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Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD.

van den Berge M, Brandsma CA, Faiz A, de Vries M, Rathnayake SNH, Paré PD, Sin DD, Bossé Y, Laviolette M, Nickle DC, Hao K, Obeidat M, Dragani TA, Colombo F, Timens W, Postma DS.

Eur Respir J. 2019 Jun 4. pii: 1702567. doi: 10.1183/13993003.02567-2017. [Epub ahead of print] No abstract available.


Effect of bronchial thermoplasty on structural changes and inflammatory mediators in the airways of subjects with severe asthma.

Ichikawa T, Panariti A, Audusseau S, Mogas AK, Olivenstein R, Chakir J, Laviolette M, Allakhverdi Z, Al Heialy S, Martin JG, Hamid Q.

Respir Med. 2019 Apr;150:165-172. doi: 10.1016/j.rmed.2019.03.005. Epub 2019 Mar 20.


20-Hydroxy- and 20-carboxy-leukotriene (LT) B4 downregulate LTB4 -mediated responses of human neutrophils and eosinophils.

Archambault AS, Poirier S, Lefebvre JS, Robichaud PP, Larose MC, Turcotte C, Martin C, Provost V, Boudreau LH, McDonald PP, Laviolette M, Surette ME, Flamand N.

J Leukoc Biol. 2019 Jun;105(6):1131-1142. doi: 10.1002/JLB.MA0718-306R. Epub 2019 Jan 24.


Persistent Reduction of Mucin Production after Bronchial Thermoplasty in Severe Asthma.

Haj Salem I, Gras D, Joubert P, Boulet LP, Lampron N, Martel S, Godbout K, Chanez P, Laviolette M, Chakir J.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):536-538. doi: 10.1164/rccm.201811-2064LE. No abstract available.


Methylation profiles of IL33 and CCL26 in bronchial epithelial cells are associated with asthma.

Larouche M, Gagné-Ouellet V, Boucher-Lafleur AM, Larose MC, Plante S, Madore AM, Laviolette M, Flamand N, Chakir J, Laprise C.

Epigenomics. 2018 Dec;10(12):1555-1568. doi: 10.2217/epi-2018-0044. Epub 2018 Nov 23.


Tumor-based gene expression biomarkers to predict survival following curative intent resection for stage I lung adenocarcinoma.

Clemenceau A, Gaudreault N, Henry C, Ugalde PA, Labbé C, Laviolette M, Joubert P, Bossé Y.

PLoS One. 2018 Nov 20;13(11):e0207513. doi: 10.1371/journal.pone.0207513. eCollection 2018.


Changes in airway inflammation and remodelling in swimmers after quitting sport competition.

Bougault V, Odashiro P, Turmel J, Orain M, Laviolette M, Joubert P, Boulet LP.

Clin Exp Allergy. 2018 Dec;48(12):1748-1751. doi: 10.1111/cea.13257. Epub 2018 Sep 14. No abstract available.


Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils.

Archambault AS, Turcotte C, Martin C, Provost V, Larose MC, Laprise C, Chakir J, Bissonnette É, Laviolette M, Bossé Y, Flamand N.

PLoS One. 2018 Aug 17;13(8):e0202424. doi: 10.1371/journal.pone.0202424. eCollection 2018.


The CD36-PPARγ Pathway in Metabolic Disorders.

Maréchal L, Laviolette M, Rodrigue-Way A, Sow B, Brochu M, Caron V, Tremblay A.

Int J Mol Sci. 2018 May 21;19(5). pii: E1529. doi: 10.3390/ijms19051529. Review.


Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations.

Lamontagne M, Bérubé JC, Obeidat M, Cho MH, Hobbs BD, Sakornsakolpat P, de Jong K, Boezen HM; International COPD Genetics Consortium, Nickle D, Hao K, Timens W, van den Berge M, Joubert P, Laviolette M, Sin DD, Paré PD, Bossé Y.

Hum Mol Genet. 2018 May 15;27(10):1819-1829. doi: 10.1093/hmg/ddy091.


Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity.

Basu T, Seyedmousavi S, Sugui JA, Balenga N, Zhao M, Kwon Chung KJ, Biardel S, Laviolette M, Druey KM.

J Allergy Clin Immunol. 2018 Jan;141(1):423-425.e7. doi: 10.1016/j.jaci.2017.07.034. Epub 2017 Sep 4. No abstract available.


Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies.

Chupp G, Laviolette M, Cohn L, McEvoy C, Bansal S, Shifren A, Khatri S, Grubb GM, McMullen E, Strauven R, Kline JN; Other members of the PAS2 Study Group.

Eur Respir J. 2017 Aug 31;50(2). pii: 1700017. doi: 10.1183/13993003.00017-2017. Print 2017 Aug. Erratum in: Eur Respir J. 2017 Oct 12;50(4):.


Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma.

Larose MC, Archambault AS, Provost V, Laviolette M, Flamand N.

Front Med (Lausanne). 2017 Aug 11;4:136. doi: 10.3389/fmed.2017.00136. eCollection 2017.


Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial.

Ferguson GT, FitzGerald JM, Bleecker ER, Laviolette M, Bernstein D, LaForce C, Mansfield L, Barker P, Wu Y, Jison M, Goldman M; BISE Study Investigators.

Lancet Respir Med. 2017 Jul;5(7):568-576. doi: 10.1016/S2213-2600(17)30190-X. Epub 2017 May 22.


Assessment of Airway Distensibility by the Forced Oscillation Technique: Reproducible and Potentially Simplifiable.

Mailhot-Larouche S, Lachance M, Bullone M, Henry C, Dandurand RJ, Boulet LP, Laviolette M, King GG, Farah CS, Bossé Y.

Front Physiol. 2017 Apr 12;8:223. doi: 10.3389/fphys.2017.00223. eCollection 2017.


Acute effects of bronchial thermoplasty: a matter of concern or an indicator of possible benefit to small airways?

Boulet LP, Laviolette M.

Eur Respir J. 2017 Mar 15;49(3). pii: 1700029. doi: 10.1183/13993003.00029-2017. Print 2017 Mar. No abstract available.


The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors.

Turcotte C, Zarini S, Jean S, Martin C, Murphy RC, Marsolais D, Laviolette M, Blanchet MR, Flamand N.

J Immunol. 2017 Apr 15;198(8):3255-3263. doi: 10.4049/jimmunol.1601767. Epub 2017 Mar 3.


Combining omics data to identify genes associated with allergic rhinitis.

Morin A, Laviolette M, Pastinen T, Boulet LP, Laprise C.

Clin Epigenetics. 2017 Jan 18;9:3. doi: 10.1186/s13148-017-0310-1. eCollection 2017.


Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients.

Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg CM, Girodet PO, Berger P, Kline JN, Chupp G, Susulic VS, Barnathan ES, Baribaud F, Loza MJ; Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study investigators.

J Allergy Clin Immunol. 2017 Sep;140(3):710-719. doi: 10.1016/j.jaci.2016.11.038. Epub 2017 Jan 13.


Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo.

Archambault AS, Turcotte C, Martin C, Lefebvre JS, Provost V, Laviolette M, Flamand N.

PLoS One. 2017 Jan 9;12(1):e0169804. doi: 10.1371/journal.pone.0169804. eCollection 2017.


Does Travel Time to a Radiation Facility Impact Patient Decision-Making Regarding Treatment for Prostate Cancer? A Study of the New Hampshire State Cancer Registry.

Ghali F, Celaya M, Laviolette M, Ingimarsson J, Carlos H, Rees J, Hyams E.

J Rural Health. 2018 Feb;34 Suppl 1:s84-s90. doi: 10.1111/jrh.12224. Epub 2016 Nov 11.


The CB2 receptor and its role as a regulator of inflammation.

Turcotte C, Blanchet MR, Laviolette M, Flamand N.

Cell Mol Life Sci. 2016 Dec;73(23):4449-4470. Epub 2016 Jul 11. Review.


PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma.

Nieuwenhuis MA, Vonk JM, Himes BE, Sarnowski C, Minelli C, Jarvis D, Bouzigon E, Nickle DC, Laviolette M, Sin D, Weiss ST, van den Berge M, Koppelman GH, Postma DS.

Allergy. 2017 May;72(5):792-801. doi: 10.1111/all.13062. Epub 2016 Nov 21.


Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs.

Turcotte C, Blanchet MR, Laviolette M, Flamand N.

Front Pharmacol. 2016 Sep 15;7:317. eCollection 2016. Review.


Long-Term Effects of Bronchial Thermoplasty on Airway Smooth Muscle and Reticular Basement Membrane Thickness in Severe Asthma.

Salem IH, Boulet LP, Biardel S, Lampron N, Martel S, Laviolette M, Chakir J.

Ann Am Thorac Soc. 2016 Aug;13(8):1426-8. doi: 10.1513/AnnalsATS.201603-182LE. No abstract available.


Identification of Susceptibility Genes of Adult Asthma in French Canadian Women.

Bérubé JC, Gaudreault N, Lavoie-Charland E, Sbarra L, Henry C, Madore AM, Paré PD, van den Berge M, Nickle D, Laviolette M, Laprise C, Boulet LP, Bossé Y.

Can Respir J. 2016;2016:3564341. doi: 10.1155/2016/3564341. Epub 2016 May 4.


Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses.

Gauvreau GM, Arm JP, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I, FitzGerald JM, Dahlen B, Killian KJ, Laviolette M, Carlsten C, Lazarinis N, Watson RM, Milot J, Swystun V, Bowen M, Hui L, Lantz AS, Meiser K, Maahs S, Lowe PJ, Skerjanec A, Drollmann A, O'Byrne PM.

J Allergy Clin Immunol. 2016 Oct;138(4):1051-1059. doi: 10.1016/j.jaci.2016.02.027. Epub 2016 Apr 7.


Susceptibility genes for lung diseases in the major histocompatibility complex revealed by lung expression quantitative trait loci analysis.

Lamontagne M, Joubert P, Timens W, Postma DS, Hao K, Nickle D, Sin DD, Pare PD, Laviolette M, Bossé Y.

Eur Respir J. 2016 Aug;48(2):573-6. doi: 10.1183/13993003.00114-2016. Epub 2016 May 12. No abstract available.


Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study.

Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg C, Girodet PO, Berger P, Kline JN, Khatri S, Chanez P, Susulic VS, Barnathan ES, Baribaud F, Loza MJ; ADEPT Investigators.

Respir Res. 2016 Apr 23;17:43. doi: 10.1186/s12931-016-0360-5.


Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study.

Silkoff PE, Strambu I, Laviolette M, Singh D, FitzGerald JM, Lam S, Kelsen S, Eich A, Ludwig-Sengpiel A, Hupp GC, Backer V, Porsbjerg C, Girodet PO, Berger P, Leigh R, Kline JN, Dransfield M, Calhoun W, Hussaini A, Khatri S, Chanez P, Susulic VS, Barnathan ES, Curran M, Das AM, Brodmerkel C, Baribaud F, Loza MJ.

Respir Res. 2015 Nov 17;16:142. doi: 10.1186/s12931-015-0299-y.


Impact of Statins on Gene Expression in Human Lung Tissues.

Lane J, van Eeden SF, Obeidat M, Sin DD, Tebbutt SJ, Timens W, Postma DS, Laviolette M, Paré PD, Bossé Y.

PLoS One. 2015 Nov 4;10(11):e0142037. doi: 10.1371/journal.pone.0142037. eCollection 2015.


Molecular mechanisms underlying variations in lung function: a systems genetics analysis.

Obeidat M, Hao K, Bossé Y, Nickle DC, Nie Y, Postma DS, Laviolette M, Sandford AJ, Daley DD, Hogg JC, Elliott WM, Fishbane N, Timens W, Hysi PG, Kaprio J, Wilson JF, Hui J, Rawal R, Schulz H, Stubbe B, Hayward C, Polasek O, Järvelin MR, Zhao JH, Jarvis D, Kähönen M, Franceschini N, North KE, Loth DW, Brusselle GG, Smith AV, Gudnason V, Bartz TM, Wilk JB, O'Connor GT, Cassano PA, Tang W, Wain LV, Soler Artigas M, Gharib SA, Strachan DP, Sin DD, Tobin MD, London SJ, Hall IP, Paré PD.

Lancet Respir Med. 2015 Oct;3(10):782-95. doi: 10.1016/S2213-2600(15)00380-X. Epub 2015 Sep 21. Erratum in: Lancet Respir Med. 2015 Dec;3(12):e44.


Effects of Bronchial Thermoplasty on Airway Smooth Muscle and Collagen Deposition in Asthma.

Chakir J, Haj-Salem I, Gras D, Joubert P, Beaudoin ÈL, Biardel S, Lampron N, Martel S, Chanez P, Boulet LP, Laviolette M.

Ann Am Thorac Soc. 2015 Nov;12(11):1612-8. doi: 10.1513/AnnalsATS.201504-208OC.


Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma.

Larose MC, Chakir J, Archambault AS, Joubert P, Provost V, Laviolette M, Flamand N.

J Allergy Clin Immunol. 2015 Oct;136(4):904-13. doi: 10.1016/j.jaci.2015.02.039. Epub 2015 May 1.


A fungal protease allergen provokes airway hyper-responsiveness in asthma.

Balenga NA, Klichinsky M, Xie Z, Chan EC, Zhao M, Jude J, Laviolette M, Panettieri RA Jr, Druey KM.

Nat Commun. 2015 Apr 13;6:6763. doi: 10.1038/ncomms7763.


Trends in initial management of prostate cancer in New Hampshire.

Ingimarsson JP, Celaya MO, Laviolette M, Rees JR, Hyams ES.

Cancer Causes Control. 2015 Jun;26(6):923-9. doi: 10.1007/s10552-015-0574-8. Epub 2015 Apr 4.


Validation of a multiprotein plasma classifier to identify benign lung nodules.

Vachani A, Pass HI, Rom WN, Midthun DE, Edell ES, Laviolette M, Li XJ, Fong PY, Hunsucker SW, Hayward C, Mazzone PJ, Madtes DK, Miller YE, Walker MG, Shi J, Kearney P, Fang KC, Massion PP.

J Thorac Oncol. 2015 Apr;10(4):629-37. doi: 10.1097/JTO.0000000000000447.


Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis.

Saferali A, Obeidat M, Bérubé JC, Lamontagne M, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD, Postma DS, Strug LJ, Gallins PJ, Paré PD, Bingle CD, Sandford AJ.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):607-14. doi: 10.1165/rcmb.2014-0182OC.


[Bronchial thermoplasty in the treatment of severe adult asthma].

Chanez P, Boulet LP, Brillet PY, Joos G, Laviolette M, Louis R, Rochat T, Soccal P, Aubier M.

Rev Mal Respir. 2015 Feb;32(2):97-109. doi: 10.1016/j.rmr.2014.09.009. Epub 2014 Dec 19. Review. French.


Bronchial thermoplasty: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults.

Dombret MC, Alagha K, Boulet LP, Brillet PY, Joos G, Laviolette M, Louis R, Rochat T, Soccal P, Aubier M, Chanez P.

Eur Respir Rev. 2014 Dec;23(134):510-8. doi: 10.1183/09059180.00005114. Review.


Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung.

Nguyen JD, Lamontagne M, Couture C, Conti M, Paré PD, Sin DD, Hogg JC, Nickle D, Postma DS, Timens W, Laviolette M, Bossé Y.

Carcinogenesis. 2014 Dec;35(12):2653-9. doi: 10.1093/carcin/bgu184. Epub 2014 Sep 3.


Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction.

Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, Lenburg ME, Spira A, Paré PD, Nickle D, Sin DD, Postma DS.

Thorax. 2014 Nov;69(11):997-1004. doi: 10.1136/thoraxjnl-2014-205630. Epub 2014 Sep 2.


A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD.

Brandsma CA, van den Berge M, Postma DS, Jonker MR, Brouwer S, Paré PD, Sin DD, Bossé Y, Laviolette M, Karjalainen J, Fehrmann RS, Nickle DC, Hao K, Spanjer AI, Timens W, Franke L.

Thorax. 2015 Jan;70(1):21-32. doi: 10.1136/thoraxjnl-2014-205091. Epub 2014 Jul 2.


Lung expression quantitative trait loci data set identifies important functional polymorphisms in the asthma-associated IL1RL1 region.

Akhabir L, Bérubé JC, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD, Paré PD, Postma DS, Sandford AJ.

J Allergy Clin Immunol. 2014 Sep;134(3):729-31. doi: 10.1016/j.jaci.2014.02.039. Epub 2014 Apr 18. No abstract available.


Impact of cigarette smoke on the human and mouse lungs: a gene-expression comparison study.

Morissette MC, Lamontagne M, Bérubé JC, Gaschler G, Williams A, Yauk C, Couture C, Laviolette M, Hogg JC, Timens W, Halappanavar S, Stampfli MR, Bossé Y.

PLoS One. 2014 Mar 24;9(3):e92498. doi: 10.1371/journal.pone.0092498. eCollection 2014.


Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol.

Larose MC, Turcotte C, Chouinard F, Ferland C, Martin C, Provost V, Laviolette M, Flamand N.

J Allergy Clin Immunol. 2014 May;133(5):1480-2, 1482.e1-3. doi: 10.1016/j.jaci.2013.12.1081. Epub 2014 Feb 13. No abstract available.


The relationship between eosinophilia and airway remodelling in mild asthma.

Wilson SJ, Rigden HM, Ward JA, Laviolette M, Jarjour NN, Djukanović R.

Clin Exp Allergy. 2013 Dec;43(12):1342-50. doi: 10.1111/cea.12156.


OX40L blockade and allergen-induced airway responses in subjects with mild asthma.

Gauvreau GM, Boulet LP, Cockcroft DW, FitzGerald JM, Mayers I, Carlsten C, Laviolette M, Killian KJ, Davis BE, Larché M, Kipling C, Dua B, Mosesova S, Putnam W, Zheng Y, Scheerens H, McClintock D, Matthews JG, O'Byrne PM.

Clin Exp Allergy. 2014 Jan;44(1):29-37. doi: 10.1111/cea.12235.


Fibroblast growth factor-2 is a sputum remodeling biomarker of severe asthma.

Bissonnette ÉY, Madore AM, Chakir J, Laviolette M, Boulet LP, Hamid Q, Bergeron C, Maghni K, Laprise C.

J Asthma. 2014 Mar;51(2):119-26. doi: 10.3109/02770903.2013.860164. Epub 2013 Nov 25.


Disconnect between sputum neutrophils and other measures of airway inflammation in asthma.

Arron JR, Choy DF, Laviolette M, Kelsen SG, Hatab A, Leigh R, Thomson NC, Bleecker ER, Olivenstein R, Avila PC, Jarjour NN, Castro M, Gauvreau GM, Good JT, Kline JN, Mansur A, Mayers I, Heaney LG, Hamid Q, Harris JM.

Eur Respir J. 2014 Feb;43(2):627-9. doi: 10.1183/09031936.00117013. Epub 2013 Oct 31. No abstract available.

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