Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 329

1.

Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt.

Dutton LR, Hoare OP, McCorry AMB, Redmond KL, Adam NE, Canamara S, Bingham V, Mullan PB, Lawler M, Dunne PD, Brazil DP.

Oncotarget. 2019 Jul 23;10(45):4630-4639. doi: 10.18632/oncotarget.27050. eCollection 2019 Jul 23.

2.

Early detection of HPV-associated oropharyngeal cancer-Authors' reply.

Graham D, Prue G, Baker P, Nutting C, Greenhouse P, Lawler M.

Lancet. 2019 May 25;393(10186):2123-2124. doi: 10.1016/S0140-6736(19)30291-0. No abstract available.

PMID:
31226047
3.

Magnetic field-induced pair density wave state in the cuprate vortex halo.

Edkins SD, Kostin A, Fujita K, Mackenzie AP, Eisaki H, Uchida S, Sachdev S, Lawler MJ, Kim EA, Séamus Davis JC, Hamidian MH.

Science. 2019 Jun 7;364(6444):976-980. doi: 10.1126/science.aat1773.

PMID:
31171694
4.

Molecular biomarkers and precision medicine in colorectal cancer: a systematic review of health economic analyses.

Henderson R, French D, Sullivan R, Maughan T, Clarke M, Lawler M.

Oncotarget. 2019 May 21;10(36):3408-3423. doi: 10.18632/oncotarget.26909. eCollection 2019 May 21. Review.

5.

Evidence for a vestigial nematic state in the cuprate pseudogap phase.

Mukhopadhyay S, Sharma R, Kim CK, Edkins SD, Hamidian MH, Eisaki H, Uchida SI, Kim EA, Lawler MJ, Mackenzie AP, Davis JCS, Fujita K.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13249-13254. doi: 10.1073/pnas.1821454116. Epub 2019 Jun 3.

PMID:
31160468
6.

The Value and Future Developments of Multidisciplinary Team Cancer Care.

Selby P, Popescu R, Lawler M, Butcher H, Costa A.

Am Soc Clin Oncol Educ Book. 2019 Jan;39:332-340. doi: 10.1200/EDBK_236857. Epub 2019 May 17.

PMID:
31099640
7.

A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic.

Salvucci M, Rahman A, Resler AJ, Udupi GM, McNamara DA, Kay EW, Laurent-Puig P, Longley DB, Johnston PG, Lawler M, Wilson R, Salto-Tellez M, Van Schaeybroeck S, Rafferty M, Gallagher WM, Rehm M, Prehn JHM.

JCO Clin Cancer Inform. 2019 Apr;3:1-17. doi: 10.1200/CCI.18.00056.

8.

Effect of combined fish oil & Curcumin on murine skeletal muscle morphology and stress response proteins during mechanical unloading.

Lawler JM, Garcia-Villatoro EL, Guzzoni V, Hord JM, Botchlett R, Holly D, Lawler MS, Janini Gomes M, Ryan P, Rodriguez D, Kuczmarski JM, Fluckey JD, Talcott S.

Nutr Res. 2019 May;65:17-28. doi: 10.1016/j.nutres.2018.12.013. Epub 2019 Jan 7.

PMID:
30954343
9.

Primary intraosseous mucoepidermoid carcinoma of the mandible: radiographic evolution and clinicopathological features.

Abt NB, Lawler ME, Zacharias J, Lahey ET.

BMJ Case Rep. 2019 Apr 3;12(4). pii: e224612. doi: 10.1136/bcr-2018-224612.

PMID:
30948389
10.

Identification of Rigosertib for the Treatment of Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma.

Atanasova VS, Pourreyron C, Farshchian M, Lawler M, Brown CA 4th, Watt SA, Wright S, Warkala M, Guttmann-Gruber C, Hofbauer JP, Fuentes I, Prisco M, Rashidghamat E, Has C, Salas-Alanis JC, Palisson F, Hovnanian A, McGrath JA, Mellerio JE, Bauer JW, South AP.

Clin Cancer Res. 2019 Jun 1;25(11):3384-3391. doi: 10.1158/1078-0432.CCR-18-2661. Epub 2019 Mar 7.

PMID:
30846478
11.

Molecular-Level Understanding of Synergistic Effects in Sulfuric Acid-Amine-Ammonia Mixed Clusters.

Myllys N, Chee S, Olenius T, Lawler M, Smith J.

J Phys Chem A. 2019 Mar 28;123(12):2420-2425. doi: 10.1021/acs.jpca.9b00909. Epub 2019 Mar 12.

PMID:
30821984
12.

ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA.

Gilmore AR, Alderdice M, Savage KI, O'Reilly PG, Roddy AC, Dunne PD, Lawler M, McDade SS, Waugh DJ, McArt DG.

Cancer Res. 2019 Apr 15;79(8):2072-2075. doi: 10.1158/0008-5472.CAN-18-1976. Epub 2019 Feb 13.

PMID:
30760519
13.

Therapeutic drug monitoring of darunavir/ritonavir in pregnancy.

Murtagh R, Else LJ, Kuan KB, Khoo SH, Jackson V, Patel A, Lawler M, McDonald G, Le Blanc D, Avramovic G, Redmond N, Lambert JS.

Antivir Ther. 2019;24(3):229-233. doi: 10.3851/IMP3291.

PMID:
30728322
14.

Integrating Genomics into Healthcare: A Global Responsibility.

Stark Z, Dolman L, Manolio TA, Ozenberger B, Hill SL, Caulfied MJ, Levy Y, Glazer D, Wilson J, Lawler M, Boughtwood T, Braithwaite J, Goodhand P, Birney E, North KN.

Am J Hum Genet. 2019 Jan 3;104(1):13-20. doi: 10.1016/j.ajhg.2018.11.014.

15.

Quantum Spin Liquid Intertwining Nematic and Superconducting Order in Fese.

She JH, Lawler MJ, Kim EA.

Phys Rev Lett. 2018 Dec 7;121(23):237002. doi: 10.1103/PhysRevLett.121.237002.

PMID:
30576170
16.

Synthesis and Structure-Activity Relationships of Inhibitors That Target the C-Terminal MEEVD on Heat Shock Protein 90.

Rahimi MN, Buckton LK, Zaiter SS, Kho J, Chan V, Guo A, Konesan J, Kwon S, Lam LKO, Lawler MF, Leong M, Moldovan GD, Neale DA, Thornton G, McAlpine SR.

ACS Med Chem Lett. 2017 Dec 13;9(2):73-77. doi: 10.1021/acsmedchemlett.7b00310. eCollection 2018 Feb 8.

17.

Multicomponent new particle formation from sulfuric acid, ammonia, and biogenic vapors.

Lehtipalo K, Yan C, Dada L, Bianchi F, Xiao M, Wagner R, Stolzenburg D, Ahonen LR, Amorim A, Baccarini A, Bauer PS, Baumgartner B, Bergen A, Bernhammer AK, Breitenlechner M, Brilke S, Buchholz A, Mazon SB, Chen D, Chen X, Dias A, Dommen J, Draper DC, Duplissy J, Ehn M, Finkenzeller H, Fischer L, Frege C, Fuchs C, Garmash O, Gordon H, Hakala J, He X, Heikkinen L, Heinritzi M, Helm JC, Hofbauer V, Hoyle CR, Jokinen T, Kangasluoma J, Kerminen VM, Kim C, Kirkby J, Kontkanen J, Kürten A, Lawler MJ, Mai H, Mathot S, Mauldin RL 3rd, Molteni U, Nichman L, Nie W, Nieminen T, Ojdanic A, Onnela A, Passananti M, Petäjä T, Piel F, Pospisilova V, Quéléver LLJ, Rissanen MP, Rose C, Sarnela N, Schallhart S, Schuchmann S, Sengupta K, Simon M, Sipilä M, Tauber C, Tomé A, Tröstl J, Väisänen O, Vogel AL, Volkamer R, Wagner AC, Wang M, Weitz L, Wimmer D, Ye P, Ylisirniö A, Zha Q, Carslaw KS, Curtius J, Donahue NM, Flagan RC, Hansel A, Riipinen I, Virtanen A, Winkler PM, Baltensperger U, Kulmala M, Worsnop DR.

Sci Adv. 2018 Dec 12;4(12):eaau5363. doi: 10.1126/sciadv.aau5363. eCollection 2018 Dec.

18.

Coherent Superconductivity with a Large Gap Ratio from Incoherent Metals.

Patel AA, Lawler MJ, Kim EA.

Phys Rev Lett. 2018 Nov 2;121(18):187001. doi: 10.1103/PhysRevLett.121.187001.

PMID:
30444391
19.

Topology and Geometry of Spin Origami.

Roychowdhury K, Rocklin DZ, Lawler MJ.

Phys Rev Lett. 2018 Oct 26;121(17):177201. doi: 10.1103/PhysRevLett.121.177201.

PMID:
30411943
20.

C-H Arylation in the Formation of a Complex Pyrrolopyridine, the Commercial Synthesis of the Potent JAK2 Inhibitor, BMS-911543.

Fox RJ, Cuniere NL, Bakrania L, Wei C, Strotman NA, Hay M, Fanfair D, Regens C, Beutner GL, Lawler M, Lobben P, Soumeillant MC, Cohen B, Zhu K, Skliar D, Rosner T, Markwalter CE, Hsiao Y, Tran K, Eastgate MD.

J Org Chem. 2019 Apr 19;84(8):4661-4669. doi: 10.1021/acs.joc.8b02383. Epub 2018 Nov 12.

PMID:
30388009
21.

Mapping cancer research across Central and Eastern Europe, the Russian Federation and Central Asia: Implications for future national cancer control planning.

Begum M, Lewison G, Jassem J, Mixich V, Cufer T, Nurgozhin T, Shabalkin P, Kutluk T, Voko Z, Radosavljevic D, Vrdoljiak E, Eniu A, Walewski J, Aggarwal A, Lawler M, Sullivan R.

Eur J Cancer. 2018 Nov;104:127-136. doi: 10.1016/j.ejca.2018.08.024. Epub 2018 Oct 20.

PMID:
30347288
22.

The value of European immigration for high-level UK research and clinical care: cross-sectional study.

Begum M, Lewison G, Lawler M, Sullivan R.

J R Soc Med. 2019 Jan;112(1):29-35. doi: 10.1177/0141076818803427. Epub 2018 Oct 10.

23.

The impact of Brexit on UK cancer research.

Lawler M, Begum M, Lewison G, Aggarwal A, Selby P, Sullivan R.

Lancet Oncol. 2018 Oct;19(10):1276-1278. doi: 10.1016/S1470-2045(18)30518-7. Epub 2018 Oct 1. No abstract available.

PMID:
30303111
24.

It is time for universal HPV vaccination.

Prue G, Baker P, Graham D, Nutting C, Greenhouse P, Lawler M.

Lancet. 2018 Sep 15;392(10151):913-914. doi: 10.1016/S0140-6736(18)31821-X. No abstract available.

PMID:
30238882
25.

Multilevel Analysis of Child and Adolescent Subjective Well-Being Across 14 Countries: Child- and Country-Level Predictors.

Newland LA, Giger JT, Lawler MJ, Roh S, Brockevelt BL, Schweinle A.

Child Dev. 2019 Mar;90(2):395-413. doi: 10.1111/cdev.13134. Epub 2018 Sep 1.

PMID:
30171770
26.

Rapid growth of organic aerosol nanoparticles over a wide tropospheric temperature range.

Stolzenburg D, Fischer L, Vogel AL, Heinritzi M, Schervish M, Simon M, Wagner AC, Dada L, Ahonen LR, Amorim A, Baccarini A, Bauer PS, Baumgartner B, Bergen A, Bianchi F, Breitenlechner M, Brilke S, Buenrostro Mazon S, Chen D, Dias A, Draper DC, Duplissy J, El Haddad I, Finkenzeller H, Frege C, Fuchs C, Garmash O, Gordon H, He X, Helm J, Hofbauer V, Hoyle CR, Kim C, Kirkby J, Kontkanen J, Kürten A, Lampilahti J, Lawler M, Lehtipalo K, Leiminger M, Mai H, Mathot S, Mentler B, Molteni U, Nie W, Nieminen T, Nowak JB, Ojdanic A, Onnela A, Passananti M, Petäjä T, Quéléver LLJ, Rissanen MP, Sarnela N, Schallhart S, Tauber C, Tomé A, Wagner R, Wang M, Weitz L, Wimmer D, Xiao M, Yan C, Ye P, Zha Q, Baltensperger U, Curtius J, Dommen J, Flagan RC, Kulmala M, Smith JN, Worsnop DR, Hansel A, Donahue NM, Winkler PM.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9122-9127. doi: 10.1073/pnas.1807604115. Epub 2018 Aug 28.

27.

Personalized management of elderly patients with rectal cancer: Expert recommendations of the European Society of Surgical Oncology, European Society of Coloproctology, International Society of Geriatric Oncology, and American College of Surgeons Commission on Cancer.

Montroni I, Ugolini G, Saur NM, Spinelli A, Rostoft S, Millan M, Wolthuis A, Daniels IR, Hompes R, Penna M, Fürst A, Papamichael D, Desai AM, Cascinu S, Gèrard JP, Myint AS, Lemmens VEPP, Berho M, Lawler M, De Liguori Carino N, Potenti F, Nanni O, Altini M, Beets G, Rutten H, Winchester D, Wexner SD, Audisio RA.

Eur J Surg Oncol. 2018 Nov;44(11):1685-1702. doi: 10.1016/j.ejso.2018.08.003. Epub 2018 Aug 15. Review.

PMID:
30150158
28.

Epithelial-to-mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition.

McCorry AM, Loughrey MB, Longley DB, Lawler M, Dunne PD.

J Pathol. 2018 Dec;246(4):422-426. doi: 10.1002/path.5155.

29.

A roadmap for restoring trust in Big Data.

Lawler M, Morris AD, Sullivan R, Birney E, Middleton A, Makaroff L, Knoppers BM, Horgan D, Eggermont A.

Lancet Oncol. 2018 Aug;19(8):1014-1015. doi: 10.1016/S1470-2045(18)30425-X. No abstract available.

PMID:
30102210
30.

Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy.

Allen WL, Dunne PD, McDade S, Scanlon E, Loughrey M, Coleman H, McCann C, McLaughlin K, Nemeth Z, Syed N, Jithesh P, Arthur K, Wilson R, Coyle V, McArt D, Murray GI, Samuel L, Nuciforo P, Jimenez J, Argiles G, Dienstmann R, Tabernero J, Messerini L, Nobili S, Mini E, Sheahan K, Ryan E, Johnston PG, Van Schaeybroeck S, Lawler M, Longley DB.

JCO Precis Oncol. 2018 Jun 13;2018. doi: 10.1200/PO.17.00241.

31.

Mapping the European cancer research landscape: An evidence base for national and Pan-European research and funding.

Begum M, Lewison G, Lawler M, Sullivan R.

Eur J Cancer. 2018 Sep;100:75-84. doi: 10.1016/j.ejca.2018.04.017. Epub 2018 Jul 4.

32.

Title V Maternal and Child Health Services Block Grant Priority Needs and Linked Performance Measures: Current Patterns and Trends (2000-2015).

Kandasamy V, Hirai AH, Kogan MD, Lawler M, Volpe E.

Matern Child Health J. 2018 Dec;22(12):1725-1737. doi: 10.1007/s10995-018-2568-0.

PMID:
29995296
33.

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer.

Dunne PD, Coleman HG, Bankhead P, Alderdice M, Gray RT, McQuaid S, Bingham V, Loughrey MB, James JA, McCorry AMB, Gilmore A, Holohan C, Klingbiel D, Tejpar S, Johnston PG, McArt DG, Di Nicolantonio F, Longley DB, Lawler M.

Oncotarget. 2018 Feb 13;9(17):13834-13847. doi: 10.18632/oncotarget.24481. eCollection 2018 Mar 2.

34.

Delivering modern, high-quality, affordable pathology and laboratory medicine to low-income and middle-income countries: a call to action.

Horton S, Sullivan R, Flanigan J, Fleming KA, Kuti MA, Looi LM, Pai SA, Lawler M.

Lancet. 2018 May 12;391(10133):1953-1964. doi: 10.1016/S0140-6736(18)30460-4. Epub 2018 Mar 15. Review.

PMID:
29550030
35.

Improving pathology and laboratory medicine in low-income and middle-income countries: roadmap to solutions.

Sayed S, Cherniak W, Lawler M, Tan SY, El Sadr W, Wolf N, Silkensen S, Brand N, Looi LM, Pai SA, Wilson ML, Milner D, Flanigan J, Fleming KA.

Lancet. 2018 May 12;391(10133):1939-1952. doi: 10.1016/S0140-6736(18)30459-8. Epub 2018 Mar 15. Review.

PMID:
29550027
36.

Text mining-based in silico drug discovery in oral mucositis caused by high-dose cancer therapy.

Kirk J, Shah N, Noll B, Stevens CB, Lawler M, Mougeot FB, Mougeot JC.

Support Care Cancer. 2018 Aug;26(8):2695-2705. doi: 10.1007/s00520-018-4096-2. Epub 2018 Feb 23.

PMID:
29476419
37.

Mapping the cancer patient information landscape: A comparative analysis of patient groups across Europe and North America.

Lawler M, Prue G, Banks I, Law K, Selby P, McVie G, Sullivan R.

Eur J Cancer. 2018 Mar;92:88-95. doi: 10.1016/j.ejca.2018.01.074. Epub 2018 Feb 9.

PMID:
29428868
38.

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies.

Alderdice M, Richman SD, Gollins S, Stewart JP, Hurt C, Adams R, McCorry AM, Roddy AC, Vimalachandran D, Isella C, Medico E, Maughan T, McArt DG, Lawler M, Dunne PD.

J Pathol. 2018 May;245(1):19-28. doi: 10.1002/path.5051. Epub 2018 Mar 25.

39.

Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges.

Bradley CA, Salto-Tellez M, Laurent-Puig P, Bardelli A, Rolfo C, Tabernero J, Khawaja HA, Lawler M, Johnston PG, Van Schaeybroeck S; MErCuRIC consortium.

Nat Rev Clin Oncol. 2018 Jan 23;15(3):150. doi: 10.1038/nrclinonc.2018.13. [Epub ahead of print]

PMID:
29358775
40.

Effect of Eukarion-134 on Akt-mTOR signalling in the rat soleus during 7 days of mechanical unloading.

Kuczmarski JM, Hord JM, Lee Y, Guzzoni V, Rodriguez D, Lawler MS, Garcia-Villatoro EL, Holly D, Ryan P, Falcon K, Garcia M, Janini Gomes M, Fluckey JD, Lawler JM.

Exp Physiol. 2018 Apr 1;103(4):545-558. doi: 10.1113/EP086649. Epub 2018 Feb 28.

PMID:
29315934
41.

Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer.

Lawler M, Alsina D, Adams RA, Anderson AS, Brown G, Fearnhead NS, Fenwick SW, Halloran SP, Hochhauser D, Hull MA, Koelzer VH, McNair AGK, Monahan KJ, Näthke I, Norton C, Novelli MR, Steele RJC, Thomas AL, Wilde LM, Wilson RH, Tomlinson I; Bowel Cancer UK Critical Research Gaps in Colorectal Cancer Initiative.

Gut. 2018 Jan;67(1):179-193. doi: 10.1136/gutjnl-2017-315333. Review.

42.

Comparison of the Spectral-Temporally Modulated Ripple Test With the Arizona Biomedical Institute Sentence Test in Cochlear Implant Users.

Lawler M, Yu J, Aronoff JM.

Ear Hear. 2017 Nov/Dec;38(6):760-766. doi: 10.1097/AUD.0000000000000496.

43.

The European Cancer Patient's Bill of Rights, update and implementation 2016.

Højgaard L, Löwenberg B, Selby P, Lawler M, Banks I, Law K, Albreht T, Armand JP, Barbacid M, Barzach M, Bergh J, Cameron D, Conte P, de Braud F, de Gramont A, De Lorenzo F, Diehl V, Diler S, Erdem S, Geissler J, Gore-Booth J, Henning G, Horgan D, Jassem J, Johnson P, Kaasa S, Kapitein P, Karjalainen S, Kelly J, Kienesberger A, La Vecchia C, Lacombe D, Lindahl T, Luzzatto L, Malby R, Mastris K, Meunier F, Murphy M, Naredi P, Nurse P, Oliver K, Pearce J, Pelouchov J, Piccart M, Pinedo B, Spurrier-Bernard G, Sullivan R, Tabernero J, Van de Velde C, van Herk B, Vedsted P, Waldmann A, Weller D, Wilking N, Wilson R, Yared W, Zielinski C, Zur Hausen H, Le Chevalier T, Johnston P.

ESMO Open. 2017 Jan 6;1(6):e000127. doi: 10.1136/esmoopen-2016-000127. eCollection 2016. Review.

44.

Variations in adolescents' motivational characteristics across gender and physical activity patterns: A latent class analysis approach.

Lawler M, Heary C, Nixon E.

BMC Public Health. 2017 Aug 17;17(1):661. doi: 10.1186/s12889-017-4677-x.

45.

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival.

Alderdice M, Dunne PD, Cole AJ, O'Reilly PG, McArt DG, Bingham V, Fuchs MA, McQuaid S, Loughrey MB, Murray GI, Samuel LM, Lawler M, Wilson RH, Salto-Tellez M, Coyle VM.

Mod Pathol. 2017 Sep;30(9):1287-1298. doi: 10.1038/modpathol.2017.47. Epub 2017 Jun 16.

46.

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies.

Alvi MA, Loughrey MB, Dunne P, McQuaid S, Turkington R, Fuchs MA, McGready C, Bingham V, Pang B, Moore W, Maxwell P, Lawler M, James JA, Murray GI, Wilson RH, Salto-Tellez M.

Br J Cancer. 2017 Jul 11;117(2):203-209. doi: 10.1038/bjc.2017.168. Epub 2017 Jun 8.

47.

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification.

Dunne PD, Alderdice M, O'Reilly PG, Roddy AC, McCorry AMB, Richman S, Maughan T, McDade SS, Johnston PG, Longley DB, Kay E, McArt DG, Lawler M.

Nat Commun. 2017 May 31;8:15657. doi: 10.1038/ncomms15657.

48.

Standardising RNA profiling based biomarker application in cancer-The need for robust control of technical variables.

Stewart JP, Richman S, Maughan T, Lawler M, Dunne PD, Salto-Tellez M.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):258-272. doi: 10.1016/j.bbcan.2017.05.005. Epub 2017 May 23. Review.

49.

Sharing Clinical and Genomic Data on Cancer - The Need for Global Solutions.

Clinical Cancer Genome Task Team of the Global Alliance for Genomics and Health, Lawler M, Haussler D, Siu LL, Haendel MA, McMurry JA, Knoppers BM, Chanock SJ, Calvo F, The BT, Walia G, Banks I, Yu PP, Staudt LM, Sawyers CL.

N Engl J Med. 2017 May 25;376(21):2006-2009. doi: 10.1056/NEJMp1612254. No abstract available.

50.

From Rosalind Franklin to Barack Obama: Data Sharing Challenges and Solutions in Genomics and Personalised Medicine.

Lawler M, Maughan T.

New Bioeth. 2017 Apr;23(1):64-73. doi: 10.1080/20502877.2017.1314883.

Supplemental Content

Loading ...
Support Center