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Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway.

Liang L, Chen J, Li Y, Lai X, Sun H, Li C, Zhang M, Yang T, Meng F, Law PY, Loh HH, Zheng H.

Cell Rep. 2020 Mar 17;30(11):3625-3631.e6. doi: 10.1016/j.celrep.2020.02.075.


Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway.

Chen J, Liang L, Li Y, Zhang Y, Zhang M, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Law PY, Loh HH, Pei D, Sun H, Zheng H.

FASEB J. 2020 Apr;34(4):5917-5930. doi: 10.1096/fj.201902873R. Epub 2020 Mar 10.


Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study.

Lo SW, Gladstone RA, van Tonder AJ, Lees JA, du Plessis M, Benisty R, Givon-Lavi N, Hawkins PA, Cornick JE, Kwambana-Adams B, Law PY, Ho PL, Antonio M, Everett DB, Dagan R, von Gottberg A, Klugman KP, McGee L, Breiman RF, Bentley SD; Global Pneumococcal Sequencing Consortium.

Lancet Infect Dis. 2019 Jul;19(7):759-769. doi: 10.1016/S1473-3099(19)30297-X. Epub 2019 Jun 10.


Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice.

Yang PP, Yeh TK, Loh HH, Law PY, Wang Y, Tao PL.

Eur J Pharmacol. 2019 Jun 5;852:265-273. doi: 10.1016/j.ejphar.2019.04.009. Epub 2019 Apr 6.


M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt.

Zhao LX, Ge YH, Li JB, Xiong CH, Law PY, Xu JR, Qiu Y, Chen HZ.

FASEB J. 2019 May;33(5):6622-6631. doi: 10.1096/fj.201802351R. Epub 2019 Feb 22.


Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice.

Chao PK, Chang HF, Ou LC, Chuang JY, Lee PT, Chang WT, Chen SC, Ueng SH, Hsu JT, Tao PL, Law PY, Loh HH, Yeh SH.

Sci Rep. 2019 Feb 20;9(1):2405. doi: 10.1038/s41598-019-39555-x.


The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone.

Lin SY, Kuo YH, Tien YW, Ke YY, Chang WT, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, Ueng SH.

Eur J Med Chem. 2019 Apr 1;167:312-323. doi: 10.1016/j.ejmech.2019.01.063. Epub 2019 Feb 2.


Analysis of Patient-Reported Barriers to Diabetic Retinopathy Follow-Up.

Lu AJ, Chen AJ, Hwang V, Law PY, Stewart JM, Chao DL.

Ophthalmic Surg Lasers Imaging Retina. 2019 Feb 1;50(2):99-105. doi: 10.3928/23258160-20190129-06.


Non-nociceptive roles of opioids in the CNS: opioids' effects on neurogenesis, learning, memory and affect.

Kibaly C, Xu C, Cahill CM, Evans CJ, Law PY.

Nat Rev Neurosci. 2019 Jan;20(1):5-18. doi: 10.1038/s41583-018-0092-2. Review.


Morphine regulates adult neurogenesis and contextual memory extinction via the PKCε/Prox1 pathway.

Fan W, Wang H, Zhang Y, Loh HH, Law PY, Xu C.

Neuropharmacology. 2018 Oct;141:126-138. doi: 10.1016/j.neuropharm.2018.08.031. Epub 2018 Aug 28.


Factors Associated with Non-compliance for Diabetic Retinopathy Follow-up in an Urban Safety-Net Hospital.

Chen AJ, Hwang V, Law PY, Stewart JM, Chao DL.

Ophthalmic Epidemiol. 2018 Oct - Dec;25(5-6):443-450. doi: 10.1080/09286586.2018.1504311. Epub 2018 Aug 6.


M1 muscarinic receptor facilitates cognitive function by interplay with AMPA receptor GluA1 subunit.

Zhao LX, Ge YH, Xiong CH, Tang L, Yan YH, Law PY, Qiu Y, Chen HZ.

FASEB J. 2018 Aug;32(8):4247-4257. doi: 10.1096/fj.201800029R. Epub 2018 Mar 6.


IncX3 Epidemic Plasmid Carrying blaNDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China.

Ho PL, Wang Y, Liu MC, Lai EL, Law PY, Cao H, Chow KH.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02295-17. doi: 10.1128/AAC.02295-17. Print 2018 Mar.


Temporal effect of manipulating NeuroD1 expression with the synthetic small molecule KHS101 on morphine contextual memory.

Zhang Y, Kibaly C, Xu C, Loh HH, Law PY.

Neuropharmacology. 2017 Nov;126:58-69. doi: 10.1016/j.neuropharm.2017.08.030. Epub 2017 Aug 24.


Src-dependent phosphorylation of μ-opioid receptor at Tyr336 modulates opiate withdrawal.

Zhang L, Kibaly C, Wang YJ, Xu C, Song KY, McGarrah PW, Loh HH, Liu JG, Law PY.

EMBO Mol Med. 2017 Nov;9(11):1521-1536. doi: 10.15252/emmm.201607324.


Differential regulation of mouse and human Mu opioid receptor gene depends on the single stranded DNA structure of its promoter and α-complex protein 1.

Lee DS, Law PY, Ln W, Loh HH, Song KY, Choi HS.

Biomed Rep. 2017 May;6(5):532-538. doi: 10.3892/br.2017.877. Epub 2017 Mar 21.


1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine.

Chao PK, Ueng SH, Ou LC, Yeh TK, Chang WT, Chang HF, Chen SC, Tao PL, Law PY, Loh HH, Cheng MF, Chuang JY, Chen CT, Shih C, Yeh SH.

Anesthesiology. 2017 May;126(5):952-966. doi: 10.1097/ALN.0000000000001568.


Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo.

Kibaly C, Lin HY, Loh HH, Law PY.

Pharmacol Res. 2017 May;119:153-168. doi: 10.1016/j.phrs.2017.01.033. Epub 2017 Feb 4.


Epigenetic Activation of μ-Opioid Receptor Gene via Increased Expression and Function of Mitogen- and Stress-Activated Protein Kinase 1.

Wagley Y, Law PY, Wei LN, Loh HH.

Mol Pharmacol. 2017 Apr;91(4):357-372. doi: 10.1124/mol.116.106567. Epub 2017 Feb 2.


Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists.

Chen SR, Ke YY, Yeh TK, Lin SY, Ou LC, Chen SC, Chang WT, Chang HF, Wu ZH, Hsieh CC, Law PY, Loh HH, Shih C, Lai YK, Yeh SH, Ueng SH.

Eur J Med Chem. 2017 Jan 27;126:202-217. doi: 10.1016/j.ejmech.2016.09.003. Epub 2016 Sep 20.


A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain.

Kibaly C, Loh HH, Law PY.

Int Rev Cell Mol Biol. 2016;327:89-161. doi: 10.1016/bs.ircmb.2016.06.002. Epub 2016 Jul 30. Review.


Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice.

Yang PP, Yeh GC, Yeh TK, Xi J, Loh HH, Law PY, Tao PL.

Pharmacol Res. 2016 Sep;111:867-876. doi: 10.1016/j.phrs.2016.05.034. Epub 2016 Aug 2.


Post-Transcriptional Regulation of the Human Mu-Opioid Receptor (MOR) by Morphine-Induced RNA Binding Proteins hnRNP K and PCBP1.

Song KY, Choi HS, Law PY, Wei LN, Loh HH.

J Cell Physiol. 2017 Mar;232(3):576-584. doi: 10.1002/jcp.25455. Epub 2016 Jun 24.


Effect of Opioid on Adult Hippocampal Neurogenesis.

Zhang Y, Loh HH, Law PY.

ScientificWorldJournal. 2016;2016:2601264. doi: 10.1155/2016/2601264. Epub 2016 Apr 5. Review.


Morphine Modulates Adult Neurogenesis and Contextual Memory by Impeding the Maturation of Neural Progenitors.

Zhang Y, Xu C, Zheng H, Loh HH, Law PY.

PLoS One. 2016 Apr 14;11(4):e0153628. doi: 10.1371/journal.pone.0153628. eCollection 2016.


Therapeutic intervention for internalized stigma of severe mental illness: A systematic review and meta-analysis.

Tsang HW, Ching SC, Tang KH, Lam HT, Law PY, Wan CN.

Schizophr Res. 2016 May;173(1-2):45-53. doi: 10.1016/j.schres.2016.02.013. Epub 2016 Mar 9. Review.


Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels.

Huang Z, Liang L, Li L, Xu M, Li X, Sun H, He S, Lin L, Zhang Y, Song Y, Yang M, Luo Y, Loh HH, Law PY, Zheng D, Zheng H.

Lipids Health Dis. 2016 Mar 8;15:47. doi: 10.1186/s12944-016-0212-9.


Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli.

Ho PL, Ng KY, Lo WU, Law PY, Lai EL, Wang Y, Chow KH.

Antimicrob Agents Chemother. 2015 Nov 9;60(1):537-43. doi: 10.1128/AAC.02156-15. Print 2016 Jan.


Effects of addictive drugs on adult neural stem/progenitor cells.

Xu C, Loh HH, Law PY.

Cell Mol Life Sci. 2016 Jan;73(2):327-48. doi: 10.1007/s00018-015-2067-z. Epub 2015 Oct 14. Review.


Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice.

Yang PP, Yeh GC, Huang EY, Law PY, Loh HH, Tao PL.

J Biomed Sci. 2015 Sep 22;22:81. doi: 10.1186/s12929-015-0186-3.


Emergence of Macrolide-Resistant Mycoplasma pneumoniae in Hong Kong Is Linked to Increasing Macrolide Resistance in Multilocus Variable-Number Tandem-Repeat Analysis Type 4-5-7-2.

Ho PL, Law PY, Chan BW, Wong CW, To KK, Chiu SS, Cheng VC, Yam WC.

J Clin Microbiol. 2015 Nov;53(11):3560-4. doi: 10.1128/JCM.01983-15. Epub 2015 Sep 2.


Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12.

Wang Y, Ge YH, Wang YX, Liu T, Law PY, Loh HH, Chen HZ, Qiu Y.

CNS Neurosci Ther. 2015 Jul;21(7):591-8. doi: 10.1111/cns.12409.


Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion.

Kibaly C, Kam AY, Loh HH, Law PY.

Biol Psychiatry. 2016 Jun 1;79(11):906-16. doi: 10.1016/j.biopsych.2015.04.019. Epub 2015 May 2.


Clonal diversity of CTX-M-producing, multidrug-resistant Escherichia coli from rodents.

Ho PL, Lo WU, Lai EL, Law PY, Leung SM, Wang Y, Chow KH.

J Med Microbiol. 2015 Feb;64(Pt 2):185-90. doi: 10.1099/jmm.0.000001-0. Erratum in: J Med Microbiol. 2015 May;64(Pt 5):586.


High prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients.

Ho PL, Chu YP, Lo WU, Chow KH, Law PY, Tse CW, Ng TK, Cheng VC, Que TL.

J Med Microbiol. 2015 Mar;64(Pt 3):243-247. doi: 10.1099/jmm.0.000012. Epub 2015 Jan 13.


Increase in the nasopharyngeal carriage of non-vaccine serogroup 15 Streptococcus pneumoniae after introduction of children pneumococcal conjugate vaccination in Hong Kong.

Ho PL, Chiu SS, Law PY, Chan EL, Lai EL, Chow KH.

Diagn Microbiol Infect Dis. 2015 Feb;81(2):145-8. doi: 10.1016/j.diagmicrobio.2014.11.006. Epub 2014 Nov 20.


Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling.

Lee PT, Chao PK, Ou LC, Chuang JY, Lin YC, Chen SC, Chang HF, Law PY, Loh HH, Chao YS, Su TP, Yeh SH.

Nucleic Acids Res. 2014 Dec 1;42(21):13012-25. doi: 10.1093/nar/gku1016. Epub 2014 Oct 31.


Analysis of epigenetic mechanisms regulating opioid receptor gene transcription.

Hwang CK, Wagley Y, Law PY, Wei LN, Loh HH.

Methods Mol Biol. 2015;1230:39-51. doi: 10.1007/978-1-4939-1708-2_3.


μ-Opioid receptor attenuates Aβ oligomers-induced neurotoxicity through mTOR signaling.

Wang Y, Wang YX, Liu T, Law PY, Loh HH, Qiu Y, Chen HZ.

CNS Neurosci Ther. 2015 Jan;21(1):8-14. doi: 10.1111/cns.12316. Epub 2014 Aug 21.


Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists.

Cheng MF, Ou LC, Chen SC, Chang WT, Law PY, Loh HH, Chao YS, Shih C, Yeh SH, Ueng SH.

Bioorg Med Chem. 2014 Sep 1;22(17):4694-703. doi: 10.1016/j.bmc.2014.07.012. Epub 2014 Jul 16.


Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms.

Li W, He S, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, Zheng H.

Biol Psychiatry. 2014 Nov 15;76(10):775-84. doi: 10.1016/j.biopsych.2014.05.013. Epub 2014 Jun 2.


Clonal diversity of Escherichia coli isolates carrying plasmid-mediated fosfomycin resistance gene fosA3 from livestock and other animals.

Chan J, Lo WU, Chow KH, Lai EL, Law PY, Ho PL.

Antimicrob Agents Chemother. 2014 Sep;58(9):5638-9. doi: 10.1128/AAC.02700-14. Epub 2014 Jun 30. No abstract available.


Morphine modulates mouse hippocampal progenitor cell lineages by upregulating miR-181a level.

Xu C, Zhang Y, Zheng H, Loh HH, Law PY.

Stem Cells. 2014 Nov;32(11):2961-72. doi: 10.1002/stem.1774.


Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord.

Kao JH, Gao MJ, Yang PP, Law PY, Loh HH, Tao PL.

Br J Pharmacol. 2015 Jan;172(2):630-41. doi: 10.1111/bph.12790.


Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.

Glück L, Loktev A, Moulédous L, Mollereau C, Law PY, Schulz S.

Biol Psychiatry. 2014 Nov 15;76(10):767-74. doi: 10.1016/j.biopsych.2014.01.021. Epub 2014 Feb 3.


Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization.

Yan YH, Wang Y, Zhao LX, Jiang S, Loh HH, Law PY, Chen HZ, Qiu Y.

Neurosci Lett. 2014 Apr 30;566:231-235. doi: 10.1016/j.neulet.2014.02.059. Epub 2014 Mar 6.


Highly conjugative IncX4 plasmids carrying blaCTX-M in Escherichia coli from humans and food animals.

Lo WU, Chow KH, Law PY, Ng KY, Cheung YY, Lai EL, Ho PL.

J Med Microbiol. 2014 Jun;63(Pt 6):835-840. doi: 10.1099/jmm.0.074021-0. Epub 2014 Mar 4.


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