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Adolescent nicotine induces depressive and anxiogenic effects through ERK 1-2 and Akt-GSK-3 pathways and neuronal dysregulation in the nucleus accumbens.

Hudson R, Green M, Wright DJ, Renard J, Jobson CEL, Jung T, Rushlow W, Laviolette SR.

Addict Biol. 2020 Mar 5:e12891. doi: 10.1111/adb.12891. [Epub ahead of print]


Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta.

Natale BV, Gustin KN, Lee K, Holloway AC, Laviolette SR, Natale DRC, Hardy DB.

Sci Rep. 2020 Jan 17;10(1):544. doi: 10.1038/s41598-019-57318-6.


Deciphering midbrain mechanisms underlying prepulse inhibition of startle.

Fulcher N, Azzopardi E, De Oliveira C, Hudson R, Schormans AL, Zaman T, Allman BL, Laviolette SR, Schmid S.

Prog Neurobiol. 2020 Feb;185:101734. doi: 10.1016/j.pneurobio.2019.101734. Epub 2019 Dec 19.


Exploring the impact of adolescent exposure to cannabinoids and nicotine on psychiatric risk: insights from translational animal models.

Laviolette SR.

Psychol Med. 2019 Dec 5:1-8. doi: 10.1017/S0033291719003325. [Epub ahead of print]


Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1-2 Phosphorylation.

Hudson R, Renard J, Norris C, Rushlow WJ, Laviolette SR.

J Neurosci. 2019 Oct 30;39(44):8762-8777. doi: 10.1523/JNEUROSCI.0708-19.2019. Epub 2019 Sep 30.


Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors.

Szkudlarek HJ, Desai SJ, Renard J, Pereira B, Norris C, Jobson CEL, Rajakumar N, Allman BL, Laviolette SR.

Neuropsychopharmacology. 2019 Mar;44(4):817-825. doi: 10.1038/s41386-018-0282-7. Epub 2018 Nov 27.


The Role of Cholinergic Midbrain Neurons in Startle and Prepulse Inhibition.

Azzopardi E, Louttit AG, DeOliveira C, Laviolette SR, Schmid S.

J Neurosci. 2018 Oct 10;38(41):8798-8808. doi: 10.1523/JNEUROSCI.0984-18.2018. Epub 2018 Aug 31.


Adolescent Nicotine Exposure Induces Dysregulation of Mesocorticolimbic Activity States and Depressive and Anxiety-like Prefrontal Cortical Molecular Phenotypes Persisting into Adulthood.

Jobson CLM, Renard J, Szkudlarek H, Rosen LG, Pereira B, Wright DJ, Rushlow W, Laviolette SR.

Cereb Cortex. 2019 Jul 5;29(7):3140-3153. doi: 10.1093/cercor/bhy179.


Effects of Adolescent THC Exposure on the Prefrontal GABAergic System: Implications for Schizophrenia-Related Psychopathology.

Renard J, Rushlow WJ, Laviolette SR.

Front Psychiatry. 2018 Jul 2;9:281. doi: 10.3389/fpsyt.2018.00281. eCollection 2018. Review.


Delta-9-tetrahydrocannabinol potentiates fear memory salience through functional modulation of mesolimbic dopaminergic activity states.

Fitoussi A, Zunder J, Tan H, Laviolette SR.

Eur J Neurosci. 2018 Jun;47(11):1385-1400. doi: 10.1111/ejn.13951.


Fear Memory Recall Potentiates Opiate Reward Sensitivity through Dissociable Dopamine D1 versus D4 Receptor-Dependent Memory Mechanisms in the Prefrontal Cortex.

Jing Li J, Szkudlarek H, Renard J, Hudson R, Rushlow W, Laviolette SR.

J Neurosci. 2018 May 9;38(19):4543-4555. doi: 10.1523/JNEUROSCI.3113-17.2018. Epub 2018 Apr 23.


Phytocannabinoids modulate emotional memory processing through interactions with the ventral hippocampus and mesolimbic dopamine system: implications for neuropsychiatric pathology.

Hudson R, Rushlow W, Laviolette SR.

Psychopharmacology (Berl). 2018 Feb;235(2):447-458. doi: 10.1007/s00213-017-4766-7. Epub 2017 Oct 24. Review.


Adolescent THC Exposure Causes Enduring Prefrontal Cortical Disruption of GABAergic Inhibition and Dysregulation of Sub-Cortical Dopamine Function.

Renard J, Szkudlarek HJ, Kramar CP, Jobson CEL, Moura K, Rushlow WJ, Laviolette SR.

Sci Rep. 2017 Sep 12;7(1):11420. doi: 10.1038/s41598-017-11645-8.


Palmitoylethanolamide Modulates GPR55 Receptor Signaling in the Ventral Hippocampus to Regulate Mesolimbic Dopamine Activity, Social Interaction, and Memory Processing.

Kramar C, Loureiro M, Renard J, Laviolette SR.

Cannabis Cannabinoid Res. 2017 Jan 1;2(1):8-20. doi: 10.1089/can.2016.0030. eCollection 2017.


Opiate exposure state controls dopamine D3 receptor and cdk5/calcineurin signaling in the basolateral amygdala during reward and withdrawal aversion memory formation.

Rosen LG, Rushlow WJ, Laviolette SR.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):59-66. doi: 10.1016/j.pnpbp.2017.06.009. Epub 2017 Jun 14.


Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments.

Renard J, Norris C, Rushlow W, Laviolette SR.

Neurosci Biobehav Rev. 2017 Apr;75:157-165. doi: 10.1016/j.neubiorev.2017.02.006. Epub 2017 Feb 7. Review.


Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks.

Silveira MM, Arnold JC, Laviolette SR, Hillard CJ, Celorrio M, Aymerich MS, Adams WK.

Neurosci Biobehav Rev. 2017 May;76(Pt B):380-395. doi: 10.1016/j.neubiorev.2016.09.007. Epub 2016 Sep 14. Review.


The CB1 Neutral Antagonist AM4113 Retains the Therapeutic Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and Weight Loss with Better Psychiatric Tolerability.

Gueye AB, Pryslawsky Y, Trigo JM, Poulia N, Delis F, Antoniou K, Loureiro M, Laviolette SR, Vemuri K, Makriyannis A, Le Foll B.

Int J Neuropsychopharmacol. 2016 Dec 30;19(12). pii: pyw068. doi: 10.1093/ijnp/pyw068. Print 2016 Dec.


Cannabidiol Modulates Fear Memory Formation Through Interactions with Serotonergic Transmission in the Mesolimbic System.

Norris C, Loureiro M, Kramar C, Zunder J, Renard J, Rushlow W, Laviolette SR.

Neuropsychopharmacology. 2016 Nov;41(12):2839-2850. doi: 10.1038/npp.2016.93. Epub 2016 Jun 14.


What Can Rats Tell Us about Adolescent Cannabis Exposure? Insights from Preclinical Research.

Renard J, Rushlow WJ, Laviolette SR.

Can J Psychiatry. 2016 Jun;61(6):328-34. doi: 10.1177/0706743716645288. Review.


Bi-directional cannabinoid signalling in the basolateral amygdala controls rewarding and aversive emotional processing via functional regulation of the nucleus accumbens.

Ahmad T, Sun N, Lyons D, Laviolette SR.

Addict Biol. 2017 Sep;22(5):1218-1231. doi: 10.1111/adb.12406. Epub 2016 May 27.


Cannabidiol Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway through a Novel mTOR/p70S6 Kinase Signaling Pathway.

Renard J, Loureiro M, Rosen LG, Zunder J, de Oliveira C, Schmid S, Rushlow WJ, Laviolette SR.

J Neurosci. 2016 May 4;36(18):5160-9. doi: 10.1523/JNEUROSCI.3387-15.2016.


Adolescent Cannabinoid Exposure Induces a Persistent Sub-Cortical Hyper-Dopaminergic State and Associated Molecular Adaptations in the Prefrontal Cortex.

Renard J, Rosen LG, Loureiro M, De Oliveira C, Schmid S, Rushlow WJ, Laviolette SR.

Cereb Cortex. 2017 Feb 1;27(2):1297-1310. doi: 10.1093/cercor/bhv335.


Cannabinoid Transmission in the Hippocampus Activates Nucleus Accumbens Neurons and Modulates Reward and Aversion-Related Emotional Salience.

Loureiro M, Kramar C, Renard J, Rosen LG, Laviolette SR.

Biol Psychiatry. 2016 Aug 1;80(3):216-25. doi: 10.1016/j.biopsych.2015.10.016. Epub 2015 Oct 31.


Molecular and neuronal plasticity mechanisms in the amygdala-prefrontal cortical circuit: implications for opiate addiction memory formation.

Rosen LG, Sun N, Rushlow W, Laviolette SR.

Front Neurosci. 2015 Nov 5;9:399. doi: 10.3389/fnins.2015.00399. eCollection 2015. Review.


Opiate Exposure State Controls a D2-CaMKIIα-Dependent Memory Switch in the Amygdala-Prefrontal Cortical Circuit.

Rosen LG, Zunder J, Renard J, Fu J, Rushlow W, Laviolette SR.

Neuropsychopharmacology. 2016 Feb;41(3):847-57. doi: 10.1038/npp.2015.211. Epub 2015 Jul 15.


Dopamine Receptor Blockade Modulates the Rewarding and Aversive Properties of Nicotine via Dissociable Neuronal Activity Patterns in the Nucleus Accumbens.

Sun N, Laviolette SR; Addiction Research Group.

Neuropsychopharmacology. 2015 Feb;40(3):791. doi: 10.1038/npp.2014.289. No abstract available.


Hippocampal cannabinoid transmission modulates dopamine neuron activity: impact on rewarding memory formation and social interaction.

Loureiro M, Renard J, Zunder J, Laviolette SR.

Neuropsychopharmacology. 2015 May;40(6):1436-47. doi: 10.1038/npp.2014.329. Epub 2014 Dec 16.


Cannabinoid transmission in the prefrontal cortex bi-phasically controls emotional memory formation via functional interactions with the ventral tegmental area.

Draycott B, Loureiro M, Ahmad T, Tan H, Zunder J, Laviolette SR.

J Neurosci. 2014 Sep 24;34(39):13096-109. doi: 10.1523/JNEUROSCI.1297-14.2014.


The role of cannabinoid transmission in emotional memory formation: implications for addiction and schizophrenia.

Tan H, Ahmad T, Loureiro M, Zunder J, Laviolette SR.

Front Psychiatry. 2014 Jun 30;5:73. doi: 10.3389/fpsyt.2014.00073. eCollection 2014. Review.


Endogenous opioid-induced neuroplasticity of dopaminergic neurons in the ventral tegmental area influences natural and opiate reward.

Pitchers KK, Coppens CM, Beloate LN, Fuller J, Van S, Frohmader KS, Laviolette SR, Lehman MN, Coolen LM.

J Neurosci. 2014 Jun 25;34(26):8825-36. doi: 10.1523/JNEUROSCI.0133-14.2014.


Dopamine receptor blockade modulates the rewarding and aversive properties of nicotine via dissociable neuronal activity patterns in the nucleus accumbens.

Sun N, Laviolette SR; Addiction Research Group.

Neuropsychopharmacology. 2014 Nov;39(12):2799-815. doi: 10.1038/npp.2014.130. Epub 2014 Jun 4. Erratum in: Neuropsychopharmacology. 2015 Feb;40(3):791.


NMDA receptor blockade in the prelimbic cortex activates the mesolimbic system and dopamine-dependent opiate reward signaling.

Tan H, Rosen LG, Ng GA, Rushlow WJ, Laviolette SR; Addiction Research Group.

Psychopharmacology (Berl). 2014 Dec;231(24):4669-79. doi: 10.1007/s00213-014-3616-0. Epub 2014 May 29.


Opiate exposure and withdrawal induces a molecular memory switch in the basolateral amygdala between ERK1/2 and CaMKIIα-dependent signaling substrates.

Lyons D, de Jaeger X, Rosen LG, Ahmad T, Lauzon NM, Zunder J, Coolen LM, Rushlow W, Laviolette SR.

J Neurosci. 2013 Sep 11;33(37):14693-704. doi: 10.1523/JNEUROSCI.1226-13.2013.


Early versus late-phase consolidation of opiate reward memories requires distinct molecular and temporal mechanisms in the amygdala-prefrontal cortical pathway.

Gholizadeh S, Sun N, De Jaeger X, Bechard M, Coolen L, Laviolette SR.

PLoS One. 2013 May 16;8(5):e63612. doi: 10.1371/journal.pone.0063612. Print 2013.


Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator.

Pitchers KK, Vialou V, Nestler EJ, Laviolette SR, Lehman MN, Coolen LM.

J Neurosci. 2013 Feb 20;33(8):3434-42. doi: 10.1523/JNEUROSCI.4881-12.2013.


Supra-normal stimulation of dopamine D1 receptors in the prelimbic cortex blocks behavioral expression of both aversive and rewarding associative memories through a cyclic-AMP-dependent signaling pathway.

Lauzon NM, Bechard M, Ahmad T, Laviolette SR.

Neuropharmacology. 2013 Apr;67:104-14. doi: 10.1016/j.neuropharm.2012.10.029. Epub 2012 Nov 16.


The effects of AMPA receptor blockade in the prelimbic cortex on systemic and ventral tegmental area opiate reward sensitivity.

De Jaeger X, Bishop SF, Ahmad T, Lyons D, Ng GA, Laviolette SR.

Psychopharmacology (Berl). 2013 Feb;225(3):687-95. doi: 10.1007/s00213-012-2852-4. Epub 2012 Sep 13.


Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens.

Pitchers KK, Schmid S, Di Sebastiano AR, Wang X, Laviolette SR, Lehman MN, Coolen LM.

PLoS One. 2012;7(4):e34700. doi: 10.1371/journal.pone.0034700. Epub 2012 Apr 18.


Inactivation of the basolateral amygdala during opiate reward learning disinhibits prelimbic cortical neurons and modulates associative memory extinction.

Sun N, Laviolette SR.

Psychopharmacology (Berl). 2012 Aug;222(4):645-61. doi: 10.1007/s00213-012-2665-5. Epub 2012 Mar 21.


Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal.

Grieder TE, George O, Tan H, George SR, Le Foll B, Laviolette SR, van der Kooy D.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3101-6. doi: 10.1073/pnas.1114422109. Epub 2012 Jan 20.


Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission.

Lintas A, Chi N, Lauzon NM, Bishop SF, Sun N, Tan H, Laviolette SR.

Eur J Neurosci. 2012 Jan;35(2):279-90. doi: 10.1111/j.1460-9568.2011.07943.x. Epub 2012 Jan 12.


Dopamine D4 receptor transmission in the prefrontal cortex controls the salience of emotional memory via modulation of calcium calmodulin-dependent kinase II.

Lauzon NM, Ahmad T, Laviolette SR.

Cereb Cortex. 2012 Nov;22(11):2486-94. doi: 10.1093/cercor/bhr326. Epub 2011 Nov 24.


Concurrent exposure to methamphetamine and sexual behavior enhances subsequent drug reward and causes compulsive sexual behavior in male rats.

Frohmader KS, Lehman MN, Laviolette SR, Coolen LM.

J Neurosci. 2011 Nov 9;31(45):16473-82. doi: 10.1523/JNEUROSCI.4013-11.2011.


Identification of a dopamine receptor-mediated opiate reward memory switch in the basolateral amygdala-nucleus accumbens circuit.

Lintas A, Chi N, Lauzon NM, Bishop SF, Gholizadeh S, Sun N, Tan H, Laviolette SR.

J Neurosci. 2011 Aug 3;31(31):11172-83. doi: 10.1523/JNEUROSCI.1781-11.2011.


Acquisition, extinction, and recall of opiate reward memory are signaled by dynamic neuronal activity patterns in the prefrontal cortex.

Sun N, Chi N, Lauzon N, Bishop S, Tan H, Laviolette SR.

Cereb Cortex. 2011 Dec;21(12):2665-80. doi: 10.1093/cercor/bhr031. Epub 2011 Apr 29.


Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex.

Tan H, Lauzon NM, Bishop SF, Chi N, Bechard M, Laviolette SR.

J Neurosci. 2011 Apr 6;31(14):5300-12. doi: 10.1523/JNEUROSCI.4718-10.2011.

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