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Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses.

Ovchinnikov DA, Withey SL, Leeson HC, Lei UW, Sundarrajan A, Junday K, Pewarchuk M, Yeo AJ, Kijas AW, Lavin MF, Wolvetang EJ.

Hum Mol Genet. 2020 Feb 10. pii: ddaa023. doi: 10.1093/hmg/ddaa023. [Epub ahead of print]


Rapid serum tube technology overcomes problems associated with use of anticoagulants.

Zhao KN, Dimeski G, de Jersey J, Johnson LA, Grant M, Masci PP, Lavin MF.

Biochem Med (Zagreb). 2019 Oct 15;29(3):030706. doi: 10.11613/BM.2019.030706.


Thymic stromal lymphopoietin (TSLP) and Toluene-diisocyanate-induced airway inflammation: Alleviation by TSLP neutralizing antibody.

Yu G, Zhang Y, Wang X, Sai L, Bo C, Yeo AJ, Lavin MF, Peng C, Jia Q, Shao H.

Toxicol Lett. 2019 Dec 15;317:59-67. doi: 10.1016/j.toxlet.2019.09.021. Epub 2019 Sep 29.


SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.

Ho U, Luff J, James A, Lee CS, Quek H, Lai HC, Apte S, Lim YC, Lavin MF, Roberts TL.

J Cell Mol Med. 2019 Dec;23(12):8151-8160. doi: 10.1111/jcmm.14685. Epub 2019 Sep 29.


Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis.

Yang Y, Du X, Wang Q, Liu J, Zhang E, Sai L, Peng C, Lavin MF, Yeo AJ, Yang X, Shao H, Du Z.

Int J Mol Med. 2019 Sep;44(3):903-912. doi: 10.3892/ijmm.2019.4265. Epub 2019 Jul 5.


Simultaneous Targeting of DNA Replication and Homologous Recombination in Glioblastoma with a Polyether Ionophore.

Lim YC, Ensbey KS, Offenhäuser C, D'Souza RCJ, Cullen JK, Stringer BW, Quek H, Bruce ZC, Kijas A, Cianfanelli V, Mahboubi B, Smith F, Jeffree RL, Wiesmüeller L, Wiegmans AP, Bain A, Lombard FJ, Roberts TL, Khanna KK, Lavin MF, Baek K, Hamerlik P, Johns TG, Coster MJ, Boyd AW, Day BW.

Neuro Oncol. 2019 Aug 30. pii: noz159. doi: 10.1093/neuonc/noz159. [Epub ahead of print]


Efficacy of bone marrow mesenchymal stem cell transplantation in animal models of pulmonary fibrosis after exposure to bleomycin: A meta-analysis.

Zhang E, Yang Y, Zhang J, Ding G, Chen S, Peng C, Lavin MF, Yeo AJ, Du Z, Shao H.

Exp Ther Med. 2019 Mar;17(3):2247-2255. doi: 10.3892/etm.2019.7205. Epub 2019 Jan 28.


Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity.

Yeo AJ, Henningham A, Fantino E, Galbraith S, Krause L, Wainwright CE, Sly PD, Lavin MF.

Sci Rep. 2019 Feb 22;9(1):2627. doi: 10.1038/s41598-019-38901-3.


Disruption of Spermatogenesis and Infertility in Ataxia with Oculomotor Apraxia Type 2 (AOA2).

Becherel OJ, Fogel BL, Zeitlin SI, Samaratunga H, Greaney J, Homer H, Lavin MF.

Cerebellum. 2019 Jun;18(3):448-456. doi: 10.1007/s12311-019-01012-w.


Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation.

Du Z, Chen S, Cui G, Yang Y, Zhang E, Wang Q, Lavin MF, Yeo AJ, Bo C, Zhang Y, Li C, Liu X, Yang X, Peng C, Shao H.

Int J Mol Med. 2019 Mar;43(3):1229-1240. doi: 10.3892/ijmm.2018.4045. Epub 2018 Dec 31.


A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response Defect.

McKay MJ, Craig J, Kalitsis P, Kozlov S, Verschoor S, Chen P, Lobachevsky P, Vasireddy R, Yan Y, Ryan J, McGillivray G, Savarirayan R, Lavin MF, Ramsay RG, Xu H.

Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1194-1202. doi: 10.1016/j.ijrobp.2018.11.047. Epub 2018 Nov 30.


Bone marrow mesenchymal stromal cells attenuate silica-induced pulmonary fibrosis potentially by attenuating Wnt/β-catenin signaling in rats.

Zhang E, Yang Y, Chen S, Peng C, Lavin MF, Yeo AJ, Li C, Liu X, Guan Y, Du X, Du Z, Shao H.

Stem Cell Res Ther. 2018 Nov 14;9(1):311. doi: 10.1186/s13287-018-1045-4.


Next-generation rapid serum tube technology using prothrombin activator coagulant: fast, high-quality serum from normal samples.

Zhao KN, Dimeski G, de Jersey J, Johnson LA, Grant M, Masci PP, Lavin MF.

Clin Chem Lab Med. 2019 Mar 26;57(4):483-497. doi: 10.1515/cclm-2018-0397.


Relationship between occupational noise exposure and the risk factors of cardiovascular disease in China: A meta-analysis.

Yang Y, Zhang E, Zhang J, Chen S, Yu G, Liu X, Peng C, Lavin MF, Du Z, Shao H.

Medicine (Baltimore). 2018 Jul;97(30):e11720. doi: 10.1097/MD.0000000000011720. Review.


Design and Clinical Verification of Surface-Enhanced Raman Spectroscopy Diagnostic Technology for Individual Cancer Risk Prediction.

Koo KM, Wang J, Richards RS, Farrell A, Yaxley JW, Samaratunga H, Teloken PE, Roberts MJ, Coughlin GD, Lavin MF, Mainwaring PN, Wang Y, Gardiner RA, Trau M.

ACS Nano. 2018 Aug 28;12(8):8362-8371. doi: 10.1021/acsnano.8b03698. Epub 2018 Jul 26.


Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: 24-month outcomes from a randomised controlled study.

Coughlin GD, Yaxley JW, Chambers SK, Occhipinti S, Samaratunga H, Zajdlewicz L, Teloken P, Dunglison N, Williams S, Lavin MF, Gardiner RA.

Lancet Oncol. 2018 Aug;19(8):1051-1060. doi: 10.1016/S1470-2045(18)30357-7. Epub 2018 Jul 17.


Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats.

Chen S, Cui G, Peng C, Lavin MF, Sun X, Zhang E, Yang Y, Guan Y, Du Z, Shao H.

Stem Cell Res Ther. 2018 Apr 19;9(1):110. doi: 10.1186/s13287-018-0846-9.


PIKKing a way to regulate inflammation.

Quek H, Lim YC, Lavin MF, Roberts TL.

Immunol Cell Biol. 2018 Jan;96(1):8-20. doi: 10.1111/imcb.1001. Epub 2017 Nov 14. Review.


Seminal plasma enables selection and monitoring of active surveillance candidates using nuclear magnetic resonance-based metabolomics: A preliminary investigation.

Roberts MJ, Richards RS, Chow CWK, Buck M, Yaxley J, Lavin MF, Schirra HJ, Gardiner RA.

Prostate Int. 2017 Dec;5(4):149-157. doi: 10.1016/j.prnil.2017.03.005. Epub 2017 Mar 23.


Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks.

Nayler SP, Powell JE, Vanichkina DP, Korn O, Wells CA, Kanjhan R, Sun J, Taft RJ, Lavin MF, Wolvetang EJ.

Front Cell Neurosci. 2017 Oct 13;11:321. doi: 10.3389/fncel.2017.00321. eCollection 2017.


Lentiviral Reprogramming of A-T Patient Fibroblasts to Induced Pluripotent Stem Cells.

Nayler S, Kozlov SV, Lavin MF, Wolvetang E.

Methods Mol Biol. 2017;1599:401-418. doi: 10.1007/978-1-4939-6955-5_29.


A Patient-Specific Stem Cell Model to Investigate the Neurological Phenotype Observed in Ataxia-Telangiectasia.

Stewart R, Wali G, Perry C, Lavin MF, Féron F, Mackay-Sim A, Sutharsan R.

Methods Mol Biol. 2017;1599:391-400. doi: 10.1007/978-1-4939-6955-5_28.


Identification of ATM Protein Kinase Phosphorylation Sites by Mass Spectrometry.

Graham ME, Lavin MF, Kozlov SV.

Methods Mol Biol. 2017;1599:127-144. doi: 10.1007/978-1-4939-6955-5_10.


Assaying for Radioresistant DNA Synthesis, the Hallmark Feature of the Intra-S-Phase Checkpoint Using a DNA Fiber Technique.

Kijas AW, Lavin MF.

Methods Mol Biol. 2017;1599:13-23. doi: 10.1007/978-1-4939-6955-5_2.


Loss of ATM in Airway Epithelial Cells Is Associated with Susceptibility to Oxidative Stress.

Yeo AJ, Fantino E, Czovek D, Wainwright CE, Sly PD, Lavin MF.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):391-393. doi: 10.1164/rccm.201611-2210LE. No abstract available.


A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.

Quek H, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF.

Hum Mol Genet. 2017 Jan 1;26(1):109-123. doi: 10.1093/hmg/ddw371.


Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage.

Quek H, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF.

J Leukoc Biol. 2017 Apr;101(4):927-947. doi: 10.1189/jlb.4VMA0716-316R. Epub 2016 Nov 28.


Prostate-based biofluids for the detection of prostate cancer: A comparative study of the diagnostic performance of cell-sourced RNA biomarkers.

Roberts MJ, Richards RS, Chow CW, Doi SA, Schirra HJ, Buck M, Samaratunga H, Perry-Keene J, Payton D, Yaxley J, Lavin MF, Gardiner RA.

Prostate Int. 2016 Sep;4(3):97-102. doi: 10.1016/j.prnil.2016.04.002. Epub 2016 May 5.


Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: early outcomes from a randomised controlled phase 3 study.

Yaxley JW, Coughlin GD, Chambers SK, Occhipinti S, Samaratunga H, Zajdlewicz L, Dunglison N, Carter R, Williams S, Payton DJ, Perry-Keene J, Lavin MF, Gardiner RA.

Lancet. 2016 Sep 10;388(10049):1057-1066. doi: 10.1016/S0140-6736(16)30592-X. Epub 2016 Jul 26. Erratum in: Lancet. 2017 Apr 8;389(10077):e5.


Correction: AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation.

Cullen JK, Abdul Murad N, Yeo A, McKenzie M, Ward M, Chong KL, Schieber NL, Parton RG, Lim YC, Wolvetang E, Maghzal GJ, Stocker R, Lavin MF.

PLoS One. 2016 Jul 21;11(7):e0160162. doi: 10.1371/journal.pone.0160162. eCollection 2016.


Can atorvastatin with metformin change the natural history of prostate cancer as characterized by molecular, metabolomic, imaging and pathological variables? A randomized controlled trial protocol.

Roberts MJ, Yaxley JW, Coughlin GD, Gianduzzo TR, Esler RC, Dunglison NT, Chambers SK, Medcraft RJ, Chow CW, Schirra HJ, Richards RS, Kienzle N, Lu M, Brereton I, Samaratunga H, Perry-Keene J, Payton D, Oyama C, Doi SA, Lavin MF, Gardiner RA.

Contemp Clin Trials. 2016 Sep;50:16-20. doi: 10.1016/j.cct.2016.06.014. Epub 2016 Jun 28.


Integrating Molecular Profiling of Liquid Biopsy Samples with a Calculator Algorithm To Detect High-risk Prostate Cancer.

Gardiner RA, Mainwaring P, Lavin MF.

Eur Urol. 2016 Nov;70(5):749-750. doi: 10.1016/j.eururo.2016.05.012. Epub 2016 May 24. No abstract available.


AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation.

Cullen JK, Abdul Murad N, Yeo A, McKenzie M, Ward M, Chong KL, Schieber NL, Parton RG, Lim YC, Wolvetang E, Maghzal GJ, Stocker R, Lavin MF.

PLoS One. 2016 Feb 11;11(2):e0148213. doi: 10.1371/journal.pone.0148213. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0160162.


Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venom.

Du QS, Trabi M, Richards RS, Mirtschin P, Madaras F, Nouwens A, Zhao KN, de Jersey J, Lavin MF, Guddat LW, Masci PP.

Toxicon. 2016 Mar 1;111:37-49. doi: 10.1016/j.toxicon.2015.12.017. Epub 2015 Dec 30.


ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor.

Lavin MF, Kozlov S, Gatei M, Kijas AW.

Biomolecules. 2015 Oct 23;5(4):2877-902. doi: 10.3390/biom5042877. Review.


ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.

Kijas AW, Lim YC, Bolderson E, Cerosaletti K, Gatei M, Jakob B, Tobias F, Taucher-Scholz G, Gueven N, Oakley G, Concannon P, Wolvetang E, Khanna KK, Wiesmüller L, Lavin MF.

Nucleic Acids Res. 2015 Sep 30;43(17):8352-67. doi: 10.1093/nar/gkv754. Epub 2015 Aug 3.


A new model to study neurodegeneration in ataxia oculomotor apraxia type 2.

Becherel OJ, Sun J, Yeo AJ, Nayler S, Fogel BL, Gao F, Coppola G, Criscuolo C, De Michele G, Wolvetang E, Lavin MF.

Hum Mol Genet. 2015 Oct 15;24(20):5759-74. doi: 10.1093/hmg/ddv296. Epub 2015 Jul 30.


Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.

Miller MS, Rialdi A, Ho JS, Tilove M, Martinez-Gil L, Moshkina NP, Peralta Z, Noel J, Melegari C, Maestre AM, Mitsopoulos P, Madrenas J, Heinz S, Benner C, Young JA, Feagins AR, Basler CF, Fernandez-Sesma A, Becherel OJ, Lavin MF, van Bakel H, Marazzi I.

Nat Immunol. 2015 May;16(5):485-94. doi: 10.1038/ni.3132. Epub 2015 Mar 30.


Diagnostic performance of expression of PCA3, Hepsin and miR biomarkers inejaculate in combination with serum PSA for the detection of prostate cancer.

Roberts MJ, Chow CW, Schirra HJ, Richards R, Buck M, Selth LA, Doi SA, Samaratunga H, Perry-Keene J, Payton D, Yaxley J, Lavin MF, Gardiner RA.

Prostate. 2015 Apr 1;75(5):539-49. doi: 10.1002/pros.22942. Epub 2015 Jan 18.


Senataxin controls meiotic silencing through ATR activation and chromatin remodeling.

Yeo AJ, Becherel OJ, Luff JE, Graham ME, Richard D, Lavin MF.

Cell Discov. 2015 Sep 29;1:15025. doi: 10.1038/celldisc.2015.25. eCollection 2015.


β-Adducin siRNA disruption of the spectrin-based cytoskeleton in differentiating keratinocytes prevented by calcium acting through calmodulin/epidermal growth factor receptor/cadherin pathway.

Wu J, Masci PP, Chen C, Chen J, Lavin MF, Zhao KN.

Cell Signal. 2015 Jan;27(1):15-25. doi: 10.1016/j.cellsig.2014.10.001. Epub 2014 Oct 7.


Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells.

Lim YC, Roberts TL, Day BW, Stringer BW, Kozlov S, Fazry S, Bruce ZC, Ensbey KS, Walker DG, Boyd AW, Lavin MF.

Mol Oncol. 2014 Dec;8(8):1603-15. doi: 10.1016/j.molonc.2014.06.012. Epub 2014 Jun 27.


Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers.

Selth LA, Roberts MJ, Chow CW, Marshall VR, Doi SA, Vincent AD, Butler LM, Lavin MF, Tilley WD, Gardiner RA.

Endocr Relat Cancer. 2014 Aug;21(4):L17-21. doi: 10.1530/ERC-14-0234. Epub 2014 May 23. No abstract available.


Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2.

Fogel BL, Cho E, Wahnich A, Gao F, Becherel OJ, Wang X, Fike F, Chen L, Criscuolo C, De Michele G, Filla A, Collins A, Hahn AF, Gatti RA, Konopka G, Perlman S, Lavin MF, Geschwind DH, Coppola G.

Hum Mol Genet. 2014 Sep 15;23(18):4758-69. doi: 10.1093/hmg/ddu190. Epub 2014 Apr 23.


RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.

Gatei M, Kijas AW, Biard D, Dörk T, Lavin MF.

Hum Mol Genet. 2014 Aug 15;23(16):4232-48. doi: 10.1093/hmg/ddu141. Epub 2014 Apr 2.


R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias.

Yeo AJ, Becherel OJ, Luff JE, Cullen JK, Wongsurawat T, Jenjaroenpun P, Kuznetsov VA, McKinnon PJ, Lavin MF.

PLoS One. 2014 Mar 17;9(3):e90219. doi: 10.1371/journal.pone.0090219. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e105258. Jenjaroenpoon, Piroon [corrected to Jenjaroenpun, Piroon].


Protective role of RAD50 on chromatin bridges during abnormal cytokinesis.

Schröder-Heurich B, Wieland B, Lavin MF, Schindler D, Dörk T.

FASEB J. 2014 Mar;28(3):1331-41. doi: 10.1096/fj.13-236984. Epub 2013 Dec 16.


Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.

Puccini J, Shalini S, Voss AK, Gatei M, Wilson CH, Hiwase DK, Lavin MF, Dorstyn L, Kumar S.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19920-5. doi: 10.1073/pnas.1311947110. Epub 2013 Nov 18.


A progress report on a prospective randomised trial of open and robotic prostatectomy.

Gardiner RA, Coughlin GD, Yaxley JW, Dunglison NT, Occhipinti S, Younie SJ, Carter RC, Williams SG, Medcraft RJ, Samaratunga HM, Perry-Keene JL, Payton DJ, Lavin MF, Chambers SK.

Eur Urol. 2014 Mar;65(3):512-5. doi: 10.1016/j.eururo.2013.10.031. Epub 2013 Oct 31.


BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells.

Harris JL, Richards RS, Chow CW, Lee S, Kim M, Buck M, Teng L, Clarke R, Gardiner RA, Lavin MF.

PLoS One. 2013 Sep 6;8(9):e73880. doi: 10.1371/journal.pone.0073880. eCollection 2013.

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