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Items: 1 to 50 of 64

1.

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression.

Bachmann A, Bruske E, Krumkamp R, Turner L, Wichers JS, Petter M, Held J, Duffy MF, Sim BKL, Hoffman SL, Kremsner PG, Lell B, Lavstsen T, Frank M, Mordmüller B, Tannich E.

PLoS Pathog. 2019 Jul 11;15(7):e1007906. doi: 10.1371/journal.ppat.1007906. [Epub ahead of print]

PMID:
31295334
Free Article
2.

Meta-analysis of Plasmodium falciparum var Signatures Contributing to Severe Malaria in African Children and Indian Adults.

Duffy F, Bernabeu M, Babar PH, Kessler A, Wang CW, Vaz M, Chery L, Mandala WL, Rogerson SJ, Taylor TE, Seydel KB, Lavstsen T, Gomes E, Kim K, Lusingu J, Rathod PK, Aitchison JD, Smith JD.

MBio. 2019 Apr 30;10(2). pii: e00217-19. doi: 10.1128/mBio.00217-19.

3.

Modified MHC Class II-Associated Invariant Chain Induces Increased Antibody Responses against Plasmodium falciparum Antigens after Adenoviral Vaccination.

Fougeroux C, Turner L, Bojesen AM, Lavstsen T, Holst PJ.

J Immunol. 2019 Apr 15;202(8):2320-2331. doi: 10.4049/jimmunol.1801210. Epub 2019 Mar 4.

4.

Cerebral malaria is associated with differential cytoadherence to brain endothelial cells.

Storm J, Jespersen JS, Seydel KB, Szestak T, Mbewe M, Chisala NV, Phula P, Wang CW, Taylor TE, Moxon CA, Lavstsen T, Craig AG.

EMBO Mol Med. 2019 Feb;11(2). pii: e9164. doi: 10.15252/emmm.201809164.

5.

Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies.

Derkach A, Otim I, Pfeiffer RM, Onabajo OO, Legason ID, Nabalende H, Ogwang MD, Kerchan P, Talisuna AO, Ayers LW, Reynolds SJ, Nkrumah F, Neequaye J, Bhatia K, Theander TG, Prokunina-Olsson L, Turner L, Goedert JJ, Lavstsen T, Mbulaiteye SM.

EBioMedicine. 2019 Jan;39:358-368. doi: 10.1016/j.ebiom.2018.12.020. Epub 2018 Dec 20.

6.

Acquisition of Antibodies Against Endothelial Protein C Receptor-Binding Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Severe Malaria.

Rambhatla JS, Turner L, Manning L, Laman M, Davis TME, Beeson JG, Mueller I, Warrel J, Theander TG, Lavstsen T, Rogerson SJ.

J Infect Dis. 2019 Feb 15;219(5):808-818. doi: 10.1093/infdis/jiy564.

PMID:
30365003
7.

Plasmodium falciparum-CD36 Structure-Function Relationships Defined by Ortholog Scanning Mutagenesis.

Cabrera A, Neculai D, Tran V, Lavstsen T, Turner L, Kain KC.

J Infect Dis. 2019 Feb 23;219(6):945-954. doi: 10.1093/infdis/jiy607.

PMID:
30335152
8.

Immunization with Recombinant Plasmodium falciparum Erythrocyte Membrane Protein 1 CIDRα1 Domains Induces Domain Subtype Inhibitory Antibodies.

Turner L, Theander TG, Lavstsen T.

Infect Immun. 2018 Oct 25;86(11). pii: e00435-18. doi: 10.1128/IAI.00435-18. Print 2018 Nov.

9.

A vaccine targeted specifically to prevent cerebral malaria - is there hope?

Hviid L, Lavstsen T, Jensen AT.

Expert Rev Vaccines. 2018 Jul;17(7):565-567. doi: 10.1080/14760584.2018.1488591. Epub 2018 Jun 25. No abstract available.

PMID:
29898617
10.

Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLβ Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea.

Tessema SK, Utama D, Chesnokov O, Hodder AN, Lin CS, Harrison GLA, Jespersen JS, Petersen B, Tavul L, Siba P, Kwiatkowski D, Lavstsen T, Hansen DS, Oleinikov AV, Mueller I, Barry AE.

Infect Immun. 2018 Jul 23;86(8). pii: e00485-17. doi: 10.1128/IAI.00485-17. Print 2018 Aug.

11.

Corrigendum: Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors.

Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S, Takashima E, Tsuboi T, Kohyama M, Suenaga T, Colonna M, Takagi J, Lavstsen T, Horii T, Arase H.

Nature. 2018 Feb 22;554(7693):554. doi: 10.1038/nature25498. Epub 2018 Feb 14.

PMID:
29443969
12.

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors.

Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S, Takashima E, Tsuboi T, Kohyama M, Suenaga T, Colonna M, Takagi J, Lavstsen T, Horii T, Arase H.

Nature. 2017 Dec 7;552(7683):101-105. doi: 10.1038/nature24994. Epub 2017 Nov 29. Erratum in: Nature. 2018 Feb 14;:.

13.

Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria.

Shabani E, Hanisch B, Opoka RO, Lavstsen T, John CC.

BMC Med. 2017 Oct 13;15(1):183. doi: 10.1186/s12916-017-0945-y.

14.

Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1.

Tuikue Ndam N, Moussiliou A, Lavstsen T, Kamaliddin C, Jensen ATR, Mama A, Tahar R, Wang CW, Jespersen JS, Alao JM, Gamain B, Theander TG, Deloron P.

J Infect Dis. 2017 Jun 15;215(12):1918-1925. doi: 10.1093/infdis/jix230.

PMID:
28863469
15.

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria.

Lennartz F, Adams Y, Bengtsson A, Olsen RW, Turner L, Ndam NT, Ecklu-Mensah G, Moussiliou A, Ofori MF, Gamain B, Lusingu JP, Petersen JE, Wang CW, Nunes-Silva S, Jespersen JS, Lau CK, Theander TG, Lavstsen T, Hviid L, Higgins MK, Jensen AT.

Cell Host Microbe. 2017 Mar 8;21(3):403-414. doi: 10.1016/j.chom.2017.02.009.

16.

Cellulose filtration of blood from malaria patients for improving ex vivo growth of Plasmodium falciparum parasites.

Mkumbaye SI, Minja DT, Jespersen JS, Alifrangis M, Kavishe RA, Mwakalinga SB, Lusingu JP, Theander TG, Lavstsen T, Wang CW.

Malar J. 2017 Feb 10;16(1):69. doi: 10.1186/s12936-017-1714-2.

17.

The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1.

Mkumbaye SI, Wang CW, Lyimo E, Jespersen JS, Manjurano A, Mosha J, Kavishe RA, Mwakalinga SB, Minja DTR, Lusingu JP, Theander TG, Lavstsen T.

Infect Immun. 2017 Mar 23;85(4). pii: e00841-16. doi: 10.1128/IAI.00841-16. Print 2017 Apr.

18.

Cytoadhesion to gC1qR through Plasmodium falciparum Erythrocyte Membrane Protein 1 in Severe Malaria.

Magallón-Tejada A, Machevo S, Cisteró P, Lavstsen T, Aide P, Rubio M, Jiménez A, Turner L, Valmaseda A, Gupta H, De Las Salas B, Mandomando I, Wang CW, Petersen JE, Muñoz J, Gascón J, Macete E, Alonso PL, Chitnis CE, Bassat Q, Mayor A.

PLoS Pathog. 2016 Nov 11;12(11):e1006011. doi: 10.1371/journal.ppat.1006011. eCollection 2016 Nov.

19.

Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1.

Petersen JE, Mkumbaye SI, Vaaben AV, Manjurano A, Lyimo E, Kavishe RA, Mwakalinga SB, Mosha J, Minja DT, Lusingu JP, Theander TG, Lavstsen T, Wang CW.

Sci Rep. 2016 Oct 27;6:35950. doi: 10.1038/srep35950.

20.

The structural basis for CD36 binding by the malaria parasite.

Hsieh FL, Turner L, Bolla JR, Robinson CV, Lavstsen T, Higgins MK.

Nat Commun. 2016 Sep 26;7:12837. doi: 10.1038/ncomms12837.

21.

Breaking down brain barrier breaches in cerebral malaria.

Petersen JE, Lavstsen T, Craig A.

J Clin Invest. 2016 Oct 3;126(10):3725-3727. doi: 10.1172/JCI90188. Epub 2016 Sep 19.

22.

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains.

Jespersen JS, Wang CW, Mkumbaye SI, Minja DT, Petersen B, Turner L, Petersen JE, Lusingu JP, Theander TG, Lavstsen T.

EMBO Mol Med. 2016 Aug 1;8(8):839-50. doi: 10.15252/emmm.201606188. Print 2016 Aug.

23.

The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria.

Shabani E, Opoka RO, Bangirana P, Park GS, Vercellotti GM, Guan W, Hodges JS, Lavstsen T, John CC.

Sci Rep. 2016 Jun 3;6:27084. doi: 10.1038/srep27084.

24.

Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria.

Pehrson C, Mathiesen L, Heno KK, Salanti A, Resende M, Dzikowski R, Damm P, Hansson SR, King CL, Schneider H, Wang CW, Lavstsen T, Theander TG, Knudsen LE, Nielsen MA.

Malar J. 2016 May 26;15(1):292. doi: 10.1186/s12936-016-1342-2.

25.

The role of EPCR in the pathogenesis of severe malaria.

Mosnier LO, Lavstsen T.

Thromb Res. 2016 May;141 Suppl 2:S46-9. doi: 10.1016/S0049-3848(16)30364-4. Review.

26.

Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria.

Duffy MF, Noviyanti R, Tsuboi T, Feng ZP, Trianty L, Sebayang BF, Takashima E, Sumardy F, Lampah DA, Turner L, Lavstsen T, Fowkes FJ, Siba P, Rogerson SJ, Theander TG, Marfurt J, Price RN, Anstey NM, Brown GV, Papenfuss AT.

Malar J. 2016 May 5;15(1):258. doi: 10.1186/s12936-016-1296-4.

27.

Plasmodium falciparum Plasmodium helical interspersed subtelomeric proteins contribute to cytoadherence and anchor P. falciparum erythrocyte membrane protein 1 to the host cell cytoskeleton.

Oberli A, Zurbrügg L, Rusch S, Brand F, Butler ME, Day JL, Cutts EE, Lavstsen T, Vakonakis I, Beck HP.

Cell Microbiol. 2016 Oct;18(10):1415-28. doi: 10.1111/cmi.12583. Epub 2016 Apr 26.

28.

Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania.

Hansson HH, Turner L, Møller L, Wang CW, Minja DT, Gesase S, Mmbando B, Bygbjerg IC, Theander TG, Lusingu JP, Alifrangis M, Lavstsen T.

Malar J. 2015 Dec 1;14:474. doi: 10.1186/s12936-015-1007-6.

29.

Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant.

Petersen JE, Bouwens EA, Tamayo I, Turner L, Wang CW, Stins M, Theander TG, Hermida J, Mosnier LO, Lavstsen T.

Thromb Haemost. 2015 Nov;114(5):1038-48. doi: 10.1160/TH15-01-0018. Epub 2015 Jul 9.

PMID:
26155776
30.

IgG antibodies to endothelial protein C receptor-binding cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria.

Turner L, Lavstsen T, Mmbando BP, Wang CW, Magistrado PA, Vestergaard LS, Ishengoma DS, Minja DT, Lusingu JP, Theander TG.

Infect Immun. 2015 Aug;83(8):3096-103. doi: 10.1128/IAI.00271-15. Epub 2015 May 26.

31.

Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria.

Lau CK, Turner L, Jespersen JS, Lowe ED, Petersen B, Wang CW, Petersen JE, Lusingu J, Theander TG, Lavstsen T, Higgins MK.

Cell Host Microbe. 2015 Jan 14;17(1):118-29. doi: 10.1016/j.chom.2014.11.007. Epub 2014 Dec 4.

32.

DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families.

Sander AF, Lavstsen T, Rask TS, Lisby M, Salanti A, Fordyce SL, Jespersen JS, Carter R, Deitsch KW, Theander TG, Pedersen AG, Arnot DE.

Nucleic Acids Res. 2014 Feb;42(4):2270-81. doi: 10.1093/nar/gkt1174. Epub 2013 Nov 18.

33.

Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes.

Smith JD, Rowe JA, Higgins MK, Lavstsen T.

Cell Microbiol. 2013 Dec;15(12):1976-83. doi: 10.1111/cmi.12183. Epub 2013 Sep 4. Review.

34.

Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin.

Bertin GI, Lavstsen T, Guillonneau F, Doritchamou J, Wang CW, Jespersen JS, Ezimegnon S, Fievet N, Alao MJ, Lalya F, Massougbodji A, Ndam NT, Theander TG, Deloron P.

PLoS One. 2013 Jul 29;8(7):e68368. doi: 10.1371/journal.pone.0068368. Print 2013.

35.

Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1.

Berger SS, Turner L, Wang CW, Petersen JE, Kraft M, Lusingu JP, Mmbando B, Marquard AM, Bengtsson DB, Hviid L, Nielsen MA, Theander TG, Lavstsen T.

PLoS One. 2013 Jul 9;8(7):e69117. doi: 10.1371/journal.pone.0069117. Print 2013.

36.

PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum.

Jiang L, Mu J, Zhang Q, Ni T, Srinivasan P, Rayavara K, Yang W, Turner L, Lavstsen T, Theander TG, Peng W, Wei G, Jing Q, Wakabayashi Y, Bansal A, Luo Y, Ribeiro JM, Scherf A, Aravind L, Zhu J, Zhao K, Miller LH.

Nature. 2013 Jul 11;499(7457):223-7. doi: 10.1038/nature12361. Epub 2013 Jul 3.

37.

Severe malaria is associated with parasite binding to endothelial protein C receptor.

Turner L, Lavstsen T, Berger SS, Wang CW, Petersen JE, Avril M, Brazier AJ, Freeth J, Jespersen JS, Nielsen MA, Magistrado P, Lusingu J, Smith JD, Higgins MK, Theander TG.

Nature. 2013 Jun 27;498(7455):502-5. doi: 10.1038/nature12216. Epub 2013 Jun 5.

38.

Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes.

Mwakalinga SB, Wang CW, Bengtsson DC, Turner L, Dinko B, Lusingu JP, Arnot DE, Sutherland CJ, Theander TG, Lavstsen T.

Malar J. 2012 Dec 21;11:429. doi: 10.1186/1475-2875-11-429.

39.

Early gametocytes of the malaria parasite Plasmodium falciparum specifically remodel the adhesive properties of infected erythrocyte surface.

Tibúrcio M, Silvestrini F, Bertuccini L, Sander AF, Turner L, Lavstsen T, Alano P.

Cell Microbiol. 2013 Apr;15(4):647-59. doi: 10.1111/cmi.12062. Epub 2012 Nov 21.

PMID:
23114006
40.

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children.

Lavstsen T, Turner L, Saguti F, Magistrado P, Rask TS, Jespersen JS, Wang CW, Berger SS, Baraka V, Marquard AM, Seguin-Orlando A, Willerslev E, Gilbert MT, Lusingu J, Theander TG.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1791-800. doi: 10.1073/pnas.1120455109. Epub 2012 May 22.

41.

Evidence for in vitro and in vivo expression of the conserved VAR3 (type 3) plasmodium falciparum erythrocyte membrane protein 1.

Wang CW, Lavstsen T, Bengtsson DC, Magistrado PA, Berger SS, Marquard AM, Alifrangis M, Lusingu JP, Theander TG, Turner L.

Malar J. 2012 Apr 25;11:129. doi: 10.1186/1475-2875-11-129.

42.

Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers.

Turner L, Wang CW, Lavstsen T, Mwakalinga SB, Sauerwein RW, Hermsen CC, Theander TG.

PLoS One. 2011;6(12):e29025. doi: 10.1371/journal.pone.0029025. Epub 2011 Dec 12.

43.

Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites.

Bejon P, Turner L, Lavstsen T, Cham G, Olotu A, Drakeley CJ, Lievens M, Vekemans J, Savarese B, Lusingu J, von Seidlein L, Bull PC, Marsh K, Theander TG.

PLoS One. 2011;6(6):e21711. doi: 10.1371/journal.pone.0021711. Epub 2011 Jun 29.

44.

Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.

Sander AF, Salanti A, Lavstsen T, Nielsen MA, Theander TG, Leke RG, Lo YY, Bobbili N, Arnot DE, Taylor DW.

J Infect Dis. 2011 Jun 1;203(11):1679-85. doi: 10.1093/infdis/jir168.

45.

Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquer.

Rask TS, Hansen DA, Theander TG, Gorm Pedersen A, Lavstsen T.

PLoS Comput Biol. 2010 Sep 16;6(9). pii: e1000933. doi: 10.1371/journal.pcbi.1000933.

46.

Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1.

Joergensen L, Bengtsson DC, Bengtsson A, Ronander E, Berger SS, Turner L, Dalgaard MB, Cham GK, Victor ME, Lavstsen T, Theander TG, Arnot DE, Jensen AT.

PLoS Pathog. 2010 Sep 2;6(9):e1001083. doi: 10.1371/journal.ppat.1001083.

47.

Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children.

Cham GK, Turner L, Kurtis JD, Mutabingwa T, Fried M, Jensen AT, Lavstsen T, Hviid L, Duffy PE, Theander TG.

Infect Immun. 2010 Nov;78(11):4653-9. doi: 10.1128/IAI.00593-10. Epub 2010 Sep 7.

48.

Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum.

Wang CW, Mwakalinga SB, Sutherland CJ, Schwank S, Sharp S, Hermsen CC, Sauerwein RW, Theander TG, Lavstsen T.

Malar J. 2010 May 28;9:147. doi: 10.1186/1475-2875-9-147.

49.

Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates.

Sander AF, Salanti A, Lavstsen T, Nielsen MA, Magistrado P, Lusingu J, Ndam NT, Arnot DE.

PLoS One. 2009 Aug 19;4(8):e6667. doi: 10.1371/journal.pone.0006667.

50.

Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains.

Cham GK, Turner L, Lusingu J, Vestergaard L, Mmbando BP, Kurtis JD, Jensen AT, Salanti A, Lavstsen T, Theander TG.

J Immunol. 2009 Sep 1;183(5):3356-63. doi: 10.4049/jimmunol.0901331. Epub 2009 Aug 12.

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