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Items: 1 to 50 of 157

1.

Detection and isolation of H5N1 influenza virus from large volumes of natural water.

Khalenkov A, Laver WG, Webster RG.

J Virol Methods. 2008 Apr;149(1):180-3. doi: 10.1016/j.jviromet.2008.01.001. Epub 2008 Mar 5.

2.

Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.

Maring CJ, Stoll VS, Zhao C, Sun M, Krueger AC, Stewart KD, Madigan DL, Kati WM, Xu Y, Carrick RJ, Montgomery DA, Kempf-Grote A, Marsh KC, Molla A, Steffy KR, Sham HL, Laver WG, Gu YG, Kempf DJ, Kohlbrenner WE.

J Med Chem. 2005 Jun 16;48(12):3980-90.

PMID:
15943472
3.

From the Great Barrier Reef to a "cure" for the flu: tall tales, but true.

Laver WG.

Perspect Biol Med. 2004 Autumn;47(4):590-6.

PMID:
15467180
4.

Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm.

Hanessian S, Wang J, Montgomery D, Stoll V, Stewart KD, Kati W, Maring C, Kempf D, Hutchins C, Laver WG.

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3425-9. Erratum in: Bioorg Med Chem Lett. 2003 May 19;13(10):1837.

PMID:
12419376
5.

Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).

Gulati U, Hwang CC, Venkatramani L, Gulati S, Stray SJ, Lee JT, Laver WG, Bochkarev A, Zlotnick A, Air GM.

J Virol. 2002 Dec;76(23):12274-80.

6.

Novel alpha- and beta-amino acid inhibitors of influenza virus neuraminidase.

Kati WM, Montgomery D, Maring C, Stoll VS, Giranda V, Chen X, Laver WG, Kohlbrenner W, Norbeck DW.

Antimicrob Agents Chemother. 2001 Sep;45(9):2563-70.

7.

Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

Wang GT, Chen Y, Wang S, Gentles R, Sowin T, Kati W, Muchmore S, Giranda V, Stewart K, Sham H, Kempf D, Laver WG.

J Med Chem. 2001 Apr 12;44(8):1192-201.

PMID:
11312919
8.

The origin and control of pandemic influenza.

Laver WG, Bischofberger N, Webster RG.

Perspect Biol Med. 2000 Winter;43(2):173-92. No abstract available.

PMID:
10804584
9.

Influenza--a new problem?

Laver WG, Kelly GD.

Med J Aust. 1999 Nov 1;171(9):504. No abstract available.

PMID:
10615357
10.

Approaches and strategies for the treatment of influenza virus infections.

Colacino JM, Staschke KA, Laver WG.

Antivir Chem Chemother. 1999 Jul;10(4):155-85. Review.

PMID:
10480736
11.

Drug development in space?

Laver WG.

Science. 1999 Jun 25;284(5423):2089. No abstract available.

PMID:
10409063
12.

Chu chi ming (1917-1998)

Laver WG, Webster RG.

Virology. 1999 Mar 1;255(1):F12-1. No abstract available.

PMID:
10049835
13.

Disarming flu viruses.

Laver WG, Bischofberger N, Webster RG.

Sci Am. 1999 Jan;280(1):78-87. No abstract available.

PMID:
9891421
14.

A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.

Lew W, Wu H, Mendel DB, Escarpe PA, Chen X, Laver WG, Graves BJ, Kim CU.

Bioorg Med Chem Lett. 1998 Dec 1;8(23):3321-4.

PMID:
9873727
15.

Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors.

Kim CU, Lew W, Williams MA, Wu H, Zhang L, Chen X, Escarpe PA, Mendel DB, Laver WG, Stevens RC.

J Med Chem. 1998 Jul 2;41(14):2451-60.

PMID:
9651151
16.

GS4071 is a slow-binding inhibitor of influenza neuraminidase from both A and B strains.

Kati WM, Saldivar AS, Mohamadi F, Sham HL, Laver WG, Kohlbrenner WE.

Biochem Biophys Res Commun. 1998 Mar 17;244(2):408-13.

PMID:
9514938
17.

Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design.

Chand P, Babu YS, Bantia S, Chu N, Cole LB, Kotian PL, Laver WG, Montgomery JA, Pathak VP, Petty SL, Shrout DP, Walsh DA, Walsh GM.

J Med Chem. 1997 Dec 5;40(25):4030-52.

PMID:
9406595
18.

A single sequence change destabilizes the influenza virus neuraminidase tetramer.

Colacino JM, Chirgadze NY, Garman E, Murti KG, Loncharich RJ, Baxter AJ, Staschke KA, Laver WG.

Virology. 1997 Sep 15;236(1):66-75.

19.

Selection of influenza A and B viruses for resistance to 4-guanidino-Neu5Ac2en in cell culture.

Colacino JM, Laver WG, Air GM.

J Infect Dis. 1997 Aug;176 Suppl 1:S66-8.

PMID:
9240698
20.

Guanidinobenzoic acid inhibitors of influenza virus neuraminidase.

Sudbeck EA, Jedrzejas MJ, Singh S, Brouillette WJ, Air GM, Laver WG, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Luo M.

J Mol Biol. 1997 Apr 4;267(3):584-94.

PMID:
9126840
21.

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity.

Kim CU, Lew W, Williams MA, Liu H, Zhang L, Swaminathan S, Bischofberger N, Chen MS, Mendel DB, Tai CY, Laver WG, Stevens RC.

J Am Chem Soc. 1997 Jan 29;119(4):681-90.

PMID:
16526129
22.

The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.

Crennell SJ, Garman EF, Philippon C, Vasella A, Laver WG, Vimr ER, Taylor GL.

J Mol Biol. 1996 Jun 7;259(2):264-80.

PMID:
8656428
23.

Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en.

Staschke KA, Colacino JM, Baxter AJ, Air GM, Bansal A, Hornback WJ, Munroe JE, Laver WG.

Virology. 1995 Dec 20;214(2):642-6.

24.

Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction.

Singh S, Jedrzejas MJ, Air GM, Luo M, Laver WG, Brouillette WJ.

J Med Chem. 1995 Aug 18;38(17):3217-25.

PMID:
7650674
25.
26.

Benzoic acid inhibitors of influenza virus neuraminidase.

Luo M, Jedrzejas MJ, Singh S, White CL, Brouillette WJ, Air GM, Laver WG.

Acta Crystallogr D Biol Crystallogr. 1995 Jul 1;51(Pt 4):504-10.

PMID:
15299837
27.

Structures of aromatic inhibitors of influenza virus neuraminidase.

Jedrzejas MJ, Singh S, Brouillette WJ, Laver WG, Air GM, Luo M.

Biochemistry. 1995 Mar 14;34(10):3144-51.

PMID:
7880809
28.

A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies.

White CL, Janakiraman MN, Laver WG, Philippon C, Vasella A, Air GM, Luo M.

J Mol Biol. 1995 Feb 3;245(5):623-34.

PMID:
7844831
29.

The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody.

Malby RL, Tulip WR, Harley VR, McKimm-Breschkin JL, Laver WG, Webster RG, Colman PM.

Structure. 1994 Aug 15;2(8):733-46.

PMID:
7994573
30.
31.
32.

Crystal structure of a bacterial sialidase (from Salmonella typhimurium LT2) shows the same fold as an influenza virus neuraminidase.

Crennell SJ, Garman EF, Laver WG, Vimr ER, Taylor GL.

Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):9852-6.

33.

Three-dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid.

Bossart-Whitaker P, Carson M, Babu YS, Smith CD, Laver WG, Air GM.

J Mol Biol. 1993 Aug 20;232(4):1069-83.

PMID:
8371267
34.

Crystals of hemagglutinin-neuraminidase of parainfluenza virus contain triple-stranded helices.

Murti KG, Takimoto T, Laver WG, Portner A.

Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1523-5.

36.

Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.

Tulip WR, Varghese JN, Webster RG, Laver WG, Colman PM.

J Mol Biol. 1992 Sep 5;227(1):149-59.

PMID:
1522584
37.

Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.

Tulip WR, Varghese JN, Laver WG, Webster RG, Colman PM.

J Mol Biol. 1992 Sep 5;227(1):122-48.

PMID:
1381757
38.

Unusual diffraction of type B influenza virus neuraminidase crystals.

Luo M, Laver WG, Air G.

Acta Crystallogr A. 1992 May 1;48 ( Pt 3):263-6.

PMID:
1605932
39.

Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.

Tulip WR, Varghese JN, Baker AT, van Donkelaar A, Laver WG, Webster RG, Colman PM.

J Mol Biol. 1991 Sep 20;221(2):487-97.

PMID:
1920429
40.
41.
42.

New crystalline forms of neuraminidase of type B human influenza virus.

Lin YJ, Luo M, Laver WG, Air GM, Smith CD, Webster RG.

J Mol Biol. 1990 Aug 5;214(3):639-40.

PMID:
2388263
43.

Antigenic, sequence, and crystal variation in influenza B neuraminidase.

Air GM, Laver WG, Luo M, Stray SJ, Legrone G, Webster RG.

Virology. 1990 Aug;177(2):578-87.

PMID:
1695410
44.

Epitopes on protein antigens: misconceptions and realities.

Laver WG, Air GM, Webster RG, Smith-Gill SJ.

Cell. 1990 May 18;61(4):553-6. Review. No abstract available. Erratum in: Cell 1990 Aug 10;62(3):following 608.

PMID:
1693095
45.

Evolutionary changes in influenza B are not primarily governed by antibody selection.

Air GM, Gibbs AJ, Laver WG, Webster RG.

Proc Natl Acad Sci U S A. 1990 May;87(10):3884-8. Erratum in: Proc Natl Acad Sci U S A 1990 Aug;87(15):6007.

46.

Crystallization of Sendai virus HN protein complexed with monoclonal antibody Fab fragments.

Laver WG, Thompson SD, Murti KG, Portner A.

Virology. 1989 Jul;171(1):291-3.

PMID:
2545033
47.

Three-dimensional structures of influenza virus neuraminidase-antibody complexes.

Colman PM, Tulip WR, Varghese JN, Tulloch PA, Baker AT, Laver WG, Air GM, Webster RG.

Philos Trans R Soc Lond B Biol Sci. 1989 Jun 12;323(1217):511-8.

PMID:
2569208
49.

Crystal structures of neuraminidase-antibody complexes.

Tulip WR, Varghese JN, Webster RG, Air GM, Laver WG, Colman PM.

Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:257-63. No abstract available.

PMID:
2484162
50.

Antibody recognition of the influenza virus neuraminidase.

Air GM, Laver WG, Webster RG, Els MC, Luo M.

Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:247-55. Review. No abstract available.

PMID:
2484161

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