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Items: 1 to 50 of 414

1.

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress.

Shemorry A, Harnoss JM, Guttman O, Marsters SA, Kőműves LG, Lawrence DA, Ashkenazi A.

Elife. 2019 Aug 27;8. pii: e47084. doi: 10.7554/eLife.47084.

2.

Disruption of IRE1α through its kinase domain attenuates multiple myeloma.

Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16420-16429. doi: 10.1073/pnas.1906999116. Epub 2019 Aug 1.

3.

The cationic (calcium and lead) and enzyme conundrum.

Kasten-Jolly J, Lawrence DA.

J Toxicol Environ Health B Crit Rev. 2018;21(6-8):400-413. doi: 10.1080/10937404.2019.1592728. Epub 2019 Mar 27. Review.

PMID:
30917763
4.

PAI-1 augments mucosal damage in colitis.

Kaiko GE, Chen F, Lai CW, Chiang IL, Perrigoue J, Stojmirović A, Li K, Muegge BD, Jain U, VanDussen KL, Goggins BJ, Keely S, Weaver J, Foster PS, Lawrence DA, Liu TC, Stappenbeck TS.

Sci Transl Med. 2019 Mar 6;11(482). pii: eaat0852. doi: 10.1126/scitranslmed.aat0852.

PMID:
30842312
5.

CpaA Is a Glycan-Specific Adamalysin-like Protease Secreted by Acinetobacter baumannii That Inactivates Coagulation Factor XII.

Waack U, Warnock M, Yee A, Huttinger Z, Smith S, Kumar A, Deroux A, Ginsburg D, Mobley HLT, Lawrence DA, Sandkvist M.

MBio. 2018 Dec 18;9(6). pii: e01606-18. doi: 10.1128/mBio.01606-18.

6.

Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate.

Reinke AA, Li SH, Warnock M, Shaydakov ME, Guntaka NS, Su EJ, Diaz JA, Emal CD, Lawrence DA.

J Biol Chem. 2019 Feb 1;294(5):1464-1477. doi: 10.1074/jbc.RA118.004885. Epub 2018 Dec 3.

PMID:
30510136
7.

Wheeze and Food Allergies in Children Born via Cesarean Delivery: The Upstate KIDS Study.

Adeyeye TE, Yeung EH, McLain AC, Lin S, Lawrence DA, Bell EM.

Am J Epidemiol. 2019 Feb 1;188(2):355-362. doi: 10.1093/aje/kwy257.

PMID:
30475936
8.

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.

Chang TK, Lawrence DA, Lu M, Tan J, Harnoss JM, Marsters SA, Liu P, Sandoval W, Martin SE, Ashkenazi A.

Mol Cell. 2018 Aug 16;71(4):629-636.e5. doi: 10.1016/j.molcel.2018.06.038.

9.

Characterization of Tissue Plasminogen Activator Expression and Trafficking in the Adult Murine Brain.

Stevenson TK, Lawrence DA.

eNeuro. 2018 Aug 6;5(4). pii: ENEURO.0119-18.2018. doi: 10.1523/ENEURO.0119-18.2018. eCollection 2018 Jul-Aug.

10.

Update on the electrolytic IVC model for pre-clinical studies of venous thrombosis.

Palmer OR, Shaydakov ME, Rainey JP, Lawrence DA, Greve JM, Diaz JA.

Res Pract Thromb Haemost. 2018 Jan 31;2(2):266-273. doi: 10.1002/rth2.12074. eCollection 2018 Apr.

11.

Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress.

Lam M, Lawrence DA, Ashkenazi A, Walter P.

Cell Death Differ. 2018 Aug;25(8):1530-1531. doi: 10.1038/s41418-018-0155-y. Epub 2018 Jul 10.

12.

Concentrations of immune marker in newborn dried blood spots and early childhood development: Results from the Upstate KIDS Study.

Ghassabian A, Sundaram R, Chahal N, McLain AC, Bell EM, Lawrence DA, Gilman SE, Yeung EH.

Paediatr Perinat Epidemiol. 2018 Jul;32(4):337-345. doi: 10.1111/ppe.12485. Epub 2018 Jul 4.

PMID:
29972605
13.

Upregulation of P2Y2R, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome.

Bondu V, Bitting C, Poland VL, Hanson JA, Harkins MS, Lathrop S, Nolte KB, Lawrence DA, Buranda T.

Front Cell Infect Microbiol. 2018 May 23;8:169. doi: 10.3389/fcimb.2018.00169. eCollection 2018.

14.

Newborn adipokines and early childhood growth.

Yeung EH, Sundaram R, Xie Y, Lawrence DA.

Pediatr Obes. 2018 Aug;13(8):505-513. doi: 10.1111/ijpo.12283. Epub 2018 May 20.

15.

Traumatic Brain Injury Leads to Accelerated Atherosclerosis in Apolipoprotein E Deficient Mice.

Wang J, Su E, Wang H, Guo C, Lawrence DA, Eitzman DT.

Sci Rep. 2018 Apr 4;8(1):5639. doi: 10.1038/s41598-018-23959-2.

16.

Plasminogen Activator Inhibitor-1 Reduces Tissue-Type Plasminogen Activator-Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose.

Pant A, Kopec AK, Baker KS, Cline-Fedewa H, Lawrence DA, Luyendyk JP.

Am J Pathol. 2018 May;188(5):1204-1212. doi: 10.1016/j.ajpath.2018.01.010. Epub 2018 Feb 16.

17.

From Infections to Anthropogenic Inflicted Pathologies: Involvement of Immune Balance.

Lee F, Lawrence DA.

J Toxicol Environ Health B Crit Rev. 2018;21(1):24-46. doi: 10.1080/10937404.2017.1412212. Epub 2017 Dec 18. Review.

PMID:
29252129
18.

Sex-specific effects of developmental lead exposure on the immune-neuroendocrine network.

Kasten-Jolly J, Lawrence DA.

Toxicol Appl Pharmacol. 2017 Nov 1;334:142-157. doi: 10.1016/j.taap.2017.09.009. Epub 2017 Sep 11. Review.

PMID:
28911972
19.

Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo.

Bohannon KP, Bittner MA, Lawrence DA, Axelrod D, Holz RW.

J Gen Physiol. 2017 Oct 2;149(10):921-934. doi: 10.1085/jgp.201711842. Epub 2017 Sep 7.

20.

Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.

Su EJ, Cao C, Fredriksson L, Nilsson I, Stefanitsch C, Stevenson TK, Zhao J, Ragsdale M, Sun YY, Yepes M, Kuan CY, Eriksson U, Strickland DK, Lawrence DA, Zhang L.

Acta Neuropathol. 2017 Oct;134(4):585-604. doi: 10.1007/s00401-017-1749-z. Epub 2017 Jul 19.

21.

Determinants of neonatal brain-derived neurotrophic factor and association with child development.

Ghassabian A, Sundaram R, Chahal N, McLain AC, Bell E, Lawrence DA, Yeung EH.

Dev Psychopathol. 2017 Oct;29(4):1499-1511. doi: 10.1017/S0954579417000414. Epub 2017 May 2.

22.

Maternal Smoking and Newborn Cytokine and Immunoglobulin Levels.

Chahal N, McLain AC, Ghassabian A, Michels KA, Bell EM, Lawrence DA, Yeung EH.

Nicotine Tob Res. 2017 Jul 1;19(7):789-796. doi: 10.1093/ntr/ntw324.

23.

Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1.

Pautus S, Alami M, Adam F, Bernadat G, Lawrence DA, De Carvalho A, Ferry G, Rupin A, Hamze A, Champy P, Bonneau N, Gloanec P, Peglion JL, Brion JD, Bianchini EP, Borgel D.

Sci Rep. 2016 Nov 23;6:36462. doi: 10.1038/srep36462.

24.

Impact of parental obesity on neonatal markers of inflammation and immune response.

Broadney MM, Chahal N, Michels KA, McLain AC, Ghassabian A, Lawrence DA, Yeung EH.

Int J Obes (Lond). 2017 Jan;41(1):30-37. doi: 10.1038/ijo.2016.187. Epub 2016 Oct 26.

25.

Editorial: The Role of the Plasminogen Activating System in Neurobiology.

Medcalf RL, Lawrence DA.

Front Cell Neurosci. 2016 Oct 4;10:222. eCollection 2016. No abstract available.

26.

tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS.

Fredriksson L, Lawrence DA, Medcalf RL.

Semin Thromb Hemost. 2017 Mar;43(2):154-168. doi: 10.1055/s-0036-1586229. Epub 2016 Sep 27. Review.

27.

Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders.

Lewandowski SA, Fredriksson L, Lawrence DA, Eriksson U.

Pharmacol Ther. 2016 Nov;167:108-119. doi: 10.1016/j.pharmthera.2016.07.016. Epub 2016 Aug 12. Review.

28.

Imaging characteristics of cervical spine extra-arachnoid fluid collections managed conservatively.

Lawrence DA, Trotta B, Shen FH, Druzgal JT, Fox MG.

Skeletal Radiol. 2016 Sep;45(9):1285-9. doi: 10.1007/s00256-016-2428-1. Epub 2016 Jul 5.

PMID:
27380319
29.

Neuroserpin Differentiates Between Forms of Tissue Type Plasminogen Activator via pH Dependent Deacylation.

Carlson KS, Nguyen L, Schwartz K, Lawrence DA, Schwartz BS.

Front Cell Neurosci. 2016 Jun 15;10:154. doi: 10.3389/fncel.2016.00154. eCollection 2016.

30.

Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures.

Kremer JM, Lawrence DA, Hamilton R, McInnes IB.

RMD Open. 2016 Jun 9;2(1):e000287. doi: 10.1136/rmdopen-2016-000287. eCollection 2016.

31.

Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains.

Szabo R, Samson AL, Lawrence DA, Medcalf RL, Bugge TH.

J Thromb Haemost. 2016 Aug;14(8):1618-28. doi: 10.1111/jth.13338. Epub 2016 Jun 20.

32.

Prevalence of asymptomatic chondrocalcinosis in the pelvis.

Stensby JD, Lawrence DA, Patrie JT, Gaskin CM.

Skeletal Radiol. 2016 Jul;45(7):949-54. doi: 10.1007/s00256-016-2376-9. Epub 2016 Apr 2.

PMID:
27037810
33.

Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.

Lewandowski SA, Nilsson I, Fredriksson L, Lönnerberg P, Muhl L, Zeitelhofer M, Adzemovic MZ, Nichterwitz S, Lawrence DA, Hedlund E, Eriksson U.

Acta Neuropathol. 2016 Mar;131(3):453-64. doi: 10.1007/s00401-015-1520-2. Epub 2015 Dec 19.

34.

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

Motley MP, Madsen DH, Jürgensen HJ, Spencer DE, Szabo R, Holmbeck K, Flick MJ, Lawrence DA, Castellino FJ, Weigert R, Bugge TH.

Blood. 2016 Mar 3;127(9):1085-96. doi: 10.1182/blood-2015-05-644260. Epub 2015 Dec 8.

35.

Grating coupled SPR microarray analysis of proteins and cells in blood from mice with breast cancer.

Mendoza A, Torrisi DM, Sell S, Cady NC, Lawrence DA.

Analyst. 2016 Jan 21;141(2):704-12. doi: 10.1039/c5an01749a.

PMID:
26539568
36.

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury.

Su EJ, Fredriksson L, Kanzawa M, Moore S, Folestad E, Stevenson TK, Nilsson I, Sashindranath M, Schielke GP, Warnock M, Ragsdale M, Mann K, Lawrence AL, Medcalf RL, Eriksson U, Murphy GG, Lawrence DA.

Front Cell Neurosci. 2015 Oct 7;9:385. doi: 10.3389/fncel.2015.00385. eCollection 2015.

37.

Mechanisms Underlying Astrocyte Endfeet Swelling in Stroke.

Xiang J, Tang Y, Li C, Su EJ, Lawrence DA, Keep RF.

Acta Neurochir Suppl. 2016;121:19-22. doi: 10.1007/978-3-319-18497-5_4. Review.

PMID:
26463917
38.

Membrane display and functional analysis of juxtacrine ligand-receptor signaling.

Nair PM, Ngu H, Torres E, Marsters S, Lawrence DA, Stephan JP, Komuves L, Ashkenazi A.

Biotechniques. 2015 Oct 1;59(4):231-8, 240. doi: 10.2144/000114342. eCollection 2015 Oct.

39.

A physical/psychological and biological stress combine to enhance endoplasmic reticulum stress.

Mondal TK, Emeny RT, Gao D, Ault JG, Kasten-Jolly J, Lawrence DA.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):313-22. doi: 10.1016/j.taap.2015.09.013. Epub 2015 Sep 21.

40.

Identification of a neurovascular signaling pathway regulating seizures in mice.

Fredriksson L, Stevenson TK, Su EJ, Ragsdale M, Moore S, Craciun S, Schielke GP, Murphy GG, Lawrence DA.

Ann Clin Transl Neurol. 2015 Jul;2(7):722-38. doi: 10.1002/acn3.209. Epub 2015 May 1.

41.

Analysis of septic biomarker patterns: prognostic value in predicting septic state.

Carlyn CJ, Andersen NJ, Baltch AL, Smith R, Reilly AA, Lawrence DA.

Diagn Microbiol Infect Dis. 2015 Nov;83(3):312-8. doi: 10.1016/j.diagmicrobio.2015.07.003. Epub 2015 Jul 11.

PMID:
26272282
42.

Metallothionein differentially affects the host response to Listeria infection both with and without an additional stress from cold-restraint.

Emeny RT, Kasten-Jolly J, Mondal T, Lynes MA, Lawrence DA.

Cell Stress Chaperones. 2015 Nov;20(6):1013-22. doi: 10.1007/s12192-015-0630-z. Epub 2015 Aug 13.

43.

Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display.

Nair PM, Flores H, Gogineni A, Marsters S, Lawrence DA, Kelley RF, Ngu H, Sagolla M, Komuves L, Bourgon R, Settleman J, Ashkenazi A.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5679-84. doi: 10.1073/pnas.1418962112. Epub 2015 Apr 20.

44.

TRAF2 is a biologically important necroptosis suppressor.

Petersen SL, Chen TT, Lawrence DA, Marsters SA, Gonzalvez F, Ashkenazi A.

Cell Death Differ. 2015 Nov;22(11):1846-57. doi: 10.1038/cdd.2015.35. Epub 2015 Apr 17.

45.

Elevated cytokines, thrombin and PAI-1 in severe HCPS patients due to Sin Nombre virus.

Bondu V, Schrader R, Gawinowicz MA, McGuire P, Lawrence DA, Hjelle B, Buranda T.

Viruses. 2015 Feb 10;7(2):559-89. doi: 10.3390/v7020559.

46.

The wonderful world of the windpipe: a review of central airway anatomy and pathology.

Lawrence DA, Branson B, Oliva I, Rubinowitz A.

Can Assoc Radiol J. 2015 Feb;66(1):30-43. doi: 10.1016/j.carj.2014.08.003. Review.

47.

Undetected intraocular metallic foreign body causing hyphema in a patient undergoing MRI: a rare occurrence demonstrating the limitations of pre-MRI safety screening.

Lawrence DA, Lipman AT, Gupta SK, Nacey NC.

Magn Reson Imaging. 2015 Apr;33(3):358-61. doi: 10.1016/j.mri.2014.12.009. Epub 2014 Dec 15.

PMID:
25523608
48.

Low-molecular-weight heparin modulates vein wall fibrotic response in a plasminogen activator inhibitor 1-dependent manner.

Obi AT, Diaz JA, Ballard-Lipka NL, Roelofs KJ, Farris DM, Lawrence DA, Henke PK, Wakefield TW.

J Vasc Surg Venous Lymphat Disord. 2014 Oct 1;2(4):441-450.e1.

49.

α2 Antiplasmin and microvascular thrombosis in ischemic stroke.

Su EJ, Lawrence DA.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2522-3. doi: 10.1161/ATVBAHA.114.304616. No abstract available.

PMID:
25411105
50.

Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-αVβ3 integrin cross talk.

Wu J, Strawn TL, Luo M, Wang L, Li R, Ren M, Xia J, Zhang Z, Ma W, Luo T, Lawrence DA, Fay WP.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):111-20. doi: 10.1161/ATVBAHA.114.304554. Epub 2014 Nov 6.

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