel PO, Ferringer T, Fung MA, Hosler GA, Lazar AJ, Lowe L, Plaza JA, Robinson JK, Schaffer A.

J Cutan Pathol. 2019 Mar 20. doi: 10.1111/cup.13459. [Epub ahead of print]

PMID:
30895633
2.

Toward an effective use of β-catenin immunohistochemistry in the evaluation of challenging melanocytic lesions.

Erstine EM, Lazar AJ.

Virchows Arch. 2019 Mar 13. doi: 10.1007/s00428-019-02552-6. [Epub ahead of print] No abstract available.

PMID:
30868296
3.

Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications.

Dinescu S, Ignat SR, Lazar AD, Marin Ș, Danilă E, Marin MM, Udeanu DI, Ghica MV, Albu-Kaya MG, Costache M.

J Immunol Res. 2019 Feb 5;2019:4513108. doi: 10.1155/2019/4513108. eCollection 2019.

4.

Delayed Diagnosis of an Acute Epidural Hematoma Due to MRI Artifact from Reinforced Catheter.

Lazar A, Anitescu M.

Pain Med. 2019 Mar 6. pii: pnz018. doi: 10.1093/pm/pnz018. [Epub ahead of print] No abstract available.

PMID:
30840072
5.

B7-H3 expression in Merkel cell carcinoma-associated endothelial cells correlates with locally aggressive primary tumor features and increased vascular density.

Aung PP, Parra ER, Barua S, Sui D, Ning J, Mino B, Ledesma DA, Curry JL, Nagarajan P, Torres Cabala CA, Efstathiou E, Hoang A, Wong MKK, Wargo JA, Lazar AJ, Rao A, Prieto VG, Wistuba II, Tetzlaff MT.

Clin Cancer Res. 2019 Feb 26. pii: clincanres.2355.2018. doi: 10.1158/1078-0432.CCR-18-2355. [Epub ahead of print]

PMID:
30808776
6.

Tyrosine Kinase Inhibitor and Immune Checkpoint Inhibitor Responses in KIT-Mutant Metastatic Melanoma.

McKean M, Oba J, Ma J, Roth KG, Wang WL, Macedo MP, Carapeto FCL, Haydu LE, Siroy AE, Vo P, Hong DS, Eterovic AK, Patel KP, Bassett RL Jr, Grimm EA, Lazar AJ, Woodman SE.

J Invest Dermatol. 2019 Mar;139(3):728-731. doi: 10.1016/j.jid.2018.10.009. Epub 2018 Oct 25. No abstract available.

PMID:
30798855
7.

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases.

Fischer GM, Jalali A, Kircher DA, Lee WC, McQuade JL, Haydu LE, Joon AY, Reuben A, de Macedo MP, Carapeto FCL, Yang C, Srivastava A, Ambati CR, Sreekumar A, Hudgens CW, Knighton B, Deng W, Ferguson SD, Tawbi HA, Glitza IC, Gershenwald JE, Vashisht Gopal YN, Hwu P, Huse JT, Wargo JA, Futreal PA, Putluri N, Lazar AJ, DeBerardinis RJ, Marszalek JR, Zhang J, Holmen SL, Tetzlaff MT, Davies MA.

Cancer Discov. 2019 Feb 20. pii: CD-18-1489. doi: 10.1158/2159-8290.CD-18-1489. [Epub ahead of print]

PMID:
30787016
8.

Hypercalcaemic Crisis Due to Primary Hyperparathyroidism: Report of Two Cases.

Sala TD, Mureşan S, Roman R, Lazăr A, Ion R, Paşcanu I.

J Crit Care Med (Targu Mures). 2019 Feb 4;5(1):34-39. doi: 10.2478/jccm-2019-0004. eCollection 2019 Jan.

9.

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G.

Cancer Cell. 2019 Feb 11;35(2):204-220.e9. doi: 10.1016/j.ccell.2019.01.006.

PMID:
30753823
10.

Chronic lower extremity wounds in a patient with Klippel Trenaunay syndrome.

Shahbahrami K, Resnikoff M, Shah AY, Lydon RP, Lazar A, Cavallo G.

J Vasc Surg Cases Innov Tech. 2019 Jan 28;5(1):45-48. doi: 10.1016/j.jvscit.2018.11.003. eCollection 2019 Mar.

11.

Rapid Changes in Laboratory Parameters and Early Response to Adalimumab: A Pooled Analysis From Patients With Ulcerative Colitis in 2 Clinical Trials.

Hanauer S, Sandborn WJ, Colombel JF, Vermeire S, Petersson J, Kligys K, Zhou Q, Lazar A, Reinisch W.

J Crohns Colitis. 2019 Feb 6. doi: 10.1093/ecco-jcc/jjz031. [Epub ahead of print]

PMID:
30726897
12.

Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy.

Wong J, Sampson SL, Bell-Briones H, Ouyang A, Lazar AA, Lotz JC, Fields AJ.

Osteoarthritis Cartilage. 2019 Feb 2. pii: S1063-4584(19)30039-1. doi: 10.1016/j.joca.2019.01.013. [Epub ahead of print]

PMID:
30721733
13.

Stimulus complexity shapes response correlations in primary visual cortex.

Bányai M, Lazar A, Klein L, Klon-Lipok J, Stippinger M, Singer W, Orbán G.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2723-2732. doi: 10.1073/pnas.1816766116. Epub 2019 Jan 28.

14.

Epitranscriptomic Signatures in lncRNAs and Their Possible Roles in Cancer.

Dinescu S, Ignat S, Lazar AD, Constantin C, Neagu M, Costache M.

Genes (Basel). 2019 Jan 16;10(1). pii: E52. doi: 10.3390/genes10010052. Review.

15.

Extraskeletal Osteosarcomas: A Case Made for Combined Modality Local Therapy With Radiation and Surgery.

Bishop AJ, Livingston JA, Araujo DM, Moon BS, Patel S, Wang WL, Lazar AJ, Roland CL, Guadagnolo BA.

Am J Clin Oncol. 2019 Mar;42(3):238-242. doi: 10.1097/COC.0000000000000515.

PMID:
30614820
16.

Infraslow oscillations in human sleep spindle activity.

Lázár ZI, Dijk DJ, Lázár AS.

J Neurosci Methods. 2019 Mar 15;316:22-34. doi: 10.1016/j.jneumeth.2018.12.002. Epub 2018 Dec 17.

17.

Cephalad Migration of an Epidural Catheter in an Infant After Thoracotomy.

Lazar A, Anitescu M.

Pain Med. 2018 Dec 17. doi: 10.1093/pm/pny267. [Epub ahead of print] No abstract available.

PMID:
30561703
18.

Long-Term Outcomes for Patients With Desmoid Fibromatosis Treated With Radiation Therapy: A 10-Year Update and Re-evaluation of the Role of Radiation Therapy for Younger Patients.

Bishop AJ, Zarzour MA, Ratan R, Torres KE, Feig BW, Wang WL, Lazar AJ, Moon BS, Roland CL, Guadagnolo BA.

Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1167-1174. doi: 10.1016/j.ijrobp.2018.12.012. Epub 2018 Dec 12.

PMID:
30552963
19.

Use of otoacoustic emissions to improve outcomes and reduce disparities in a community preschool hearing screening program.

Cedars E, Kriss H, Lazar AA, Chan C, Chan DK.

PLoS One. 2018 Dec 10;13(12):e0208050. doi: 10.1371/journal.pone.0208050. eCollection 2018.

20.

The effects of concomitant immunomodulators on the pharmacokinetics, efficacy and safety of adalimumab in paediatric patients with Crohn's disease: a post hoc analysis.

Hyams JS, Dubinsky M, Rosh J, Ruemmele FM, Eichner SF, Maa JF, Lazar A, Alperovich G, Mostafa NM, Robinson AM.

Aliment Pharmacol Ther. 2019 Jan;49(2):155-164. doi: 10.1111/apt.15054. Epub 2018 Dec 2.

PMID:
30506693
21.

Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.

Wang Y, Wiesnoski DH, Helmink BA, Gopalakrishnan V, Choi K, DuPont HL, Jiang ZD, Abu-Sbeih H, Sanchez CA, Chang CC, Parra ER, Francisco-Cruz A, Raju GS, Stroehlein JR, Campbell MT, Gao J, Subudhi SK, Maru DM, Blando JM, Lazar AJ, Allison JP, Sharma P, Tetzlaff MT, Wargo JA, Jenq RR.

Nat Med. 2019 Jan;25(1):188. doi: 10.1038/s41591-018-0305-2.

PMID:
30479380
22.

Distribution of water in the pores of periodic mesoporous organosilicates - a proton solid state MAS NMR study.

Veena VS, Illath K, Lazar A, Vinod CP, Ajithkumar TG, Jayanthi S.

Phys Chem Chem Phys. 2018 Nov 28;20(46):29351-29361. doi: 10.1039/c8cp04902e.

PMID:
30444506
23.

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.

Wang Y, Wiesnoski DH, Helmink BA, Gopalakrishnan V, Choi K, DuPont HL, Jiang ZD, Abu-Sbeih H, Sanchez CA, Chang CC, Parra ER, Francisco-Cruz A, Raju GS, Stroehlein JR, Campbell MT, Gao J, Subudhi SK, Maru DM, Blando JM, Lazar AJ, Allison JP, Sharma P, Tetzlaff MT, Wargo JA, Jenq RR.

Nat Med. 2018 Dec;24(12):1804-1808. doi: 10.1038/s41591-018-0238-9. Epub 2018 Nov 12. Erratum in: Nat Med. 2018 Nov 27;:.

PMID:
30420754
24.

Proficiency Testing of Standardized Samples Shows Very High Interlaboratory Agreement for Clinical Next-Generation Sequencing-Based Oncology Assays.

Merker JD, Devereaux K, Iafrate AJ, Kamel-Reid S, Kim AS, Moncur JT, Montgomery SB, Nagarajan R, Portier BP, Routbort MJ, Smail C, Surrey LF, Vasalos P, Lazar AJ, Lindeman NI.

Arch Pathol Lab Med. 2018 Oct 30. doi: 10.5858/arpa.2018-0336-CP. [Epub ahead of print]

PMID:
30376374
25.

Publisher Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.

Amaria RN, Reddy SM, Tawbi HA, Davies MA, Ross MI, Glitza IC, Cormier JN, Lewis C, Hwu WJ, Hanna E, Diab A, Wong MK, Royal R, Gross N, Weber R, Lai SY, Ehlers R, Blando J, Milton DR, Woodman S, Kageyama R, Wells DK, Hwu P, Patel SP, Lucci A, Hessel A, Lee JE, Gershenwald J, Simpson L, Burton EM, Posada L, Haydu L, Wang L, Zhang S, Lazar AJ, Hudgens CW, Gopalakrishnan V, Reuben A, Andrews MC, Spencer CN, Prieto V, Sharma P, Allison J, Tetzlaff MT, Wargo JA.

Nat Med. 2018 Dec;24(12):1942. doi: 10.1038/s41591-018-0252-y.

PMID:
30361511
26.

Author Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.

Amaria RN, Reddy SM, Tawbi HA, Davies MA, Ross MI, Glitza IC, Cormier JN, Lewis C, Hwu WJ, Hanna E, Diab A, Wong MK, Royal R, Gross N, Weber R, Lai SY, Ehlers R, Blando J, Milton DR, Woodman S, Kageyama R, Wells DK, Hwu P, Patel SP, Lucci A, Hessel A, Lee JE, Gershenwald J, Simpson L, Burton EM, Posada L, Haydu L, Wang L, Zhang S, Lazar AJ, Hudgens CW, Gopalakrishnan V, Reuben A, Andrews MC, Spencer CN, Prieto V, Sharma P, Allison J, Tetzlaff MT, Wargo JA.

Nat Med. 2018 Dec;24(12):1941. doi: 10.1038/s41591-018-0251-z.

PMID:
30361510
27.

T-cell trafficking plays an essential role in tumor immunity.

Aires DJ, Yoshida M, Richardson SK, Bai M, Liu L, Moreno R, Lazar AJF, Wick JA, Rich BE, Murphy G, Blumberg RS, Fuhlbrigge RC, Kupper TS.

Lab Invest. 2019 Jan;99(1):85-92. doi: 10.1038/s41374-018-0124-6. Epub 2018 Oct 23.

PMID:
30353131
28.

Clinical trials involving carbon-ion radiation therapy and the path forward.

Lazar AA, Schulte R, Faddegon B, Blakely EA, Roach M 3rd.

Cancer. 2018 Dec 1;124(23):4467-4476. doi: 10.1002/cncr.31662. Epub 2018 Oct 11. Review.

PMID:
30307603
29.

Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.

Amaria RN, Reddy SM, Tawbi HA, Davies MA, Ross MI, Glitza IC, Cormier JN, Lewis C, Hwu WJ, Hanna E, Diab A, Wong MK, Royal R, Gross N, Weber R, Lai SY, Ehlers R, Blando J, Milton DR, Woodman S, Kageyama R, Wells DK, Hwu P, Patel SP, Lucci A, Hessel A, Lee JE, Gershenwald J, Simpson L, Burton EM, Posada L, Haydu L, Wang L, Zhang S, Lazar AJ, Hudgens CW, Gopalakrishnan V, Reuben A, Andrews MC, Spencer CN, Prieto V, Sharma P, Allison J, Tetzlaff MT, Wargo JA.

Nat Med. 2018 Nov;24(11):1649-1654. doi: 10.1038/s41591-018-0197-1. Epub 2018 Oct 8. Erratum in: Nat Med. 2018 Oct 25;:. Nat Med. 2018 Oct 25;:.

PMID:
30297909
30.

Gene Expression Analysis Identifies Novel Targets for Cervical Cancer Therapy.

Roszik J, Ring KL, Wani KM, Lazar AJ, Yemelyanova AV, Soliman PT, Frumovitz M, Jazaeri AA.

Front Immunol. 2018 Sep 19;9:2102. doi: 10.3389/fimmu.2018.02102. eCollection 2018.

31.

Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.

Keung EZ, Lazar AJ, Torres KE, Wang WL, Cormier JN, Ashleigh Guadagnolo B, Bishop AJ, Lin H, Hunt KK, Bird J, Lewis VO, Patel SR, Wargo JA, Somaiah N, Roland CL.

BMC Cancer. 2018 Sep 24;18(1):913. doi: 10.1186/s12885-018-4829-0.

32.

Diet and Activity Assessments and Interventions Using Technology in Older Adults.

Takemoto M, Manini TM, Rosenberg DE, Lazar A, Zlatar ZZ, Das SK, Kerr J.

Am J Prev Med. 2018 Oct;55(4):e105-e115. doi: 10.1016/j.amepre.2018.06.005.

33.

Positive Tumor Response to Combined Checkpoint Inhibitors in a Patient With Refractory Alveolar Soft Part Sarcoma: A Case Report.

Conley AP, Trinh VA, Zobniw CM, Posey K, Martinez JD, Arrieta OG, Wang WL, Lazar AJ, Somaiah N, Roszik J, Patel SR.

J Glob Oncol. 2018 Sep;4:1-6. doi: 10.1200/JGO.2017.009993. Epub 2017 Jul 6. No abstract available.

34.

Comfort and Attitudes Towards Robots Among Young, Middle-Aged, and Older Adults: A Cross-Sectional Study.

Backonja U, Hall AK, Painter I, Kneale L, Lazar A, Cakmak M, Thompson HJ, Demiris G.

J Nurs Scholarsh. 2018 Nov;50(6):623-633. doi: 10.1111/jnu.12430. Epub 2018 Sep 19.

PMID:
30230692
35.

Efficacy and Safety of Dose Escalation to Adalimumab 80 mg Every Other Week in Japanese Patients with Crohn's Disease Who Lost Response to Maintenance Therapy.

Motoya S, Watanabe M, Wallace K, Lazar A, Nishimura Y, Ozawa M, Thakkar R, Robinson AM, Singh RSP, Mostafa NM, Suzuki Y, Hibi T.

Inflamm Intest Dis. 2018 Jul;2(4):228-235. doi: 10.1159/000486786. Epub 2018 May 15.

36.

Assessing inter-component heterogeneity of biphasic uterine carcinosarcomas.

Liu Y, Weber Z, San Lucas FA, Deshpande A, Jakubek YA, Sulaiman R, Fagerness M, Flier N, Sulaiman J, Davis CM, Fowler J, Starks D, Rojas-Espaillat L, Lazar AJ, Davies GE, Ehli EA, Scheet P.

Gynecol Oncol. 2018 Nov;151(2):243-249. doi: 10.1016/j.ygyno.2018.08.043. Epub 2018 Sep 5.

PMID:
30194005
37.

Hypereosinophilic syndrome with cardiac involvement in a patient with multiple malignancies.

Dregoesc MI, Iancu AC, Lazar AA, Balanescu S.

Med Ultrason. 2018 Aug 30;20(3):399-400. doi: 10.11152/mu-1574.

38.

Comprehensive Characterization of Cancer Driver Genes and Mutations.

Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Kwok-Shing Ng P, Jeong KJ, Cao S, Wang Z, Gao J, Gao Q, Wang F, Liu EM, Mularoni L, Rubio-Perez C, Nagarajan N, Cortés-Ciriano I, Zhou DC, Liang WW, Hess JM, Yellapantula VD, Tamborero D, Gonzalez-Perez A, Suphavilai C, Ko JY, Khurana E, Park PJ, Van Allen EM, Liang H; MC3 Working Group; Cancer Genome Atlas Research Network, Lawrence MS, Godzik A, Lopez-Bigas N, Stuart J, Wheeler D, Getz G, Chen K, Lazar AJ, Mills GB, Karchin R, Ding L.

Cell. 2018 Aug 9;174(4):1034-1035. doi: 10.1016/j.cell.2018.07.034. No abstract available.

39.

Targeting the HGF/MET Axis Counters Primary Resistance to KIT Inhibition in KIT-Mutant Melanoma.

Oba J, Kim SH, Wang WL, Macedo MP, Carapeto F, McKean MA, Van Arnam J, Eterovic AK, Sen S, Kale CR, Yu X, Haymaker CL, Routbort M, Haydu LE, Bernatchez C, Lazar AJ, Grimm EA, Hong DS, Woodman SE.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.18.00055. Epub 2018 Jun 5. No abstract available.

40.

Safety of Adalimumab in Pediatric Patients with Polyarticular Juvenile Idiopathic Arthritis, Enthesitis-Related Arthritis, Psoriasis, and Crohn's Disease.

Horneff G, Seyger MMB, Arikan D, Kalabic J, Anderson JK, Lazar A, Williams DA, Wang C, Tarzynski-Potempa R, Hyams JS.

J Pediatr. 2018 Oct;201:166-175.e3. doi: 10.1016/j.jpeds.2018.05.042. Epub 2018 Jul 25.

41.

The Importance of Lymphovascular Invasion in Uterine Adenosarcomas: Analysis of Clinical, Prognostic, and Treatment Outcomes.

Nathenson MJ, Conley AP, Lin H, Fleming N, Lazar A, Wang WL, Ravi V.

Int J Gynecol Cancer. 2018 Sep;28(7):1297-1310. doi: 10.1097/IGC.0000000000001306.

PMID:
30044322
42.

Challenges in next generation sequencing analysis of somatic mutations in transplant patients.

Chen H, Luthra R, Patel KP, Routbort M, Rashid A, Roy-Chowdhuri S, Lazar A, Broaddus R, Manekia J, Singh RR, Yemelyanova A.

Cancer Genet. 2018 Oct;226-227:17-22. doi: 10.1016/j.cancergen.2018.04.119. Epub 2018 May 10.

PMID:
30005850
43.

TERT promoter mutations in solitary fibrous tumour.

Demicco EG, Wani K, Ingram D, Wagner M, Maki RG, Rizzo A, Meeker A, Lazar AJ, Wang WL.

Histopathology. 2018 Nov;73(5):843-851. doi: 10.1111/his.13703. Epub 2018 Sep 19.

PMID:
29985536
44.

PAX7 expression in sarcomas bearing the EWSR1-NFATC2 translocation.

Charville GW, Wang WL, Ingram DR, Roy A, Thomas D, Patel RM, Hornick JL, van de Rijn M, Lazar AJ.

Mod Pathol. 2019 Jan;32(1):154-156. doi: 10.1038/s41379-018-0095-6. Epub 2018 Jul 9. No abstract available.

PMID:
29985454
45.

Prognostic gene expression signatures in sarcoma: finding clarity in complexity.

Charville GW, Lazar AJ.

Ann Oncol. 2018 Aug 1;29(8):1632-1633. doi: 10.1093/annonc/mdy233. No abstract available.

PMID:
29982358
46.

Efficacy of Adalimumab for Treatment of Perianal Fistula in Children with Moderately to Severely Active Crohn's Disease: Results from IMAgINE 1 and IMAgINE 2.

Ruemmele FM, Rosh J, Faubion WA, Dubinsky MC, Turner D, Lazar A, Eichner S, Maa JF, Alperovich G, Robinson AM, Hyams JS.

J Crohns Colitis. 2018 Nov 9;12(10):1249-1254. doi: 10.1093/ecco-jcc/jjy087.

47.

Between-Leg Mechanical Differences as Measured by the Bulgarian Split-Squat: Exploring Asymmetries and Relationships with Sprint Acceleration.

Lockie RG, Risso FG, Lazar A, Giuliano DV, Stage AA, Liu TM, Beiley MD, Hurley JM, Torne IA, Stokes JJ, Birmingham-Babauta SA, Davis DL, Orjalo AJ, Moreno MR.

Sports (Basel). 2017 Sep 1;5(3). pii: E65. doi: 10.3390/sports5030065.

48.

An Investigation of the Mechanics and Sticking Region of a One-Repetition Maximum Close-Grip Bench Press versus the Traditional Bench Press.

Lockie RG, Callaghan SJ, Moreno MR, Risso FG, Liu TM, Stage AA, Birmingham-Babauta SA, Stokes JJ, Giuliano DV, Lazar A, Davis DL, Orjalo AJ.

Sports (Basel). 2017 Jun 24;5(3). pii: E46. doi: 10.3390/sports5030046.

49.

Development of a scale quantifying expectations regarding active processes in therapy: The Expectations of Active Processes in Psychotherapy Scale (EAPPS).

Tzur Bitan D, Lazar A, Siton B.

Psychiatry Res. 2018 Sep;267:131-139. doi: 10.1016/j.psychres.2018.05.040. Epub 2018 May 21.

PMID:
29890376
50.

Emergence of an Israel faith-based community organization facilitating live donor kidney transplantation.

Wasser WG, Boner G, Koslowsky M, Lazar A.

BMC Nephrol. 2018 Jun 7;19(1):128. doi: 10.1186/s12882-018-0923-4.

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