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Items: 1 to 50 of 87

1.

Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia.

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE.

Circ Arrhythm Electrophysiol. 2019 Apr;12(4):e007045. doi: 10.1161/CIRCEP.118.007045.

PMID:
30943765
2.

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814.

Walweel K, Gomez-Hurtado N, Rebbeck RT, Oo YW, Beard NA, Molenaar P, Dos Remedios C, van Helden DF, Cornea RL, Knollmann BC, Laver DR.

J Mol Cell Cardiol. 2019 May;130:96-106. doi: 10.1016/j.yjmcc.2019.03.018. Epub 2019 Mar 27.

PMID:
30928430
3.

Regulation of the RyR channel gating by Ca2+ and Mg2.

Laver DR.

Biophys Rev. 2018 Aug;10(4):1087-1095. doi: 10.1007/s12551-018-0433-4. Epub 2018 Jun 20. Review.

4.

Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells.

Korol SV, Jin Z, Jin Y, Bhandage AK, Tengholm A, Gandasi NR, Barg S, Espes D, Carlsson PO, Laver D, Birnir B.

EBioMedicine. 2018 Apr;30:273-282. doi: 10.1016/j.ebiom.2018.03.014. Epub 2018 Mar 22.

5.

Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels.

Walweel K, Gomez-Hurtado N, Oo YW, Beard NA, Dos Remedios C, Johnson CN, Chazin WJ, van Helden DF, Knollmann BC, Laver DR.

J Am Coll Cardiol. 2017 Jul 4;70(1):115-117. doi: 10.1016/j.jacc.2017.04.055. No abstract available.

6.

Nerve-induced responses of mouse vaginal smooth muscle.

van Helden DF, Kamiya A, Kelsey S, Laver DR, Jobling P, Mitsui R, Hashitani H.

Pflugers Arch. 2017 Oct;469(10):1373-1385. doi: 10.1007/s00424-017-1995-x. Epub 2017 May 27.

PMID:
28551705
7.

Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts.

Walweel K, Molenaar P, Imtiaz MS, Denniss A, Dos Remedios C, van Helden DF, Dulhunty AF, Laver DR, Beard NA.

J Mol Cell Cardiol. 2017 Mar;104:53-62. doi: 10.1016/j.yjmcc.2017.01.016. Epub 2017 Jan 26.

PMID:
28131631
8.

Cardiac Calcium Release Channel (Ryanodine Receptor 2) Regulation by Halogenated Anesthetics.

Laver DR, Attia J, Oldmeadow C, Quail AW.

Anesthesiology. 2017 Mar;126(3):495-506. doi: 10.1097/ALN.0000000000001519.

PMID:
28079567
9.

The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.

Walweel K, Oo YW, Laver DR.

Clin Exp Pharmacol Physiol. 2017 Jan;44(1):135-142. doi: 10.1111/1440-1681.12669. Review.

PMID:
27626620
10.

Balancing SR Ca(2+) uptake and release in the cycle of heart rhythm.

Laver DR.

J Physiol. 2016 Jun 1;594(11):2779-80. doi: 10.1113/JP272063. No abstract available.

11.

Essential Role of Calmodulin in RyR Inhibition by Dantrolene.

Oo YW, Gomez-Hurtado N, Walweel K, van Helden DF, Imtiaz MS, Knollmann BC, Laver DR.

Mol Pharmacol. 2015 Jul;88(1):57-63. doi: 10.1124/mol.115.097691. Epub 2015 Apr 28.

12.

Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons.

Nikolaev YA, Dosen PJ, Laver DR, van Helden DF, Hamill OP.

Brain Res. 2015 May 22;1608:1-13. doi: 10.1016/j.brainres.2015.02.051. Epub 2015 Mar 9.

PMID:
25765154
13.

Mechanisms of SR calcium release in healthy and failing human hearts.

Walweel K, Laver DR.

Biophys Rev. 2015 Mar;7(1):33-41. doi: 10.1007/s12551-014-0152-4. Epub 2014 Dec 16.

14.

Polarized and persistent Ca²⁺ plumes define loci for formation of wall ingrowth papillae in transfer cells.

Zhang HM, Imtiaz MS, Laver DR, McCurdy DW, Offler CE, van Helden DF, Patrick JW.

J Exp Bot. 2015 Mar;66(5):1179-90. doi: 10.1093/jxb/eru460. Epub 2014 Dec 10.

15.

Multiple modes of ryanodine receptor 2 inhibition by flecainide.

Mehra D, Imtiaz MS, van Helden DF, Knollmann BC, Laver DR.

Mol Pharmacol. 2014 Dec;86(6):696-706. doi: 10.1124/mol.114.094623. Epub 2014 Oct 1.

16.

Differences in the regulation of RyR2 from human, sheep, and rat by Ca²⁺ and Mg²⁺ in the cytoplasm and in the lumen of the sarcoplasmic reticulum.

Walweel K, Li J, Molenaar P, Imtiaz MS, Quail A, dos Remedios CG, Beard NA, Dulhunty AF, van Helden DF, Laver DR.

J Gen Physiol. 2014 Sep;144(3):263-71. doi: 10.1085/jgp.201311157.

17.

Pharmacological approaches that slow lymphatic flow as a snakebite first aid.

van Helden DF, Thomas PA, Dosen PJ, Imtiaz MS, Laver DR, Isbister GK.

PLoS Negl Trop Dis. 2014 Feb 27;8(2):e2722. doi: 10.1371/journal.pntd.0002722. eCollection 2014 Feb.

18.

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.

Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL Jr, Cornea RL, Bers DM, Knollmann BC.

Circ Res. 2014 Mar 28;114(7):1114-24. doi: 10.1161/CIRCRESAHA.114.303391. Epub 2014 Feb 21.

19.
20.

ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.

Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne R, vanHelden DF, Laver DR.

PLoS One. 2013;8(3):e58334. doi: 10.1371/journal.pone.0058334. Epub 2013 Mar 22.

21.

Extraction of sub-microscopic Ca fluxes from blurred and noisy fluorescent indicator images with a detailed model fitting approach.

Kong CH, Laver DR, Cannell MB.

PLoS Comput Biol. 2013;9(2):e1002931. doi: 10.1371/journal.pcbi.1002931. Epub 2013 Feb 28.

22.

Termination of calcium-induced calcium release by induction decay: an emergent property of stochastic channel gating and molecular scale architecture.

Laver DR, Kong CH, Imtiaz MS, Cannell MB.

J Mol Cell Cardiol. 2013 Jan;54:98-100. doi: 10.1016/j.yjmcc.2012.10.009. Epub 2012 Nov 1.

PMID:
23123322
23.

Selective modulation of different GABAA receptor isoforms by diazepam and etomidate in hippocampal neurons.

Seymour VA, Curmi JP, Howitt SM, Casarotto MG, Laver DR, Tierney ML.

Int J Biochem Cell Biol. 2012 Sep;44(9):1491-500. doi: 10.1016/j.biocel.2012.06.001. Epub 2012 Jun 13.

PMID:
22704937
24.

Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels.

Laver DR, van Helden DF.

J Mol Cell Cardiol. 2011 Sep;51(3):357-69. doi: 10.1016/j.yjmcc.2011.05.009. Epub 2011 May 19.

PMID:
21624373
25.

Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.

Hwang HS, Hasdemir C, Laver D, Mehra D, Turhan K, Faggioni M, Yin H, Knollmann BC.

Circ Arrhythm Electrophysiol. 2011 Apr;4(2):128-35. doi: 10.1161/CIRCEP.110.959916. Epub 2011 Jan 26.

26.

SR Ca2+ store refill--a key factor in cardiac pacemaking.

Imtiaz MS, von der Weid PY, Laver DR, van Helden DF.

J Mol Cell Cardiol. 2010 Sep;49(3):412-26. doi: 10.1016/j.yjmcc.2010.03.015. Epub 2010 Mar 29.

PMID:
20353793
27.

Regulation of RyR Channel Gating by Ca(2+), Mg(2+) and ATP.

Laver DR.

Curr Top Membr. 2010;66:69-89. doi: 10.1016/S1063-5823(10)66004-8. Epub 2010 Jul 25. No abstract available.

PMID:
22353477
28.

Generation and propagation of gastric slow waves.

van Helden DF, Laver DR, Holdsworth J, Imtiaz MS.

Clin Exp Pharmacol Physiol. 2010 Apr;37(4):516-24. doi: 10.1111/j.1440-1681.2009.05331.x. Epub 2009 Nov 23. Review.

PMID:
19930430
29.

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.

Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, Piston DW, Huke S, Knollmann BC.

J Mol Cell Cardiol. 2010 Feb;48(2):293-301. doi: 10.1016/j.yjmcc.2009.10.005. Epub 2009 Oct 14.

30.

Protein interactions involving the gamma2 large cytoplasmic loop of GABA(A) receptors modulate conductance.

Everitt AB, Seymour VA, Curmi J, Laver DR, Gage PW, Tierney ML.

FASEB J. 2009 Dec;23(12):4361-9. doi: 10.1096/fj.09-137042. Epub 2009 Aug 24.

31.

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans.

Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AA, Knollmann BC.

Nat Med. 2009 Apr;15(4):380-3. doi: 10.1038/nm.1942. Epub 2009 Mar 29.

32.

Luminal Ca(2+) activation of cardiac ryanodine receptors by luminal and cytoplasmic domains.

Laver DR.

Eur Biophys J. 2009 Dec;39(1):19-26. doi: 10.1007/s00249-009-0417-1. Epub 2009 Mar 3. Review.

PMID:
19255753
33.

Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle.

Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, LaFerla FM, Ikemoto N, Querfurth HW.

Neurobiol Aging. 2010 Dec;31(12):2080-90. doi: 10.1016/j.neurobiolaging.2008.11.003. Epub 2008 Dec 23.

34.

Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release.

Chopra N, Laver D, Davies SS, Knollmann BC.

Mol Pharmacol. 2009 Jan;75(1):183-95. doi: 10.1124/mol.108.051490. Epub 2008 Oct 9.

35.
36.

A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites.

Laver DR, Honen BN, Lamb GD, Ikemoto N.

Eur Biophys J. 2008 Apr;37(4):455-67. Epub 2007 Nov 24.

PMID:
18038129
37.

The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca(2+) binding site.

Laver DR, Hamada T, Fessenden JD, Ikemoto N.

J Membr Biol. 2007 Dec;220(1-3):11-20. Epub 2007 Sep 18.

PMID:
17879109
38.

Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites.

Laver DR.

Clin Exp Pharmacol Physiol. 2007 Sep;34(9):889-96. Review.

PMID:
17645636
39.
40.

Regulation of ryanodine receptors from skeletal and cardiac muscle during rest and excitation.

Laver DR.

Clin Exp Pharmacol Physiol. 2006 Nov;33(11):1107-13. Review.

PMID:
17042923
41.

Disulfonic stilbene permeation and block of the anion channel from the sarcoplasmic reticulum of rabbit skeletal muscle.

Laver DR, Bradley KM.

Am J Physiol Cell Physiol. 2006 Jun;290(6):C1666-77. Epub 2006 Jan 18.

42.

The mechanism of SR95531 inhibition at GABA receptors examined in human alpha1beta1 and alpha1beta1gamma2S receptors.

Lindquist CE, Laver DR, Birnir B.

J Neurochem. 2005 Jul;94(2):491-501. Erratum in: J Neurochem. 2006 Apr;97(1):302.

43.

Coupled calcium release channels and their regulation by luminal and cytosolic ions.

Laver DR.

Eur Biophys J. 2005 Jul;34(5):359-68. Epub 2005 May 25. Review.

PMID:
15915341
44.

Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation.

Beard NA, Casarotto MG, Wei L, Varsányi M, Laver DR, Dulhunty AF.

Biophys J. 2005 May;88(5):3444-54. Epub 2005 Feb 24.

45.

Luminal Ca2+-regulated Mg2+ inhibition of skeletal RyRs reconstituted as isolated channels or coupled clusters.

Laver DR, O'Neill ER, Lamb GD.

J Gen Physiol. 2004 Dec;124(6):741-58. Epub 2004 Nov 15.

46.
47.

Negative pressure wound therapy in the management of orthopedic wounds.

Webb LX, Laver D, DeFranzo A.

Ostomy Wound Manage. 2004 Apr;50(4A Suppl):26-7. Review. No abstract available.

PMID:
15317242
48.

Calsequestrin and the calcium release channel of skeletal and cardiac muscle.

Beard NA, Laver DR, Dulhunty AF.

Prog Biophys Mol Biol. 2004 May;85(1):33-69. Review.

PMID:
15050380
49.
50.

The random-coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors.

Haarmann CS, Green D, Casarotto MG, Laver DR, Dulhunty AF.

Biochem J. 2003 Jun 1;372(Pt 2):305-16.

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