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Items: 1 to 50 of 76

1.

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.

La Regina G, Bai R, Coluccia A, Naccarato V, Famiglini V, Nalli M, Masci D, Verrico A, Rovella P, Mazzoccoli C, Da Pozzo E, Cavallini C, Martini C, Vultaggio S, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.

Eur J Med Chem. 2018 May 25;152:283-297. doi: 10.1016/j.ejmech.2018.04.042. Epub 2018 Apr 25.

PMID:
29730191
2.

Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays.

Di Francesco L, Verrico A, Asteriti IA, Rovella P, Cirigliano P, Guarguaglini G, Schininà ME, Lavia P.

Sci Rep. 2018 Jan 30;8(1):1850. doi: 10.1038/s41598-018-19351-9.

3.

The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme.

Abbruzzese C, Catalogna G, Gallo E, di Martino S, Mileo AM, Carosi M, Dattilo V, Schenone S, Musumeci F, Lavia P, Perrotti N, Amato R, Paggi MG.

Oncotarget. 2017 Nov 18;8(67):110743-110755. doi: 10.18632/oncotarget.22500. eCollection 2017 Dec 19.

4.

Subcellular localization of the five members of the human steroid 5α-reductase family.

Scaglione A, Montemiglio LC, Parisi G, Asteriti IA, Bruni R, Cerutti G, Testi C, Savino C, Mancia F, Lavia P, Vallone B.

Biochim Open. 2017 Jun;4:99-106. doi: 10.1016/j.biopen.2017.03.003. Epub 2017 Mar 21.

5.

Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.

Gilistro E, de Turris V, Damizia M, Verrico A, Moroni S, De Santis R, Rosa A, Lavia P.

J Cell Sci. 2017 Aug 1;130(15):2564-2578. doi: 10.1242/jcs.197905. Epub 2017 Jun 9.

6.

PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma.

Colicchia V, Petroni M, Guarguaglini G, Sardina F, Sahún-Roncero M, Carbonari M, Ricci B, Heil C, Capalbo C, Belardinilli F, Coppa A, Peruzzi G, Screpanti I, Lavia P, Gulino A, Giannini G.

Oncogene. 2017 Aug 17;36(33):4682-4691. doi: 10.1038/onc.2017.40. Epub 2017 Apr 10.

PMID:
28394338
7.

Identification of small molecule inhibitors of the Aurora-A/TPX2 complex.

Asteriti IA, Daidone F, Colotti G, Rinaldo S, Lavia P, Guarguaglini G, Paiardini A.

Oncotarget. 2017 May 9;8(19):32117-32133. doi: 10.18632/oncotarget.16738.

8.

p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells.

Soriani A, Borrelli C, Ricci B, Molfetta R, Zingoni A, Fionda C, Carnevale S, Abruzzese MP, Petrucci MT, Ricciardi MR, La Regina G, Di Cesare E, Lavia P, Silvestri R, Paolini R, Cippitelli M, Santoni A.

Oncoimmunology. 2016 Dec 2;6(1):e1264564. doi: 10.1080/2162402X.2016.1264564. eCollection 2017.

9.

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.

Di Cesare E, Verrico A, Miele A, Giubettini M, Rovella P, Coluccia A, Famiglini V, La Regina G, Cundari E, Silvestri R, Lavia P.

Oncotarget. 2017 Mar 21;8(12):19738-19759. doi: 10.18632/oncotarget.14980.

10.

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential.

Stelma T, Chi A, van der Watt PJ, Verrico A, Lavia P, Leaner VD.

IUBMB Life. 2016 Apr;68(4):268-80. doi: 10.1002/iub.1484. Epub 2016 Mar 11. Review.

11.

The GTPase RAN regulates multiple steps of the centrosome life cycle.

Lavia P.

Chromosome Res. 2016 Jan;24(1):53-65. doi: 10.1007/s10577-015-9514-4.

PMID:
26725228
12.

Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.

Talarico C, D'Antona L, Scumaci D, Barone A, Gigliotti F, Fiumara CV, Dattilo V, Gallo E, Visca P, Ortuso F, Abbruzzese C, Botta L, Schenone S, Cuda G, Alcaro S, Bianco C, Lavia P, Paggi MG, Perrotti N, Amato R.

Oncotarget. 2015 Nov 10;6(35):37511-25. doi: 10.18632/oncotarget.5527.

13.

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Ricci B, Soriani A, Santoni A, Caraglia M, Porto S, Da Pozzo E, Martini C, Brancale A, Marinelli L, Novellino E, Vultaggio S, Varasi M, Mercurio C, Bigogno C, Dondio G, Hamel E, Lavia P, Silvestri R.

J Med Chem. 2015 Aug 13;58(15):5789-807. doi: 10.1021/acs.jmedchem.5b00310. Epub 2015 Jul 20.

14.

The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy.

Asteriti IA, Di Cesare E, De Mattia F, Hilsenstein V, Neumann B, Cundari E, Lavia P, Guarguaglini G.

Oncotarget. 2014 Aug 15;5(15):6229-42.

15.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Sisinni L, Bolognesi A, Rensen WM, Miele A, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Brancale A, Novellino E, Dondio G, Vultaggio S, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.

J Med Chem. 2014 Aug 14;57(15):6531-52. doi: 10.1021/jm500561a. Epub 2014 Jul 29.

16.

Immunofluorescence methods in studies of the GTPase RAN and its effectors in interphase and in mitotic cells.

Guarguaglini G, de Turris V, Lavia P.

Methods Mol Biol. 2014;1120:241-52. doi: 10.1007/978-1-62703-791-4_16.

PMID:
24470030
17.

Research: Boycott challenges research tactics.

Amato U, Lavia P, Mocella V.

Nature. 2013 Sep 19;501(7467):316. doi: 10.1038/501316d. No abstract available.

PMID:
24048059
18.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

La Regina G, Bai R, Rensen WM, Di Cesare E, Coluccia A, Piscitelli F, Famiglini V, Reggio A, Nalli M, Pelliccia S, Da Pozzo E, Costa B, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Santoni A, Li J, Miranda Cona M, Chen F, Ni Y, Brancale A, Dondio G, Vultaggio S, Varasi M, Mercurio C, Martini C, Hamel E, Lavia P, Novellino E, Silvestri R.

J Med Chem. 2013 Jan 10;56(1):123-49. doi: 10.1021/jm3013097. Epub 2012 Dec 27.

19.

Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.

Amato R, Scumaci D, D'Antona L, Iuliano R, Menniti M, Di Sanzo M, Faniello MC, Colao E, Malatesta P, Zingone A, Agosti V, Costanzo FS, Mileo AM, Paggi MG, Lang F, Cuda G, Lavia P, Perrotti N.

Oncogene. 2013 Sep 19;32(38):4572-8. doi: 10.1038/onc.2012.470. Epub 2012 Oct 29.

PMID:
23108393
20.

Segmental chromosome aberrations converge on overexpression of mitotic spindle regulatory genes in high-risk neuroblastoma.

Ooi WF, Re A, Sidarovich V, Canella V, Arseni N, Adami V, Guarguaglini G, Giubettini M, Scaruffi P, Stigliani S, Lavia P, Tonini GP, Quattrone A.

Genes Chromosomes Cancer. 2012 Jun;51(6):545-56. doi: 10.1002/gcc.21940. Epub 2012 Feb 15.

PMID:
22337647
21.

Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores.

Roscioli E, Di Francesco L, Bolognesi A, Giubettini M, Orlando S, Harel A, Schininà ME, Lavia P.

J Cell Biol. 2012 Feb 20;196(4):435-50. doi: 10.1083/jcb.201109104. Epub 2012 Feb 13.

22.

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

La Regina G, Bai R, Rensen W, Coluccia A, Piscitelli F, Gatti V, Bolognesi A, Lavecchia A, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Mariani M, Santoni A, Brancale A, Ferlini C, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Novellino E, Silvestri R.

J Med Chem. 2011 Dec 22;54(24):8394-406. doi: 10.1021/jm2012886. Epub 2011 Nov 21.

23.

Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces.

Asteriti IA, Giubettini M, Lavia P, Guarguaglini G.

Mol Cancer. 2011 Oct 19;10:131. doi: 10.1186/1476-4598-10-131.

24.

Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors.

Sbardella G, Mai A, Bartolini S, Castellano S, Cirilli R, Rotili D, Milite C, Santoriello M, Orlando S, Sciamanna I, Serafino A, Lavia P, Spadafora C.

J Med Chem. 2011 Aug 25;54(16):5927-36. doi: 10.1021/jm200734j. Epub 2011 Jul 22.

PMID:
21755950
25.

Control of Aurora-A stability through interaction with TPX2.

Giubettini M, Asteriti IA, Scrofani J, De Luca M, Lindon C, Lavia P, Guarguaglini G.

J Cell Sci. 2011 Jan 1;124(Pt 1):113-22. doi: 10.1242/jcs.075457. Epub 2010 Dec 8.

26.

Ran control of mitosis in human cells: gradients and local signals.

Roscioli E, Bolognesi A, Guarguaglini G, Lavia P.

Biochem Soc Trans. 2010 Dec;38(6):1709-14. doi: 10.1042/BST0381709.

PMID:
21118152
27.

The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?

Asteriti IA, Rensen WM, Lindon C, Lavia P, Guarguaglini G.

Biochim Biophys Acta. 2010 Dec;1806(2):230-9. doi: 10.1016/j.bbcan.2010.08.001. Epub 2010 Aug 12. Review.

PMID:
20708655
28.

Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells.

Ciciarello M, Roscioli E, Di Fiore B, Di Francesco L, Sobrero F, Bernard D, Mangiacasale R, Harel A, Schininà ME, Lavia P.

Chromosoma. 2010 Dec;119(6):651-68. doi: 10.1007/s00412-010-0286-5. Epub 2010 Jul 24.

PMID:
20658144
29.

RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner.

Rensen WM, Roscioli E, Tedeschi A, Mangiacasale R, Ciciarello M, Di Gioia SA, Lavia P.

Oncogene. 2009 Apr 16;28(15):1748-58. doi: 10.1038/onc.2009.24. Epub 2009 Mar 9.

PMID:
19270727
30.

Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity.

De Luca M, Brunetto L, Asteriti IA, Giubettini M, Lavia P, Guarguaglini G.

Oncogene. 2008 Nov 20;27(51):6539-49. doi: 10.1038/onc.2008.252. Epub 2008 Jul 28.

PMID:
18663358
31.

The GTPase Ran: regulation of cell life and potential roles in cell transformation.

Rensen WM, Mangiacasale R, Ciciarello M, Lavia P.

Front Biosci. 2008 May 1;13:4097-121. Review.

PMID:
18508502
32.

Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cells.

Torosantucci L, De Luca M, Guarguaglini G, Lavia P, Degrassi F.

Mol Biol Cell. 2008 May;19(5):1873-82. doi: 10.1091/mbc.E07-10-1050. Epub 2008 Feb 20.

33.

RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.

Tedeschi A, Ciciarello M, Mangiacasale R, Roscioli E, Rensen WM, Lavia P.

J Cell Sci. 2007 Nov 1;120(Pt 21):3748-61. Epub 2007 Oct 16.

34.

Spatial control of mitosis by the GTPase Ran.

Ciciarello M, Mangiacasale R, Lavia P.

Cell Mol Life Sci. 2007 Aug;64(15):1891-914. Review.

PMID:
17483873
35.
36.

A role for endogenous reverse transcriptase in tumorigenesis and as a target in differentiating cancer therapy.

Sinibaldi-Vallebona P, Lavia P, Garaci E, Spadafora C.

Genes Chromosomes Cancer. 2006 Jan;45(1):1-10. Review.

PMID:
16175572
37.

New CRIME plots. Ran and transport factors regulate mitosis.

Ciciarello M, Lavia P.

EMBO Rep. 2005 Aug;6(8):714-6. Review. No abstract available.

38.

A role of p73 in mitotic exit.

Merlo P, Fulco M, Costanzo A, Mangiacasale R, Strano S, Blandino G, Taya Y, Lavia P, Levrero M.

J Biol Chem. 2005 Aug 26;280(34):30354-60. Epub 2005 Jun 28.

39.

Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells.

Ciciarello M, Mangiacasale R, Thibier C, Guarguaglini G, Marchetti E, Di Fiore B, Lavia P.

J Cell Sci. 2004 Dec 15;117(Pt 26):6511-22. Epub 2004 Nov 30.

40.

p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation.

Tritarelli A, Oricchio E, Ciciarello M, Mangiacasale R, Palena A, Lavia P, Soddu S, Cundari E.

Mol Biol Cell. 2004 Aug;15(8):3751-7. Epub 2004 Jun 4.

41.

Mitotic functions of the Ran GTPase network: the importance of being in the right place at the right time.

Di Fiore B, Ciciarello M, Lavia P.

Cell Cycle. 2004 Mar;3(3):305-13. Epub 2004 Mar 1. Review.

PMID:
14726649
42.

Emerging roles of DNA tumor viruses in cell proliferation: new insights into genomic instability.

Lavia P, Mileo AM, Giordano A, Paggi MG.

Oncogene. 2003 Sep 29;22(42):6508-16. Review.

PMID:
14528275
43.

Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.

Keryer G, Di Fiore B, Celati C, Lechtreck KF, Mogensen M, Delouvee A, Lavia P, Bornens M, Tassin AM.

Mol Biol Cell. 2003 Oct;14(10):4260-71. Epub 2003 Jul 11.

44.

p73 is regulated by phosphorylation at the G2/M transition.

Fulco M, Costanzo A, Merlo P, Mangiacasale R, Strano S, Blandino G, Balsano C, Lavia P, Levrero M.

J Biol Chem. 2003 Dec 5;278(49):49196-202. Epub 2003 Aug 13.

45.

Mammalian RanBP1 regulates centrosome cohesion during mitosis.

Di Fiore B, Ciciarello M, Mangiacasale R, Palena A, Tassin AM, Cundari E, Lavia P.

J Cell Sci. 2003 Aug 15;116(Pt 16):3399-411. Epub 2003 Jul 2. Erratum in: J Cell Sci. 2003 Sep 1;116(Pt 17):3659.

46.

Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation.

Mangiacasale R, Pittoggi C, Sciamanna I, Careddu A, Mattei E, Lorenzini R, Travaglini L, Landriscina M, Barone C, Nervi C, Lavia P, Spadafora C.

Oncogene. 2003 May 8;22(18):2750-61.

PMID:
12747369
47.

E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner.

De Luca A, Mangiacasale R, Severino A, Malquori L, Baldi A, Palena A, Mileo AM, Lavia P, Paggi MG.

Cancer Res. 2003 Mar 15;63(6):1430-7.

48.

p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle.

Ciciarello M, Mangiacasale R, Casenghi M, Zaira Limongi M, D'Angelo M, Soddu S, Lavia P, Cundari E.

J Biol Chem. 2001 Jun 1;276(22):19205-13. Epub 2001 Feb 28.

49.

Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields.

Mangiacasale R, Tritarelli A, Sciamanna I, Cannone M, Lavia P, Barberis MC, Lorenzini R, Cundari E.

FEBS Lett. 2001 Jan 5;487(3):397-403.

50.

E2F transcription factors are differentially expressed in murine gametes and early embryos.

Palena A, Mangiacasale R, Magnano AR, Barberi L, Giordano R, Spadafora C, Lavia P.

Mech Dev. 2000 Oct;97(1-2):211-5.

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