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The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.

Pang SS, Bayly-Jones C, Radjainia M, Spicer BA, Law RHP, Hodel AW, Parsons ES, Ekkel SM, Conroy PJ, Ramm G, Venugopal H, Bird PI, Hoogenboom BW, Voskoboinik I, Gambin Y, Sierecki E, Dunstone MA, Whisstock JC.

Nat Commun. 2019 Sep 19;10(1):4288. doi: 10.1038/s41467-019-12279-2.


Valuing Innovative Endoscopic Techniques: Endoscopic Suturing to Prevent Stent Migration for Benign Esophageal Disease.

Shah ED, Hosmer AE, Patel A, Morales S, Law R.

Gastrointest Endosc. 2019 Aug 23. pii: S0016-5107(19)32189-3. doi: 10.1016/j.gie.2019.08.020. [Epub ahead of print]


Protocol for a feasibility randomised trial of low-intensity interventions for antenatal depression: ADAGIO trial comparing interpersonal counselling with cognitive behavioural therapy.

Ingram J, Johnson D, Johnson S, O'Mahen HA, Kessler D, Taylor H, Law R, Round J, Ford J, Hopley R, Glynn J, Culpin I, Evans J.

BMJ Open. 2019 Aug 18;9(8):e032649. doi: 10.1136/bmjopen-2019-032649.


Noninfectious Foodborne Exposures Reported to 2 National Reporting Systems, United States, 2000-2010.

Law RKY, Kisselburgh H, Roblin D, Choudhary E, Schier J, Fraser M, Taylor E.

Public Health Rep. 2019 Sep/Oct;134(5):552-558. doi: 10.1177/0033354919862690. Epub 2019 Aug 6.


Building a synthetic mechanosensitive signaling pathway in compartmentalized artificial cells.

Hindley JW, Zheleva DG, Elani Y, Charalambous K, Barter LMC, Booth PJ, Bevan CL, Law RV, Ces O.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16711-16716. doi: 10.1073/pnas.1903500116. Epub 2019 Aug 1.


Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.

Yuan Y, Ayinuola YA, Singh D, Ayinuola O, Mayfield JA, Quek A, Whisstock JC, Law RHP, Lee SW, Ploplis VA, Castellino FJ.

J Struct Biol. 2019 Oct 1;208(1):18-29. doi: 10.1016/j.jsb.2019.07.005. Epub 2019 Jul 10.


Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.

Quek AJH, Mazzitelli BA, Wu G, Leung EWW, Caradoc-Davies TT, Lloyd GJ, Jeevarajah D, Conroy PJ, Sanderson-Smith M, Yuan Y, Ayinuola YA, Castellino FJ, Whisstock JC, Law RHP.

J Mol Biol. 2019 Sep 6;431(19):3804-3813. doi: 10.1016/j.jmb.2019.07.003. Epub 2019 Jul 8.


Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin-; the role of phosphodiesterase 3A.

Berger M, Raslan Z, Aburima A, Magwenzi S, Wraith KS, SPurgeon BEJ, Hindle MS, Law R, Febbraio M, Naseem KM.

Haematologica. 2019 Jul 9. pii: haematol.2018.213348. doi: 10.3324/haematol.2018.213348. [Epub ahead of print]


Endoscopic reversal of vertical banded gastroplasty: a novel use of electroincision.

Yu JX, Patel A, Law R.

Endoscopy. 2019 Jul 1. doi: 10.1055/a-0934-5301. [Epub ahead of print] No abstract available.


Management of a windsock diverticulum by the use of novel submucosal dissection scissors.

Bhalla S, Yu J, Law R.

VideoGIE. 2019 Apr 16;4(6):247-248. doi: 10.1016/j.vgie.2019.03.005. eCollection 2019 Jun. No abstract available.


Safety and efficacy of the use of lumen-apposing metal stents in the management of postoperative fluid collections: a large, international, multicenter study.

Yang J, Kaplan JH, Sethi A, Dawod E, Sharaiha RZ, Chiang A, Kowalski T, Nieto J, Law R, Hammad H, Wani S, Wagh MS, Yang D, Draganov PV, Messallam A, Cai Q, Kushnir V, Cosgrove N, Ahmed AM, Anderloni A, Adler DG, Kumta NA, Nagula S, Vleggaar FP, Irani S, Robles-Medranda C, El Chafic AH, Pawa R, Brewer O, Sanaei O, Dbouk M, Singh VK, Kumbhari V, Khashab MA.

Endoscopy. 2019 Aug;51(8):715-721. doi: 10.1055/a-0924-5591. Epub 2019 Jun 7.


Development of a short form of the Hong Kong Chinese orebro musculoskeletal pain screening questionnaire.

Tsang RCC, Lee EWC, Lau JSY, Kwong SSF, So EML, Wong TFY, Law RKY.

Hong Kong Physiother J. 2019 Jun;39(1):57-66. doi: 10.1142/S1013702519500057. Epub 2018 Sep 13.


Endoscopic Management of Acute Cholecystitis Following Metal Stent Placement for Malignant Biliary Strictures: A View from the Inside Looking in.

Bhalla S, Law R.

Clin Endosc. 2019 May;52(3):209-211. doi: 10.5946/ce.2019.097. Epub 2019 May 23. No abstract available.


Regional and racial variations in the utilization of endoscopic retrograde cholangiopancreatography among pancreatic cancer patients in the United States.

Tavakkoli A, Singal AG, Waljee AK, Scheiman JM, Murphy CC, Pruitt SL, Xuan L, Kwon RS, Law RJ, Elta GH, Wright-Slaughter P, Valley TS, Kubiliun N, Nathan H, Rubenstein JH, Elmunzer BJ.

Cancer Med. 2019 Jul;8(7):3420-3427. doi: 10.1002/cam4.2225. Epub 2019 May 14.


Evaluation of Oklahoma's Electronic Death Registration System and Event Fatality Markers for Disaster-Related Mortality Surveillance - Oklahoma USA, May 2013.

Issa AN, Baker K, Pate D, Law R, Bayleyegn T, Noe RS.

Prehosp Disaster Med. 2019 Apr;34(2):125-131. doi: 10.1017/S1049023X19000189.


A Direct Podocalyxin-Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells.

Wong BS, Shea DJ, Mistriotis P, Tuntithavornwat S, Law RA, Bieber JM, Zheng L, Konstantopoulos K.

Cancer Res. 2019 Jun 1;79(11):2878-2891. doi: 10.1158/0008-5472.CAN-18-3369. Epub 2019 Apr 11.


Skin involvement as the presenting sign of anorectal adenocarcinoma.

Leiker AJ, Beg M, McIlwee B, Law R, Khosama L, Meyer J.

Proc (Bayl Univ Med Cent). 2018 Oct 26;31(4):519-521. doi: 10.1080/08998280.2018.1499295. eCollection 2018 Oct.


General endotracheal anesthesia for ERCP: Don't sleep on it!

Law R, Cardenas A.

Gastrointest Endosc. 2019 Apr;89(4):863-864. doi: 10.1016/j.gie.2018.10.044. No abstract available.


Clip Closure Prevents Bleeding After Endoscopic Resection of Large Colon Polyps in a Randomized Trial.

Pohl H, Grimm IS, Moyer MT, Hasan MK, Pleskow D, Elmunzer BJ, Khashab MA, Sanaei O, Al-Kawas FH, Gordon SR, Mathew A, Levenick JM, Aslanian HR, Antaki F, von Renteln D, Crockett SD, Rastogi A, Gill JA, Law RJ, Elias PA, Pellise M, Wallace MB, Mackenzie TA, Rex DK.

Gastroenterology. 2019 Mar 15. pii: S0016-5085(19)33573-5. doi: 10.1053/j.gastro.2019.03.019. [Epub ahead of print]


Structural studies of plasmin inhibition.

Wu G, Quek AJ, Caradoc-Davies TT, Ekkel SM, Mazzitelli B, Whisstock JC, Law RHP.

Biochem Soc Trans. 2019 Apr 30;47(2):541-557. doi: 10.1042/BST20180211. Epub 2019 Mar 5. Review.


Lumen apposing metal stents are superior to plastic stents in pancreatic walled-off necrosis: a large international multicenter study.

Chen YI, Yang J, Friedland S, Holmes I, Law R, Hosmer A, Stevens T, Franco MC, Jang S, Pawa R, Mathur N, Sejpal DV, Inamdar S, Trindade AJ, Nieto J, Berzin TM, Sawhney M, DeSimone ML, DiMaio C, Kumta NA, Gupta S, Yachimski P, Anderloni A, Baron TH, James TW, Jamil LH, Ona MA, Lo SK, Gaddam S, Dollhopf M, Bukhari MA, Moran R, Gutierrez OB, Sanaei O, Fayad L, Ngamruengphong S, Kumbhari V, Singh V, Repici A, Khashab MA.

Endosc Int Open. 2019 Mar;7(3):E347-E354. doi: 10.1055/a-0828-7630. Epub 2019 Feb 28.


Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.

Wu G, Mazzitelli BA, Quek AJ, Veldman MJ, Conroy PJ, Caradoc-Davies TT, Ooms LM, Tuck KL, Schoenecker JG, Whisstock JC, Law RHP.

Blood Adv. 2019 Mar 12;3(5):729-733. doi: 10.1182/bloodadvances.2018025429. No abstract available.


Lumen-apposing stents versus plastic stents in the management of pancreatic pseudocysts: a large, comparative, international, multicenter study.

Yang J, Chen YI, Friedland S, Holmes I, Paiji C, Law R, Hosmer A, Stevens T, Matheus F, Pawa R, Mathur N, Sejpal D, Inamdar S, Berzin TM, DiMaio CJ, Gupta S, Yachimski PS, Anderloni A, Repici A, James T, Jamil LH, Ona M, Lo SK, Gaddam S, Dollhopf M, Alammar N, Shieh E, Bukhari M, Kumbhari V, Singh V, Brewer O, Sanaei O, Fayad L, Ngamruengphong S, Shin EJ, Baron TH, Khashab MA.

Endoscopy. 2019 Feb 15. doi: 10.1055/a-0852-9243. [Epub ahead of print]


A lifestyle management programme focused on exercise, diet and physiotherapy support for patients with hip or knee osteoarthritis and a body mass index over 35: A qualitative study.

Law RJ, Nafees S, Hiscock J, Wynne C, Williams NH.

Musculoskeletal Care. 2019 Mar;17(1):145-151. doi: 10.1002/msc.1382. Epub 2019 Jan 24.


Development of an intervention to expedite cancer diagnosis through primary care: a protocol.

Stanciu MA, Law RJ, Nafees S, Hendry M, Yeo ST, Hiscock J, Lewis R, Edwards RT, Williams NH, Brain K, Brocklehurst P, Carson-Stevens A, Dolwani S, Emery J, Hamilton W, Hoare Z, Lyratzopoulos G, Rubin G, Smits S, Vedsted P, Walter F, Wilkinson C, Neal RD; WICKED Team on behalf of.

BJGP Open. 2018 Sep 5;2(3):bjgpopen18X101595. doi: 10.3399/bjgpopen18X101595. eCollection 2018 Oct.


Lumen-apposing stents versus plastic stents in the management of pancreatic pseudocysts: a large, comparative, international, multicenter study.

Yang J, Chen YI, Friedland S, Holmes I, Paiji C, Law R, Hosmer A, Stevens T, Matheus F, Pawa R, Mathur N, Sejpal D, Inamdar S, Berzin TM, DiMaio CJ, Gupta S, Yachimski PS, Anderloni A, Repici A, James T, Jamil LH, Ona M, Lo SK, Gaddam S, Dollhopf M, Alammar N, Shieh E, Bukhari M, Kumbhari V, Singh V, Brewer O, Sanaei O, Fayad L, Ngamruengphong S, Shin EJ, Baron TH, Khashab MA.

Endoscopy. 2018 Dec 7. doi: 10.1055/a-0759-1353. [Epub ahead of print]


Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.

Swedberg JE, Wu G, Mahatmanto T, Durek T, Caradoc-Davies TT, Whisstock JC, Law RHP, Craik DJ.

J Med Chem. 2019 Jan 24;62(2):552-560. doi: 10.1021/acs.jmedchem.8b01139. Epub 2018 Dec 26.


Health Consequences of an Armed Conflict in Zamboanga, Philippines Using a Syndromic Surveillance Database.

Salazar MA, Law R, Winkler V.

Int J Environ Res Public Health. 2018 Nov 29;15(12). pii: E2690. doi: 10.3390/ijerph15122690.


Effect of glycerol with sodium chloride on the Krafft point of sodium dodecyl sulfate using surface tension.

Khan H, Seddon JM, Law RV, Brooks NJ, Robles E, Cabral JT, Ces O.

J Colloid Interface Sci. 2019 Mar 7;538:75-82. doi: 10.1016/j.jcis.2018.11.021. Epub 2018 Nov 8.


Physiologically Important Electrolytes as Regulators of TDP-43 Aggregation and Droplet-Phase Behavior.

Sun Y, Medina Cruz A, Hadley KC, Galant NJ, Law R, Vernon RM, Morris VK, Robertson J, Chakrabartty A.

Biochemistry. 2019 Feb 12;58(6):590-607. doi: 10.1021/acs.biochem.8b00842. Epub 2018 Dec 13.


Diagnostic routes and time intervals for patients with colorectal cancer in 10 international jurisdictions; findings from a cross-sectional study from the International Cancer Benchmarking Partnership (ICBP).

Weller D, Menon U, Zalounina Falborg A, Jensen H, Barisic A, Knudsen AK, Bergin RJ, Brewster DH, Cairnduff V, Gavin AT, Grunfeld E, Harland E, Lambe M, Law RJ, Lin Y, Malmberg M, Turner D, Neal RD, White V, Harrison S, Reguilon I; ICBP Module 4 Working Group, Vedsted P.

BMJ Open. 2018 Nov 27;8(11):e023870. doi: 10.1136/bmjopen-2018-023870.


Preoperative predictors of choledocholithiasis in patients presenting with acute calculous cholecystitis.

Chisholm PR, Patel AH, Law RJ, Schulman AR, Bedi AO, Kwon RS, Wamsteker EJ, Anderson MA, Elta GH, Govani SM, Prabhu A.

Gastrointest Endosc. 2019 May;89(5):977-983.e2. doi: 10.1016/j.gie.2018.11.017. Epub 2018 Nov 19.


A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.

Sadek MM, Barlow N, Leung EWW, Williams-Noonan BJ, Yap BK, Shariff FM, Caradoc-Davies TT, Nicholson SE, Chalmers DK, Thompson PE, Law RHP, Norton RS.

ACS Chem Biol. 2018 Oct 19;13(10):2930-2938. doi: 10.1021/acschembio.8b00561. Epub 2018 Sep 18.


Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library.

Li CY, de Veer SJ, Law RHP, Whisstock JC, Craik DJ, Swedberg JE.

Chembiochem. 2019 Jan 2;20(1):46-50. doi: 10.1002/cbic.201800395. Epub 2018 Oct 24.


Alleles Causing Resistance to Isoxaben and Flupoxam Highlight the Significance of Transmembrane Domains for CESA Protein Function.

Shim I, Law R, Kileeg Z, Stronghill P, Northey JGB, Strap JL, Bonetta DT.

Front Plant Sci. 2018 Aug 24;9:1152. doi: 10.3389/fpls.2018.01152. eCollection 2018.


Emergency Management of Anaphylaxis: A High Fidelity Interprofessional Simulation Scenario to Foster Teamwork Among Senior Nursing, Medicine, and Pharmacy Undergraduate Students.

MacDonald S, Manuel A, Dubrowski A, Bandrauk N, Law R, Curran V, Lee YW.

Cureus. 2018 Jul 3;10(7):e2915. doi: 10.7759/cureus.2915.


EUS-guided cystesophagostomy using a lumen-apposing metal stent for drainage of a pancreatic fluid collection in a pediatric patient.

Law R, Badillo R, Kwon RS, Zacur G.

VideoGIE. 2018 Apr 4;3(7):209-210. doi: 10.1016/j.vgie.2018.03.002. eCollection 2018 Jul. No abstract available.


The first transmembrane region of complement component-9 acts as a brake on its self-assembly.

Spicer BA, Law RHP, Caradoc-Davies TT, Ekkel SM, Bayly-Jones C, Pang SS, Conroy PJ, Ramm G, Radjainia M, Venugopal H, Whisstock JC, Dunstone MA.

Nat Commun. 2018 Aug 15;9(1):3266. doi: 10.1038/s41467-018-05717-0.


Fast Exfoliation and Functionalisation of Two-Dimensional Crystalline Carbon Nitride by Framework Charging.

Jia J, White ER, Clancy AJ, Rubio N, Suter T, Miller TS, McColl K, McMillan PF, Brázdová V, Corà F, Howard CA, Law RV, Mattevi C, Shaffer MSP.

Angew Chem Int Ed Engl. 2018 Sep 24;57(39):12656-12660. doi: 10.1002/anie.201800875. Epub 2018 Aug 29.


Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma.

Voon HPJ, Udugama M, Lin W, Hii L, Law RHP, Steer DL, Das PP, Mann JR, Wong LH.

Nat Commun. 2018 Aug 7;9(1):3142. doi: 10.1038/s41467-018-05607-5.


Characteristics of Tianeptine Exposures Reported to the National Poison Data System - United States, 2000-2017.

El Zahran T, Schier J, Glidden E, Kieszak S, Law R, Bottei E, Aaron C, King A, Chang A.

MMWR Morb Mortal Wkly Rep. 2018 Aug 3;67(30):815-818. doi: 10.15585/mmwr.mm6730a2.


Putting function first: redesigning the primary care management of long-term conditions.

Williams NH, Law RJ.

Br J Gen Pract. 2018 Aug;68(673):388-389. doi: 10.3399/bjgp18X698249. No abstract available.


EUS-guided biliary drainage for internalization of percutaneous transhepatic biliary drainage.

Law R, Sanchez-Ocana Hernandez R, de la Serna-Higuera C, Perez-Miranda M.

VideoGIE. 2017 Jul 14;2(11):301-302. doi: 10.1016/j.vgie.2017.06.011. eCollection 2017 Nov. No abstract available.


Electroincision and extraction of a gallstone from the duodenal wall for the prevention of gallstone ileus.

Hosmer A, Law R, Elta G.

VideoGIE. 2018 Feb 14;3(4):115-116. doi: 10.1016/j.vgie.2018.01.003. eCollection 2018 Apr. No abstract available.


Engineering thermoresponsive phase separated vesicles formed via emulsion phase transfer as a content-release platform.

Karamdad K, Hindley JW, Bolognesi G, Friddin MS, Law RV, Brooks NJ, Ces O, Elani Y.

Chem Sci. 2018 May 11;9(21):4851-4858. doi: 10.1039/c7sc04309k. eCollection 2018 Jun 7.


Management of an esophagojejunal anastomotic stricture using a lumen-apposing metal stent.

Hosmer A, Shuster D, Prabhu A, Law R.

VideoGIE. 2017 Nov 11;3(1):1-2. doi: 10.1016/j.vgie.2017.09.015. eCollection 2018 Jan. No abstract available.


Relaxin Family Member Insulin-Like Peptide 6 Ameliorates Cardiac Fibrosis and Prevents Cardiac Remodeling in Murine Heart Failure Models.

Maruyama S, Wu CL, Yoshida S, Zhang D, Li PH, Wu F, Parker Duffen J, Yao R, Jardin B, Adham IM, Law R, Berger J, Di Marchi R, Walsh K.

J Am Heart Assoc. 2018 Jun 10;7(12). pii: e008441. doi: 10.1161/JAHA.117.008441.


Valuing innovative endoscopic techniques: per-oral endoscopic myotomy for the management of achalasia.

Shah ED, Chang AC, Law R.

Gastrointest Endosc. 2019 Feb;89(2):264-273.e3. doi: 10.1016/j.gie.2018.04.2341. Epub 2018 Apr 21.


Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain.

Law RP, Atkinson SJ, Bamborough P, Chung CW, Demont EH, Gordon LJ, Lindon M, Prinjha RK, Watson AJB, Hirst DJ.

J Med Chem. 2018 May 24;61(10):4317-4334. doi: 10.1021/acs.jmedchem.7b01666. Epub 2018 May 3.


Light-triggered enzymatic reactions in nested vesicle reactors.

Hindley JW, Elani Y, McGilvery CM, Ali S, Bevan CL, Law RV, Ces O.

Nat Commun. 2018 Mar 15;9(1):1093. doi: 10.1038/s41467-018-03491-7.

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