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A new target for fetal hemoglobin reactivation.

Rivers A, Molokie R, Lavelle D.

Haematologica. 2019 Dec;104(12):2325-2327. doi: 10.3324/haematol.2019.230904. No abstract available.


The alternative reality of plant mitochondrial DNA: One ring does not rule them all.

Kozik A, Rowan BA, Lavelle D, Berke L, Schranz ME, Michelmore RW, Christensen AC.

PLoS Genet. 2019 Aug 30;15(8):e1008373. doi: 10.1371/journal.pgen.1008373. eCollection 2019 Aug.


Correction to: The LsVe1L allele provides a molecular marker for resistance to Verticillium dahliae race 1 in lettuce.

Inderbitzin P, Christopoulou M, Lavelle D, Reyes-Chin-Wo S, Michelmore RW, Subbarao KV, Simko I.

BMC Plant Biol. 2019 Aug 26;19(1):374. doi: 10.1186/s12870-019-1966-9.


Characterization of four polymorphic genes controlling red leaf colour in lettuce that have undergone disruptive selection since domestication.

Su W, Tao R, Liu W, Yu C, Yue Z, He S, Lavelle D, Zhang W, Zhang L, An G, Zhang Y, Hu Q, Larkin RM, Michelmore RW, Kuang H, Chen J.

Plant Biotechnol J. 2019 Jul 20. doi: 10.1111/pbi.13213. [Epub ahead of print]


The LsVe1L allele provides a molecular marker for resistance to Verticillium dahliae race 1 in lettuce.

Inderbitzin P, Christopoulou M, Lavelle D, Reyes-Chin-Wo S, Michelmore RW, Subbarao KV, Simko I.

BMC Plant Biol. 2019 Jul 10;19(1):305. doi: 10.1186/s12870-019-1905-9. Erratum in: BMC Plant Biol. 2019 Aug 26;19(1):374.


Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons.

Rivers A, Vaitkus K, Jagadeeswaran R, Ruiz MA, Ibanez V, Ciceri F, Cavalcanti F, Molokie RE, Saunthararajah Y, Engel JD, DeSimone J, Lavelle D.

Exp Hematol. 2018 Nov;67:60-64.e2. doi: 10.1016/j.exphem.2018.08.003. Epub 2018 Aug 17.


Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data.

Rivers A, Jagadeeswaran R, Lavelle D.

Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R840-R847. doi: 10.1152/ajpregu.00440.2017. Epub 2018 Aug 1. Review.


Fetal Hemoglobin Induction by Epigenetic Drugs.

Lavelle D, Engel JD, Saunthararajah Y.

Semin Hematol. 2018 Apr;55(2):60-67. doi: 10.1053/j.seminhematol.2018.04.008. Epub 2018 Apr 22. Review.


RNA sequencing provides insights into the evolution of lettuce and the regulation of flavonoid biosynthesis.

Zhang L, Su W, Tao R, Zhang W, Chen J, Wu P, Yan C, Jia Y, Larkin RM, Lavelle D, Truco MJ, Chin-Wo SR, Michelmore RW, Kuang H.

Nat Commun. 2017 Dec 22;8(1):2264. doi: 10.1038/s41467-017-02445-9.


Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.

Molokie R, Lavelle D, Gowhari M, Pacini M, Krauz L, Hassan J, Ibanez V, Ruiz MA, Ng KP, Woost P, Radivoyevitch T, Pacelli D, Fada S, Rump M, Hsieh M, Tisdale JF, Jacobberger J, Phelps M, Engel JD, Saraf S, Hsu LL, Gordeuk V, DeSimone J, Saunthararajah Y.

PLoS Med. 2017 Sep 7;14(9):e1002382. doi: 10.1371/journal.pmed.1002382. eCollection 2017 Sep.


Genome assembly with in vitro proximity ligation data and whole-genome triplication in lettuce.

Reyes-Chin-Wo S, Wang Z, Yang X, Kozik A, Arikit S, Song C, Xia L, Froenicke L, Lavelle DO, Truco MJ, Xia R, Zhu S, Xu C, Xu H, Xu X, Cox K, Korf I, Meyers BC, Michelmore RW.

Nat Commun. 2017 Apr 12;8:14953. doi: 10.1038/ncomms14953.


Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease.

Jagadeeswaran R, Vazquez BA, Thiruppathi M, Ganesh BB, Ibanez V, Cui S, Engel JD, Diamond AM, Molokie RE, DeSimone J, Lavelle D, Rivers A.

Exp Hematol. 2017 Jun;50:46-52. doi: 10.1016/j.exphem.2017.02.003. Epub 2017 Feb 24.


Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons.

Ibanez V, Vaitkus K, Rivers A, Molokie R, Cui S, Engel JD, DeSimone J, Lavelle D.

Blood. 2017 Jan 12;129(2):260-263. doi: 10.1182/blood-2016-10-746727. Epub 2016 Dec 1. No abstract available.


Diabetes Self-Management Education in the Home.

Lavelle D, Zeitoun J, Stern M, Butkiewicz E, Wegner E, Reinisch C.

Cureus. 2016 Jul 25;8(7):e710. doi: 10.7759/cureus.710.


The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).

Rivers A, Vaitkus K, Ibanez V, Ruiz MA, Jagadeeswaran R, Saunthararajah Y, Cui S, Engel JD, DeSimone J, Lavelle D.

Haematologica. 2016 Jun;101(6):688-97. doi: 10.3324/haematol.2015.140749. Epub 2016 Feb 8.


The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice.

Cui S, Lim KC, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, Campbell A, Harro D, Iwase S, Trievel RC, Rivers A, DeSimone J, Lavelle D, Saunthararajah Y, Engel JD.

Blood. 2015 Jul 16;126(3):386-96. doi: 10.1182/blood-2015-02-626259. Epub 2015 Jun 1.


Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation.

Ruiz MA, Rivers A, Ibanez V, Vaitkus K, Mahmud N, DeSimone J, Lavelle D.

Epigenetics. 2015;10(5):397-407. doi: 10.1080/15592294.2015.1039220.


RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model.

Rivers A, Vaitkus K, Ruiz MA, Ibanez V, Jagadeeswaran R, Kouznetsova T, DeSimone J, Lavelle D.

Exp Hematol. 2015 Jul;43(7):546-53.e1-3. doi: 10.1016/j.exphem.2015.04.005. Epub 2015 Apr 27.


Cytokine-free rapid red cell regeneration.

Mahmud N, Lavelle D.

Blood. 2015 Feb 5;125(6):895-6. doi: 10.1182/blood-2014-11-609024. No abstract available.


Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells.

Mahmud N, Petro B, Baluchamy S, Li X, Taioli S, Lavelle D, Quigley JG, Suphangul M, Araki H.

Biol Blood Marrow Transplant. 2014 Apr;20(4):480-9. doi: 10.1016/j.bbmt.2013.12.562. Epub 2013 Dec 26.


Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.

Madzo J, Liu H, Rodriguez A, Vasanthakumar A, Sundaravel S, Caces DBD, Looney TJ, Zhang L, Lepore JB, Macrae T, Duszynski R, Shih AH, Song CX, Yu M, Yu Y, Grossman R, Raumann B, Verma A, He C, Levine RL, Lavelle D, Lahn BT, Wickrema A, Godley LA.

Cell Rep. 2014 Jan 16;6(1):231-244. doi: 10.1016/j.celrep.2013.11.044. Epub 2013 Dec 27.


Consequences of normalizing transcriptomic and genomic libraries of plant genomes using a duplex-specific nuclease and tetramethylammonium chloride.

Matvienko M, Kozik A, Froenicke L, Lavelle D, Martineau B, Perroud B, Michelmore R.

PLoS One. 2013;8(2):e55913. doi: 10.1371/journal.pone.0055913. Epub 2013 Feb 8.


Effect of AGM and fetal liver-derived stromal cell lines on globin expression in adult baboon (P. anubis) bone marrow-derived erythroid progenitors.

Lavelle D, Vaitkus K, Ruiz MA, Ibanez V, Kouznetsova T, Saunthararajah Y, Mahmud N, DeSimone J.

PLoS One. 2012;7(5):e36846. doi: 10.1371/journal.pone.0036846. Epub 2012 May 31.


Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine.

Lavelle D, Vaitkus K, Ling Y, Ruiz MA, Mahfouz R, Ng KP, Negrotto S, Smith N, Terse P, Engelke KJ, Covey J, Chan KK, Desimone J, Saunthararajah Y.

Blood. 2012 Feb 2;119(5):1240-7. doi: 10.1182/blood-2011-08-371690. Epub 2011 Dec 7.


Standard clinical practice underestimates the role and significance of erythropoietin deficiency in sickle cell disease.

Saraf S, Farooqui M, Infusino G, Oza B, Sidhwani S, Gowhari M, Vara S, Gao W, Krauz L, Lavelle D, DeSimone J, Molokie R, Saunthararajah Y.

Br J Haematol. 2011 May;153(3):386-92. doi: 10.1111/j.1365-2141.2010.08479.x. Epub 2011 Mar 21.


siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures.

Banzon V, Ibanez V, Vaitkus K, Ruiz MA, Peterson K, DeSimone J, Lavelle D.

Exp Hematol. 2011 Jan;39(1):26-36.e1. doi: 10.1016/j.exphem.2010.10.003. Epub 2010 Oct 23.


S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis).

Lavelle D, Saunthararajah Y, Vaitkus K, Singh M, Banzon V, Phiasivongsva P, Redkar S, Kanekal S, Bearss D, Shi C, Inloes R, DeSimone J.

J Transl Med. 2010 Oct 8;8:92. doi: 10.1186/1479-5876-8-92.


Dual bronchodilatory and pulmonary anti-inflammatory activity of RO5024118, a novel agonist at vasoactive intestinal peptide VPAC2 receptors.

Tannu SA, Renzetti LM, Tare N, Ventre JD, Lavelle D, Lin TA, Morschauser A, Paciorek J, Bolin DR, Michel H, Singer L, Hargaden M, Knowles I, Gardiner P, Cazzola M, Calzetta L, Matera MG, Hicks A.

Br J Pharmacol. 2010 Nov;161(6):1329-42. doi: 10.1111/j.1476-5381.2010.00975.x.


Decitabine increases fetal hemoglobin in Papio anubis by increasing γ-globin gene transcription.

Akpan I, Banzon V, Ibanez V, Vaitkus K, DeSimone J, Lavelle D.

Exp Hematol. 2010 Nov;38(11):989-993.e1. doi: 10.1016/j.exphem.2010.08.001. Epub 2010 Aug 14.


Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1.

Goodnow RA Jr, Hicks A, Sidduri A, Kowalczyk A, Dominique R, Qiao Q, Lou JP, Gillespie P, Fotouhi N, Tilley J, Cohen N, Choudhry S, Cavallo G, Tannu SA, Ventre JD, Lavelle D, Tare NS, Oh H, Lamb M, Kurylko G, Hamid R, Wright MB, Pamidimukkala A, Egan T, Gubler U, Hoffman AF, Wei X, Li YL, O'Neil J, Marcano R, Pozzani K, Molinaro T, Santiago J, Singer L, Hargaden M, Moore D, Catala AR, Chao LC, Hermann G, Venkat R, Mancebo H, Renzetti LM.

J Med Chem. 2010 May 13;53(9):3502-16. doi: 10.1021/jm1001919.


Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates.

Hicks A, Goodnow R Jr, Cavallo G, Tannu SA, Ventre JD, Lavelle D, Lora JM, Satjawatcharaphong J, Brovarney M, Dabbagh K, Tare NS, Oh H, Lamb M, Sidduri A, Dominique R, Qiao Q, Lou JP, Gillespie P, Fotouhi N, Kowalczyk A, Kurylko G, Hamid R, Wright MB, Pamidimukkala A, Egan T, Gubler U, Hoffman AF, Wei X, Li YL, O'Neil J, Marcano R, Pozzani K, Molinaro T, Santiago J, Singer L, Hargaden M, Moore D, Catala AR, Chao LC, Benson J, March T, Venkat R, Mancebo H, Renzetti LM.

Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):33-43. doi: 10.1016/j.prostaglandins.2010.02.003. Epub 2010 Mar 7.


Globally, unrelated protein sequences appear random.

Lavelle DT, Pearson WR.

Bioinformatics. 2010 Feb 1;26(3):310-8. doi: 10.1093/bioinformatics/btp660. Epub 2009 Nov 30.


Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms.

Chin J, Singh M, Banzon V, Vaitkus K, Ibanez V, Kouznetsova T, Mahmud N, DeSimone J, Lavelle D.

Exp Hematol. 2009 Oct;37(10):1131-42. doi: 10.1016/j.exphem.2009.06.007. Epub 2009 Jul 2.


Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues.

Araki H, Baluchamy S, Yoshinaga K, Petro B, Petiwala S, Parajuli R, Milhem M, Lavelle D, DeSimone J, Mahmud N.

Exp Hematol. 2009 Sep;37(9):1084-95. doi: 10.1016/j.exphem.2009.05.012. Epub 2009 Jun 6.


Total knee arthroplasty with asymmetric femoral condyles and tibial tray.

Crockarell JR Jr, Hicks JM, Schroeder RJ, Guyton JL, Harkess JW, Lavelle DG.

J Arthroplasty. 2010 Jan;25(1):108-13. doi: 10.1016/j.arth.2008.11.002. Epub 2009 Jan 15.


Clinical effectiveness of decitabine in severe sickle cell disease.

Saunthararajah Y, Molokie R, Saraf S, Sidhwani S, Gowhari M, Vara S, Lavelle D, DeSimone J.

Br J Haematol. 2008 Apr;141(1):126-9. doi: 10.1111/j.1365-2141.2008.07027.x. No abstract available.


DNA methylation and mechanism of action of 5-azacytidine.

Lavelle D, Saunthararajah Y, Desimone J.

Blood. 2008 Feb 15;111(4):2485; author reply 2486. doi: 10.1182/blood-2007-10-119867. No abstract available.


A high-density, integrated genetic linkage map of lettuce (Lactuca spp.).

Truco MJ, Antonise R, Lavelle D, Ochoa O, Kozik A, Witsenboer H, Fort SB, Jeuken MJ, Kesseli RV, Lindhout P, Michelmore RW, Peleman J.

Theor Appl Genet. 2007 Oct;115(6):735-46. Epub 2007 Sep 8.


Oral decitabine reactivates expression of the methylated gamma-globin gene in Papio anubis.

Lavelle D, Chin J, Vaitkus K, Redkar S, Phiasivongsa P, Tang C, Will R, Hankewych M, Roxas B, Singh M, Saunthararajah Y, Desimone J.

Am J Hematol. 2007 Nov;82(11):981-5.


Analyses of synteny between Arabidopsis thaliana and species in the Asteraceae reveal a complex network of small syntenic segments and major chromosomal rearrangements.

Timms L, Jimenez R, Chase M, Lavelle D, McHale L, Kozik A, Lai Z, Heesacker A, Knapp S, Rieseberg L, Michelmore R, Kesseli R.

Genetics. 2006 Aug;173(4):2227-35. Epub 2006 Jun 18.


Developmental changes in DNA methylation and covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin gene promoters in Papio anubis.

Lavelle D, Vaitkus K, Hankewych M, Singh M, DeSimone J.

Blood Cells Mol Dis. 2006 Mar-Apr;36(2):269-78. Epub 2006 Mar 9.


The molecular mechanism of fetal hemoglobin reactivation.

Lavelle DE.

Semin Hematol. 2004 Oct;41(4 Suppl 6):3-10. Review.


DNA hypo-methylating agents and sickle cell disease.

Saunthararajah Y, Lavelle D, DeSimone J.

Br J Haematol. 2004 Sep;126(5):629-36. Review.


Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.

Milhem M, Mahmud N, Lavelle D, Araki H, DeSimone J, Saunthararajah Y, Hoffman R.

Blood. 2004 Jun 1;103(11):4102-10. Epub 2004 Feb 19.


Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease.

Saunthararajah Y, Hillery CA, Lavelle D, Molokie R, Dorn L, Bressler L, Gavazova S, Chen YH, Hoffman R, DeSimone J.

Blood. 2003 Dec 1;102(12):3865-70. Epub 2003 Aug 7.


Decitabine induces cell cycle arrest at the G1 phase via p21(WAF1) and the G2/M phase via the p38 MAP kinase pathway.

Lavelle D, DeSimone J, Hankewych M, Kousnetzova T, Chen YH.

Leuk Res. 2003 Nov;27(11):999-1007.


Regulation of myeloma cell growth through Akt/Gsk3/forkhead signaling pathway.

G-Amlak M, Uddin S, Mahmud D, Damacela I, Lavelle D, Ahmed M, van Besien K, Wickrema A.

Biochem Biophys Res Commun. 2002 Oct 4;297(4):760-4.


Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia.

DeSimone J, Koshy M, Dorn L, Lavelle D, Bressler L, Molokie R, Talischy N.

Blood. 2002 Jun 1;99(11):3905-8.


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