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Items: 1 to 50 of 81

1.

Rational Design of Fluorogenic and Spontaneously Blinking Labels for Super-Resolution Imaging.

Zheng Q, Ayala AX, Chung I, Weigel AV, Ranjan A, Falco N, Grimm JB, Tkachuk AN, Wu C, Lippincott-Schwartz J, Singer RH, Lavis LD.

ACS Cent Sci. 2019 Sep 25;5(9):1602-1613. doi: 10.1021/acscentsci.9b00676. Epub 2019 Sep 5.

2.

Isomeric Tuning Yields Bright and Targetable Red Ca2+ Indicators.

Deo C, Sheu SH, Seo J, Clapham DE, Lavis LD.

J Am Chem Soc. 2019 Sep 4;141(35):13734-13738. doi: 10.1021/jacs.9b06092. Epub 2019 Aug 23.

PMID:
31430138
3.

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging.

Abdelfattah AS, Kawashima T, Singh A, Novak O, Liu H, Shuai Y, Huang YC, Campagnola L, Seeman SC, Yu J, Zheng J, Grimm JB, Patel R, Friedrich J, Mensh BD, Paninski L, Macklin JJ, Murphy GJ, Podgorski K, Lin BJ, Chen TW, Turner GC, Liu Z, Koyama M, Svoboda K, Ahrens MB, Lavis LD, Schreiter ER.

Science. 2019 Aug 16;365(6454):699-704. doi: 10.1126/science.aav6416. Epub 2019 Aug 1.

PMID:
31371562
4.

Bioorthogonal labeling with tetrazine-dyes for super-resolution microscopy.

Beliu G, Kurz AJ, Kuhlemann AC, Behringer-Pliess L, Meub M, Wolf N, Seibel J, Shi ZD, Schnermann M, Grimm JB, Lavis LD, Doose S, Sauer M.

Commun Biol. 2019 Jul 19;2:261. doi: 10.1038/s42003-019-0518-z. eCollection 2019.

5.

Multi-Color Single-Molecule Imaging Uncovers Extensive Heterogeneity in mRNA Decoding.

Boersma S, Khuperkar D, Verhagen BMP, Sonneveld S, Grimm JB, Lavis LD, Tanenbaum ME.

Cell. 2019 Jul 11;178(2):458-472.e19. doi: 10.1016/j.cell.2019.05.001. Epub 2019 Jun 6.

6.

Chemistry of Photosensitive Fluorophores for Single-Molecule Localization Microscopy.

Jradi FM, Lavis LD.

ACS Chem Biol. 2019 Jun 21;14(6):1077-1090. doi: 10.1021/acschembio.9b00197. Epub 2019 May 13.

PMID:
30997987
7.

Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine.

Arvin MC, Wokosin DL, Banala S, Lavis LD, Drenan RM.

J Vis Exp. 2019 Jan 25;(143). doi: 10.3791/58873.

8.

Whole-Cell, 3D, and Multicolor STED Imaging with Exchangeable Fluorophores.

Spahn C, Grimm JB, Lavis LD, Lampe M, Heilemann M.

Nano Lett. 2019 Jan 9;19(1):500-505. doi: 10.1021/acs.nanolett.8b04385. Epub 2018 Dec 14.

PMID:
30525682
9.

A toolbox for multiplexed super-resolution imaging of the E. coli nucleoid and membrane using novel PAINT labels.

Spahn CK, Glaesmann M, Grimm JB, Ayala AX, Lavis LD, Heilemann M.

Sci Rep. 2018 Oct 3;8(1):14768. doi: 10.1038/s41598-018-33052-3.

10.

Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair.

Gruber TD, Krishnamurthy C, Grimm JB, Tadross MR, Wysocki LM, Gartner ZJ, Lavis LD.

ACS Chem Biol. 2018 Oct 19;13(10):2888-2896. doi: 10.1021/acschembio.8b00524. Epub 2018 Aug 29.

11.

Optimization of fluorophores for chemical tagging and immunohistochemistry of Drosophila neurons.

Meissner GW, Grimm JB, Johnston RM, Sutcliffe B, Ng J, Jefferis GSXE, Cachero S, Lavis LD, Malkesman O.

PLoS One. 2018 Aug 15;13(8):e0200759. doi: 10.1371/journal.pone.0200759. eCollection 2018.

12.

Fluorogenic structure activity library pinpoints molecular variations in substrate specificity of structurally homologous esterases.

White A, Koelper A, Russell A, Larsen EM, Kim C, Lavis LD, Hoops GC, Johnson RJ.

J Biol Chem. 2018 Sep 7;293(36):13851-13862. doi: 10.1074/jbc.RA118.003972. Epub 2018 Jul 13.

13.

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission.

Yan Y, Peng C, Arvin MC, Jin XT, Kim VJ, Ramsey MD, Wang Y, Banala S, Wokosin DL, McIntosh JM, Lavis LD, Drenan RM.

Cell Rep. 2018 May 22;23(8):2236-2244. doi: 10.1016/j.celrep.2018.04.062.

14.

Measuring the Global Substrate Specificity of Mycobacterial Serine Hydrolases Using a Library of Fluorogenic Ester Substrates.

Bassett B, Waibel B, White A, Hansen H, Stephens D, Koelper A, Larsen EM, Kim C, Glanzer A, Lavis LD, Hoops GC, Johnson RJ.

ACS Infect Dis. 2018 Jun 8;4(6):904-911. doi: 10.1021/acsinfecdis.7b00263. Epub 2018 Apr 16.

15.

Photoactivatable drugs for nicotinic optopharmacology.

Banala S, Arvin MC, Bannon NM, Jin XT, Macklin JJ, Wang Y, Peng C, Zhao G, Marshall JJ, Gee KR, Wokosin DL, Kim VJ, McIntosh JM, Contractor A, Lester HA, Kozorovitskiy Y, Drenan RM, Lavis LD.

Nat Methods. 2018 May;15(5):347-350. doi: 10.1038/nmeth.4637. Epub 2018 Mar 26.

16.

Synthetic and genetically encoded fluorescent neural activity indicators.

Deo C, Lavis LD.

Curr Opin Neurobiol. 2018 Jun;50:101-108. doi: 10.1016/j.conb.2018.01.003. Epub 2018 Feb 16. Review.

PMID:
29454295
17.

Robust model-based analysis of single-particle tracking experiments with Spot-On.

Hansen AS, Woringer M, Grimm JB, Lavis LD, Tjian R, Darzacq X.

Elife. 2018 Jan 4;7. pii: e33125. doi: 10.7554/eLife.33125.

18.

Visualizing long-term single-molecule dynamics in vivo by stochastic protein labeling.

Liu H, Dong P, Ioannou MS, Li L, Shea J, Pasolli HA, Grimm JB, Rivlin PK, Lavis LD, Koyama M, Liu Z.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):343-348. doi: 10.1073/pnas.1713895115. Epub 2017 Dec 28.

19.

Semisynthetic fluorescent pH sensors for imaging exocytosis and endocytosis.

Martineau M, Somasundaram A, Grimm JB, Gruber TD, Choquet D, Taraska JW, Lavis LD, Perrais D.

Nat Commun. 2017 Nov 10;8(1):1412. doi: 10.1038/s41467-017-01752-5.

20.

Nuclear microenvironments modulate transcription from low-affinity enhancers.

Tsai A, Muthusamy AK, Alves MR, Lavis LD, Singer RH, Stern DL, Crocker J.

Elife. 2017 Nov 2;6. pii: e28975. doi: 10.7554/eLife.28975.

21.

General Synthetic Method for Si-Fluoresceins and Si-Rhodamines.

Grimm JB, Brown TA, Tkachuk AN, Lavis LD.

ACS Cent Sci. 2017 Sep 27;3(9):975-985. doi: 10.1021/acscentsci.7b00247. Epub 2017 Aug 9.

22.

Cohesin Can Remain Associated with Chromosomes during DNA Replication.

Rhodes JDP, Haarhuis JHI, Grimm JB, Rowland BD, Lavis LD, Nasmyth KA.

Cell Rep. 2017 Sep 19;20(12):2749-2755. doi: 10.1016/j.celrep.2017.08.092.

23.

Synthesis of Janelia Fluor HaloTag and SNAP-Tag Ligands and Their Use in Cellular Imaging Experiments.

Grimm JB, Brown TA, English BP, Lionnet T, Lavis LD.

Methods Mol Biol. 2017;1663:179-188. doi: 10.1007/978-1-4939-7265-4_15.

PMID:
28924668
24.

A general method to fine-tune fluorophores for live-cell and in vivo imaging.

Grimm JB, Muthusamy AK, Liang Y, Brown TA, Lemon WC, Patel R, Lu R, Macklin JJ, Keller PJ, Ji N, Lavis LD.

Nat Methods. 2017 Oct;14(10):987-994. doi: 10.1038/nmeth.4403. Epub 2017 Sep 4.

25.

Chemistry Is Dead. Long Live Chemistry!

Lavis LD.

Biochemistry. 2017 Oct 3;56(39):5165-5170. doi: 10.1021/acs.biochem.7b00529. Epub 2017 Aug 9. Review.

PMID:
28704030
26.

Desensitized D2 autoreceptors are resistant to trafficking.

Robinson BG, Bunzow JR, Grimm JB, Lavis LD, Dudman JT, Brown J, Neve KA, Williams JT.

Sci Rep. 2017 Jun 29;7(1):4379. doi: 10.1038/s41598-017-04728-z.

27.

Development of photostable fluorophores for molecular imaging.

Zheng Q, Lavis LD.

Curr Opin Chem Biol. 2017 Aug;39:32-38. doi: 10.1016/j.cbpa.2017.04.017. Epub 2017 May 23. Review.

PMID:
28544971
28.

Unraveling cell-to-cell signaling networks with chemical biology.

Gartner ZJ, Prescher JA, Lavis LD.

Nat Chem Biol. 2017 May 17;13(6):564-568. doi: 10.1038/nchembio.2391. No abstract available.

PMID:
28514428
29.

Teaching Old Dyes New Tricks: Biological Probes Built from Fluoresceins and Rhodamines.

Lavis LD.

Annu Rev Biochem. 2017 Jun 20;86:825-843. doi: 10.1146/annurev-biochem-061516-044839. Epub 2017 Apr 7. Review.

PMID:
28399656
30.

Deconstructing behavioral neuropharmacology with cellular specificity.

Shields BC, Kahuno E, Kim C, Apostolides PF, Brown J, Lindo S, Mensh BD, Dudman JT, Lavis LD, Tadross MR.

Science. 2017 Apr 7;356(6333). pii: eaaj2161. doi: 10.1126/science.aaj2161.

PMID:
28385956
31.

Quantifying transcription factor binding dynamics at the single-molecule level in live cells.

Presman DM, Ball DA, Paakinaho V, Grimm JB, Lavis LD, Karpova TS, Hager GL.

Methods. 2017 Jul 1;123:76-88. doi: 10.1016/j.ymeth.2017.03.014. Epub 2017 Mar 15.

32.

Glutamate-induced RNA localization and translation in neurons.

Yoon YJ, Wu B, Buxbaum AR, Das S, Tsai A, English BP, Grimm JB, Lavis LD, Singer RH.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6877-E6886. Epub 2016 Oct 17.

33.

Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis.

Zhang Z, English BP, Grimm JB, Kazane SA, Hu W, Tsai A, Inouye C, You C, Piehler J, Schultz PG, Lavis LD, Revyakin A, Tjian R.

Genes Dev. 2016 Sep 15;30(18):2106-2118.

34.

Bright photoactivatable fluorophores for single-molecule imaging.

Grimm JB, English BP, Choi H, Muthusamy AK, Mehl BP, Dong P, Brown TA, Lippincott-Schwartz J, Liu Z, Lionnet T, Lavis LD.

Nat Methods. 2016 Dec;13(12):985-988. doi: 10.1038/nmeth.4034. Epub 2016 Oct 24.

PMID:
27776112
35.

Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.

Zhen CY, Tatavosian R, Huynh TN, Duc HN, Das R, Kokotovic M, Grimm JB, Lavis LD, Lee J, Mejia FJ, Li Y, Yao T, Ren X.

Elife. 2016 Oct 10;5. pii: e17667. doi: 10.7554/eLife.17667.

36.

Real-time imaging of Huntingtin aggregates diverting target search and gene transcription.

Li L, Liu H, Dong P, Li D, Legant WR, Grimm JB, Lavis LD, Betzig E, Tjian R, Liu Z.

Elife. 2016 Aug 3;5. pii: e17056. doi: 10.7554/eLife.17056.

37.

Evaluation of the Ser-His Dipeptide, a Putative Catalyst of Amide and Ester Hydrolysis.

MacDonald MJ, Lavis LD, Hilvert D, Gellman SH.

Org Lett. 2016 Aug 5;18(15):3518-21. doi: 10.1021/acs.orglett.6b01279. Epub 2016 Jul 11.

PMID:
27400366
38.

Real-time quantification of single RNA translation dynamics in living cells.

Morisaki T, Lyon K, DeLuca KF, DeLuca JG, English BP, Zhang Z, Lavis LD, Grimm JB, Viswanathan S, Looger LL, Lionnet T, Stasevich TJ.

Science. 2016 Jun 17;352(6292):1425-9. doi: 10.1126/science.aaf0899. Epub 2016 May 5.

39.

Design and Synthesis of a Calcium-Sensitive Photocage.

Heckman LM, Grimm JB, Schreiter ER, Kim C, Verdecia MA, Shields BC, Lavis LD.

Angew Chem Int Ed Engl. 2016 Jul 11;55(29):8363-6. doi: 10.1002/anie.201602941. Epub 2016 May 24.

40.

RNA Polymerase II cluster dynamics predict mRNA output in living cells.

Cho WK, Jayanth N, English BP, Inoue T, Andrews JO, Conway W, Grimm JB, Spille JH, Lavis LD, Lionnet T, Cisse II.

Elife. 2016 May 3;5. pii: e13617. doi: 10.7554/eLife.13617.

41.

Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions.

Swinstead EE, Miranda TB, Paakinaho V, Baek S, Goldstein I, Hawkins M, Karpova TS, Ball D, Mazza D, Lavis LD, Grimm JB, Morisaki T, Grøntved L, Presman DM, Hager GL.

Cell. 2016 Apr 21;165(3):593-605. doi: 10.1016/j.cell.2016.02.067. Epub 2016 Apr 7.

42.

High-density three-dimensional localization microscopy across large volumes.

Legant WR, Shao L, Grimm JB, Brown TA, Milkie DE, Avants BB, Lavis LD, Betzig E.

Nat Methods. 2016 Apr;13(4):359-65. doi: 10.1038/nmeth.3797. Epub 2016 Mar 7.

43.

A platform for brain-wide imaging and reconstruction of individual neurons.

Economo MN, Clack NG, Lavis LD, Gerfen CR, Svoboda K, Myers EW, Chandrashekar J.

Elife. 2016 Jan 20;5:e10566. doi: 10.7554/eLife.10566.

44.

Synthesis of a Far-Red Photoactivatable Silicon-Containing Rhodamine for Super-Resolution Microscopy.

Grimm JB, Klein T, Kopek BG, Shtengel G, Hess HF, Sauer M, Lavis LD.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1723-7. doi: 10.1002/anie.201509649. Epub 2015 Dec 11.

45.

Virginia Orange: A Versatile, Red-Shifted Fluorescein Scaffold for Single- and Dual-Input Fluorogenic Probes.

Grimm JB, Gruber TD, Ortiz G, Brown TA, Lavis LD.

Bioconjug Chem. 2016 Feb 17;27(2):474-80. doi: 10.1021/acs.bioconjchem.5b00566. Epub 2015 Dec 22.

46.

Ketamine inside neurons?

Lester HA, Lavis LD, Dougherty DA.

Am J Psychiatry. 2015 Nov 1;172(11):1064-6. doi: 10.1176/appi.ajp.2015.14121537. Epub 2015 Jul 17. No abstract available.

47.

Imaging live-cell dynamics and structure at the single-molecule level.

Liu Z, Lavis LD, Betzig E.

Mol Cell. 2015 May 21;58(4):644-59. doi: 10.1016/j.molcel.2015.02.033. Review.

48.

A general method to improve fluorophores for live-cell and single-molecule microscopy.

Grimm JB, English BP, Chen J, Slaughter JP, Zhang Z, Revyakin A, Patel R, Macklin JJ, Normanno D, Singer RH, Lionnet T, Lavis LD.

Nat Methods. 2015 Mar;12(3):244-50, 3 p following 250. doi: 10.1038/nmeth.3256. Epub 2015 Jan 19.

49.

3D imaging of Sox2 enhancer clusters in embryonic stem cells.

Liu Z, Legant WR, Chen BC, Li L, Grimm JB, Lavis LD, Betzig E, Tjian R.

Elife. 2014 Dec 24;3:e04236. doi: 10.7554/eLife.04236.

50.

Evolved differences in larval social behavior mediated by novel pheromones.

Mast JD, De Moraes CM, Alborn HT, Lavis LD, Stern DL.

Elife. 2014 Dec 12;3:e04205. doi: 10.7554/eLife.04205.

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