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Biphenyl Acid Derivatives as APJ Receptor Agonists.

Su S, Clarke A, Han Y, Chao HJ, Bostwick J, Schumacher W, Wang T, Yan M, Hsu MY, Simmons E, Luk C, Xu C, Dabros M, Galella M, Onorato J, Gordon D, Wexler R, Gargalovic PS, Lawrence RM.

J Med Chem. 2019 Nov 14. doi: 10.1021/acs.jmedchem.9b01513. [Epub ahead of print]


Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs.

Wang Y, Dix MM, Bianco G, Remsberg JR, Lee HY, Kalocsay M, Gygi SP, Forli S, Vite G, Lawrence RM, Parker CG, Cravatt BF.

Nat Chem. 2019 Oct 28. doi: 10.1038/s41557-019-0351-5. [Epub ahead of print]


Biographical films as a person-centered approach to reduce neuropsychiatric symptoms of dementia in residential care: A feasibility study.

Francis ER, Smith JG, Qayyum M, Lee J, Woodgate P, Lawrence RM.

J Clin Psychol. 2019 Aug 30. doi: 10.1002/jclp.22853. [Epub ahead of print]


Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.

Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A.

J Med Chem. 2019 Aug 22;62(16):7400-7416. doi: 10.1021/acs.jmedchem.9b00186. Epub 2019 Aug 5.


Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.

Finlay HJ, Jiang J, Rampulla R, Salvati ME, Qiao JX, Wang TC, Lawrence RM, Harikrishnan LS, Kamau MG, Taylor DS, Chen AYA, Yin X, Huang CS, Chang M, Chen XQ, Sleph PG, Xu C, Li J, Levesque P, Adam LP, Wexler RR.

ACS Med Chem Lett. 2019 May 6;10(6):911-916. doi: 10.1021/acsmedchemlett.9b00086. eCollection 2019 Jun 13.


Intravenous Immunoglobulin as a Therapeutic Option for Mycoplasma pneumoniae Encephalitis.

Daba M, Kang PB, Sladky J, Bidari SS, Lawrence RM, Ghosh S.

J Child Neurol. 2019 Oct;34(11):687-691. doi: 10.1177/0883073819854854. Epub 2019 Jun 11.


Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents.

Onorato JM, Xu C, Chen XQ, Rose AV, Generaux C, Lentz K, Shipkova P, Arthur S, Hennan JK, Haskell R, Myers MC, Lawrence RM, Finlay HJ, Basso M, Bostwick J, Fernando G, Garcia R, Hellings S, Hsu MY, Zhang R, Zhao L, Gargalovic P.

Anal Biochem. 2019 Mar 1;568:41-50. doi: 10.1016/j.ab.2018.12.022. Epub 2018 Dec 31.


Safety of a 2-Day Antibiotic Regimen After Delayed Chest Closure Post Pediatric Cardiac Surgery.

Philip J, Kegg C, Lopez-Colon D, Kelly BJ, Lawrence RM, Robinson MA, Samraj RS, Bleiweis MS.

J Intensive Care Med. 2018 Aug 8:885066618792849. doi: 10.1177/0885066618792849. [Epub ahead of print]


PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.

Hangeland JJ, Abell LM, Adam LP, Jiang J, Friends TJ, Haque LE, Neels J, Onorato JM, Chen AYA, Taylor DS, Yin X, Harrity TW, Basso MD, Yang R, Sleph PG, Gordon DA, Huang CS, Wexler RR, Finlay HJ, Lawrence RM.

ACS Med Chem Lett. 2018 Jun 15;9(7):673-678. doi: 10.1021/acsmedchemlett.8b00138. eCollection 2018 Jul 12.


Corrigendum: Diffraction data of core-shell nanoparticles from an X-ray free electron laser.

Li X, Chiu CY, Wang HJ, Kassemeyer S, Botha S, Shoeman RL, Lawrence RM, Kupitz C, Kirian R, James D, Wang D, Nelson G, Messerschmidt M, Boutet S, Williams GJ, Hartmann E, Jafarpour A, Foucar LM, Barty A, Chapman H, Liang M, Menzel A, Wang F, Basu S, Fromme R, Doak RB, Fromme P, Weierstall U, Huang MH, Spence JCH, Schlichting I, Hogue BG, Liu H.

Sci Data. 2017 Oct 24;4:170154. doi: 10.1038/sdata.2017.154.


Innate Immunity and Breast Milk.

Cacho NT, Lawrence RM.

Front Immunol. 2017 May 29;8:584. doi: 10.3389/fimmu.2017.00584. eCollection 2017. Review.


Diffraction data of core-shell nanoparticles from an X-ray free electron laser.

Li X, Chiu CY, Wang HJ, Kassemeyer S, Botha S, Shoeman RL, Lawrence RM, Kupitz C, Kirian R, James D, Wang D, Nelson G, Messerschmidt M, Boutet S, Williams GJ, Hartmann E, Jafarpour A, Foucar LM, Barty A, Chapman H, Liang M, Menzel A, Wang F, Basu S, Fromme R, Doak RB, Fromme P, Weierstall U, Huang MH, Spence JC, Schlichting I, Hogue BG, Liu H.

Sci Data. 2017 Apr 11;4:170048. doi: 10.1038/sdata.2017.48. Erratum in: Sci Data. 2017 Oct 24;4:170154.


Ligand and Target Discovery by Fragment-Based Screening in Human Cells.

Parker CG, Galmozzi A, Wang Y, Correia BE, Sasaki K, Joslyn CM, Kim AS, Cavallaro CL, Lawrence RM, Johnson SR, Narvaiza I, Saez E, Cravatt BF.

Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.


Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.

Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J.

Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf5294. doi: 10.1126/scitranslmed.aaf5294.


Full inactivation of alphaviruses in single particle and crystallized forms.

Lawrence RM, Zook JD, Hogue BG.

J Virol Methods. 2016 Oct;236:237-244. doi: 10.1016/j.jviromet.2016.07.020. Epub 2016 Jul 25.


Characterization of monoacylglycerol acyltransferase 2 inhibitors by a novel probe in binding assays.

Ma Z, Chao HJ, Turdi H, Hangeland JJ, Friends T, Kopcho LM, Lawrence RM, Cheng D.

Anal Biochem. 2016 May 15;501:48-55. doi: 10.1016/j.ab.2016.02.012. Epub 2016 Feb 27.


Concentration of Sindbis virus with optimized gradient insulator-based dielectrophoresis.

Ding J, Lawrence RM, Jones PV, Hogue BG, Hayes MA.

Analyst. 2016 Mar 21;141(6):1997-2008. doi: 10.1039/c5an02430g.


Serial femtosecond X-ray diffraction of enveloped virus microcrystals.

Lawrence RM, Conrad CE, Zatsepin NA, Grant TD, Liu H, James D, Nelson G, Subramanian G, Aquila A, Hunter MS, Liang M, Boutet S, Coe J, Spence JC, Weierstall U, Liu W, Fromme P, Cherezov V, Hogue BG.

Struct Dyn. 2015 Aug 20;2(4):041720. doi: 10.1063/1.4929410. eCollection 2015 Jul.


Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).

Qiao JX, Wang TC, Adam LP, Chen AY, Taylor DS, Yang RZ, Zhuang S, Sleph PG, Li JP, Li D, Yin X, Chang M, Chen XQ, Shen H, Li J, Smith D, Wu DR, Leith L, Harikrishnan LS, Kamau MG, Miller MM, Bilder D, Rampulla R, Li YX, Xu C, Lawrence RM, Poss MA, Levesque P, Gordon DA, Huang CS, Finlay HJ, Wexler RR, Salvati ME.

J Med Chem. 2015 Nov 25;58(22):9010-26. doi: 10.1021/acs.jmedchem.5b01363. Epub 2015 Nov 17.


Review article: BK virus in systemic lupus erythematosus.

Gupta N, Lawrence RM, Nguyen C, Modica RF.

Pediatr Rheumatol Online J. 2015 Aug 21;13:34. doi: 10.1186/s12969-015-0033-9. Review.


Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS.

Onorato JM, Chu CH, Ma Z, Kopcho LM, Chao HJ, Lawrence RM, Cheng D.

J Lipid Res. 2015 Mar;56(3):747-53. doi: 10.1194/jlr.D055020. Epub 2015 Jan 18.


Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1.

Lee HH, Cherni I, Yu H, Fromme R, Doran JD, Grotjohann I, Mittman M, Basu S, Deb A, Dörner K, Aquila A, Barty A, Boutet S, Chapman HN, Doak RB, Hunter MS, James D, Kirian RA, Kupitz C, Lawrence RM, Liu H, Nass K, Schlichting I, Schmidt KE, Seibert MM, Shoeman RL, Spence JC, Stellato F, Weierstall U, Williams GJ, Yoon C, Wang D, Zatsepin NA, Hogue BG, Matoba N, Fromme P, Mor TS.

IUCrJ. 2014 Aug 20;1(Pt 5):305-17. doi: 10.1107/S2052252514014900. eCollection 2014 Sep 1.


1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity.

Khandelwal P, Stryker S, Chao H, Aranibar N, Lawrence RM, Madireddi M, Zhao W, Chen L, Reily MD.

J Lipid Res. 2014 Jul;55(7):1366-74. doi: 10.1194/jlr.M049155. Epub 2014 Apr 22.


Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors.

Wang Y, Yang W, Finlay HJ, Harikrishnan LS, Jiang J, Kamau MG, Van Kirk K, Nirschl DS, Taylor DS, Chen AY, Yin X, Sleph PG, Yang RZ, Huang CS, Adam LP, Lawrence RM, Wexler RR, Salvati ME.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):860-4. doi: 10.1016/j.bmcl.2013.12.088. Epub 2014 Jan 6.


B-Cell depletion and immunomodulation before initiation of enzyme replacement therapy blocks the immune response to acid alpha-glucosidase in infantile-onset Pompe disease.

Elder ME, Nayak S, Collins SW, Lawson LA, Kelley JS, Herzog RW, Modica RF, Lew J, Lawrence RM, Byrne BJ.

J Pediatr. 2013 Sep;163(3):847-54.e1. doi: 10.1016/j.jpeds.2013.03.002. Epub 2013 Apr 16.


Examining the evidence, seeking solutions.

Lawrence RM.

Breastfeed Med. 2013 Apr;8:147-8. doi: 10.1089/bfm.2013.9995. Epub 2013 Mar 6. No abstract available.


Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.

Chao H, Turdi H, Herpin TF, Roberge JY, Liu Y, Schnur DM, Poss MA, Rehfuss R, Hua J, Wu Q, Price LA, Abell LM, Schumacher WA, Bostwick JS, Steinbacher TE, Stewart AB, Ogletree ML, Huang CS, Chang M, Cacace AM, Arcuri MJ, Celani D, Wexler RR, Lawrence RM.

J Med Chem. 2013 Feb 28;56(4):1704-14. doi: 10.1021/jm301708u. Epub 2013 Feb 18.


Circumstances when breastfeeding is contraindicated.

Lawrence RM.

Pediatr Clin North Am. 2013 Feb;60(1):295-318. doi: 10.1016/j.pcl.2012.09.012. Epub 2012 Oct 30. Review.


Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors.

Miller MM, Liu Y, Jiang J, Johnson JA, Kamau M, Nirschl DS, Wang Y, Harikrishnan L, Taylor DS, Chen AY, Yin X, Seethala R, Peterson TL, Zvyaga T, Zhang J, Huang CS, Wexler RR, Poss MA, Lawrence RM, Adam LP, Salvati ME.

Bioorg Med Chem Lett. 2012 Oct 15;22(20):6503-8. doi: 10.1016/j.bmcl.2012.08.011. Epub 2012 Aug 9.


Infected urachal cyst--an uncommon cause for incessant cry in newborns.

Lawrence RM, Chandrasekhar G.

Indian Pediatr. 2012 May;49(5):418. No abstract available.


Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.

Harikrishnan LS, Finlay HJ, Qiao JX, Kamau MG, Jiang J, Wang TC, Li J, Cooper CB, Poss MA, Adam LP, Taylor DS, Chen AY, Yin X, Sleph PG, Yang RZ, Sitkoff DF, Galella MA, Nirschl DS, Van Kirk K, Miller AV, Huang CS, Chang M, Chen XQ, Salvati ME, Wexler RR, Lawrence RM.

J Med Chem. 2012 Jul 12;55(13):6162-75. doi: 10.1021/jm300611v. Epub 2012 Jun 22.


Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors.

Shi Y, O'Connor SP, Sitkoff D, Zhang J, Shi M, Bisaha SN, Wang Y, Li C, Ruan Z, Lawrence RM, Klei HE, Kish K, Liu EC, Seiler SM, Schweizer L, Steinbacher TE, Schumacher WA, Robl JA, Macor JE, Atwal KS, Stein PD.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7516-21. doi: 10.1016/j.bmcl.2011.06.098. Epub 2011 Jun 28.


Sensitive detection of BCR-ABL1 mutations in patients with chronic myeloid leukemia after imatinib resistance is predictive of outcome during subsequent therapy.

Parker WT, Lawrence RM, Ho M, Irwin DL, Scott HS, Hughes TP, Branford S.

J Clin Oncol. 2011 Nov 10;29(32):4250-9. doi: 10.1200/JCO.2011.35.0934. Epub 2011 Oct 11.


Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy.

Roongta UV, Pabalan JG, Wang X, Ryseck RP, Fargnoli J, Henley BJ, Yang WP, Zhu J, Madireddi MT, Lawrence RM, Wong TW, Rupnow BA.

Mol Cancer Res. 2011 Nov;9(11):1551-61. doi: 10.1158/1541-7786.MCR-11-0126. Epub 2011 Sep 27.


Breastfeeding: more than just good nutrition.

Lawrence RM, Lawrence RA.

Pediatr Rev. 2011 Jul;32(7):267-80. doi: 10.1542/pir.32-7-267. Review. No abstract available.


Piloting behavioral family systems therapy to improve adherence among adolescents with HIV: a case series intervention study.

Gray WN, Janicke DM, Fennell EB, Driscoll DC, Lawrence RM.

J Health Psychol. 2011 Jul;16(5):828-42. doi: 10.1177/1359105310394230. Epub 2011 Mar 25.


Recombinant production and purification of the subunit c of chloroplast ATP synthase.

Lawrence RM, Varco-Merth B, Bley CJ, Chen JJ, Fromme P.

Protein Expr Purif. 2011 Mar;76(1):15-24. doi: 10.1016/j.pep.2010.10.009. Epub 2010 Oct 30.


Genetic determinants in HIV-1 Gag and Env V3 are related to viral response to combination antiretroviral therapy with a protease inhibitor.

Ho SK, Perez EE, Rose SL, Coman RM, Lowe AC, Hou W, Ma C, Lawrence RM, Dunn BM, Sleasman JW, Goodenow MM.

AIDS. 2009 Aug 24;23(13):1631-40. doi: 10.1097/QAD.0b013e32832e0599.


Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.

O'Neill PM, Park BK, Shone AE, Maggs JL, Roberts P, Stocks PA, Biagini GA, Bray PG, Gibbons P, Berry N, Winstanley PA, Mukhtar A, Bonar-Law R, Hindley S, Bambal RB, Davis CB, Bates M, Hart TK, Gresham SL, Lawrence RM, Brigandi RA, Gomez-delas-Heras FM, Gargallo DV, Ward SA.

J Med Chem. 2009 Mar 12;52(5):1408-15. doi: 10.1021/jm8012618.


Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker.

Roberge JY, Harikrishnan LS, Kamau MG, Ruan Z, Van Kirk K, Liu Y, Cooper CB, Poss MA, Dickson JK Jr, Gavai AV, Chao ST, Leith LW, Bednarz MS, Mathur A, Kakarla R, Schnur DM, Vaz R, Lawrence RM.

J Comb Chem. 2009 Jan-Feb;11(1):72-82. doi: 10.1021/cc800051u.


A simple homogeneous scintillation proximity assay for acyl-coenzyme A:diacylglycerol acyltransferase.

Seethala R, Peterson T, Dong J, Chu CH, Chen L, Golla R, Ma Z, Panemangalore R, Lawrence RM, Cheng D.

Anal Biochem. 2008 Dec 15;383(2):144-50. doi: 10.1016/j.ab.2008.09.013. Epub 2008 Sep 15.


Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption.

Cheng D, Iqbal J, Devenny J, Chu CH, Chen L, Dong J, Seethala R, Keim WJ, Azzara AV, Lawrence RM, Pelleymounter MA, Hussain MM.

J Biol Chem. 2008 Oct 31;283(44):29802-11. doi: 10.1074/jbc.M800494200. Epub 2008 Sep 3.


Effects of sepsis on neonatal thrombopoiesis.

Brown RE, Rimsza LM, Pastos K, Young L, Saxonhouse MA, Bailey M, Lawrence RM, Sola-Visner MC.

Pediatr Res. 2008 Oct;64(4):399-404. doi: 10.1203/PDR.0b013e318181ad49.


Reactivity of cyclic sulfamidates towards phosphonate-stabilised enolates: synthesis and applications of alpha-phosphono lactams.

Bower JF, Williams AJ, Woodward HL, Szeto P, Lawrence RM, Gallagher T.

Org Biomol Chem. 2007 Aug 21;5(16):2636-44.


Cytomegalovirus in human breast milk: risk to the premature infant.

Lawrence RM.

Breastfeed Med. 2006 Summer;1(2):99-107. Review.


2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors.

Li JJ, Wang H, Tino JA, Robl JA, Herpin TF, Lawrence RM, Biller S, Jamil H, Ponticiello R, Chen L, Chu CH, Flynn N, Cheng D, Zhao R, Chen B, Schnur D, Obermeier MT, Sasseville V, Padmanabha R, Pike K, Harrity T.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11. Epub 2007 Mar 12.


Human breast milk: current concepts of immunology and infectious diseases.

Lawrence RM, Pane CA.

Curr Probl Pediatr Adolesc Health Care. 2007 Jan;37(1):7-36. Review. No abstract available.


Clinicians' attitudes to spirituality in old age psychiatry.

Lawrence RM, Head J, Christodoulou G, Andonovska B, Karamat S, Duggal A, Hillam J, Eagger S.

Int Psychogeriatr. 2007 Oct;19(5):962-73. Epub 2006 Oct 4.


High throughput screening identified a substituted imidazole as a novel RANK pathway-selective osteoclastogenesis inhibitor.

Chen T, Knapp AC, Wu Y, Huang J, Lynch JS, Dickson JK Jr, Lawrence RM, Feyen JH, Agler ML.

Assay Drug Dev Technol. 2006 Aug;4(4):387-96.


A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice.

Kang L, McIntyre KW, Gillooly KM, Yang Y, Haycock J, Roberts S, Khanna A, Herpin TF, Yu G, Wu X, Morton GC, Tuerdi H, Koplowitz B, Walker SG, Wardwell-Swanson J, Macor JE, Lawrence RM, Carlson KE.

J Leukoc Biol. 2006 Oct;80(4):897-904. Epub 2006 Aug 3.


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