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Items: 1 to 50 of 53

1.

Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells.

Ugalde CL, Annesley SJ, Gordon SE, Mroczek K, Perugini MA, Lawson VA, Fisher PR, Finkelstein DI, Hill AF.

Dis Model Mech. 2020 Jan 17;13(1). pii: dmm040899. doi: 10.1242/dmm.040899.

2.

Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease.

Diwakarla S, Finkelstein DI, Constable R, Artaiz O, Di Natale M, McQuade RM, Lei E, Chai XY, Ringuet MT, Fothergill LJ, Lawson VA, Ellett LJ, Berger JP, Furness JB.

Neurogastroenterol Motil. 2019 Nov 10:e13755. doi: 10.1111/nmo.13755. [Epub ahead of print]

PMID:
31709672
3.

The role of lipids in α-synuclein misfolding and neurotoxicity.

Ugalde CL, Lawson VA, Finkelstein DI, Hill AF.

J Biol Chem. 2019 Jun 7;294(23):9016-9028. doi: 10.1074/jbc.REV119.007500. Epub 2019 May 7. Review.

4.

Early existence and biochemical evolution characterise acutely synaptotoxic PrPSc.

Foliaki ST, Lewis V, Islam AMT, Ellett LJ, Senesi M, Finkelstein DI, Roberts B, Lawson VA, Adlard PA, Collins SJ.

PLoS Pathog. 2019 Apr 10;15(4):e1007712. doi: 10.1371/journal.ppat.1007712. eCollection 2019 Apr.

5.

Preparation and Immunostaining of the Myenteric Plexus of Prion-Infected Mice.

Ellett LJ, Lawson VA.

Methods Mol Biol. 2017;1658:285-292. doi: 10.1007/978-1-4939-7244-9_19.

PMID:
28861796
6.

In Vivo-Near Infrared Imaging of Neurodegeneration.

Lawson VA, Tumpach C, Haigh CL, Drew SC.

Methods Mol Biol. 2017;1658:253-262. doi: 10.1007/978-1-4939-7244-9_17.

PMID:
28861794
7.

Prion Diseases.

Whitechurch BC, Welton JM, Collins SJ, Lawson VA.

Adv Neurobiol. 2017;15:335-364. doi: 10.1007/978-3-319-57193-5_13. Review.

PMID:
28674988
8.

Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.

Ugalde CL, Finkelstein DI, Lawson VA, Hill AF.

J Neurochem. 2016 Oct;139(2):162-180. doi: 10.1111/jnc.13772. Epub 2016 Sep 15. Review.

9.

Restoration of intestinal function in an MPTP model of Parkinson's Disease.

Ellett LJ, Hung LW, Munckton R, Sherratt NA, Culvenor J, Grubman A, Furness JB, White AR, Finkelstein DI, Barnham KJ, Lawson VA.

Sci Rep. 2016 Jul 29;6:30269. doi: 10.1038/srep30269.

10.

The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro.

Collins SJ, Tumpach C, Li QX, Lewis V, Ryan TM, Roberts B, Drew SC, Lawson VA, Haigh CL.

Stem Cell Res Ther. 2015 Apr 11;6:60. doi: 10.1186/s13287-015-0067-4.

11.

Glycosaminoglycan sulfation determines the biochemical properties of prion protein aggregates.

Ellett LJ, Coleman BM, Shambrook MC, Johanssen VA, Collins SJ, Masters CL, Hill AF, Lawson VA.

Glycobiology. 2015 Jul;25(7):745-55. doi: 10.1093/glycob/cwv014. Epub 2015 Feb 20.

PMID:
25701659
12.

Blood vessel cell death during prion disease: implications for disease management and infection control.

Haigh CL, Lawson VA, Drew SC.

Exp Hematol. 2014 Nov;42(11):939-40. doi: 10.1016/j.exphem.2014.06.009. Epub 2014 Jul 16. No abstract available.

PMID:
25038450
13.

Pathogenic mutations within the hydrophobic domain of the prion protein lead to the formation of protease-sensitive prion species with increased lethality.

Coleman BM, Harrison CF, Guo B, Masters CL, Barnham KJ, Lawson VA, Hill AF.

J Virol. 2014 Mar;88(5):2690-703. doi: 10.1128/JVI.02720-13. Epub 2013 Dec 18.

14.

Prion infection impairs cholesterol metabolism in neuronal cells.

Cui HL, Guo B, Scicluna B, Coleman BM, Lawson VA, Ellett L, Meikle PJ, Bukrinsky M, Mukhamedova N, Sviridov D, Hill AF.

J Biol Chem. 2014 Jan 10;289(2):789-802. doi: 10.1074/jbc.M113.535807. Epub 2013 Nov 26.

15.

The prion protein preference of sporadic Creutzfeldt-Jakob disease subtypes.

Klemm HM, Welton JM, Masters CL, Klug GM, Boyd A, Hill AF, Collins SJ, Lawson VA.

J Biol Chem. 2012 Oct 19;287(43):36465-72. doi: 10.1074/jbc.M112.368803. Epub 2012 Aug 28.

16.

Prion-infected cells regulate the release of exosomes with distinct ultrastructural features.

Coleman BM, Hanssen E, Lawson VA, Hill AF.

FASEB J. 2012 Oct;26(10):4160-73. doi: 10.1096/fj.11-202077. Epub 2012 Jul 5.

PMID:
22767229
17.

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity.

Lewis V, Haigh CL, Masters CL, Hill AF, Lawson VA, Collins SJ.

Mol Neurodegener. 2012 Apr 26;7:18. doi: 10.1186/1750-1326-7-18.

18.

Gene knockout of tau expression does not contribute to the pathogenesis of prion disease.

Lawson VA, Klemm HM, Welton JM, Masters CL, Crouch P, Cappai R, Ciccotosto GD.

J Neuropathol Exp Neurol. 2011 Nov;70(11):1036-45. doi: 10.1097/NEN.0b013e318235b471.

PMID:
22002429
19.

Acute exposure to prion infection induces transient oxidative stress progressing to be cumulatively deleterious with chronic propagation in vitro.

Haigh CL, McGlade AR, Lewis V, Masters CL, Lawson VA, Collins SJ.

Free Radic Biol Med. 2011 Aug 1;51(3):594-608. doi: 10.1016/j.freeradbiomed.2011.03.035. Epub 2011 Apr 3.

PMID:
21466851
20.

Optical imaging detects apoptosis in the brain and peripheral organs of prion-infected mice.

Drew SC, Haigh CL, Klemm HM, Masters CL, Collins SJ, Barnham KJ, Lawson VA.

J Neuropathol Exp Neurol. 2011 Feb;70(2):143-50. doi: 10.1097/NEN.0b013e3182084a8c.

PMID:
21343883
21.

Near-infrared fluorescence imaging of apoptotic neuronal cell death in a live animal model of prion disease.

Lawson VA, Haigh CL, Roberts B, Kenche VB, Klemm HM, Masters CL, Collins SJ, Barnham KJ, Drew SC.

ACS Chem Neurosci. 2010 Nov 17;1(11):720-7. doi: 10.1021/cn100068x. Epub 2010 Sep 30.

22.

The brain to gut pathway: a possible route of prion transmission.

Lawson VA, Furness JB, Klemm HM, Pontell L, Chan E, Hill AF, Chiocchetti R.

Gut. 2010 Dec;59(12):1643-51. doi: 10.1136/gut.2010.222620.

PMID:
21071583
23.

Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein.

Lawson VA, Lumicisi B, Welton J, Machalek D, Gouramanis K, Klemm HM, Stewart JD, Masters CL, Hoke DE, Collins SJ, Hill AF.

PLoS One. 2010 Aug 23;5(8):e12351. doi: 10.1371/journal.pone.0012351.

24.

Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection: insight from the resistance of rabbits to prion disease.

Nisbet RM, Harrison CF, Lawson VA, Masters CL, Cappai R, Hill AF.

J Virol. 2010 Jul;84(13):6678-86. doi: 10.1128/JVI.02709-09. Epub 2010 Apr 28.

25.

Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity.

Harrison CF, Lawson VA, Coleman BM, Kim YS, Masters CL, Cappai R, Barnham KJ, Hill AF.

J Biol Chem. 2010 Jun 25;285(26):20213-23. doi: 10.1074/jbc.M109.093310. Epub 2010 Mar 31.

26.

Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection.

Lewis V, Hill AF, Haigh CL, Klug GM, Masters CL, Lawson VA, Collins SJ.

J Neuropathol Exp Neurol. 2009 Oct;68(10):1125-35. doi: 10.1097/NEN.0b013e3181b96981.

PMID:
19918124
27.

PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site.

Haigh CL, Lewis VA, Vella LJ, Masters CL, Hill AF, Lawson VA, Collins SJ.

Cell Res. 2009 Sep;19(9):1062-78. doi: 10.1038/cr.2009.86. Epub 2009 Jul 14.

PMID:
19597535
28.

Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.

Haigh CL, Drew SC, Boland MP, Masters CL, Barnham KJ, Lawson VA, Collins SJ.

J Cell Sci. 2009 May 15;122(Pt 10):1518-28. doi: 10.1242/jcs.043604. Epub 2009 Apr 21.

29.

Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture.

Lawson VA, Vella LJ, Stewart JD, Sharples RA, Klemm H, Machalek DM, Masters CL, Cappai R, Collins SJ, Hill AF.

Int J Biochem Cell Biol. 2008;40(12):2793-801. doi: 10.1016/j.biocel.2008.05.024. Epub 2008 Jun 11.

PMID:
18590830
30.

Quantitative bioassay of surface-bound prion infectivity.

Lawson VA.

Methods Mol Biol. 2008;459:265-73. doi: 10.1007/978-1-59745-234-2_18.

PMID:
18576161
31.

Understanding the nature of prion diseases using cell-free assays.

Lawson VA.

Methods Mol Biol. 2008;459:97-103. doi: 10.1007/978-1-59745-234-2_7. Review.

PMID:
18576150
32.

Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine.

Albanese V, Lawson VA, Hill AF, Cappai R, Di Guardo G, Staikopoulos V, Thacker M, Furness JB, Chiocchetti R.

Auton Neurosci. 2008 Jun;140(1-2):17-23. doi: 10.1016/j.autneu.2008.01.008. Epub 2008 Mar 20.

PMID:
18358791
34.

Viral phenotypes and antibody responses in long-term survivors infected with attenuated human immunodeficiency virus type 1 containing deletions in the nef and long terminal repeat regions.

Verity EE, Zotos D, Wilson K, Chatfield C, Lawson VA, Dwyer DE, Cunningham A, Learmont J, Dyer W, Sullivan J, Churchill M, Wesselingh SL, Gabuzda D, Gorry PR, McPhee DA.

J Virol. 2007 Sep;81(17):9268-78. Epub 2007 Jun 13.

35.

Packaging of prions into exosomes is associated with a novel pathway of PrP processing.

Vella LJ, Sharples RA, Lawson VA, Masters CL, Cappai R, Hill AF.

J Pathol. 2007 Apr;211(5):582-90.

PMID:
17334982
36.

Correlative studies support lipid peroxidation is linked to PrP(res) propagation as an early primary pathogenic event in prion disease.

Brazier MW, Lewis V, Ciccotosto GD, Klug GM, Lawson VA, Cappai R, Ironside JW, Masters CL, Hill AF, White AR, Collins S.

Brain Res Bull. 2006 Jan 30;68(5):346-54. Epub 2005 Oct 5.

PMID:
16377442
37.

Extended period of asymptomatic prion disease after low dose inoculation: assessment of detection methods and implications for infection control.

Collins SJ, Lewis V, Brazier MW, Hill AF, Lawson VA, Klug GM, Masters CL.

Neurobiol Dis. 2005 Nov;20(2):336-46.

PMID:
16242640
38.

Prion protein glycosylation.

Lawson VA, Collins SJ, Masters CL, Hill AF.

J Neurochem. 2005 May;93(4):793-801. Review.

40.
41.

Transmissible spongiform encephalopathies.

Collins SJ, Lawson VA, Masters CL.

Lancet. 2004 Jan 3;363(9402):51-61. Review.

PMID:
14723996
42.

Gender, migration and the organisation of work under economic devolution: Ecuador, 1982-90.

Brown LA, Pavri F, Lawson VA.

Int J Popul Geogr. 1998 Sep;4(3):259-74.

PMID:
12321833
43.
44.

Adaptive changes after human immunodeficiency virus type 1 transmission.

Lawson VA, Oelrichs R, Guillon C, Imrie AA, Cooper DA, Deacon NJ, McPhee DA.

AIDS Res Hum Retroviruses. 2002 May 20;18(8):545-56.

PMID:
12036484
45.
46.

N-terminal truncation of prion protein affects both formation and conformation of abnormal protease-resistant prion protein generated in vitro.

Lawson VA, Priola SA, Wehrly K, Chesebro B.

J Biol Chem. 2001 Sep 21;276(38):35265-71. Epub 2001 Jul 20.

47.

Rapid full-length genomic sequencing of two cytopathically heterogeneous Australian primary HIV-1 isolates.

Oelrichs RB, Lawson VA, Coates KM, Chatfield C, Deacon NJ, McPhee DA.

J Biomed Sci. 2000 Mar-Apr;7(2):128-35.

PMID:
10754387
48.

Visualisation of phenotypically mixed HIV-1 and HTLV-I virus particles by electron microscopy.

Lawson VA, Lee JY, Doultree JC, Marshall JA, McPhee DA.

J Biomed Sci. 2000 Jan-Feb;7(1):71-4.

PMID:
10644892
49.

Elimination of sequence ambiguities by a single-step modification of a solid-phase, single-stranded sequencing protocol.

Lawson VA, McPhee DA, Deacon NJ.

Biotechniques. 1996 Sep;21(3):356-8. No abstract available.

50.

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients.

Deacon NJ, Tsykin A, Solomon A, Smith K, Ludford-Menting M, Hooker DJ, McPhee DA, Greenway AL, Ellett A, Chatfield C, Lawson VA, Crowe S, Maerz A, Sonza S, Learmont J, Sullivan JS, Cunningham A, Dwyer D, Dowton D, Mills J.

Science. 1995 Nov 10;270(5238):988-91.

PMID:
7481804

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