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Items: 24

1.

Predicting oral clearance in humans: how close can we get with allometry?

Sinha VK, De Buck SS, Fenu LA, Smit JW, Nijsen M, Gilissen RA, Van Peer A, Lavrijsen K, Mackie CE.

Clin Pharmacokinet. 2008;47(1):35-45.

PMID:
18076217
2.

Pharmacokinetics and tissue distribution of galantamine and galantamine-related radioactivity after single intravenous and oral administration in the rat.

van Beijsterveldt L, Geerts R, Verhaeghe T, Willems B, Bode W, Lavrijsen K, Meuldermans W.

Arzneimittelforschung. 2004;54(2):85-94.

PMID:
15038457
3.

Pharmacokinetics of galantamine, a cholinesterase inhibitor, in several animal species.

Monbaliu J, Verhaeghe T, Willems B, Bode W, Lavrijsen K, Meuldermans W.

Arzneimittelforschung. 2003;53(7):486-95.

PMID:
12918214
4.

Rapid permeability screening in drug discovery to predict human intestinal absorption.

Mannens GS, Bohets H, Verboven P, Steemans K, Lavrijsen K, Meuldermans W.

Ernst Schering Res Found Workshop. 2002;(37):49-67. Review. No abstract available.

PMID:
11975200
5.

The metabolism and excretion of galantamine in rats, dogs, and humans.

Mannens GS, Snel CA, Hendrickx J, Verhaeghe T, Le Jeune L, Bode W, van Beijsterveldt L, Lavrijsen K, Leempoels J, Van Osselaer N, Van Peer A, Meuldermans W.

Drug Metab Dispos. 2002 May;30(5):553-63.

PMID:
11950787
6.

Strategies for absorption screening in drug discovery and development.

Bohets H, Annaert P, Mannens G, Van Beijsterveldt L, Anciaux K, Verboven P, Meuldermans W, Lavrijsen K.

Curr Top Med Chem. 2001 Nov;1(5):367-83. Review.

PMID:
11899103
7.

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans.

Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M.

Pharmacogenetics. 2000 Jul;10(5):415-24.

PMID:
10898111
8.

Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: in vitro studies of potential co-medication interactions.

Bohets H, Lavrijsen K, Hendrickx J, van Houdt J, van Genechten V, Verboven P, Meuldermans W, Heykants J.

Br J Pharmacol. 2000 Apr;129(8):1655-67.

9.

Response to Iwashashi: "significantly higher plasma haloperidol level during cotreatment with carbamazepine may herald cardiac change".

Zuiderwijk PB, Lavrijsen K.

Clin Neuropharmacol. 1997 Apr;20(2):179. No abstract available.

PMID:
9099473
10.

Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans.

Lavrijsen K, van Dyck D, van Houdt J, Hendrickx J, Monbaliu J, Woestenborghs R, Meuldermans W, Heykants J.

Drug Metab Dispos. 1995 Mar;23(3):354-62.

PMID:
7628301
11.

The metabolism and excretion of risperidone after oral administration in rats and dogs.

Meuldermans W, Hendrickx J, Mannens G, Lavrijsen K, Janssen C, Bracke J, Le Jeune L, Lauwers W, Heykants J.

Drug Metab Dispos. 1994 Jan-Feb;22(1):129-38.

PMID:
7512019
12.

Comparative metabolism of flunarizine in rats, dogs and man: an in vitro study with subcellular liver fractions and isolated hepatocytes.

Lavrijsen K, van Houdt J, van Dyck D, Hendrickx J, Bockx M, Hurkmans R, Meuldermans W, Le Jeune L, Lauwers W, Heykants J.

Xenobiotica. 1992 Jul;22(7):815-36.

PMID:
1455902
13.

A predictive model for substrates of cytochrome P450-debrisoquine (2D6).

Koymans L, Vermeulen NP, van Acker SA, te Koppele JM, Heykants JJ, Lavrijsen K, Meuldermans W, Donné-Op den Kelder GM.

Chem Res Toxicol. 1992 Mar-Apr;5(2):211-9.

PMID:
1379482
14.

Biotransformation of sufentanil in liver microsomes of rats, dogs, and humans.

Lavrijsen K, Van Houdt J, Van Dyck D, Hendrickx J, Lauwers W, Hurkmans R, Bockx M, Janssen C, Meuldermans W, Heykants J.

Drug Metab Dispos. 1990 Sep-Oct;18(5):704-10.

PMID:
1981724
15.

Pharmacokinetics of oral antifungals and their clinical implications.

Heykants J, Van Peer A, Lavrijsen K, Meuldermans W, Woestenborghs R, Cauwenbergh G.

Br J Clin Pract Suppl. 1990 Sep;71:50-6. Review.

PMID:
1965419
16.

Induction potential of fluconazole toward drug-metabolizing enzymes in rats.

Lavrijsen KL, Van Houdt JM, Van Dyck DM, Meuldermans WE, Heykants JJ.

Antimicrob Agents Chemother. 1990 Mar;34(3):402-8.

17.

Narcotic analgesics and debrisoquine polymorphism.

Lavrijsen KL, Heykants JJ.

Anesthesiology. 1989 Sep;71(3):474-5. No abstract available.

PMID:
2570539
18.

The clinical pharmacokinetics of itraconazole: an overview.

Heykants J, Van Peer A, Van de Velde V, Van Rooy P, Meuldermans W, Lavrijsen K, Woestenborghs R, Van Cutsem J, Cauwenbergh G.

Mycoses. 1989;32 Suppl 1:67-87. Review.

PMID:
2561187
19.

Is the metabolism of alfentanil subject to debrisoquine polymorphism? A study using human liver microsomes.

Lavrijsen KL, Van Houdt JM, Van Dyck DM, Hendrickx JJ, Woestenborghs RJ, Lauwers W, Meuldermans WE, Heykants JJ.

Anesthesiology. 1988 Oct;69(4):535-40.

PMID:
3140691
20.

Metabolism of alfentanil by isolated hepatocytes of rat and dog.

Lavrijsen K, Van Houdt J, Meuldermans W, Knaeps F, Hendrickx J, Lauwers W, Hurkmans R, Heykants J.

Xenobiotica. 1988 Feb;18(2):183-97.

PMID:
3131971
21.

Interaction of miconazole, ketoconazole and itraconazole with rat-liver microsomes.

Lavrijsen K, van Houdt J, Thijs D, Meuldermans W, Heykants J.

Xenobiotica. 1987 Jan;17(1):45-57.

PMID:
3030012
23.

The effect of progesterone on hemoglobin synthesis in suspension cultures of fetal erythroid cells from calf liver.

Lavrijsen KL, Verwilghen RL.

Biochim Biophys Acta. 1984 Apr 16;803(4):290-301.

PMID:
6200145
24.

The synthesis of adult hemoglobins during hepatic erythropoiesis in the calf fetus.

Lavrijsen K, Verwilghen RL.

Hemoglobin. 1983;7(2):159-79.

PMID:
6200458

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