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Items: 1 to 50 of 84

1.

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease.

Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White RC, Clarke TH, Nguyen K, Torralba M, Shao Y, Liu J, Hernandez-Morales A, Lessor L, Rahman IR, Miyamoto Y, Ly M, Gao B, Sun W, Kiesel R, Hutmacher F, Lee S, Ventura-Cots M, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Tu XM, Eckmann L, van der Donk WA, Young R, Lawley TD, Stärkel P, Pride D, Fouts DE, Schnabl B.

Nature. 2019 Nov;575(7783):505-511. doi: 10.1038/s41586-019-1742-x. Epub 2019 Nov 13.

PMID:
31723265
2.

Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth.

Shao Y, Forster SC, Tsaliki E, Vervier K, Strang A, Simpson N, Kumar N, Stares MD, Rodger A, Brocklehurst P, Field N, Lawley TD.

Nature. 2019 Oct;574(7776):117-121. doi: 10.1038/s41586-019-1560-1. Epub 2019 Sep 18.

PMID:
31534227
3.

The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics.

Shaw HA, Preston MD, Vendrik KEW, Cairns MD, Browne HP, Stabler RA, Crobach MJT, Corver J, Pituch H, Ingebretsen A, Pirmohamed M, Faulds-Pain A, Valiente E, Lawley TD, Fairweather NF, Kuijper EJ, Wren BW.

Clin Microbiol Infect. 2019 Sep 13. pii: S1198-743X(19)30489-6. doi: 10.1016/j.cmi.2019.09.004. [Epub ahead of print]

4.

Adaptation of host transmission cycle during Clostridium difficile speciation.

Kumar N, Browne HP, Viciani E, Forster SC, Clare S, Harcourt K, Stares MD, Dougan G, Fairley DJ, Roberts P, Pirmohamed M, Clokie MRJ, Jensen MBF, Hargreaves KR, Ip M, Wieler LH, Seyboldt C, Norén T, Riley TV, Kuijper EJ, Wren BW, Lawley TD.

Nat Genet. 2019 Sep;51(9):1315-1320. doi: 10.1038/s41588-019-0478-8. Epub 2019 Aug 12.

PMID:
31406348
5.

Integrated genomic epidemiology and phenotypic profiling of Clostridium difficile across intra-hospital and community populations in Colombia.

Muñoz M, Restrepo-Montoya D, Kumar N, Iraola G, Camargo M, Díaz-Arévalo D, Roa-Molina NS, Tellez MA, Herrera G, Ríos-Chaparro DI, Birchenall C, Pinilla D, Pardo-Oviedo JM, Rodríguez-Leguizamón G, Josa DF, Lawley TD, Patarroyo MA, Ramírez JD.

Sci Rep. 2019 Aug 5;9(1):11293. doi: 10.1038/s41598-019-47688-2.

6.

Comparative genomics identifies potential virulence factors in Clostridium tertium and C. paraputrificum.

Muñoz M, Restrepo-Montoya D, Kumar N, Iraola G, Herrera G, Ríos-Chaparro DI, Díaz-Arévalo D, Patarroyo MA, Lawley TD, Ramírez JD.

Virulence. 2019 Dec;10(1):657-676. doi: 10.1080/21505594.2019.1637699.

7.

Identification and validation of two peptide markers for the recognition of Clostridioides difficile MLST-1 and MLST-11 by MALDI-MS.

Corver J, Sen J, Hornung BVH, Mertens BJ, Berssenbrugge EKL, Harmanus C, Sanders IMJG, Kumar N, Lawley TD, Kuijper EJ, Hensbergen PJ, Nicolardi S.

Clin Microbiol Infect. 2019 Jul;25(7):904.e1-904.e7. doi: 10.1016/j.cmi.2018.10.008. Epub 2018 Oct 26.

PMID:
31130255
8.

High-resolution mapping reveals that microniches in the gastric glands control Helicobacter pylori colonization of the stomach.

Fung C, Tan S, Nakajima M, Skoog EC, Camarillo-Guerrero LF, Klein JA, Lawley TD, Solnick JV, Fukami T, Amieva MR.

PLoS Biol. 2019 May 2;17(5):e3000231. doi: 10.1371/journal.pbio.3000231. eCollection 2019 May.

9.

A new genomic blueprint of the human gut microbiota.

Almeida A, Mitchell AL, Boland M, Forster SC, Gloor GB, Tarkowska A, Lawley TD, Finn RD.

Nature. 2019 Apr;568(7753):499-504. doi: 10.1038/s41586-019-0965-1. Epub 2019 Feb 11.

10.

A human gut bacterial genome and culture collection for improved metagenomic analyses.

Forster SC, Kumar N, Anonye BO, Almeida A, Viciani E, Stares MD, Dunn M, Mkandawire TT, Zhu A, Shao Y, Pike LJ, Louie T, Browne HP, Mitchell AL, Neville BA, Finn RD, Lawley TD.

Nat Biotechnol. 2019 Feb;37(2):186-192. doi: 10.1038/s41587-018-0009-7. Epub 2019 Feb 4.

11.

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.

Schneditz G, Elias JE, Pagano E, Zaeem Cader M, Saveljeva S, Long K, Mukhopadhyay S, Arasteh M, Lawley TD, Dougan G, Bassett A, Karlsen TH, Kaser A, Kaneider NC.

Sci Signal. 2019 Jan 1;12(562). pii: eaau9048. doi: 10.1126/scisignal.aau9048.

12.

Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells.

Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A, Speak A, Clare S, Coomber EL, Mukhopadhyay S, Kraiczy J, Schreiber F, Lawley TD, Hancock REW, Uhlig HH, Zilbauer M, Powrie F, Dougan G.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10118-10123. doi: 10.1073/pnas.1811866115. Epub 2018 Sep 14.

13.

Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans.

Fleurbaaij F, Henneman AA, Corver J, Knetsch CW, Smits WK, Nauta ST, Giera M, Dragan I, Kumar N, Lawley TD, Verhoeven A, van Leeuwen HC, Kuijper EJ, Hensbergen PJ.

Sci Rep. 2018 May 25;8(1):8181. doi: 10.1038/s41598-018-26079-z.

14.

Culturing of female bladder bacteria reveals an interconnected urogenital microbiota.

Thomas-White K, Forster SC, Kumar N, Van Kuiken M, Putonti C, Stares MD, Hilt EE, Price TK, Wolfe AJ, Lawley TD.

Nat Commun. 2018 Apr 19;9(1):1557. doi: 10.1038/s41467-018-03968-5.

15.

Dietary trehalose enhances virulence of epidemic Clostridium difficile.

Collins J, Robinson C, Danhof H, Knetsch CW, van Leeuwen HC, Lawley TD, Auchtung JM, Britton RA.

Nature. 2018 Jan 18;553(7688):291-294. doi: 10.1038/nature25178. Epub 2018 Jan 3.

16.

A pilot study to understand feasibility and acceptability of stool and cord blood sample collection for a large-scale longitudinal birth cohort.

Bailey SR, Townsend CL, Dent H, Mallet C, Tsaliki E, Riley EM, Noursadeghi M, Lawley TD, Rodger AJ, Brocklehurst P, Field N.

BMC Pregnancy Childbirth. 2017 Dec 28;17(1):439. doi: 10.1186/s12884-017-1627-7.

17.

Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans.

Knetsch CW, Kumar N, Forster SC, Connor TR, Browne HP, Harmanus C, Sanders IM, Harris SR, Turner L, Morris T, Perry M, Miyajima F, Roberts P, Pirmohamed M, Songer JG, Weese JS, Indra A, Corver J, Rupnik M, Wren BW, Riley TV, Kuijper EJ, Lawley TD.

J Clin Microbiol. 2018 Feb 22;56(3). pii: e01384-17. doi: 10.1128/JCM.01384-17. Print 2018 Mar.

18.

Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota.

Iraola G, Forster SC, Kumar N, Lehours P, Bekal S, García-Peña FJ, Paolicchi F, Morsella C, Hotzel H, Hsueh PR, Vidal A, Lévesque S, Yamazaki W, Balzan C, Vargas A, Piccirillo A, Chaban B, Hill JE, Betancor L, Collado L, Truyers I, Midwinter AC, Dagi HT, Mégraud F, Calleros L, Pérez R, Naya H, Lawley TD.

Nat Commun. 2017 Nov 8;8(1):1367. doi: 10.1038/s41467-017-01449-9.

19.

Commensal Koch's postulates: establishing causation in human microbiota research.

Neville BA, Forster SC, Lawley TD.

Curr Opin Microbiol. 2018 Apr;42:47-52. doi: 10.1016/j.mib.2017.10.001. Epub 2017 Nov 4. Review.

20.

The essential genomic landscape of the commensal Bifidobacterium breve UCC2003.

Ruiz L, Bottacini F, Boinett CJ, Cain AK, O'Connell-Motherway M, Lawley TD, van Sinderen D.

Sci Rep. 2017 Jul 17;7(1):5648. doi: 10.1038/s41598-017-05795-y.

21.

Transmission of the gut microbiota: spreading of health.

Browne HP, Neville BA, Forster SC, Lawley TD.

Nat Rev Microbiol. 2017 Sep;15(9):531-543. doi: 10.1038/nrmicro.2017.50. Epub 2017 Jun 12. Review.

22.

Correction for Cairns et al., "Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages".

Cairns MD, Preston MD, Hall CL, Gerding DN, Hawkey PM, Kato H, Kim H, Kuijper EJ, Lawley TD, Pituch H, Reid S, Kullin B, Riley TV, Solomon K, Tsai PJ, Weese JS, Stabler RA, Wren BW.

J Clin Microbiol. 2017 Jun;55(6):1971. doi: 10.1128/JCM.00487-17. No abstract available.

23.

Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes.

O Sheridan P, Martin JC, Lawley TD, Browne HP, Harris HMB, Bernalier-Donadille A, Duncan SH, O'Toole PW, P Scott K, J Flint H.

Microb Genom. 2016 Feb 9;2(2):e000043. doi: 10.1099/mgen.0.000043. eCollection 2016 Feb.

24.

Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages.

Cairns MD, Preston MD, Hall CL, Gerding DN, Hawkey PM, Kato H, Kim H, Kuijper EJ, Lawley TD, Pituch H, Reid S, Kullin B, Riley TV, Solomon K, Tsai PJ, Weese JS, Stabler RA, Wren BW.

J Clin Microbiol. 2017 Mar;55(3):865-876. doi: 10.1128/JCM.01296-16. Epub 2016 Dec 28. Erratum in: J Clin Microbiol. 2017 Jun;55(6):1971.

25.

Evaluation of PacBio sequencing for full-length bacterial 16S rRNA gene classification.

Wagner J, Coupland P, Browne HP, Lawley TD, Francis SC, Parkhill J.

BMC Microbiol. 2016 Nov 14;16(1):274.

26.

Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.

Browne HP, Forster SC, Anonye BO, Kumar N, Neville BA, Stares MD, Goulding D, Lawley TD.

Nature. 2016 May 26;533(7604):543-546. doi: 10.1038/nature17645. Epub 2016 May 4.

27.

Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism.

Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CGK, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF.

Immunity. 2016 Mar 15;44(3):634-646. doi: 10.1016/j.immuni.2016.02.019.

28.

Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.

Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E.

Infect Immun. 2016 Jan 11;84(3):856-65. doi: 10.1128/IAI.01291-15.

29.

Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence.

Kumar N, Miyajima F, He M, Roberts P, Swale A, Ellison L, Pickard D, Smith G, Molyneux R, Dougan G, Parkhill J, Wren BW, Parry CM, Pirmohamed M, Lawley TD.

Clin Infect Dis. 2016 Mar 15;62(6):746-752. doi: 10.1093/cid/civ1031. Epub 2015 Dec 18.

30.

HPMCD: the database of human microbial communities from metagenomic datasets and microbial reference genomes.

Forster SC, Browne HP, Kumar N, Hunt M, Denise H, Mitchell A, Finn RD, Lawley TD.

Nucleic Acids Res. 2016 Jan 4;44(D1):D604-9. doi: 10.1093/nar/gkv1216. Epub 2015 Nov 17.

31.

Variation in Taxonomic Composition of the Fecal Microbiota in an Inbred Mouse Strain across Individuals and Time.

Hoy YE, Bik EM, Lawley TD, Holmes SP, Monack DM, Theriot JA, Relman DA.

PLoS One. 2015 Nov 13;10(11):e0142825. doi: 10.1371/journal.pone.0142825. eCollection 2015.

32.

Pathogen Resistance Mediated by IL-22 Signaling at the Epithelial-Microbiota Interface.

Schreiber F, Arasteh JM, Lawley TD.

J Mol Biol. 2015 Nov 20;427(23):3676-82. doi: 10.1016/j.jmb.2015.10.013. Epub 2015 Oct 21. Review.

33.

Genomic Epidemiology of a Protracted Hospital Outbreak Caused by a Toxin A-Negative Clostridium difficile Sublineage PCR Ribotype 017 Strain in London, England.

Cairns MD, Preston MD, Lawley TD, Clark TG, Stabler RA, Wren BW.

J Clin Microbiol. 2015 Oct;53(10):3141-7. doi: 10.1128/JCM.00648-15. Epub 2015 Jul 15.

34.

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections.

Carter GP, Chakravorty A, Pham Nguyen TA, Mileto S, Schreiber F, Li L, Howarth P, Clare S, Cunningham B, Sambol SP, Cheknis A, Figueroa I, Johnson S, Gerding D, Rood JI, Dougan G, Lawley TD, Lyras D.

MBio. 2015 Jun 2;6(3):e00551. doi: 10.1128/mBio.00551-15.

35.

As Clear as Mud? Determining the Diversity and Prevalence of Prophages in the Draft Genomes of Estuarine Isolates of Clostridium difficile.

Hargreaves KR, Otieno JR, Thanki A, Blades MJ, Millard AD, Browne HP, Lawley TD, Clokie MR.

Genome Biol Evol. 2015 May 27;7(7):1842-55. doi: 10.1093/gbe/evv094.

36.

Clostridium sordellii genome analysis reveals plasmid localized toxin genes encoded within pathogenicity loci.

Couchman EC, Browne HP, Dunn M, Lawley TD, Songer JG, Hall V, Petrovska L, Vidor C, Awad M, Lyras D, Fairweather NF.

BMC Genomics. 2015 May 16;16:392. doi: 10.1186/s12864-015-1613-2.

37.

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.

Seo SU, Kamada N, Muñoz-Planillo R, Kim YG, Kim D, Koizumi Y, Hasegawa M, Himpsl SD, Browne HP, Lawley TD, Mobley HL, Inohara N, Núñez G.

Immunity. 2015 Apr 21;42(4):744-55. doi: 10.1016/j.immuni.2015.03.004. Epub 2015 Apr 7.

38.

A modified R-type bacteriocin specifically targeting Clostridium difficile prevents colonization of mice without affecting gut microbiota diversity.

Gebhart D, Lok S, Clare S, Tomas M, Stares M, Scholl D, Donskey CJ, Lawley TD, Govoni GR.

MBio. 2015 Mar 24;6(2). pii: e02368-14. doi: 10.1128/mBio.02368-14.

39.

High-throughput analysis of gene essentiality and sporulation in Clostridium difficile.

Dembek M, Barquist L, Boinett CJ, Cain AK, Mayho M, Lawley TD, Fairweather NF, Fagan RP.

MBio. 2015 Feb 24;6(2):e02383. doi: 10.1128/mBio.02383-14.

40.

Complete genome sequence of BS49 and draft genome sequence of BS34A, Bacillus subtilis strains carrying Tn916.

Browne HP, Anvar SY, Frank J, Lawley TD, Roberts AP, Smits WK.

FEMS Microbiol Lett. 2015 Jan;362(3):1-4. doi: 10.1093/femsle/fnu050. Epub 2014 Dec 21.

41.

Emergence of an outbreak-associated Clostridium difficile variant with increased virulence.

Quesada-Gómez C, López-Ureña D, Acuña-Amador L, Villalobos-Zúñiga M, Du T, Freire R, Guzmán-Verri C, del Mar Gamboa-Coronado M, Lawley TD, Moreno E, Mulvey MR, de Castro Brito GA, Rodríguez-Cavallini E, Rodríguez C, Chaves-Olarte E.

J Clin Microbiol. 2015 Apr;53(4):1216-26. doi: 10.1128/JCM.03058-14. Epub 2015 Feb 4.

42.

Systematic discovery of probiotics.

Forster SC, Lawley TD.

Nat Biotechnol. 2015 Jan;33(1):47-9. doi: 10.1038/nbt.3111. No abstract available.

PMID:
25574637
43.

Pathogens' exploitation of the intestinal food web.

Pham N TA, Lawley TD.

Cell Host Microbe. 2014 Dec 10;16(6):703-5. doi: 10.1016/j.chom.2014.11.012.

44.

Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011.

Knetsch CW, Connor TR, Mutreja A, van Dorp SM, Sanders IM, Browne HP, Harris D, Lipman L, Keessen EC, Corver J, Kuijper EJ, Lawley TD.

Euro Surveill. 2014 Nov 13;19(45):20954.

45.

Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.

Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD, Browne HP, Keane JA, Page AJ, Kumasaka N, Kane L, Mottram L, Harcourt K, Hale C, Arends MJ, Gaffney DJ; Sanger Mouse Genetics Project, Dougan G, Lawley TD.

Cell Host Microbe. 2014 Oct 8;16(4):504-16. doi: 10.1016/j.chom.2014.08.017. Epub 2014 Sep 25.

46.
47.

Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

Stacey MA, Marsden M, Pham N TA, Clare S, Dolton G, Stack G, Jones E, Klenerman P, Gallimore AM, Taylor PR, Snelgrove RJ, Lawley TD, Dougan G, Benedict CA, Jones SA, Wilkinson GW, Humphreys IR.

Cell Host Microbe. 2014 Apr 9;15(4):471-83. doi: 10.1016/j.chom.2014.03.003.

48.

Emerging insights on intestinal dysbiosis during bacterial infections.

Pham TA, Lawley TD.

Curr Opin Microbiol. 2014 Feb;17:67-74. doi: 10.1016/j.mib.2013.12.002. Epub 2013 Dec 29. Review.

49.

Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.

Pettit LJ, Browne HP, Yu L, Smits WK, Fagan RP, Barquist L, Martin MJ, Goulding D, Duncan SH, Flint HJ, Dougan G, Choudhary JS, Lawley TD.

BMC Genomics. 2014 Feb 25;15:160. doi: 10.1186/1471-2164-15-160.

50.

Murine models to study Clostridium difficile infection and transmission.

Lawley TD, Young VB.

Anaerobe. 2013 Dec;24:94-7. doi: 10.1016/j.anaerobe.2013.09.008. Epub 2013 Sep 25. Review.

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