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Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice.

O'Boyle C, Haley MJ, Lemarchand E, Smith CJ, Allan SM, Konkel JE, Lawrence CB.

Int J Stroke. 2019 Feb 22:1747493019834191. doi: 10.1177/1747493019834191. [Epub ahead of print]


Valuation of the flood attenuation ecosystem service in Difficult Run, VA, USA.

Lawrence CB, Pindilli EJ, Hogan DM.

J Environ Manage. 2019 Feb 1;231:1056-1064. doi: 10.1016/j.jenvman.2018.10.023. Epub 2018 Nov 13.


Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.

Green JP, Yu S, Martín-Sánchez F, Pelegrin P, Lopez-Castejon G, Lawrence CB, Brough D.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9371-E9380. doi: 10.1073/pnas.1812744115. Epub 2018 Sep 19.


Innate Immunity Induced by the Major Allergen Alt a 1 From the Fungus Alternaria Is Dependent Upon Toll-Like Receptors 2/4 in Human Lung Epithelial Cells.

Hayes T, Rumore A, Howard B, He X, Luo M, Wuenschmann S, Chapman M, Kale S, Li L, Kita H, Lawrence CB.

Front Immunol. 2018 Jul 30;9:1507. doi: 10.3389/fimmu.2018.01507. eCollection 2018.


Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

Swanton T, Cook J, Beswick JA, Freeman S, Lawrence CB, Brough D.

SLAS Discov. 2018 Dec;23(10):991-1017. doi: 10.1177/2472555218786210. Epub 2018 Jul 3.


Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30. Review.


Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary Aspergillosis.

Kale SD, Ayubi T, Chung D, Tubau-Juni N, Leber A, Dang HX, Karyala S, Hontecillas R, Lawrence CB, Cramer RA, Bassaganya-Riera J.

Sci Rep. 2017 Dec 6;7(1):17096. doi: 10.1038/s41598-017-17000-1.


Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome.

Haley MJ, Krishnan S, Burrows D, de Hoog L, Thakrar J, Schiessl I, Allan SM, Lawrence CB.

J Cereb Blood Flow Metab. 2019 Jun;39(6):1026-1037. doi: 10.1177/0271678X17744718. Epub 2017 Nov 24.


Boron-Based Inhibitors of the NLRP3 Inflammasome.

Baldwin AG, Rivers-Auty J, Daniels MJD, White CS, Schwalbe CH, Schilling T, Hammadi H, Jaiyong P, Spencer NG, England H, Luheshi NM, Kadirvel M, Lawrence CB, Rothwell NJ, Harte MK, Bryce RA, Allan SM, Eder C, Freeman S, Brough D.

Cell Chem Biol. 2017 Nov 16;24(11):1321-1335.e5. doi: 10.1016/j.chembiol.2017.08.011. Epub 2017 Sep 21.


Adipose tissue and metabolic and inflammatory responses to stroke are altered in obese mice.

Haley MJ, Mullard G, Hollywood KA, Cooper GJ, Dunn WB, Lawrence CB.

Dis Model Mech. 2017 Oct 1;10(10):1229-1243. doi: 10.1242/dmm.030411. Epub 2017 Aug 10.


The Alternaria alternata Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation.

Grover S, Lawrence CB.

Int J Mol Sci. 2017 Jul 20;18(7). pii: E1577. doi: 10.3390/ijms18071577.


Eosinophils are key regulators of perivascular adipose tissue and vascular functionality.

Withers SB, Forman R, Meza-Perez S, Sorobetea D, Sitnik K, Hopwood T, Lawrence CB, Agace WW, Else KJ, Heagerty AM, Svensson-Frej M, Cruickshank SM.

Sci Rep. 2017 Mar 17;7:44571. doi: 10.1038/srep44571.


Inflammasomes as therapeutic targets for Alzheimer's disease.

White CS, Lawrence CB, Brough D, Rivers-Auty J.

Brain Pathol. 2017 Mar;27(2):223-234. doi: 10.1111/bpa.12478. Review.


Elevated Hypothalamic Glucocorticoid Levels Are Associated With Obesity and Hyperphagia in Male Mice.

Sefton C, Harno E, Davies A, Small H, Allen TJ, Wray JR, Lawrence CB, Coll AP, White A.

Endocrinology. 2016 Nov;157(11):4257-4265. Epub 2016 Sep 20.


LaeA and VeA are involved in growth morphology, asexual development, and mycotoxin production in Alternaria alternata.

Estiarte N, Lawrence CB, Sanchis V, Ramos AJ, Crespo-Sempere A.

Int J Food Microbiol. 2016 Dec 5;238:153-164. doi: 10.1016/j.ijfoodmicro.2016.09.003. Epub 2016 Sep 8.


Obesity and stroke: Can we translate from rodents to patients?

Haley MJ, Lawrence CB.

J Cereb Blood Flow Metab. 2016 Dec;36(12):2007-2021. Epub 2016 Sep 21. Review.


Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.

Daniels MJ, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB, Brough D.

Nat Commun. 2016 Aug 11;7:12504. doi: 10.1038/ncomms12504.


Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.

Xu J, Begley P, Church SJ, Patassini S, McHarg S, Kureishy N, Hollywood KA, Waldvogel HJ, Liu H, Zhang S, Lin W, Herholz K, Turner C, Synek BJ, Curtis MA, Rivers-Auty J, Lawrence CB, Kellett KA, Hooper NM, Vardy ER, Wu D, Unwin RD, Faull RL, Dowsey AW, Cooper GJ.

Sci Rep. 2016 Jun 9;6:27524. doi: 10.1038/srep27524.


The blood-brain barrier after stroke: Structural studies and the role of transcytotic vesicles.

Haley MJ, Lawrence CB.

J Cereb Blood Flow Metab. 2017 Feb;37(2):456-470. doi: 10.1177/0271678X16629976. Epub 2016 Jul 21.


Systemic inflammation affects reperfusion following transient cerebral ischaemia.

Burrows F, Haley MJ, Scott E, Coutts G, Lawrence CB, Allan SM, Schiessl I.

Exp Neurol. 2016 Mar;277:252-260. doi: 10.1016/j.expneurol.2016.01.013. Epub 2016 Jan 18.


Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke.

Maysami S, Haley MJ, Gorenkova N, Krishnan S, McColl BW, Lawrence CB.

J Neuroinflammation. 2015 Aug 4;12:140. doi: 10.1186/s12974-015-0359-8.


The Alternaria genomes database: a comprehensive resource for a fungal genus comprised of saprophytes, plant pathogens, and allergenic species.

Dang HX, Pryor B, Peever T, Lawrence CB.

BMC Genomics. 2015 Mar 25;16:239. doi: 10.1186/s12864-015-1430-7.


Microbe-Independent Entry of Oomycete RxLR Effectors and Fungal RxLR-Like Effectors Into Plant and Animal Cells Is Specific and Reproducible.

Tyler BM, Kale SD, Wang Q, Tao K, Clark HR, Drews K, Antignani V, Rumore A, Hayes T, Plett JM, Fudal I, Gu B, Chen Q, Affeldt KJ, Berthier E, Fischer GJ, Dou D, Shan W, Keller NP, Martin F, Rouxel T, Lawrence CB.

Mol Plant Microbe Interact. 2015 Jan;2015(1):51-56. No abstract available.


Maternal high-fat diet worsens memory deficits in the triple-transgenic (3xTgAD) mouse model of Alzheimer's disease.

Martin SA, Jameson CH, Allan SM, Lawrence CB.

PLoS One. 2014 Jun 11;9(6):e99226. doi: 10.1371/journal.pone.0099226. eCollection 2014.


Allerdictor: fast allergen prediction using text classification techniques.

Dang HX, Lawrence CB.

Bioinformatics. 2014 Apr 15;30(8):1120-1128. Epub 2014 Jan 7.


High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology.

Knight EM, Martins IV, Gümüsgöz S, Allan SM, Lawrence CB.

Neurobiol Aging. 2014 Aug;35(8):1821-32. doi: 10.1016/j.neurobiolaging.2014.02.010. Epub 2014 Feb 15.


Role of the Alternaria alternata blue-light receptor LreA (white-collar 1) in spore formation and secondary metabolism.

Pruss S, Fetzner R, Seither K, Herr A, Pfeiffer E, Metzler M, Lawrence CB, Fischer R.

Appl Environ Microbiol. 2014 Apr;80(8):2582-91. doi: 10.1128/AEM.00327-14. Epub 2014 Feb 14.


Zinc depletion regulates the processing and secretion of IL-1β.

Summersgill H, England H, Lopez-Castejon G, Lawrence CB, Luheshi NM, Pahle J, Mendes P, Brough D.

Cell Death Dis. 2014 Jan 30;5:e1040. doi: 10.1038/cddis.2013.547.


Analysis of global gene expression changes in human bronchial epithelial cells exposed to spores of the allergenic fungus, Alternaria alternata.

Babiceanu MC, Howard BA, Rumore AC, Kita H, Lawrence CB.

Front Microbiol. 2013 Jul 19;4:196. doi: 10.3389/fmicb.2013.00196. eCollection 2013.


The immune system in stroke: clinical challenges and their translation to experimental research.

Smith CJ, Lawrence CB, Rodriguez-Grande B, Kovacs KJ, Pradillo JM, Denes A.

J Neuroimmune Pharmacol. 2013 Sep;8(4):867-87. doi: 10.1007/s11481-013-9469-1. Epub 2013 May 15. Review.


Cyclophilin 20-3 relays a 12-oxo-phytodienoic acid signal during stress responsive regulation of cellular redox homeostasis.

Park SW, Li W, Viehhauser A, He B, Kim S, Nilsson AK, Andersson MX, Kittle JD, Ambavaram MM, Luan S, Esker AR, Tholl D, Cimini D, Ellerström M, Coaker G, Mitchell TK, Pereira A, Dietz KJ, Lawrence CB.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9559-64. doi: 10.1073/pnas.1218872110. Epub 2013 May 13.


Microbe-independent entry of oomycete RxLR effectors and fungal RxLR-like effectors into plant and animal cells is specific and reproducible.

Tyler BM, Kale SD, Wang Q, Tao K, Clark HR, Drews K, Antignani V, Rumore A, Hayes T, Plett JM, Fudal I, Gu B, Chen Q, Affeldt KJ, Berthier E, Fischer GJ, Dou D, Shan W, Keller NP, Martin F, Rouxel T, Lawrence CB.

Mol Plant Microbe Interact. 2013 Jun;26(6):611-6. doi: 10.1094/MPMI-02-13-0051-IA.


Signatures of recombination in clonal lineages of the citrus brown spot pathogen, Alternaria alternata sensu lato.

Stewart JE, Thomas KA, Lawrence CB, Dang H, Pryor BM, Timmer LM, Peever TL.

Phytopathology. 2013 Jul;103(7):741-9. doi: 10.1094/PHYTO-08-12-0211-R.


Transcription factor Amr1 induces melanin biosynthesis and suppresses virulence in Alternaria brassicicola.

Cho Y, Srivastava A, Ohm RA, Lawrence CB, Wang KH, Grigoriev IV, Marahatta SP.

PLoS Pathog. 2012;8(10):e1002974. doi: 10.1371/journal.ppat.1002974. Epub 2012 Oct 25.


Impaired satiation and increased feeding behaviour in the triple-transgenic Alzheimer's disease mouse model.

Adebakin A, Bradley J, Gümüsgöz S, Waters EJ, Lawrence CB.

PLoS One. 2012;7(10):e45179. doi: 10.1371/journal.pone.0045179. Epub 2012 Oct 4.


Age-related changes in core body temperature and activity in triple-transgenic Alzheimer's disease (3xTgAD) mice.

Knight EM, Brown TM, Gümüsgöz S, Smith JC, Waters EJ, Allan SM, Lawrence CB.

Dis Model Mech. 2013 Jan;6(1):160-70. doi: 10.1242/dmm.010173. Epub 2012 Aug 3.


Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide.

Lawrence CB, Brough D, Knight EM.

Dis Model Mech. 2012 Sep;5(5):649-59. doi: 10.1242/dmm.009068. Epub 2012 Feb 10.


A zinc-finger-family transcription factor, AbVf19, is required for the induction of a gene subset important for virulence in Alternaria brassicicola.

Srivastava A, Ohm RA, Oxiles L, Brooks F, Lawrence CB, Grigoriev IV, Cho Y.

Mol Plant Microbe Interact. 2012 Apr;25(4):443-52. doi: 10.1094/MPMI-10-11-0275.


Letter by McColl et al regarding article, "influenza virus infection aggravates stroke outcome".

McColl BW, Allan SM, Denes A, Lawrence CB.

Stroke. 2011 Aug;42(8):e416; author reply e417. doi: 10.1161/STROKEAHA.111.621276. Epub 2011 Jun 30. No abstract available.


Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations.

Rouxel T, Grandaubert J, Hane JK, Hoede C, van de Wouw AP, Couloux A, Dominguez V, Anthouard V, Bally P, Bourras S, Cozijnsen AJ, Ciuffetti LM, Degrave A, Dilmaghani A, Duret L, Fudal I, Goodwin SB, Gout L, Glaser N, Linglin J, Kema GH, Lapalu N, Lawrence CB, May K, Meyer M, Ollivier B, Poulain J, Schoch CL, Simon A, Spatafora JW, Stachowiak A, Turgeon BG, Tyler BM, Vincent D, Weissenbach J, Amselem J, Quesneville H, Oliver RP, Wincker P, Balesdent MH, Howlett BJ.

Nat Commun. 2011 Feb 15;2:202. doi: 10.1038/ncomms1189.


Galanin-like peptide: neural regulator of energy homeostasis and reproduction.

Lawrence CB, Fraley GS.

Exp Suppl. 2010;102:263-80. Review.


External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells.

Kale SD, Gu B, Capelluto DG, Dou D, Feldman E, Rumore A, Arredondo FD, Hanlon R, Fudal I, Rouxel T, Lawrence CB, Shan W, Tyler BM.

Cell. 2010 Jul 23;142(2):284-95. doi: 10.1016/j.cell.2010.06.008. Erratum in: Cell. 2010 Sep 17;142(6):981-3.


Hypermetabolism in a triple-transgenic mouse model of Alzheimer's disease.

Knight EM, Verkhratsky A, Luckman SM, Allan SM, Lawrence CB.

Neurobiol Aging. 2012 Jan;33(1):187-93. doi: 10.1016/j.neurobiolaging.2010.02.003. Epub 2010 Mar 31.


TmpL, a transmembrane protein required for intracellular redox homeostasis and virulence in a plant and an animal fungal pathogen.

Kim KH, Willger SD, Park SW, Puttikamonkul S, Grahl N, Cho Y, Mukhopadhyay B, Cramer RA Jr, Lawrence CB.

PLoS Pathog. 2009 Nov;5(11):e1000653. doi: 10.1371/journal.ppat.1000653. Epub 2009 Nov 6.


Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils.

Matsuwaki Y, Wada K, White TA, Benson LM, Charlesworth MC, Checkel JL, Inoue Y, Hotta K, Ponikau JU, Lawrence CB, Kita H.

J Immunol. 2009 Nov 15;183(10):6708-16. doi: 10.4049/jimmunol.0901220. Epub 2009 Oct 28.


Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke.

McColl BW, Rose N, Robson FH, Rothwell NJ, Lawrence CB.

J Cereb Blood Flow Metab. 2010 Feb;30(2):267-72. doi: 10.1038/jcbfm.2009.217. Epub 2009 Oct 14.


Biosynthesis and role in virulence of the histone deacetylase inhibitor depudecin from Alternaria brassicicola.

Wight WD, Kim KH, Lawrence CB, Walton JD.

Mol Plant Microbe Interact. 2009 Oct;22(10):1258-67. doi: 10.1094/MPMI-22-10-1258.


Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2.

Kouzaki H, O'Grady SM, Lawrence CB, Kita H.

J Immunol. 2009 Jul 15;183(2):1427-34. doi: 10.4049/jimmunol.0900904. Epub 2009 Jun 26.

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