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Items: 1 to 50 of 119

1.

Editorial: Immunomodulation of Innate Immune Cells.

Almeida CR, Bottazzi B, De Nardo D, Lawlor KE.

Front Immunol. 2020 Feb 11;11:101. doi: 10.3389/fimmu.2020.00101. eCollection 2020. No abstract available.

2.

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.

Lalaoui N, Boyden SE, Oda H, Wood GM, Stone DL, Chau D, Liu L, Stoffels M, Kratina T, Lawlor KE, Zaal KJM, Hoffmann PM, Etemadi N, Shield-Artin K, Biben C, Tsai WL, Blake MD, Kuehn HS, Yang D, Anderton H, Silke N, Wachsmuth L, Zheng L, Moura NS, Beck DB, Gutierrez-Cruz G, Ombrello AK, Pinto-Patarroyo GP, Kueh AJ, Herold MJ, Hall C, Wang H, Chae JJ, Dmitrieva NI, McKenzie M, Light A, Barham BK, Jones A, Romeo TM, Zhou Q, Aksentijevich I, Mullikin JC, Gross AJ, Shum AK, Hawkins ED, Masters SL, Lenardo MJ, Boehm M, Rosenzweig SD, Pasparakis M, Voss AK, Gadina M, Kastner DL, Silke J.

Nature. 2020 Jan;577(7788):103-108. doi: 10.1038/s41586-019-1828-5. Epub 2019 Dec 11.

PMID:
31827281
3.

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.

Speir M, Nowell CJ, Chen AA, O'Donnell JA, Shamie IS, Lakin PR, D'Cruz AA, Braun RO, Babon JJ, Lewis RS, Bliss-Moreau M, Shlomovitz I, Wang S, Cengia LH, Stoica AI, Hakem R, Kelliher MA, O'Reilly LA, Patsiouras H, Lawlor KE, Weller E, Lewis NE, Roberts AW, Gerlic M, Croker BA.

Nat Immunol. 2020 Jan;21(1):54-64. doi: 10.1038/s41590-019-0550-7. Epub 2019 Dec 9.

PMID:
31819256
4.

Recreating, expanding and using nephron progenitor populations.

Little MH, Lawlor KT.

Nat Rev Nephrol. 2020 Feb;16(2):75-76. doi: 10.1038/s41581-019-0238-0. No abstract available.

PMID:
31811252
5.

Communicating Arsenic's Risks.

Rogers SH, Rardin LR, Lawlor K, Chen CY, Borsuk ME.

Int J Environ Res Public Health. 2019 Sep 16;16(18). pii: E3436. doi: 10.3390/ijerph16183436.

6.

Assessment of the performance of CHROMagar KPC and Xpert Carba-R assay for the detection of carbapenem-resistant bacteria in rectal swabs: First comparative study from Abu Dhabi, United Arab Emirates.

Moubareck CA, Hammoudi Halat D, Sartawi M, Lawlor K, Sarkis DK, Alatoom A.

J Glob Antimicrob Resist. 2020 Mar;20:147-152. doi: 10.1016/j.jgar.2019.07.021. Epub 2019 Jul 26.

7.

Correction: Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk (doi:10.1242/dev.178673).

Combes AN, Phipson B, Lawlor KT, Dorison A, Patrick R, Zappia L, Harvey RP, Oshlack A, Little MH.

Development. 2019 Jul 11;146(13). pii: dev182162. doi: 10.1242/dev.182162. No abstract available.

8.

Cell competition: the winners and losers of fitness selection.

Bowling S, Lawlor K, Rodríguez TA.

Development. 2019 Jul 5;146(13). pii: dev167486. doi: 10.1242/dev.167486. Review.

9.

Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection.

Rosli S, Kirby FJ, Lawlor KE, Rainczuk K, Drummond GR, Mansell A, Tate MD.

Br J Pharmacol. 2019 Oct;176(19):3834-3844. doi: 10.1111/bph.14787. Epub 2019 Aug 19.

10.

CASH TRANSFERS ENABLE HOUSEHOLDS TO COPE WITH AGRICULTURAL PRODUCTION AND PRICE SHOCKS: EVIDENCE FROM ZAMBIA.

Lawlor K, Handa S, Seidenfeld D; Zambia Cash Transfer Evaluation Team.

J Dev Stud. 2019;55(2):209-226. doi: 10.1080/00220388.2017.1393519. Epub 2017 Nov 6.

11.

Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling.

Liu X, D'Cruz AA, Hansen J, Croker BA, Lawlor KE, Sims NA, Wicks IP.

Osteoarthritis Cartilage. 2019 Oct;27(10):1557-1563. doi: 10.1016/j.joca.2019.05.018. Epub 2019 Jun 5.

PMID:
31176017
12.

Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk.

Combes AN, Phipson B, Lawlor KT, Dorison A, Patrick R, Zappia L, Harvey RP, Oshlack A, Little MH.

Development. 2019 Jun 12;146(12). pii: dev178673. doi: 10.1242/dev.178673. Erratum in: Development. 2019 Jul 11;146(13):.

13.

Transcriptional versus metabolic control of cell fitness during cell competition.

Lawlor K, Pérez-Montero S, Lima A, Rodríguez TA.

Semin Cancer Biol. 2019 May 15. pii: S1044-579X(19)30034-3. doi: 10.1016/j.semcancer.2019.05.010. [Epub ahead of print] Review.

14.

Sugar Fix Keeps RIPK3 at Bay.

Giogha C, Lawlor KE.

Immunity. 2019 Mar 19;50(3):539-541. doi: 10.1016/j.immuni.2019.02.018.

15.

Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells.

Kumar SV, Er PX, Lawlor KT, Motazedian A, Scurr M, Ghobrial I, Combes AN, Zappia L, Oshlack A, Stanley EG, Little MH.

Development. 2019 Mar 7;146(5). pii: dev172361. doi: 10.1242/dev.172361.

16.

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.

Erlich Z, Shlomovitz I, Edry-Botzer L, Cohen H, Frank D, Wang H, Lew AM, Lawlor KE, Zhan Y, Vince JE, Gerlic M.

Nat Immunol. 2019 Apr;20(4):397-406. doi: 10.1038/s41590-019-0313-5. Epub 2019 Feb 11.

PMID:
30742078
17.

Nephron progenitor commitment is a stochastic process influenced by cell migration.

Lawlor KT, Zappia L, Lefevre J, Park JS, Hamilton NA, Oshlack A, Little MH, Combes AN.

Elife. 2019 Jan 24;8. pii: e41156. doi: 10.7554/eLife.41156.

18.

Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation.

Yabal M, Calleja DJ, Simpson DS, Lawlor KE.

J Leukoc Biol. 2019 Feb;105(2):377-399. doi: 10.1002/JLB.MR0318-124R. Epub 2018 Dec 27. Review.

PMID:
30589456
19.

Evaluation of variability in human kidney organoids.

Phipson B, Er PX, Combes AN, Forbes TA, Howden SE, Zappia L, Yen HJ, Lawlor KT, Hale LJ, Sun J, Wolvetang E, Takasato M, Oshlack A, Little MH.

Nat Methods. 2019 Jan;16(1):79-87. doi: 10.1038/s41592-018-0253-2. Epub 2018 Dec 20.

20.

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening.

Hale LJ, Howden SE, Phipson B, Lonsdale A, Er PX, Ghobrial I, Hosawi S, Wilson S, Lawlor KT, Khan S, Oshlack A, Quinlan C, Lennon R, Little MH.

Nat Commun. 2018 Dec 4;9(1):5167. doi: 10.1038/s41467-018-07594-z.

21.

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE.

Cell Rep. 2018 Nov 27;25(9):2339-2353.e4. doi: 10.1016/j.celrep.2018.10.103.

22.

Pericytes promote skin regeneration by inducing epidermal cell polarity and planar cell divisions.

Zhuang L, Lawlor KT, Schlueter H, Pieterse Z, Yu Y, Kaur P.

Life Sci Alliance. 2018 Jul 24;1(4):e201700009. doi: 10.26508/lsa.201700009. eCollection 2018 Aug.

23.

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.

D'Cruz AA, Speir M, Bliss-Moreau M, Dietrich S, Wang S, Chen AA, Gavillet M, Al-Obeidi A, Lawlor KE, Vince JE, Kelliher MA, Hakem R, Pasparakis M, Williams DA, Ericsson M, Croker BA.

Sci Signal. 2018 Sep 4;11(546). pii: eaao1716. doi: 10.1126/scisignal.aao1716.

24.

Therapeutic Effects of a TANK-Binding Kinase 1 Inhibitor in Germinal Center-Driven Collagen-Induced Arthritis.

Louis C, Ngo D, D'Silva DB, Hansen J, Phillipson L, Jousset H, Novello P, Segal D, Lawlor KE, Burns CJ, Wicks IP.

Arthritis Rheumatol. 2019 Jan;71(1):50-62. doi: 10.1002/art.40670. Epub 2018 Nov 26.

25.

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.

Forbes TA, Howden SE, Lawlor K, Phipson B, Maksimovic J, Hale L, Wilson S, Quinlan C, Ho G, Holman K, Bennetts B, Crawford J, Trnka P, Oshlack A, Patel C, Mallett A, Simons C, Little MH.

Am J Hum Genet. 2018 May 3;102(5):816-831. doi: 10.1016/j.ajhg.2018.03.014. Epub 2018 Apr 26.

26.

Building the evidence base for REDD+: Study design and methods for evaluating the impacts of conservation interventions on local well-being.

Sills EO, de Sassi C, Jagger P, Lawlor K, Miteva DA, Pattanayak SK, Sunderlin WD.

Glob Environ Change. 2017 Mar;43:148-160. doi: 10.1016/j.gloenvcha.2017.02.002. Epub 2017 Mar 6.

27.

Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.

Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica JS, Vince JE, Schroder K.

J Immunol. 2018 May 15;200(10):3341-3346. doi: 10.4049/jimmunol.1701620. Epub 2018 Apr 16.

28.

Persistent candidemia despite appropriate fungal therapy: First case of Candida auris from the United Arab Emirates.

Alatoom A, Sartawi M, Lawlor K, AbdelWareth L, Thomsen J, Nusair A, Mirza I.

Int J Infect Dis. 2018 May;70:36-37. doi: 10.1016/j.ijid.2018.02.005. Epub 2018 Feb 13.

29.

IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans.

Stafford CA, Lawlor KE, Heim VJ, Bankovacki A, Bernardini JP, Silke J, Nachbur U.

Cell Rep. 2018 Feb 6;22(6):1496-1508. doi: 10.1016/j.celrep.2018.01.024.

30.

CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation.

Rashidi M, Bandala-Sanchez E, Lawlor KE, Zhang Y, Neale AM, Vijayaraj SL, O'Donoghue R, Wentworth JM, Adams TE, Vince JE, Harrison LC.

Cell Death Differ. 2018 Feb;25(2):392-405. doi: 10.1038/cdd.2017.173. Epub 2017 Dec 15.

31.

Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.

Combes AN, Wilson S, Phipson B, Binnie BB, Ju A, Lawlor KT, Cebrian C, Walton SL, Smyth IM, Moritz KM, Kopan R, Oshlack A, Little MH.

Kidney Int. 2018 Mar;93(3):589-598. doi: 10.1016/j.kint.2017.09.015. Epub 2017 Dec 6.

32.

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE.

Cell Rep. 2017 Jul 18;20(3):668-682. doi: 10.1016/j.celrep.2017.06.073.

33.

Comparison of antimicrobial activity between ceftolozane-tazobactam and ceftazidime-avibactam against multidrug-resistant isolates of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

Alatoom A, Elsayed H, Lawlor K, AbdelWareth L, El-Lababidi R, Cardona L, Mooty M, Bonilla MF, Nusair A, Mirza I.

Int J Infect Dis. 2017 Sep;62:39-43. doi: 10.1016/j.ijid.2017.06.007. Epub 2017 Jun 10.

34.

Caspase-8: not so silently deadly.

Feltham R, Vince JE, Lawlor KE.

Clin Transl Immunology. 2017 Jan 6;6(1):e124. doi: 10.1038/cti.2016.83. eCollection 2017 Jan. Review.

35.

Germ Cell-less Promotes Centrosome Segregation to Induce Germ Cell Formation.

Lerit DA, Shebelut CW, Lawlor KJ, Rusan NM, Gavis ER, Schedl P, Deshpande G.

Cell Rep. 2017 Jan 24;18(4):831-839. doi: 10.1016/j.celrep.2016.12.074.

36.

Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines Using TMT 10-plex Isobaric Labeling.

Huang FK, Zhang G, Lawlor K, Nazarian A, Philip J, Tempst P, Dephoure N, Neubert TA.

J Proteome Res. 2017 Mar 3;16(3):1121-1132. doi: 10.1021/acs.jproteome.6b00374. Epub 2017 Feb 3.

37.

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969. doi: 10.1073/pnas.1613305114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5762-E5763.

38.

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis.

Campbell IK, Leong D, Edwards KM, Rayzman V, Ng M, Goldberg GL, Wilson NJ, Scalzo-Inguanti K, Mackenzie-Kludas C, Lawlor KE, Wicks IP, Brown LE, Baz Morelli A, Panousis C, Wilson MJ, Nash AD, McKenzie BS, Andrews AE.

J Immunol. 2016 Dec 1;197(11):4392-4402. Epub 2016 Nov 2.

39.

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion.

Conos SA, Lawlor KE, Vaux DL, Vince JE, Lindqvist LM.

Cell Death Differ. 2016 Nov 1;23(11):1827-1838. doi: 10.1038/cdd.2016.69. Epub 2016 Jul 15.

40.

You've Got to Hand It to Them: Assessing Final Year Medical Students Knowledge of Hand Anatomy and Pathology.

Joyce CW, Shaharan S, Lawlor K, Burke ME, Kerin MJ, Kelly JL.

J Hand Surg Asian Pac Vol. 2016 Oct;21(3):388-94. doi: 10.1142/S2424835516500399.

PMID:
27595959
41.

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

Speir M, Lawlor KE, Glaser SP, Abraham G, Chow S, Vogrin A, Schulze KE, Schuelein R, O'Reilly LA, Mason K, Hartland EL, Lithgow T, Strasser A, Lessene G, Huang DC, Vince JE, Naderer T.

Nat Microbiol. 2016 Feb 24;1:15034. doi: 10.1038/nmicrobiol.2015.34.

PMID:
27572165
42.

Rumen fluke in Irish sheep: prevalence, risk factors and molecular identification of two paramphistome species.

Martinez-Ibeas AM, Munita MP, Lawlor K, Sekiya M, Mulcahy G, Sayers R.

BMC Vet Res. 2016 Jul 18;12(1):143. doi: 10.1186/s12917-016-0770-0.

43.

Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan.

Zhan Y, Chow KV, Soo P, Xu Z, Brady JL, Lawlor KE, Masters SL, O'keeffe M, Shortman K, Zhang JG, Lew AM.

Sci Rep. 2016 Apr 26;6:25060. doi: 10.1038/srep25060.

44.

New insights into the regulation of innate immunity by caspase-8.

Sagulenko V, Lawlor KE, Vince JE.

Arthritis Res Ther. 2016 Jan 13;18:4. doi: 10.1186/s13075-015-0910-0.

45.

Iron-dependent gene expression in Actinomyces oris.

Mulé MP, Giacalone D, Lawlor K, Golden A, Cook C, Lott T, Aksten E, O'Toole GA, Bergeron LJ.

J Oral Microbiol. 2015 Dec 16;7:29800. doi: 10.3402/jom.v7.29800. eCollection 2015.

46.

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.

47.

Dermal Contributions to Human Interfollicular Epidermal Architecture and Self-Renewal.

Lawlor KT, Kaur P.

Int J Mol Sci. 2015 Nov 25;16(12):28098-107. doi: 10.3390/ijms161226078. Review.

48.

Viral nematics in confined geometries.

Manyuhina OV, Lawlor KB, Marchetti MC, Bowick MJ.

Soft Matter. 2015 Aug 14;11(30):6099-105. doi: 10.1039/c5sm00670h. Epub 2015 Jul 2.

PMID:
26135676
49.

Distinctive pro-inflammatory gene signatures induced in articular chondrocytes by oncostatin M and IL-6 are regulated by Suppressor of Cytokine Signaling-3.

Liu X, Liu R, Croker BA, Lawlor KE, Smyth GK, Wicks IP.

Osteoarthritis Cartilage. 2015 Oct;23(10):1743-54. doi: 10.1016/j.joca.2015.05.011. Epub 2015 Jun 2.

50.

The Mitochondrial Genomes of the Nudibranch Mollusks, Melibe leonina and Tritonia diomedea, and Their Impact on Gastropod Phylogeny.

Sevigny JL, Kirouac LE, Thomas WK, Ramsdell JS, Lawlor KE, Sharifi O, Grewal S, Baysdorfer C, Curr K, Naimie AA, Okamoto K, Murray JA, Newcomb JM.

PLoS One. 2015 May 21;10(5):e0127519. doi: 10.1371/journal.pone.0127519. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0132861.

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