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Trimethylamine-N-oxide as One Hypothetical Link for the Relationship between Intestinal Microbiota and Cancer - Where We Are and Where Shall We Go?

Chan CWH, Law BMH, Waye MMY, Chan JYW, So WKW, Chow KM.

J Cancer. 2019 Oct 8;10(23):5874-5882. doi: 10.7150/jca.31737. eCollection 2019. Review.


Development and evaluation of a multimedia intervention to promote cervical cancer prevention among South Asian women in Hong Kong.

So WKW, Law BMH, Chan CWH, Leung DYP, Chan HYL, Chair SY.

Ethn Health. 2019 Nov 8:1-13. doi: 10.1080/13557858.2019.1687657. [Epub ahead of print]


Niacin analogue, 6-Aminonicotinamide, a novel inhibitor of hepatitis B virus replication and HBsAg production.

Ren F, Yang X, Hu ZW, Wong VKW, Xu HY, Ren JH, Zhong S, Jia XJ, Jiang H, Hu JL, Cai XF, Zhang WL, Yao FL, Yu HB, Cheng ST, Zhou HZ, Huang AL, Law BYK, Chen J.

EBioMedicine. 2019 Nov;49:232-246. doi: 10.1016/j.ebiom.2019.10.022. Epub 2019 Oct 31.


High-performance chemical- and light-inducible recombinases in mammalian cells and mice.

Weinberg BH, Cho JH, Agarwal Y, Pham NTH, Caraballo LD, Walkosz M, Ortega C, Trexler M, Tague N, Law B, Benman WKJ, Letendre J, Beal J, Wong WW.

Nat Commun. 2019 Oct 24;10(1):4845. doi: 10.1038/s41467-019-12800-7.


Novel steroidal saponin isolated from Trillium tschonoskii maxim. exhibits anti-oxidative effect via autophagy induction in cellular and Caenorhabditis elegans models.

Wu AG, Teng JF, Wong VK, Zhou XG, Qiu WQ, Tang Y, Wu JM, Xiong R, Pan R, Wang YL, Tang B, Ding TY, Yu L, Zeng W, Qin DL, Law BY.

Phytomedicine. 2019 Sep 16;65:153088. doi: 10.1016/j.phymed.2019.153088. [Epub ahead of print]


A Novel Drug Resistance Mechanism: Genetic Loss of Xeroderma Pigmentosum Complementation Group C (XPC) Enhances Glycolysis-Mediated Drug Resistance in DLD-1 Colon Cancer Cells.

Han Y, Qu YQ, Mok SWF, Chen J, Xia CL, He HQ, Li Z, Zhang W, Qiu CL, Liu L, Law BYK, Wong VKW.

Front Pharmacol. 2019 Sep 10;10:912. doi: 10.3389/fphar.2019.00912. eCollection 2019.


Effect of Inulin-Type Carbohydrates on Insulin Resistance in Patients with Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis.

Rao M, Gao C, Xu L, Jiang L, Zhu J, Chen G, Law BYK, Xu Y.

J Diabetes Res. 2019 Aug 27;2019:5101423. doi: 10.1155/2019/5101423. eCollection 2019. Review.


Seasonal variability of forest sensitivity to heat and drought stresses: A synthesis based on carbon fluxes from North American forest ecosystems.

Xu B, Arain MA, Black TA, Law BE, Pastorello GZ, Chu H.

Glob Chang Biol. 2019 Sep 17. doi: 10.1111/gcb.14843. [Epub ahead of print]


An Opportunity for Cognitive Task Analysis in Neonatal Resuscitation.

Zehnder EC, Law BHY, Schmölzer GM.

Front Pediatr. 2019 Aug 27;7:356. doi: 10.3389/fped.2019.00356. eCollection 2019. Review.


Effects of a Community Health Worker-Led Multimedia Intervention on the Uptake of Cervical Cancer Screening among South Asian Women: A Pilot Randomized Controlled Trial.

Wong CL, Choi KC, Law BMH, Chan DNS, So WKW.

Int J Environ Res Public Health. 2019 Aug 23;16(17). pii: E3072. doi: 10.3390/ijerph16173072.


Specialized Roles of Human Natural Killer Cell Subsets in Kidney Transplant Rejection.

Kildey K, Francis RS, Hultin S, Harfield M, Giuliani K, Law BMP, Wang X, See EJ, John G, Ungerer J, Wilkinson R, Kassianos AJ, Healy H.

Front Immunol. 2019 Aug 7;10:1877. doi: 10.3389/fimmu.2019.01877. eCollection 2019.


Etiological Contact Allergen Chemical Identification and Confirmation.

Siegel PD, Law BF, Warshaw EM.

Dermatitis. 2019 Aug 19. doi: 10.1097/DER.0000000000000498. [Epub ahead of print]


Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression.

Courtney DG, Tsai K, Bogerd HP, Kennedy EM, Law BA, Emery A, Swanstrom R, Holley CL, Cullen BR.

Cell Host Microbe. 2019 Aug 14;26(2):217-227.e6. doi: 10.1016/j.chom.2019.07.005.


Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer.

Teng JF, Qin DL, Mei QB, Qiu WQ, Pan R, Xiong R, Zhao Y, Law BY, Wong VK, Tang Y, Yu CL, Zhang F, Wu JM, Wu AG.

Pharmacol Res. 2019 Sep;147:104396. doi: 10.1016/j.phrs.2019.104396. Epub 2019 Aug 9.


Effect of monitor positioning on visual attention and situation awareness during neonatal resuscitation: a randomised simulation study.

Law BHY, Cheung PY, van Os S, Fray C, Schmölzer GM.

Arch Dis Child Fetal Neonatal Ed. 2019 Aug 2. pii: fetalneonatal-2019-316992. doi: 10.1136/archdischild-2019-316992. [Epub ahead of print]


Advances on Cell Autophagy and Its Potential Regulatory Factors in Renal Ischemia-Reperfusion Injury.

Hou J, Rao M, Zheng W, Fan J, Law BYK.

DNA Cell Biol. 2019 Sep;38(9):895-904. doi: 10.1089/dna.2019.4767. Epub 2019 Jul 26. Review.


Is Danggui Safe to be Taken by Breast Cancer Patients?-A Skepticism Finally Answered by Comprehensive Preclinical Evidence.

Yue GG, Wong LS, Leung HW, Gao S, Tsang JY, Lin ZX, Law BK, Tse GM, Lau CB.

Front Pharmacol. 2019 Jun 25;10:706. doi: 10.3389/fphar.2019.00706. eCollection 2019.


The Effect of Nonpharmacological Interventions on Managing Symptom Clusters Among Cancer Patients: A Systematic Review.

So WKW, Law BMH, Chan DNS, Xing W, Chan CWH, McCarthy AL.

Cancer Nurs. 2019 Jul 3. doi: 10.1097/NCC.0000000000000730. [Epub ahead of print]


Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression.

Courtney DG, Chalem A, Bogerd HP, Law BA, Kennedy EM, Holley CL, Cullen BR.

MBio. 2019 Jun 11;10(3). pii: e01209-19. doi: 10.1128/mBio.01209-19.


Human Tissue-Resident Mucosal-Associated Invariant T (MAIT) Cells in Renal Fibrosis and CKD.

Law BMP, Wilkinson R, Wang X, Kildey K, Giuliani K, Beagley KW, Ungerer J, Healy H, Kassianos AJ.

J Am Soc Nephrol. 2019 Jul;30(7):1322-1335. doi: 10.1681/ASN.2018101064. Epub 2019 Jun 11.


Fixing a snag in carbon emissions estimates from wildfires.

Stenzel JE, Bartowitz KJ, Hartman MD, Lutz JA, Kolden CA, Smith AMS, Law BE, Swanson ME, Larson AJ, Parton WJ, Hudiburg TW.

Glob Chang Biol. 2019 Nov;25(11):3985-3994. doi: 10.1111/gcb.14716. Epub 2019 Jul 8.


Effectiveness of Physical Activity Interventions on Pregnancy-Related Outcomes among Pregnant Women: A Systematic Review.

Chan CWH, Au Yeung E, Law BMH.

Int J Environ Res Public Health. 2019 May 23;16(10). pii: E1840. doi: 10.3390/ijerph16101840. Review.


Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats.

Wong VKW, Qiu C, Xu SW, Law BYK, Zeng W, Wang H, Michelangeli F, Dias IRSR, Qu YQ, Chan TW, Han Y, Zhang N, Mok SWF, Chen X, Yu L, Pan H, Hamdoun S, Efferth T, Yu WJ, Zhang W, Li Z, Xie Y, Luo R, Jiang Q, Liu L.

Br J Pharmacol. 2019 Aug;176(16):2922-2944. doi: 10.1111/bph.14718. Epub 2019 Jul 4.


The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis.

Yu L, Wu AG, Wong VK, Qu LQ, Zhang N, Qin DL, Zeng W, Tang B, Wang HM, Wang Q, Law BY.

Front Pharmacol. 2019 Mar 18;10:194. doi: 10.3389/fphar.2019.00194. eCollection 2019.


Semi-synthetic isoflavones as BACE-1 inhibitors against Alzheimer's disease.

Ribaudo G, Coghi P, Zanforlin E, Law BYK, Wu YYJ, Han Y, Qiu AC, Qu YQ, Zagotto G, Wong VKW.

Bioorg Chem. 2019 Jun;87:474-483. doi: 10.1016/j.bioorg.2019.03.034. Epub 2019 Mar 15.


Real-Time, in Vivo Correlation of Molecular Structure with Drug Distribution in the Brain Striatum Following Convection Enhanced Delivery.

Tosi U, Kommidi H, Bellat V, Marnell CS, Guo H, Adeuyan O, Schweitzer ME, Chen N, Su T, Zhang G, Maachani UB, Pisapia DJ, Law B, Souweidane MM, Ting R.

ACS Chem Neurosci. 2019 May 15;10(5):2287-2298. doi: 10.1021/acschemneuro.8b00607. Epub 2019 Mar 6.


A Singular System with Precise Dosing and Spatiotemporal Control of CRISPR-Cas9.

Manna D, Maji B, Gangopadhyay SA, Cox KJ, Zhou Q, Law BK, Mazitschek R, Choudhary A.

Angew Chem Int Ed Engl. 2019 May 6;58(19):6285-6289. doi: 10.1002/anie.201900788. Epub 2019 Apr 2.


A rare case of rectal prolapse after Deloyers procedure in a patient with Hirschsprung's disease: A case report.

Law BC, Lo OS.

Int J Surg Case Rep. 2019;56:63-65. doi: 10.1016/j.ijscr.2019.02.021. Epub 2019 Feb 23.


A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis.

Besse L, Besse A, Mendez-Lopez M, Vasickova K, Sedlackova M, Vanhara P, Kraus M, Bader J, Ferreira RB, Castellano RK, Law BK, Driessen C.

Haematologica. 2019 Sep;104(9):e415-e419. doi: 10.3324/haematol.2018.207704. Epub 2019 Feb 21. No abstract available.


Identification of Design Criteria to Improve Patient Care in Electronic Health Record Downtime.

Larsen EP, Haskins Lisle A, Law B, Gabbard JL, Kleiner BM, Ratwani RM.

J Patient Saf. 2019 Feb 9. doi: 10.1097/PTS.0000000000000580. [Epub ahead of print]


Memory effects of climate and vegetation affecting net ecosystem CO2 fluxes in global forests.

Besnard S, Carvalhais N, Arain MA, Black A, Brede B, Buchmann N, Chen J, Clevers JGPW, Dutrieux LP, Gans F, Herold M, Jung M, Kosugi Y, Knohl A, Law BE, Paul-Limoges E, Lohila A, Merbold L, Roupsard O, Valentini R, Wolf S, Zhang X, Reichstein M.

PLoS One. 2019 Feb 6;14(2):e0211510. doi: 10.1371/journal.pone.0211510. eCollection 2019. Erratum in: PLoS One. 2019 Feb 28;14(2):e0213467.


A novel proteotoxic combination therapy for EGFR+ and HER2+ cancers.

Wang M, Ferreira RB, Law ME, Davis BJ, Yaaghubi E, Ghilardi AF, Sharma A, Avery BA, Rodriguez E, Chiang CW, Narayan S, Heldermon CD, Castellano RK, Law BK.

Oncogene. 2019 May;38(22):4264-4282. doi: 10.1038/s41388-019-0717-6. Epub 2019 Feb 4.


A Functional Variant in Ubiquitin Conjugating Enzyme E2 L3 Contributes to Hepatitis B Virus Infection and Maintains Covalently Closed Circular DNA Stability by Inducing Degradation of Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A.

Zhou L, Ren JH, Cheng ST, Xu HM, Chen WX, Chen DP, Wong VKW, Law BYK, Liu Y, Cai XF, Tang H, Yu HB, Hu JL, Hu Y, Zhou HZ, Ren F, He L, Hu ZW, Jiang H, Xu HY, Huang AL, Chen J.

Hepatology. 2019 May;69(5):1885-1902. doi: 10.1002/hep.30497. Epub 2019 Mar 15.


Functional Peptide Nanofibers with Unique Tumor Targeting and Enzyme-Induced Local Retention Properties.

Bellat V, Ting R, Southard TL, Vahdat L, Molina H, Fernandez J, Aras O, Stokol T, Law B.

Adv Funct Mater. 2018 Oct 31;28(44). pii: 1803969. doi: 10.1002/adfm.201803969. Epub 2018 Sep 14.


Amide proton transfer MRI detects early changes in nasopharyngeal carcinoma: providing a potential imaging marker for treatment response.

Qamar S, King AD, Ai QY, Law BKH, Chan JSM, Poon DMC, Tong M, Mo FKF, Chen W, Bhatia KS, Ahuja AT, Ma BBY, Yeung DK, Wang YX, Yuan J.

Eur Arch Otorhinolaryngol. 2019 Feb;276(2):505-512. doi: 10.1007/s00405-018-5231-x. Epub 2018 Dec 3.


Novel dauricine derivatives suppress cancer via autophagy-dependent cell death.

Zhou X, Qu YQ, Zheng Z, Law BYK, Mok SWF, Jiang ZH, Wong VKW, Bai LP.

Bioorg Chem. 2019 Mar;83:450-460. doi: 10.1016/j.bioorg.2018.10.074. Epub 2018 Nov 2.


Near-future forest vulnerability to drought and fire varies across the western United States.

Buotte PC, Levis S, Law BE, Hudiburg TW, Rupp DE, Kent JJ.

Glob Chang Biol. 2019 Jan;25(1):290-303. doi: 10.1111/gcb.14490. Epub 2018 Nov 15.


Effects of metformin treatment on radiotherapy efficacy in patients with cancer and diabetes: a systematic review and meta-analysis.

Rao M, Gao C, Guo M, Law BYK, Xu Y.

Cancer Manag Res. 2018 Oct 24;10:4881-4890. doi: 10.2147/CMAR.S174535. eCollection 2018. Review.


ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.

Narayan S, Ramisetti S, Jaiswal AS, Law BK, Singh-Pillay A, Singh P, Amin S, Sharma AK.

Eur J Med Chem. 2019 Jan 1;161:456-467. doi: 10.1016/j.ejmech.2018.10.052. Epub 2018 Oct 23.


Passive acoustics and sound recognition provide new insights on status and resilience of an iconic endangered marsupial (koala Phascolarctos cinereus) to timber harvesting.

Law BS, Brassil T, Gonsalves L, Roe P, Truskinger A, McConville A.

PLoS One. 2018 Oct 31;13(10):e0205075. doi: 10.1371/journal.pone.0205075. eCollection 2018.


The relationship between physical literacy scores and adherence to Canadian physical activity and sedentary behaviour guidelines.

Belanger K, Barnes JD, Longmuir PE, Anderson KD, Bruner B, Copeland JL, Gregg MJ, Hall N, Kolen AM, Lane KN, Law B, MacDonald DJ, Martin LJ, Saunders TJ, Sheehan D, Stone M, Woodruff SJ, Tremblay MS.

BMC Public Health. 2018 Oct 2;18(Suppl 2):1042. doi: 10.1186/s12889-018-5897-4.


The relationship between sedentary behaviour and physical literacy in Canadian children: a cross-sectional analysis from the RBC-CAPL Learn to Play study.

Saunders TJ, MacDonald DJ, Copeland JL, Longmuir PE, Barnes JD, Belanger K, Bruner B, Gregg MJ, Hall N, Kolen AM, Law B, Martin LJ, Sheehan D, Stone MR, Woodruff SJ, Tremblay MS.

BMC Public Health. 2018 Oct 2;18(Suppl 2):1037. doi: 10.1186/s12889-018-5892-9.


Cardiorespiratory fitness is associated with physical literacy in a large sample of Canadian children aged 8 to 12 years.

Lang JJ, Chaput JP, Longmuir PE, Barnes JD, Belanger K, Tomkinson GR, Anderson KD, Bruner B, Copeland JL, Gregg MJ, Hall N, Kolen AM, Lane KN, Law B, MacDonald DJ, Martin LJ, Saunders TJ, Sheehan D, Stone MR, Woodruff SJ, Tremblay MS.

BMC Public Health. 2018 Oct 2;18(Suppl 2):1041. doi: 10.1186/s12889-018-5896-5.


Physical literacy levels of Canadian children aged 8-12 years: descriptive and normative results from the RBC Learn to Play-CAPL project.

Tremblay MS, Longmuir PE, Barnes JD, Belanger K, Anderson KD, Bruner B, Copeland JL, Delisle Nyström C, Gregg MJ, Hall N, Kolen AM, Lane KN, Law B, MacDonald DJ, Martin LJ, Saunders TJ, Sheehan D, Stone MR, Woodruff SJ.

BMC Public Health. 2018 Oct 2;18(Suppl 2):1036. doi: 10.1186/s12889-018-5891-x.


Associations between teacher training and measures of physical literacy among Canadian 8- to 12-year-old students.

Law B, Bruner B, Scharoun Benson SM, Anderson K, Gregg M, Hall N, Lane K, MacDonald DJ, Saunders TJ, Sheehan D, Stone MR, Woodruff SJ, Belanger K, Barnes JD, Longmuir PE, Tremblay MS.

BMC Public Health. 2018 Oct 2;18(Suppl 2):1039. doi: 10.1186/s12889-018-5894-7.


A cross-sectional study exploring the relationship between age, gender, and physical measures with adequacy in and predilection for physical activity.

MacDonald DJ, Saunders TJ, Longmuir PE, Barnes JD, Belanger K, Bruner B, Copeland JL, Gregg MJ, Hall N, Kolen AM, Law B, Martin LJ, Sheehan D, Woodruff SJ, Tremblay MS.

BMC Public Health. 2018 Oct 2;18(Suppl 2):1038. doi: 10.1186/s12889-018-5893-8.


Core needle biopsy as an alternative to whole section in IHC4 score assessment for breast cancer prognostication.

Liu M, Tang SX, Tsang JYS, Shi YJ, Ni YB, Law BKB, Tse GMK.

J Clin Pathol. 2018 Dec;71(12):1084-1089. doi: 10.1136/jclinpath-2018-205228. Epub 2018 Sep 18.


The Role of Oxidative Stress and Inflammation in Acute Oxalate Nephropathy Associated With Ethylene Glycol Intoxication.

Wilson GJ, Gois PHF, Zhang A, Wang X, Law BMP, Kassianos AJ, Healy HG.

Kidney Int Rep. 2018 Jun 11;3(5):1217-1221. doi: 10.1016/j.ekir.2018.05.005. eCollection 2018 Sep. No abstract available.

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