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Items: 1 to 50 of 73

1.

Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimer.

Hillert LK, Ivanisenko NV, Busse D, Espe J, König C, Peltek SE, Kolchanov NA, Ivanisenko VA, Lavrik IN.

Cell Death Differ. 2020 Jan 20. doi: 10.1038/s41418-020-0489-0. [Epub ahead of print]

PMID:
31959913
2.

Delineating the role of c-FLIP/NEMO interaction in the CD95 network via rational design of molecular probes.

Ivanisenko NV, Buchbinder JH, Espe J, Richter M, Bollmann M, Hillert LK, Ivanisenko VA, Lavrik IN.

BMC Genomics. 2019 May 8;20(Suppl 3):293. doi: 10.1186/s12864-019-5539-y.

3.

Isolation of High-Molecular-Weight Activation Complexes of Initiator Caspases in DNA Damage.

Zamaraev AV, Egorshina AY, Lavrik IN, Zhivotovsky BD, Kopeina GS.

Bull Exp Biol Med. 2019 Nov 22. doi: 10.1007/s10517-019-04663-1. [Epub ahead of print]

PMID:
31758380
4.

Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly.

Hillert LK, Ivanisenko NV, Espe J, König C, Ivanisenko VA, Kähne T, Lavrik IN.

Oncogene. 2019 Nov 18. doi: 10.1038/s41388-019-1100-3. [Epub ahead of print]

PMID:
31740779
5.

[Mechanisms of Procaspase-8 Activation in the Extrinsic Programmed Cell Death Pathway].

Ivanisenko NV, Lavrik IN.

Mol Biol (Mosk). 2019 Sep-Oct;53(5):830-837. doi: 10.1134/S0026898419050094. Review. Russian.

6.

Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors.

Bagamanshina AV, Troitskaya OS, Nushtaeva AA, Yunusova AY, Starykovych MO, Kuligina EV, Kit YY, Richter M, Wohlfromm F, Kähne T, Lavrik IN, Richter VA, Koval OA.

Biomed Res Int. 2019 Jun 17;2019:4087160. doi: 10.1155/2019/4087160. eCollection 2019.

7.

Modulation of CD95-mediated signaling by post-translational modifications: towards understanding CD95 signaling networks.

Seyrek K, Lavrik IN.

Apoptosis. 2019 Jun;24(5-6):385-394. doi: 10.1007/s10495-019-01540-0. Review.

PMID:
31069559
8.

Decoding the sweet regulation of apoptosis: the role of glycosylation and galectins in apoptotic signaling pathways.

Seyrek K, Richter M, Lavrik IN.

Cell Death Differ. 2019 Jun;26(6):981-993. doi: 10.1038/s41418-019-0317-6. Epub 2019 Mar 22. Review.

PMID:
30903104
9.

Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem.

Saik OV, Nimaev VV, Usmonov DB, Demenkov PS, Ivanisenko TV, Lavrik IN, Ivanisenko VA.

BMC Med Genomics. 2019 Mar 13;12(Suppl 2):47. doi: 10.1186/s12920-019-0492-9.

10.

Targeting RIPK1 in AML cells carrying FLT3-ITD.

Hillert LK, Bettermann-Bethge K, Nimmagadda SC, Fischer T, Naumann M, Lavrik IN.

Int J Cancer. 2019 Sep 15;145(6):1558-1569. doi: 10.1002/ijc.32246. Epub 2019 Mar 23.

PMID:
30828789
11.

[Caspase-2 as an Oncosupressor and Metabolism Regulator: What Life Will Bring over the Long Run?]

Egorshina AY, Zamaraev AV, Lavrik IN, Zhivotovsky BD, Kopeina GS.

Mol Biol (Mosk). 2018 Sep-Oct;52(5):750-763. doi: 10.1134/S0026898418050063. Review. Russian.

12.

Quantitative single cell analysis uncovers the life/death decision in CD95 network.

Buchbinder JH, Pischel D, Sundmacher K, Flassig RJ, Lavrik IN.

PLoS Comput Biol. 2018 Sep 26;14(9):e1006368. doi: 10.1371/journal.pcbi.1006368. eCollection 2018 Sep.

13.

Apoptosis regulation by subcellular relocation of caspases.

Prokhorova EA, Kopeina GS, Lavrik IN, Zhivotovsky B.

Sci Rep. 2018 Aug 15;8(1):12199. doi: 10.1038/s41598-018-30652-x.

14.

Caspase-2 is a negative regulator of necroptosis.

Zamaraev AV, Kopeina GS, Buchbinder JH, Zhivotovsky B, Lavrik IN.

Int J Biochem Cell Biol. 2018 Sep;102:101-108. doi: 10.1016/j.biocel.2018.07.006. Epub 2018 Jul 17.

PMID:
30025878
15.

Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way.

Kopeina GS, Prokhorova EA, Lavrik IN, Zhivotovsky B.

Cell Prolif. 2018 Oct;51(5):e12467. doi: 10.1111/cpr.12467. Epub 2018 Jun 26. Review.

PMID:
29947118
16.

A guide to automated apoptosis detection: How to make sense of imaging flow cytometry data.

Pischel D, Buchbinder JH, Sundmacher K, Lavrik IN, Flassig RJ.

PLoS One. 2018 May 16;13(5):e0197208. doi: 10.1371/journal.pone.0197208. eCollection 2018.

17.

Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks.

Saik OV, Demenkov PS, Ivanisenko TV, Bragina EY, Freidin MB, Goncharova IA, Dosenko VE, Zolotareva OI, Hofestaedt R, Lavrik IN, Rogaev EI, Ivanisenko VA.

BMC Med Genomics. 2018 Feb 13;11(Suppl 1):15. doi: 10.1186/s12920-018-0331-4.

18.

Modulation of Mcl-1 transcription by serum deprivation sensitizes cancer cells to cisplatin.

Senichkin VV, Kopeina GS, Prokhorova EA, Zamaraev AV, Lavrik IN, Zhivotovsky B.

Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):557-566. doi: 10.1016/j.bbagen.2017.11.021. Epub 2017 Dec 2.

PMID:
29203282
19.

Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-κB and caspase-8-dependent apoptotic cell death.

Lim MCC, Maubach G, Sokolova O, Feige MH, Diezko R, Buchbinder J, Backert S, Schlüter D, Lavrik IN, Naumann M.

Cell Death Differ. 2017 Sep;24(9):1621-1631. doi: 10.1038/cdd.2017.89. Epub 2017 Jun 2.

20.

Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation.

Zamaraev AV, Kopeina GS, Prokhorova EA, Zhivotovsky B, Lavrik IN.

Trends Cell Biol. 2017 May;27(5):322-339. doi: 10.1016/j.tcb.2017.01.003. Epub 2017 Feb 7. Review.

PMID:
28188028
21.

A study of structural properties of gene network graphs for mathematical modeling of integrated mosaic gene networks.

Petrovskaya OV, Petrovskiy ED, Lavrik IN, Ivanisenko VA.

J Bioinform Comput Biol. 2017 Apr;15(2):1650045. doi: 10.1142/S0219720016500451. Epub 2016 Dec 22.

PMID:
28152643
22.

[Nutrient restriction in combinatory therapy of tumors].

Senichkin VV, Kopeina GS, Zamaraev AV, Lavrik IN, Zhivotovsky BD.

Mol Biol (Mosk). 2016 May-Jun;50(3):416-34. doi: 10.7868/S0026898416030101. Review. Russian.

23.

Mechanism of caspase-2 activation upon DNA damage.

Aksenova VI, Kopeina GS, Zamaraev AV, Zhivotovsky BD, Lavrik IN.

Dokl Biochem Biophys. 2016 Mar;467(1):132-5. doi: 10.1134/S1607672916020150. Epub 2016 May 20.

PMID:
27193717
24.

NACE: A web-based tool for prediction of intercompartmental efficiency of human molecular genetic networks.

Popik OV, Ivanisenko TV, Saik OV, Petrovskiy ED, Lavrik IN, Ivanisenko VA.

Virus Res. 2016 Jun 15;218:79-85. doi: 10.1016/j.virusres.2015.11.029. Epub 2016 Apr 22.

PMID:
27109913
25.

Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.

Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis JS, Schott BH, Schlüter D, Gundelfinger ED, Montag D, Seifert U, Pahnke J, Dunay IR.

Acta Neuropathol Commun. 2016 Mar 16;4:25. doi: 10.1186/s40478-016-0293-8.

26.

Prediction of tissue-specific effects of gene knockout on apoptosis in different anatomical structures of human brain.

Petrovskiy ED, Saik OV, Tiys ES, Lavrik IN, Kolchanov NA, Ivanisenko VA.

BMC Genomics. 2015;16 Suppl 13:S3. doi: 10.1186/1471-2164-16-S13-S3. Epub 2015 Dec 16.

27.

Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain.

Schleich K, Buchbinder JH, Pietkiewicz S, Kähne T, Warnken U, Öztürk S, Schnölzer M, Naumann M, Krammer PH, Lavrik IN.

Cell Death Differ. 2016 Apr;23(4):681-94. doi: 10.1038/cdd.2015.137. Epub 2015 Oct 23.

28.

Mosaic gene network modelling identified new regulatory mechanisms in HCV infection.

Popik OV, Petrovskiy ED, Mishchenko EL, Lavrik IN, Ivanisenko VA.

Virus Res. 2016 Jun 15;218:71-8. doi: 10.1016/j.virusres.2015.10.004. Epub 2015 Oct 22.

29.

Combinatorial treatment of CD95L and gemcitabine in pancreatic cancer cells induces apoptotic and RIP1-mediated necroptotic cell death network.

Pietkiewicz S, Eils R, Krammer PH, Giese N, Lavrik IN.

Exp Cell Res. 2015 Nov 15;339(1):1-9. doi: 10.1016/j.yexcr.2015.10.005. Epub 2015 Oct 8.

PMID:
26453936
30.

Role of the nucleus in apoptosis: signaling and execution.

Prokhorova EA, Zamaraev AV, Kopeina GS, Zhivotovsky B, Lavrik IN.

Cell Mol Life Sci. 2015 Dec;72(23):4593-612. doi: 10.1007/s00018-015-2031-y. Epub 2015 Sep 7. Review.

PMID:
26346492
31.

Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining.

Pietkiewicz S, Schmidt JH, Lavrik IN.

J Immunol Methods. 2015 Aug;423:99-103. doi: 10.1016/j.jim.2015.04.025. Epub 2015 May 11.

PMID:
25975759
32.

Quantification of CD95-induced apoptosis and NF-κB activation at the single cell level.

Schmidt JH, Pietkiewicz S, Naumann M, Lavrik IN.

J Immunol Methods. 2015 Aug;423:12-7. doi: 10.1016/j.jim.2015.04.026. Epub 2015 May 9.

PMID:
25967949
33.

Analysis of signaling networks distributed over intracellular compartments based on protein-protein interactions.

Popik OV, Saik OV, Petrovskiy ED, Sommer B, Hofestädt R, Lavrik IN, Ivanisenko VA.

BMC Genomics. 2014;15 Suppl 12:S7. doi: 10.1186/1471-2164-15-S12-S7. Epub 2014 Dec 19.

34.

Cell death controlling complexes and their potential therapeutic role.

Zamaraev AV, Kopeina GS, Zhivotovsky B, Lavrik IN.

Cell Mol Life Sci. 2015 Feb;72(3):505-517. doi: 10.1007/s00018-014-1757-2. Epub 2014 Oct 17. Review.

PMID:
25323133
35.

Systems biology of death receptor networks: live and let die.

Lavrik IN.

Cell Death Dis. 2014 May 29;5:e1259. doi: 10.1038/cddis.2014.160. Review.

36.

Systems biology: a way to make complex problems more understandable.

Lavrik IN, Zhivotovsky B.

Cell Death Dis. 2014 May 29;5:e1256. doi: 10.1038/cddis.2014.195. No abstract available.

37.

[Caspase-2: what do we know today?].

Aksenova VI, Bylino OV, Zhivotovskiĭ BD, Lavrik IN.

Mol Biol (Mosk). 2013 Mar-Apr;47(2):187-204. Review. Russian.

38.

Mathematical modeling of apoptosis.

Schleich K, Lavrik IN.

Cell Commun Signal. 2013 Jun 26;11(1):44. doi: 10.1186/1478-811X-11-44.

39.

The chains of death: a new view on caspase-8 activation at the DISC.

Schleich K, Krammer PH, Lavrik IN.

Cell Cycle. 2013 Jan 15;12(2):193-4. doi: 10.4161/cc.23464. Epub 2012 Jan 15. No abstract available.

40.

Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model.

Schleich K, Warnken U, Fricker N, Oztürk S, Richter P, Kammerer K, Schnölzer M, Krammer PH, Lavrik IN.

Mol Cell. 2012 Jul 27;47(2):306-19. doi: 10.1016/j.molcel.2012.05.006. Epub 2012 Jun 7.

41.

Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions.

Oztürk S, Schleich K, Lavrik IN.

Exp Cell Res. 2012 Jul 1;318(11):1324-31. doi: 10.1016/j.yexcr.2012.01.019. Epub 2012 Jan 28. Review.

PMID:
22309778
42.

A modular model of the apoptosis machinery.

Kutumova EO, Kiselev IN, Sharipov RN, Lavrik IN, Kolpakov FA.

Adv Exp Med Biol. 2012;736:235-45. doi: 10.1007/978-1-4419-7210-1_13.

PMID:
22161332
43.

Regulation of CD95/Fas signaling at the DISC.

Lavrik IN, Krammer PH.

Cell Death Differ. 2012 Jan;19(1):36-41. doi: 10.1038/cdd.2011.155. Epub 2011 Nov 11. Review.

44.

Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation.

Kober AM, Legewie S, Pforr C, Fricker N, Eils R, Krammer PH, Lavrik IN.

Cell Death Dis. 2011 Oct 6;2:e212. doi: 10.1038/cddis.2011.93.

45.

Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation.

Shatnyeva OM, Kubarenko AV, Weber CE, Pappa A, Schwartz-Albiez R, Weber AN, Krammer PH, Lavrik IN.

PLoS One. 2011;6(5):e19927. doi: 10.1371/journal.pone.0019927. Epub 2011 May 18.

46.

[Regulation of death receptor-induced apoptosis induced via CD95/FAS and other death receptors].

Lavrik IN.

Mol Biol (Mosk). 2011 Jan-Feb;45(1):173-9. Review. Russian.

PMID:
21485506
47.

Understanding life and death at CD95.

Pforr C, Neumann L, Eils R, Krammer PH, Lavrik IN.

Adv Exp Med Biol. 2011;691:151-61. doi: 10.1007/978-1-4419-6612-4_16. No abstract available.

PMID:
21153319
48.

Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.

Matthess Y, Raab M, Sanhaji M, Lavrik IN, Strebhardt K.

Mol Cell Biol. 2010 Dec;30(24):5726-40. doi: 10.1128/MCB.00731-10. Epub 2010 Oct 11.

49.

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.

Fricker N, Beaudouin J, Richter P, Eils R, Krammer PH, Lavrik IN.

J Cell Biol. 2010 Aug 9;190(3):377-89. doi: 10.1083/jcb.201002060.

50.

Systems biology of apoptosis signaling networks.

Lavrik IN.

Curr Opin Biotechnol. 2010 Aug;21(4):551-5. doi: 10.1016/j.copbio.2010.07.001. Epub 2010 Jul 30. Review.

PMID:
20674332

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