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Items: 36

1.

A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis.

Gupta R, Walvekar AS, Liang S, Rashida Z, Shah P, Laxman S.

Elife. 2019 Jul 1;8. pii: e44795. doi: 10.7554/eLife.44795.

2.

Metabolic constraints drive self-organization of specialized cell groups.

Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S.

Elife. 2019 Jun 26;8. pii: e46735. doi: 10.7554/eLife.46735.

3.

Methionine coordinates a hierarchically organized anabolic program enabling proliferation.

Walvekar AS, Srinivasan R, Gupta R, Laxman S.

Mol Biol Cell. 2018 Oct 24:mbcE18080515. doi: 10.1091/mbc.E18-08-0515. [Epub ahead of print]

4.

A versatile LC-MS/MS approach for comprehensive, quantitative analysis of central metabolic pathways.

Walvekar A, Rashida Z, Maddali H, Laxman S.

Wellcome Open Res. 2018 Sep 20;3:122. doi: 10.12688/wellcomeopenres.14832.1. eCollection 2018.

5.

Breast Lump: A Rare Presentation of Tuberculosis.

Kumar RM, Laxman S, Parandekar P.

Int J Appl Basic Med Res. 2018 Jul-Sep;8(3):187-189. doi: 10.4103/ijabmr.IJABMR_238_17.

6.

A minimal "push-pull" bistability model explains oscillations between quiescent and proliferative cell states.

Krishna S, Laxman S.

Mol Biol Cell. 2018 Sep 15;29(19):2243-2258. doi: 10.1091/mbc.E18-01-0017. Epub 2018 Jul 25.

7.

Conceptualizing Eukaryotic Metabolic Sensing and Signaling.

Laxman S.

J Indian Inst Sci. 2017 Mar;97(1):59-77. doi: 10.1007/s41745-016-0013-1. Epub 2017 Mar 22.

8.

Thiol trapping and metabolic redistribution of sulfur metabolites enable cells to overcome cysteine overload.

Deshpande AA, Bhatia M, Laxman S, Bachhawat AK.

Microb Cell. 2017 Mar 27;4(4):112-126. doi: 10.15698/mic2017.04.567.

9.

The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast.

Erkut C, Gade VR, Laxman S, Kurzchalia TV.

Elife. 2016 Apr 19;5. pii: e13614. doi: 10.7554/eLife.13614.

10.

Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.

Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu BP, MacMillan JB, De Brabander JK, Veech RL, Uyeda K.

J Biol Chem. 2016 May 13;291(20):10515-27. doi: 10.1074/jbc.M115.708982. Epub 2016 Mar 16.

11.

Decoding the stem cell quiescence cycle--lessons from yeast for regenerative biology.

Dhawan J, Laxman S.

J Cell Sci. 2015 Dec 15;128(24):4467-74. doi: 10.1242/jcs.177758. Review.

12.

Symmetry Based Automatic Evolution of Clusters: A New Approach to Data Clustering.

Vijendra S, Laxman S.

Comput Intell Neurosci. 2015;2015:796276. doi: 10.1155/2015/796276. Epub 2015 Aug 3.

13.

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.

Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP.

Cell Rep. 2015 Jul 21;12(3):371-9. doi: 10.1016/j.celrep.2015.06.042. Epub 2015 Jul 9.

14.

Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites.

Laxman S, Sutter BM, Shi L, Tu BP.

Sci Signal. 2014 Dec 16;7(356):ra120. doi: 10.1126/scisignal.2005948.

15.

Concerted effort: oscillations in global gene expression during nematode development.

Laxman S, Tu BP, McKnight SL.

Mol Cell. 2014 Feb 6;53(3):363-4. doi: 10.1016/j.molcel.2014.01.023.

16.

Improved multiple sequence alignments using coupled pattern mining.

Hossain KS, Patnaik D, Laxman S, Jain P, Bailey-Kellogg C, Ramakrishnan N.

IEEE/ACM Trans Comput Biol Bioinform. 2013 Sep-Oct;10(5):1098-112. doi: 10.1109/TCBB.2013.36.

PMID:
24384701
17.

Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A.

Laxman S, Sutter BM, Tu BP.

Autophagy. 2014 Feb;10(2):386-7. doi: 10.4161/auto.27485. Epub 2013 Dec 18.

18.

Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation.

Laxman S, Sutter BM, Wu X, Kumar S, Guo X, Trudgian DC, Mirzaei H, Tu BP.

Cell. 2013 Jul 18;154(2):416-29. doi: 10.1016/j.cell.2013.06.043.

19.

Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A.

Sutter BM, Wu X, Laxman S, Tu BP.

Cell. 2013 Jul 18;154(2):403-15. doi: 10.1016/j.cell.2013.06.041.

20.

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.

Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9728-33. doi: 10.1073/pnas.1303220110. Epub 2013 May 28.

21.

Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae.

Laxman S, Tu BP.

PLoS One. 2011;6(10):e26081. doi: 10.1371/journal.pone.0026081. Epub 2011 Oct 17.

22.

Systems approaches for the study of metabolic cycles in yeast.

Laxman S, Tu BP.

Curr Opin Genet Dev. 2010 Dec;20(6):599-604. doi: 10.1016/j.gde.2010.09.008. Epub 2010 Nov 2. Review.

23.

Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters.

Laxman S, Sutter BM, Tu BP.

PLoS One. 2010 Sep 7;5(9):e12595. doi: 10.1371/journal.pone.0012595.

24.

Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents.

Laxman S, Beavo JA.

Mol Interv. 2007 Aug;7(4):203-15. Review.

PMID:
17827441
25.

Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.

Laxman S, Riechers A, Sadilek M, Schwede F, Beavo JA.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19194-9. Epub 2006 Dec 1.

26.

Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi.

Díaz-Benjumea R, Laxman S, Hinds TR, Beavo JA, Rascón A.

Biochem J. 2006 Oct 15;399(2):305-14.

27.

Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature.

Kunz S, Beavo JA, D'Angelo MA, Flawia MM, Francis SH, Johner A, Laxman S, Oberholzer M, Rascon A, Shakur Y, Wentzinger L, Zoraghi R, Seebeck T.

Mol Biochem Parasitol. 2006 Jan;145(1):133-5. Epub 2005 Oct 21. No abstract available.

PMID:
16280178
28.

Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain.

Laxman S, Rascón A, Beavo JA.

J Biol Chem. 2005 Feb 4;280(5):3771-9. Epub 2004 Nov 24.

29.

Incidence of Hb. S and Hb. E in twin cities of Hyderabad and Secunderabad.

Reddi YR, Laxman S, Nagaraj Rao M.

Indian Pediatr. 1978 Jul;15(7):535-6. No abstract available.

PMID:
721275
31.

Cerebrospinal fluid and blood sugar ratio in health and disease: diagnostic and prognostic significance in intracranial infections.

Reddi YR, Rao VS, Parthasaradhi J, Laxman S.

Indian Pediatr. 1975 May;12(5):401-5. No abstract available.

PMID:
1158514
32.

Thalassemias in Andhra Pradesh: a clinical haematologic study.

Reddi YR, Sudhakar Rao V, Niranjan A, Laxman S.

Indian Pediatr. 1975 Feb;12(2):195-6. No abstract available.

PMID:
1158479
33.

Acute intermittent porphyria.

Reddi YR, Raj S, Laxman S, Kusuma G, Rao VS.

Indian Pediatr. 1973 Dec;10(12):743-5. No abstract available.

PMID:
4788857
34.

Alkaptonuria in siblings.

Reddi YR, Rao MN, Laxman S.

Indian J Pediatr. 1973 Sep;40(308):330-1. No abstract available.

PMID:
4784732
35.

Haemoglobinopathy in Andhra Pradesh.

Laxman S, Mathur YC, Chandra H, Reddi YR.

Indian J Pediatr. 1971 Sep;38(284):365-7. No abstract available.

PMID:
5141733
36.

Thalassemia hemoglobin E disease.

Laxman S, Mathur YC, Chandra H.

Indian Pediatr. 1970 Feb;7(2):124-6. No abstract available.

PMID:
5506679

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