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Is Danggui Safe to be Taken by Breast Cancer Patients?-A Skepticism Finally Answered by Comprehensive Preclinical Evidence.

Yue GG, Wong LS, Leung HW, Gao S, Tsang JY, Lin ZX, Law BK, Tse GM, Lau CB.

Front Pharmacol. 2019 Jun 25;10:706. doi: 10.3389/fphar.2019.00706. eCollection 2019.

Free PMC Article

A Singular System with Precise Dosing and Spatiotemporal Control of CRISPR-Cas9.

Manna D, Maji B, Gangopadhyay SA, Cox KJ, Zhou Q, Law BK, Mazitschek R, Choudhary A.

Angew Chem Int Ed Engl. 2019 May 6;58(19):6285-6289. doi: 10.1002/anie.201900788. Epub 2019 Apr 2.


A metabolic switch in proteasome inhibitor resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis.

Besse L, Besse A, Mendez-Lopez M, Vasickova K, Sedlackova M, Vanhara P, Kraus M, Bader J, Ferreira RB, Castellano RK, Law BK, Driessen C.

Haematologica. 2019 Feb 21. pii: haematol.2018.207704. doi: 10.3324/haematol.2018.207704. [Epub ahead of print]


A novel proteotoxic combination therapy for EGFR+ and HER2+ cancers.

Wang M, Ferreira RB, Law ME, Davis BJ, Yaaghubi E, Ghilardi AF, Sharma A, Avery BA, Rodriguez E, Chiang CW, Narayan S, Heldermon CD, Castellano RK, Law BK.

Oncogene. 2019 May;38(22):4264-4282. doi: 10.1038/s41388-019-0717-6. Epub 2019 Feb 4.


Amide proton transfer MRI detects early changes in nasopharyngeal carcinoma: providing a potential imaging marker for treatment response.

Qamar S, King AD, Ai QY, Law BKH, Chan JSM, Poon DMC, Tong M, Mo FKF, Chen W, Bhatia KS, Ahuja AT, Ma BBY, Yeung DK, Wang YX, Yuan J.

Eur Arch Otorhinolaryngol. 2019 Feb;276(2):505-512. doi: 10.1007/s00405-018-5231-x. Epub 2018 Dec 3.


ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.

Narayan S, Ramisetti S, Jaiswal AS, Law BK, Singh-Pillay A, Singh P, Amin S, Sharma AK.

Eur J Med Chem. 2019 Jan 1;161:456-467. doi: 10.1016/j.ejmech.2018.10.052. Epub 2018 Oct 23.


Core needle biopsy as an alternative to whole section in IHC4 score assessment for breast cancer prognostication.

Liu M, Tang SX, Tsang JYS, Shi YJ, Ni YB, Law BKB, Tse GMK.

J Clin Pathol. 2018 Dec;71(12):1084-1089. doi: 10.1136/jclinpath-2018-205228. Epub 2018 Sep 18.


Head and Neck Tumors: Amide Proton Transfer MRI.

Law BKH, King AD, Ai QY, Poon DMC, Chen W, Bhatia KS, Ahuja AT, Ma BB, Ka-Wai Yeung D, Fai Mo FK, Wang YX, Yuan J.

Radiology. 2018 Sep;288(3):782-790. doi: 10.1148/radiol.2018171528. Epub 2018 Jun 12.


The unfolded protein response as a target for anticancer therapeutics.

Wang M, Law ME, Castellano RK, Law BK.

Crit Rev Oncol Hematol. 2018 Jul;127:66-79. doi: 10.1016/j.critrevonc.2018.05.003. Epub 2018 May 26. Review.


Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers.

Chun SK, Lee S, Flores-Toro J, U RY, Yang MJ, Go KL, Biel TG, Miney CE, Pierre Louis S, Law BK, Law ME, Thomas EM, Behrns KE, Leeuwenburgh C, Kim JS.

Aging Cell. 2018 Aug;17(4):e12761. doi: 10.1111/acel.12761. Epub 2018 May 17.


Staging nodal metastases in nasopharyngeal carcinoma: which method should be used to measure nodal dimension on MRI?

Ai QY, King AD, Mo FKF, Law BKH, Bhatia KS, Poon DMC, Kam MKM, Ma BB.

Clin Radiol. 2018 Jul;73(7):640-646. doi: 10.1016/j.crad.2017.12.015. Epub 2018 Apr 7.


MR Imaging Criteria for the Detection of Nasopharyngeal Carcinoma: Discrimination of Early-Stage Primary Tumors from Benign Hyperplasia.

King AD, Wong LYS, Law BKH, Bhatia KS, Woo JKS, Ai QY, Tan TY, Goh J, Chuah KL, Mo FKF, Chan KCA, Chan ATC, Vlantis AC.

AJNR Am J Neuroradiol. 2018 Mar;39(3):515-523. doi: 10.3174/ajnr.A5493. Epub 2017 Dec 28.


Nasopharyngeal carcinoma: relationship between invasion of the prevertebral space and distant metastases.

Ai QY, Hu CW, Bhatia KS, Poon DMC, Hui EP, Mo FKF, Law BKH, Tong M, Ma BB, Chan ATC, King AD.

Eur Arch Otorhinolaryngol. 2018 Feb;275(2):497-505. doi: 10.1007/s00405-017-4825-z. Epub 2017 Nov 29.


Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer.

Al-Awadhi FH, Law BK, Paul VJ, Luesch H.

J Nat Prod. 2017 Nov 22;80(11):2969-2986. doi: 10.1021/acs.jnatprod.7b00551. Epub 2017 Oct 31.


Kempopeptin C, a Novel Marine-Derived Serine Protease Inhibitor Targeting Invasive Breast Cancer.

Al-Awadhi FH, Salvador LA, Law BK, Paul VJ, Luesch H.

Mar Drugs. 2017 Sep 16;15(9). pii: E290. doi: 10.3390/md15090290.


NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.

Narayan S, Jaiswal AS, Sharma R, Nawab A, Duckworth LV, Law BK, Zajac-Kaye M, George TJ, Sharma J, Sharma AK, Hromas RA.

Oncotarget. 2017 Aug 1;8(34):57246-57264. doi: 10.18632/oncotarget.19778. eCollection 2017 Aug 22.


Prediction of distant metastases from nasopharyngeal carcinoma: Improved diagnostic performance of MRI using nodal volume in N1 and N2 stage disease.

Ai QY, King AD, Mo FKF, Law BKH, Bhatia KS, Ma BB, Poon DMC, Kam MKM.

Oral Oncol. 2017 Jun;69:74-79. doi: 10.1016/j.oraloncology.2017.04.008. Epub 2017 Apr 18.


Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells.

Ferreira RB, Wang M, Law ME, Davis BJ, Bartley AN, Higgins PJ, Kilberg MS, Santostefano KE, Terada N, Heldermon CD, Castellano RK, Law BK.

Oncotarget. 2017 Apr 25;8(17):28971-28989. doi: 10.18632/oncotarget.15952.


Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells.

Shenoy AK, Jin Y, Luo H, Tang M, Pampo C, Shao R, Siemann DW, Wu L, Heldermon CD, Law BK, Chang LJ, Lu J.

J Clin Invest. 2016 Nov 1;126(11):4174-4186. doi: 10.1172/JCI86623. Epub 2016 Oct 10.


MRI of diffuse large B-cell non-Hodgkin's lymphoma of the head and neck: comparison of Waldeyer's ring and sinonasal lymphoma.

King AD, Law BK, Tang WK, Mo FK, Raghupathy R, Bhatia KS, Lei KI.

Eur Arch Otorhinolaryngol. 2017 Feb;274(2):1079-1087. doi: 10.1007/s00405-016-4337-2. Epub 2016 Oct 13.


Diffusion-weighted imaging of nasopharyngeal carcinoma to predict distant metastases.

Ai QY, King AD, Law BK, Yeung DK, Bhatia KS, Yuan J, Ahuja AT, Wong LY, Ma BB, Mo FK, Kam MK.

Eur Arch Otorhinolaryngol. 2017 Feb;274(2):1045-1051. doi: 10.1007/s00405-016-4333-6. Epub 2016 Oct 8.


CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment.

Law ME, Ferreira RB, Davis BJ, Higgins PJ, Kim JS, Castellano RK, Chen S, Luesch H, Law BK.

Breast Cancer Res. 2016 Aug 5;18(1):80. doi: 10.1186/s13058-016-0741-1.


Diffusion-Weighted Imaging of Nasopharyngeal Carcinoma: Can Pretreatment DWI Predict Local Failure Based on Long-Term Outcome?

Law BK, King AD, Bhatia KS, Ahuja AT, Kam MK, Ma BB, Ai QY, Mo FK, Yuan J, Yeung DK.

AJNR Am J Neuroradiol. 2016 Sep;37(9):1706-12. doi: 10.3174/ajnr.A4792. Epub 2016 May 5.


Interaction between APC and Fen1 during breast carcinogenesis.

Narayan S, Jaiswal AS, Law BK, Kamal MA, Sharma AK, Hromas RA.

DNA Repair (Amst). 2016 May;41:54-62. doi: 10.1016/j.dnarep.2016.04.003. Epub 2016 Apr 7. Review.


Cervical nodal metastases from head and neck squamous cell carcinoma: MRI criteria for treatment assessment.

King AD, Yu KH, Mo FK, Law BK, Yuen TW, Bhatia KS, Vlantis AC.

Head Neck. 2016 Apr;38 Suppl 1:E1598-604. doi: 10.1002/hed.24285. Epub 2016 Feb 15.


DCE-MRI for Pre-Treatment Prediction and Post-Treatment Assessment of Treatment Response in Sites of Squamous Cell Carcinoma in the Head and Neck.

King AD, Chow SK, Yu KH, Mo FK, Yeung DK, Yuan J, Law BK, Bhatia KS, Vlantis AC, Ahuja AT.

PLoS One. 2015 Dec 10;10(12):e0144770. doi: 10.1371/journal.pone.0144770. eCollection 2015.


Detection of Nasopharyngeal Carcinoma by MR Imaging: Diagnostic Accuracy of MRI Compared with Endoscopy and Endoscopic Biopsy Based on Long-Term Follow-Up.

King AD, Vlantis AC, Yuen TW, Law BK, Bhatia KS, Zee BC, Woo JK, Chan AT, Chan KC, Ahuja AT.

AJNR Am J Neuroradiol. 2015 Dec;36(12):2380-5. doi: 10.3174/ajnr.A4456. Epub 2015 Aug 27.


Sirtuin 1 suppresses mitochondrial dysfunction of ischemic mouse livers in a mitofusin 2-dependent manner.

Biel TG, Lee S, Flores-Toro JA, Dean JW, Go KL, Lee MH, Law BK, Law ME, Dunn WA Jr, Zendejas I, Behrns KE, Kim JS.

Cell Death Differ. 2016 Feb;23(2):279-90. doi: 10.1038/cdd.2015.96. Epub 2015 Jul 17.


Targeted Inhibition of PAI-1 Activity Impairs Epithelial Migration and Wound Closure Following Cutaneous Injury.

Simone TM, Longmate WM, Law BK, Higgins PJ.

Adv Wound Care (New Rochelle). 2015 Jun 1;4(6):321-328.


Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics.

Law ME, Corsino PE, Narayan S, Law BK.

Mol Pharmacol. 2015 Nov;88(5):846-52. doi: 10.1124/mol.115.099325. Epub 2015 May 27.


NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer Cells.

Jaiswal AS, Panda H, Law BK, Sharma J, Jani J, Hromas R, Narayan S.

PLoS One. 2015 May 1;10(5):e0123808. doi: 10.1371/journal.pone.0123808. eCollection 2015.


Novel agents that downregulate EGFR, HER2, and HER3 in parallel.

Ferreira RB, Law ME, Jahn SC, Davis BJ, Heldermon CD, Reinhard M, Castellano RK, Law BK.

Oncotarget. 2015 Apr 30;6(12):10445-59.


VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFβR signaling-dependent manner.

Pham K, Luo D, Siemann DW, Law BK, Reynolds BA, Hothi P, Foltz G, Harrison JK.

Cancer Lett. 2015 Apr 28;360(1):60-7. doi: 10.1016/j.canlet.2015.02.005. Epub 2015 Feb 9.


Signaling mechanisms that suppress the cytostatic actions of rapamycin.

Jahn SC, Law ME, Corsino PE, Davis BJ, Harrison JK, Law BK.

PLoS One. 2014 Jun 13;9(6):e99927. doi: 10.1371/journal.pone.0099927. eCollection 2014.


The basic helix-loop-helix/leucine zipper transcription factor USF2 integrates serum-induced PAI-1 expression and keratinocyte growth.

Qi L, Higgins CE, Higgins SP, Law BK, Simone TM, Higgins PJ.

J Cell Biochem. 2014 Oct;115(10):1840-7. doi: 10.1002/jcb.24861.


SERPINE1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-"Activated" Keratinocytes.

Simone TM, Higgins CE, Czekay RP, Law BK, Higgins SP, Archambeault J, Kutz SM, Higgins PJ.

Adv Wound Care (New Rochelle). 2014 Mar 1;3(3):281-290. Review.


Androgen receptor expression shows distinctive significance in ER positive and negative breast cancers.

Tsang JY, Ni YB, Chan SK, Shao MM, Law BK, Tan PH, Tse GM.

Ann Surg Oncol. 2014 Jul;21(7):2218-28. doi: 10.1245/s10434-014-3629-2. Epub 2014 Mar 18.


Lymphocytic infiltrate is associated with favorable biomarkers profile in HER2-overexpressing breast cancers and adverse biomarker profile in ER-positive breast cancers.

Tsang JY, Hui SW, Ni YB, Chan SK, Yamaguchi R, Kwong A, Law BK, Tse GM.

Breast Cancer Res Treat. 2014 Jan;143(1):1-9. doi: 10.1007/s10549-013-2781-x. Epub 2013 Nov 24.


Sustained elevation of systemic oxidative stress and inflammation in exacerbation and remission of asthma.

Mak JC, Ho SP, Ho AS, Law BK, Cheung AH, Ho JC, Ip MS, Chan-Yeung MM.

ISRN Allergy. 2013 Aug 29;2013:561831. doi: 10.1155/2013/561831. eCollection 2013.


Anterior cruciate ligament bundle measurement by MRI.

Ng AW, Lee RK, Ho EP, Law BK, Griffith JF.

Skeletal Radiol. 2013 Nov;42(11):1549-54. doi: 10.1007/s00256-013-1705-5. Epub 2013 Aug 18.


The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.

Tang M, Shen H, Jin Y, Lin T, Cai Q, Pinard MA, Biswas S, Tran Q, Li G, Shenoy AK, Tongdee E, Lin S, Gu Y, Law BK, Zhou L, McKenna R, Wu L, Lu J.

J Biol Chem. 2013 Sep 20;288(38):27680-91. doi: 10.1074/jbc.M113.482349. Epub 2013 Aug 8.


Assembly, activation, and substrate specificity of cyclin D1/Cdk2 complexes.

Jahn SC, Law ME, Corsino PE, Rowe TC, Davis BJ, Law BK.

Biochemistry. 2013 May 21;52(20):3489-501. doi: 10.1021/bi400047u. Epub 2013 May 9.


Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.

Yang H, Pinello CE, Luo J, Li D, Wang Y, Zhao LY, Jahn SC, Saldanha SA, Chase P, Planck J, Geary KR, Ma H, Law BK, Roush WR, Hodder P, Liao D.

Mol Cancer Ther. 2013 May;12(5):610-20. doi: 10.1158/1535-7163.MCT-12-0930. Epub 2013 Apr 26. Erratum in: Mol Cancer Ther. 2013 Aug;12(8):1688. Chase, Peter [added].


Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints.

Jahn SC, Corsino PE, Davis BJ, Law ME, Nørgaard P, Law BK.

J Cell Sci. 2013 Mar 1;126(Pt 5):1207-17. doi: 10.1242/jcs.117382. Epub 2013 Jan 15.


Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development.

Ruan Q, Xi L, Boye SL, Han S, Chen ZJ, Hauswirth WW, Lewin AS, Boulton ME, Law BK, Jiang WG, Jiang H, Cai J.

Cancer Lett. 2013 May 10;332(1):120-9. doi: 10.1016/j.canlet.2012.11.016. Epub 2012 Nov 27.


An in vivo model of epithelial to mesenchymal transition reveals a mitogenic switch.

Jahn SC, Law ME, Corsino PE, Parker NN, Pham K, Davis BJ, Lu J, Law BK.

Cancer Lett. 2012 Dec 30;326(2):183-90. doi: 10.1016/j.canlet.2012.08.013. Epub 2012 Aug 17.


Keratin expression in breast cancers.

Shao MM, Chan SK, Yu AM, Lam CC, Tsang JY, Lui PC, Law BK, Tan PH, Tse GM.

Virchows Arch. 2012 Sep;461(3):313-22. doi: 10.1007/s00428-012-1289-9. Epub 2012 Aug 1.


Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms.

Law ME, Corsino PE, Jahn SC, Davis BJ, Chen S, Patel B, Pham K, Lu J, Sheppard B, Nørgaard P, Hong J, Higgins P, Kim JS, Luesch H, Law BK.

Oncogene. 2013 Mar 7;32(10):1316-29. doi: 10.1038/onc.2012.138. Epub 2012 Apr 30.


Imaging of the anterior cruciate ligament.

Ng WH, Griffith JF, Hung EH, Paunipagar B, Law BK, Yung PS.

World J Orthop. 2011 Aug 18;2(8):75-84. doi: 10.5312/wjo.v2.i8.75.


TGF-beta antiproliferative effects in tumor suppression.

Jahn SC, Law ME, Corsino PE, Law BK.

Front Biosci (Schol Ed). 2012 Jan 1;4:749-66. Review.


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