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Items: 48

1.

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.

Lalaoui N, Boyden SE, Oda H, Wood GM, Stone DL, Chau D, Liu L, Stoffels M, Kratina T, Lawlor KE, Zaal KJM, Hoffmann PM, Etemadi N, Shield-Artin K, Biben C, Tsai WL, Blake MD, Kuehn HS, Yang D, Anderton H, Silke N, Wachsmuth L, Zheng L, Moura NS, Beck DB, Gutierrez-Cruz G, Ombrello AK, Pinto-Patarroyo GP, Kueh AJ, Herold MJ, Hall C, Wang H, Chae JJ, Dmitrieva NI, McKenzie M, Light A, Barham BK, Jones A, Romeo TM, Zhou Q, Aksentijevich I, Mullikin JC, Gross AJ, Shum AK, Hawkins ED, Masters SL, Lenardo MJ, Boehm M, Rosenzweig SD, Pasparakis M, Voss AK, Gadina M, Kastner DL, Silke J.

Nature. 2020 Jan;577(7788):103-108. doi: 10.1038/s41586-019-1828-5. Epub 2019 Dec 11.

PMID:
31827281
2.

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.

Speir M, Nowell CJ, Chen AA, O'Donnell JA, Shamie IS, Lakin PR, D'Cruz AA, Braun RO, Babon JJ, Lewis RS, Bliss-Moreau M, Shlomovitz I, Wang S, Cengia LH, Stoica AI, Hakem R, Kelliher MA, O'Reilly LA, Patsiouras H, Lawlor KE, Weller E, Lewis NE, Roberts AW, Gerlic M, Croker BA.

Nat Immunol. 2020 Jan;21(1):54-64. doi: 10.1038/s41590-019-0550-7. Epub 2019 Dec 9.

PMID:
31819256
3.

Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection.

Rosli S, Kirby FJ, Lawlor KE, Rainczuk K, Drummond GR, Mansell A, Tate MD.

Br J Pharmacol. 2019 Oct;176(19):3834-3844. doi: 10.1111/bph.14787. Epub 2019 Aug 19.

4.

Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling.

Liu X, D'Cruz AA, Hansen J, Croker BA, Lawlor KE, Sims NA, Wicks IP.

Osteoarthritis Cartilage. 2019 Oct;27(10):1557-1563. doi: 10.1016/j.joca.2019.05.018. Epub 2019 Jun 5.

PMID:
31176017
5.

Sugar Fix Keeps RIPK3 at Bay.

Giogha C, Lawlor KE.

Immunity. 2019 Mar 19;50(3):539-541. doi: 10.1016/j.immuni.2019.02.018.

PMID:
30893581
6.

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.

Erlich Z, Shlomovitz I, Edry-Botzer L, Cohen H, Frank D, Wang H, Lew AM, Lawlor KE, Zhan Y, Vince JE, Gerlic M.

Nat Immunol. 2019 Apr;20(4):397-406. doi: 10.1038/s41590-019-0313-5. Epub 2019 Feb 11.

PMID:
30742078
7.

Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation.

Yabal M, Calleja DJ, Simpson DS, Lawlor KE.

J Leukoc Biol. 2019 Feb;105(2):377-399. doi: 10.1002/JLB.MR0318-124R. Epub 2018 Dec 27. Review.

PMID:
30589456
8.

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE.

Cell Rep. 2018 Nov 27;25(9):2339-2353.e4. doi: 10.1016/j.celrep.2018.10.103.

9.

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.

D'Cruz AA, Speir M, Bliss-Moreau M, Dietrich S, Wang S, Chen AA, Gavillet M, Al-Obeidi A, Lawlor KE, Vince JE, Kelliher MA, Hakem R, Pasparakis M, Williams DA, Ericsson M, Croker BA.

Sci Signal. 2018 Sep 4;11(546). pii: eaao1716. doi: 10.1126/scisignal.aao1716.

10.

Therapeutic Effects of a TANK-Binding Kinase 1 Inhibitor in Germinal Center-Driven Collagen-Induced Arthritis.

Louis C, Ngo D, D'Silva DB, Hansen J, Phillipson L, Jousset H, Novello P, Segal D, Lawlor KE, Burns CJ, Wicks IP.

Arthritis Rheumatol. 2019 Jan;71(1):50-62. doi: 10.1002/art.40670. Epub 2018 Nov 26.

11.

Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.

Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica JS, Vince JE, Schroder K.

J Immunol. 2018 May 15;200(10):3341-3346. doi: 10.4049/jimmunol.1701620. Epub 2018 Apr 16.

12.

IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans.

Stafford CA, Lawlor KE, Heim VJ, Bankovacki A, Bernardini JP, Silke J, Nachbur U.

Cell Rep. 2018 Feb 6;22(6):1496-1508. doi: 10.1016/j.celrep.2018.01.024.

13.

CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation.

Rashidi M, Bandala-Sanchez E, Lawlor KE, Zhang Y, Neale AM, Vijayaraj SL, O'Donoghue R, Wentworth JM, Adams TE, Vince JE, Harrison LC.

Cell Death Differ. 2018 Feb;25(2):392-405. doi: 10.1038/cdd.2017.173. Epub 2017 Dec 15.

14.

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE.

Cell Rep. 2017 Jul 18;20(3):668-682. doi: 10.1016/j.celrep.2017.06.073.

15.

Caspase-8: not so silently deadly.

Feltham R, Vince JE, Lawlor KE.

Clin Transl Immunology. 2017 Jan 6;6(1):e124. doi: 10.1038/cti.2016.83. eCollection 2017 Jan. Review.

16.

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969. doi: 10.1073/pnas.1613305114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5762-E5763.

17.

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis.

Campbell IK, Leong D, Edwards KM, Rayzman V, Ng M, Goldberg GL, Wilson NJ, Scalzo-Inguanti K, Mackenzie-Kludas C, Lawlor KE, Wicks IP, Brown LE, Baz Morelli A, Panousis C, Wilson MJ, Nash AD, McKenzie BS, Andrews AE.

J Immunol. 2016 Dec 1;197(11):4392-4402. Epub 2016 Nov 2.

18.

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion.

Conos SA, Lawlor KE, Vaux DL, Vince JE, Lindqvist LM.

Cell Death Differ. 2016 Nov 1;23(11):1827-1838. doi: 10.1038/cdd.2016.69. Epub 2016 Jul 15.

19.

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

Speir M, Lawlor KE, Glaser SP, Abraham G, Chow S, Vogrin A, Schulze KE, Schuelein R, O'Reilly LA, Mason K, Hartland EL, Lithgow T, Strasser A, Lessene G, Huang DC, Vince JE, Naderer T.

Nat Microbiol. 2016 Feb 24;1:15034. doi: 10.1038/nmicrobiol.2015.34.

PMID:
27572165
20.

Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan.

Zhan Y, Chow KV, Soo P, Xu Z, Brady JL, Lawlor KE, Masters SL, O'keeffe M, Shortman K, Zhang JG, Lew AM.

Sci Rep. 2016 Apr 26;6:25060. doi: 10.1038/srep25060.

21.

New insights into the regulation of innate immunity by caspase-8.

Sagulenko V, Lawlor KE, Vince JE.

Arthritis Res Ther. 2016 Jan 13;18:4. doi: 10.1186/s13075-015-0910-0.

22.

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.

23.

Distinctive pro-inflammatory gene signatures induced in articular chondrocytes by oncostatin M and IL-6 are regulated by Suppressor of Cytokine Signaling-3.

Liu X, Liu R, Croker BA, Lawlor KE, Smyth GK, Wicks IP.

Osteoarthritis Cartilage. 2015 Oct;23(10):1743-54. doi: 10.1016/j.joca.2015.05.011. Epub 2015 Jun 2.

24.

The Mitochondrial Genomes of the Nudibranch Mollusks, Melibe leonina and Tritonia diomedea, and Their Impact on Gastropod Phylogeny.

Sevigny JL, Kirouac LE, Thomas WK, Ramsdell JS, Lawlor KE, Sharifi O, Grewal S, Baysdorfer C, Curr K, Naimie AA, Okamoto K, Murray JA, Newcomb JM.

PLoS One. 2015 May 21;10(5):e0127519. doi: 10.1371/journal.pone.0127519. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0132861.

25.

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE.

Nat Commun. 2015 Feb 18;6:6282. doi: 10.1038/ncomms7282.

26.

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, Mocarski ES, Murphy JM, Alexander WS, Voss AK, Vaux DL, Kaiser WJ, Walczak H, Silke J.

Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03464.

27.

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O'Reilly LA, Alexander W, Kile BT, Vaux DL, Vince JE.

EMBO Rep. 2014 Sep;15(9):982-90. doi: 10.15252/embr.201438463. Epub 2014 Jul 2.

28.

Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis.

Liu X, Croker BA, Campbell IK, Gauci SJ, Alexander WS, Tonkin BA, Walsh NC, Linossi EM, Nicholson SE, Lawlor KE, Wicks IP.

Arthritis Rheumatol. 2014 Sep;66(9):2391-402. doi: 10.1002/art.38701.

29.

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J.

Cell. 2014 May 22;157(5):1175-88. doi: 10.1016/j.cell.2014.04.019. Epub 2014 May 8.

30.

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling.

Khan N, Lawlor KE, Murphy JM, Vince JE.

Curr Opin Immunol. 2014 Feb;26:76-89. doi: 10.1016/j.coi.2013.10.017. Epub 2013 Nov 30. Review.

PMID:
24556404
31.

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.

Wong WW, Vince JE, Lalaoui N, Lawlor KE, Chau D, Bankovacki A, Anderton H, Metcalf D, O'Reilly L, Jost PJ, Murphy JM, Alexander WS, Strasser A, Vaux DL, Silke J.

Blood. 2014 Apr 17;123(16):2562-72. doi: 10.1182/blood-2013-06-510743. Epub 2014 Feb 4.

32.

Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.

Vandenberg CJ, Josefsson EC, Campbell KJ, James C, Lawlor KE, Kile BT, Cory S.

Cell Death Differ. 2014 May;21(5):676-84. doi: 10.1038/cdd.2013.201. Epub 2014 Jan 24.

33.

Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?

Lawlor KE, Vince JE.

Biochim Biophys Acta. 2014 Apr;1840(4):1433-40. doi: 10.1016/j.bbagen.2013.08.014. Epub 2013 Aug 27. Review.

PMID:
23994495
34.

Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis.

Lawlor KE, van Nieuwenhuijze A, Parker KL, Drake SF, Campbell IK, Smith SD, Vince JE, Strasser A, Wicks IP.

J Leukoc Biol. 2013 Apr;93(4):585-97. doi: 10.1189/jlb.0412190. Epub 2013 Jan 22. Erratum in: J Leukoc Biol. 2013 Dec;94(6):1345. J Leukoc Biol. 2013 Dec;94(6):1345.

PMID:
23341540
35.

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

Moujalled DM, Cook WD, Okamoto T, Murphy J, Lawlor KE, Vince JE, Vaux DL.

Cell Death Dis. 2013 Jan 17;4:e465. doi: 10.1038/cddis.2012.201.

36.

Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.

Espéli M, Clatworthy MR, Bökers S, Lawlor KE, Cutler AJ, Köntgen F, Lyons PA, Smith KG.

J Exp Med. 2012 Nov 19;209(12):2307-19. doi: 10.1084/jem.20121752. Epub 2012 Oct 29.

37.

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

Vince JE, Wong WW, Gentle I, Lawlor KE, Allam R, O'Reilly L, Mason K, Gross O, Ma S, Guarda G, Anderton H, Castillo R, Häcker G, Silke J, Tschopp J.

Immunity. 2012 Feb 24;36(2):215-27. doi: 10.1016/j.immuni.2012.01.012.

38.

Evaluation of the Bcl-2 family antagonist ABT-737 in collagen-induced arthritis.

Lawlor KE, Smith SD, van Nieuwenhuijze A, Huang DC, Wicks IP.

J Leukoc Biol. 2011 Oct;90(4):819-29. doi: 10.1189/jlb.0311174. Epub 2011 Jun 30.

PMID:
21719460
39.

Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.

Brownlie RJ, Lawlor KE, Niederer HA, Cutler AJ, Xiang Z, Clatworthy MR, Floto RA, Greaves DR, Lyons PA, Smith KG.

J Exp Med. 2008 Apr 14;205(4):883-95. doi: 10.1084/jem.20072565. Epub 2008 Mar 24.

40.

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair.

Little CB, Meeker CT, Golub SB, Lawlor KE, Farmer PJ, Smith SM, Fosang AJ.

J Clin Invest. 2007 Jun;117(6):1627-36. Epub 2007 May 17. Erratum in: J Clin Invest. 2008 Nov;118(11):3812.

41.

FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis.

Xiang Z, Cutler AJ, Brownlie RJ, Fairfax K, Lawlor KE, Severinson E, Walker EU, Manz RA, Tarlinton DM, Smith KG.

Nat Immunol. 2007 Apr;8(4):419-29. Epub 2007 Feb 18.

PMID:
17322888
43.

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.

Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ.

Nature. 2005 Mar 31;434(7033):648-52.

44.

Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.

Little CB, Meeker CT, Hembry RM, Sims NA, Lawlor KE, Golub SB, Last K, Fosang AJ.

Mol Cell Biol. 2005 Apr;25(8):3388-99.

45.

Critical role for granulocyte colony-stimulating factor in inflammatory arthritis.

Lawlor KE, Campbell IK, Metcalf D, O'Donnell K, van Nieuwenhuijze A, Roberts AW, Wicks IP.

Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11398-403. Epub 2004 Jul 22.

46.

Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation.

Egan PJ, Lawlor KE, Alexander WS, Wicks IP.

J Clin Invest. 2003 Mar;111(6):915-24.

47.

Severe inflammatory arthritis and lymphadenopathy in the absence of TNF.

Campbell IK, O'Donnell K, Lawlor KE, Wicks IP.

J Clin Invest. 2001 Jun;107(12):1519-27.

48.

Molecular and cellular mediators of interleukin-1-dependent acute inflammatory arthritis.

Lawlor KE, Campbell IK, O'Donnell K, Wu L, Wicks IP.

Arthritis Rheum. 2001 Feb;44(2):442-50.

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