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Items: 1 to 50 of 260

1.

The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion.

Parra-Flores P, Riquelme JA, Valenzuela-Bustamante P, Leiva-Navarrete S, Vivar R, Cayupi-Vivanco J, Castro E, Espinoza-Pérez C, Ruz-Cortés F, Pedrozo Z, Lavandero S, Rodrigo R, Diaz-Araya G.

Antioxidants (Basel). 2019 Dec 3;8(12). pii: E614. doi: 10.3390/antiox8120614.

2.

Rho-kinase pathway activation and apoptosis in circulating leucocytes in patients with heart failure with reduced ejection fraction.

Ocaranza MP, Moya J, Jalil JE, Lavandero S, Kalergis AM, Molina C, Gabrielli L, Godoy I, Córdova S, Castro P, Mac Nab P, Rossel V, García L, González J, Mancilla C, Fierro C, Farías L.

J Cell Mol Med. 2019 Nov 28. doi: 10.1111/jcmm.14819. [Epub ahead of print]

3.

Female Sex Is Protective in a Preclinical Model of Heart Failure With Preserved Ejection Fraction.

Tong D, Schiattarella GG, Jiang N, May HI, Lavandero S, Gillette TG, Hill JA.

Circulation. 2019 Nov 19;140(21):1769-1771. doi: 10.1161/CIRCULATIONAHA.119.042267. Epub 2019 Nov 18. No abstract available.

PMID:
31738599
4.

Emerging role of mitophagy in cardiovascular physiology and pathology.

Morales PE, Arias-Durán C, Ávalos-Guajardo Y, Aedo G, Verdejo HE, Parra V, Lavandero S.

Mol Aspects Med. 2019 Oct 3. pii: S0098-2997(19)30096-2. doi: 10.1016/j.mam.2019.09.006. [Epub ahead of print] Review.

PMID:
31587811
5.

Looking back and thinking forwards - 15 years of cardiology and cardiovascular research.

Kalman JM, Lavandero S, Mahfoud F, Nahrendorf M, Yacoub MH, Zhao D.

Nat Rev Cardiol. 2019 Nov;16(11):651-660. doi: 10.1038/s41569-019-0261-7. Epub 2019 Sep 30. Review.

PMID:
31570832
6.

AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells.

Martínez-Meza S, Díaz J, Sandoval-Bórquez A, Valenzuela-Valderrama M, Díaz-Valdivia N, Rojas-Celis V, Contreras P, Huilcaman R, Ocaranza MP, Chiong M, Leyton L, Lavandero S, Quest AFG.

Cancers (Basel). 2019 Sep 3;11(9). pii: E1299. doi: 10.3390/cancers11091299.

7.

Counter-regulatory renin-angiotensin system in cardiovascular disease.

Paz Ocaranza M, Riquelme JA, García L, Jalil JE, Chiong M, Santos RAS, Lavandero S.

Nat Rev Cardiol. 2019 Aug 19. doi: 10.1038/s41569-019-0244-8. [Epub ahead of print] Review.

PMID:
31427727
8.

TGF-β1 induced up-regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts.

Catalán M, Aránguiz P, Boza P, Olmedo I, Humeres C, Vivar R, Anfossi R, Ayala P, Espinoza C, Lavandero S, Díaz-Araya G.

Mol Biol Rep. 2019 Oct;46(5):5197-5207. doi: 10.1007/s11033-019-04977-3. Epub 2019 Jul 15.

PMID:
31309451
9.

Polycystin-1 Assembles With Kv Channels to Govern Cardiomyocyte Repolarization and Contractility.

Altamirano F, Schiattarella GG, French KM, Kim SY, Engelberger F, Kyrychenko S, Villalobos E, Tong D, Schneider JW, Ramirez-Sarmiento CA, Lavandero S, Gillette TG, Hill JA.

Circulation. 2019 Sep 10;140(11):921-936. doi: 10.1161/CIRCULATIONAHA.118.034731. Epub 2019 Jun 21.

PMID:
31220931
10.

TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals.

Jiménez JM, Salazar ML, Arancibia S, Villar J, Salazar F, Brown GD, Lavelle EC, Martínez-Pomares L, Ortiz-Quintero J, Lavandero S, Manubens A, Becker MI.

Front Immunol. 2019 May 31;10:1136. doi: 10.3389/fimmu.2019.01136. eCollection 2019.

11.

Polycystin-2 Is Required for Starvation- and Rapamycin-Induced Atrophy in Myotubes.

Kretschmar C, Peña-Oyarzun D, Hernando C, Hernández-Moya N, Molina-Berríos A, Hernández-Cáceres MP, Lavandero S, Budini M, Morselli E, Parra V, Troncoso R, Criollo A.

Front Endocrinol (Lausanne). 2019 May 8;10:280. doi: 10.3389/fendo.2019.00280. eCollection 2019.

12.

GDF-11 prevents cardiomyocyte hypertrophy by maintaining the sarcoplasmic reticulum-mitochondria communication.

Garrido-Moreno V, Díaz-Vegas A, López-Crisosto C, Troncoso MF, Navarro-Marquez M, García L, Estrada M, Cifuentes M, Lavandero S.

Pharmacol Res. 2019 Aug;146:104273. doi: 10.1016/j.phrs.2019.104273. Epub 2019 May 13.

PMID:
31096010
13.

Nitrosative stress drives heart failure with preserved ejection fraction.

Schiattarella GG, Altamirano F, Tong D, French KM, Villalobos E, Kim SY, Luo X, Jiang N, May HI, Wang ZV, Hill TM, Mammen PPA, Huang J, Lee DI, Hahn VS, Sharma K, Kass DA, Lavandero S, Gillette TG, Hill JA.

Nature. 2019 Apr;568(7752):351-356. doi: 10.1038/s41586-019-1100-z. Epub 2019 Apr 10.

14.

Bafilomycin-A1 and ML9 Exert Different Lysosomal Actions to Induce Cell Death.

Shaikh S, Nandy SK, Cantí C, Lavandero S.

Curr Mol Pharmacol. 2019;12(4):261-271. doi: 10.2174/1874467212666190308131250.

PMID:
30854984
15.

Fibroblast Primary Cilia Are Required for Cardiac Fibrosis.

Villalobos E, Criollo A, Schiattarella GG, Altamirano F, French KM, May HI, Jiang N, Nguyen NUN, Romero D, Roa JC, García L, Diaz-Araya G, Morselli E, Ferdous A, Conway SJ, Sadek HA, Gillette TG, Lavandero S, Hill JA.

Circulation. 2019 May 14;139(20):2342-2357. doi: 10.1161/CIRCULATIONAHA.117.028752.

PMID:
30818997
16.

Angiotensin II-Regulated Autophagy Is Required for Vascular Smooth Muscle Cell Hypertrophy.

Mondaca-Ruff D, Riquelme JA, Quiroga C, Norambuena-Soto I, Sanhueza-Olivares F, Villar-Fincheira P, Hernández-Díaz T, Cancino-Arenas N, San Martin A, García L, Lavandero S, Chiong M.

Front Pharmacol. 2019 Feb 5;9:1553. doi: 10.3389/fphar.2018.01553. eCollection 2018.

17.

Author Correction: Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.

Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, Diaz-Valdivia N, Sanhueza C, Lopez-Crisosto C, Tahbaz N, Rothermel BA, Hill JA, Cifuentes M, Simmen T, Quest AFG, Lavandero S.

Cell Death Differ. 2019 Nov;26(11):2494. doi: 10.1038/s41418-019-0279-8.

18.

Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning.

Davidson SM, Riquelme JA, Zheng Y, Vicencio JM, Lavandero S, Yellon DM.

Sci Rep. 2018 Oct 26;8(1):15885. doi: 10.1038/s41598-018-34357-z.

19.

Heart Disease and Cancer.

Kitsis RN, Riquelme JA, Lavandero S.

Circulation. 2018 Aug 14;138(7):692-695. doi: 10.1161/CIRCULATIONAHA.118.033907. No abstract available.

20.

Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches.

Bejarano J, Navarro-Marquez M, Morales-Zavala F, Morales JO, Garcia-Carvajal I, Araya-Fuentes E, Flores Y, Verdejo HE, Castro PF, Lavandero S, Kogan MJ.

Theranostics. 2018 Sep 9;8(17):4710-4732. doi: 10.7150/thno.26284. eCollection 2018. Review.

21.

IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice.

Valladares D, Utreras-Mendoza Y, Campos C, Morales C, Diaz-Vegas A, Contreras-Ferrat A, Westermeier F, Jaimovich E, Marchi S, Pinton P, Lavandero S.

Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3685-3695. doi: 10.1016/j.bbadis.2018.08.042. Epub 2018 Sep 7.

22.

Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes.

Mattar P, Bravo-Sagua R, Tobar N, Fuentes C, Troncoso R, Breitwieser G, Lavandero S, Cifuentes M.

Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3585-3594. doi: 10.1016/j.bbadis.2018.08.020. Epub 2018 Aug 18.

23.

Editorial commentary: Cardiometabolic diseases and gut microbiota-removing the veil.

Riquelme JA, Ferreccio C, Lavandero S.

Trends Cardiovasc Med. 2019 Apr;29(3):148-149. doi: 10.1016/j.tcm.2018.08.009. Epub 2018 Sep 4. No abstract available.

PMID:
30219275
24.

Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.

Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, Diaz-Valdivia N, Sanhueza C, Lopez-Crisosto C, Tahbaz N, Rothermel BA, Hill JA, Cifuentes M, Simmen T, Quest AFG, Lavandero S.

Cell Death Differ. 2019 Jul;26(7):1195-1212. doi: 10.1038/s41418-018-0197-1. Epub 2018 Sep 12. Erratum in: Cell Death Differ. 2019 Feb 11;:.

25.

Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension.

Gonzalez L, Novoa U, Moya J, Gabrielli L, Jalil JE, García L, Chiong M, Lavandero S, Ocaranza MP.

Biochem Pharmacol. 2018 Oct;156:357-370. doi: 10.1016/j.bcp.2018.08.045. Epub 2018 Sep 1.

PMID:
30179588
26.

Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT2R and Akt-dependent mechanism.

Mendoza-Torres E, Riquelme JA, Vielma A, Sagredo AR, Gabrielli L, Bravo-Sagua R, Jalil JE, Rothermel BA, Sanchez G, Ocaranza MP, Lavandero S.

Pharmacol Res. 2018 Sep;135:112-121. doi: 10.1016/j.phrs.2018.07.022. Epub 2018 Jul 23.

PMID:
30048754
27.

Increased active phase atrial contraction is related to marathon runner performance.

Gabrielli L, Herrera S, Contreras-Briceño F, Vega J, Ocaranza MP, Yáñez F, Fernández R, Saavedra R, Sitges M, García L, Chiong M, Lavandero S, Castro PF.

Eur J Appl Physiol. 2018 Sep;118(9):1931-1939. doi: 10.1007/s00421-018-3927-7. Epub 2018 Jul 3.

PMID:
29971492
28.

Potential adverse cardiac remodelling in highly trained athletes: still unknown clinical significance.

Gabrielli L, Sitges M, Chiong M, Jalil J, Ocaranza M, Llevaneras S, Herrera S, Fernandez R, Saavedra R, Yañez F, Vergara L, Diaz A, Lavandero S, Castro P.

Eur J Sport Sci. 2018 Oct;18(9):1288-1297. doi: 10.1080/17461391.2018.1484174. Epub 2018 Jun 12. Review.

PMID:
29893180
29.

Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

Peña-Oyarzun D, Bravo-Sagua R, Diaz-Vega A, Aleman L, Chiong M, Garcia L, Bambs C, Troncoso R, Cifuentes M, Morselli E, Ferreccio C, Quest AFG, Criollo A, Lavandero S.

Free Radic Biol Med. 2018 Aug 20;124:61-78. doi: 10.1016/j.freeradbiomed.2018.05.084. Epub 2018 May 30. Review.

PMID:
29859344
30.

[Cardiotoxicity of anticancer therapies. Towards the implementation of cardio-oncology units].

Hameau R, Gabrielli L, Garrido M, Guzmán AM, Retamal I, Vacarezza MJ, Greig D, Ocqueteau M, Sánchez C, Pizarro M, Corvalán A, Lavandero S, Castro PF, Martínez G.

Rev Med Chil. 2018 Jan;146(1):68-77. doi: 10.4067/s0034-98872018000100068. Review. Spanish.

31.

Polycystin-2-dependent control of cardiomyocyte autophagy.

Criollo A, Altamirano F, Pedrozo Z, Schiattarella GG, Li DL, Rivera-Mejías P, Sotomayor-Flores C, Parra V, Villalobos E, Battiprolu PK, Jiang N, May HI, Morselli E, Somlo S, de Smedt H, Gillette TG, Lavandero S, Hill JA.

J Mol Cell Cardiol. 2018 May;118:110-121. doi: 10.1016/j.yjmcc.2018.03.002. Epub 2018 Mar 6.

PMID:
29518398
32.

Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis.

Navarro-Marquez M, Torrealba N, Troncoso R, Vásquez-Trincado C, Rodriguez M, Morales PE, Villalobos E, Eura Y, Garcia L, Chiong M, Klip A, Jaimovich E, Kokame K, Lavandero S.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1653-1662. doi: 10.1016/j.bbadis.2018.02.018. Epub 2018 Feb 24.

33.

Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network.

Parra V, Altamirano F, Hernández-Fuentes CP, Tong D, Kyrychenko V, Rotter D, Pedrozo Z, Hill JA, Eisner V, Lavandero S, Schneider JW, Rothermel BA.

Circ Res. 2018 Mar 16;122(6):e20-e33. doi: 10.1161/CIRCRESAHA.117.311522. Epub 2018 Jan 23.

34.

The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.

Shaikh S, Troncoso R, Mondaca-Ruff D, Parra V, Garcia L, Chiong M, Lavandero S.

Toxicol In Vitro. 2018 Apr;48:121-127. doi: 10.1016/j.tiv.2018.01.005. Epub 2018 Jan 12.

PMID:
29337250
35.

Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism.

Córdova-Casanova A, Olmedo I, Riquelme JA, Barrientos G, Sánchez G, Gillette TG, Lavandero S, Chiong M, Donoso P, Pedrozo Z.

Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):289-296. doi: 10.1016/j.bbamcr.2017.11.001. Epub 2017 Nov 7.

36.

Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation.

Torrealba N, Navarro-Marquez M, Garrido V, Pedrozo Z, Romero D, Eura Y, Villalobos E, Roa JC, Chiong M, Kokame K, Lavandero S.

Sci Rep. 2017 Oct 17;7(1):13402. doi: 10.1038/s41598-017-13797-z.

37.

Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy.

Duran J, Lagos D, Pavez M, Troncoso MF, Ramos S, Barrientos G, Ibarra C, Lavandero S, Estrada M.

Front Pharmacol. 2017 Sep 11;8:604. doi: 10.3389/fphar.2017.00604. eCollection 2017.

38.

Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells.

Bernal-Sore I, Navarro-Marquez M, Osorio-Fuentealba C, Díaz-Castro F, Del Campo A, Donoso-Barraza C, Porras O, Lavandero S, Troncoso R.

Mol Cell Endocrinol. 2018 Feb 5;461:277-283. doi: 10.1016/j.mce.2017.09.028. Epub 2017 Sep 21.

PMID:
28943275
39.

Hyperosmotic stress stimulates autophagy via polycystin-2.

Peña-Oyarzun D, Troncoso R, Kretschmar C, Hernando C, Budini M, Morselli E, Lavandero S, Criollo A.

Oncotarget. 2017 Jul 5;8(34):55984-55997. doi: 10.18632/oncotarget.18995. eCollection 2017 Aug 22.

40.

Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro.

Davidson SM, Riquelme JA, Takov K, Vicencio JM, Boi-Doku C, Khoo V, Doreth C, Radenkovic D, Lavandero S, Yellon DM.

J Cell Mol Med. 2018 Jan;22(1):141-151. doi: 10.1111/jcmm.13302. Epub 2017 Aug 25.

41.

Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells.

Parra V, Bravo-Sagua R, Norambuena-Soto I, Hernández-Fuentes CP, Gómez-Contreras AG, Verdejo HE, Mellado R, Chiong M, Lavandero S, Castro PF.

Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2891-2903. doi: 10.1016/j.bbadis.2017.07.018. Epub 2017 Jul 22.

42.

Mitochondria in Structural and Functional Cardiac Remodeling.

Torrealba N, Aranguiz P, Alonso C, Rothermel BA, Lavandero S.

Adv Exp Med Biol. 2017;982:277-306. doi: 10.1007/978-3-319-55330-6_15. Review.

PMID:
28551793
43.

Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation.

Del Campo A, Roldán J, Verdejo HE, Zalaquett R, Becerra E, Navarro-Marquez M, Mellado R, Lavandero S, Corbalán R, García L, Chiong M.

J Cardiol. 2017 Dec;70(6):578-583. doi: 10.1016/j.jjcc.2017.03.011. Epub 2017 May 12.

44.

Subcellular Remodeling of the T-Tubule Membrane System: The Limits of Myocardial Recovery Revealed?

Rame JE, Lavandero S.

Circulation. 2017 Apr 25;135(17):1646-1650. doi: 10.1161/CIRCULATIONAHA.117.025319. No abstract available.

PMID:
28438805
45.

Calcium Transport and Signaling in Mitochondria.

Bravo-Sagua R, Parra V, López-Crisosto C, Díaz P, Quest AF, Lavandero S.

Compr Physiol. 2017 Mar 16;7(2):623-634. doi: 10.1002/cphy.c160013. Review.

PMID:
28333383
46.

Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology.

Lopez-Crisosto C, Pennanen C, Vasquez-Trincado C, Morales PE, Bravo-Sagua R, Quest AFG, Chiong M, Lavandero S.

Nat Rev Cardiol. 2017 Jun;14(6):342-360. doi: 10.1038/nrcardio.2017.23. Epub 2017 Mar 9. Review.

PMID:
28275246
47.

Novel Therapies Targeting Cardioprotection and Regeneration.

Garrido V, Mendoza-Torres E, Riquelme JA, Díaz A, Pizarro M, Bustamante M, Chavez MN, Ocaranza MP, Mellado R, Corbalan R, Allende ML, Lavandero S.

Curr Pharm Des. 2017;23(18):2592-2615. doi: 10.2174/1381612823666170112122637. Review.

PMID:
28079007
48.

mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling.

Bravo-Sagua R, López-Crisosto C, Parra V, Rodriguez-Peña M, Rothermel BA, Quest AF, Lavandero S.

Sci Rep. 2016 Nov 3;6:36394. doi: 10.1038/srep36394.

49.

Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity.

Pizarro M, Troncoso R, Martínez GJ, Chiong M, Castro PF, Lavandero S.

Toxicology. 2016 Aug 31;370:41-48. doi: 10.1016/j.tox.2016.09.011. Epub 2016 Sep 22.

PMID:
27666003
50.

Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension.

Gabrielli L, Ocaranza MP, Sitges M, Kanacri A, Saavedra R, Sepulveda P, Sepulveda L, Rossel V, Zagolin M, Verdejo HE, Baraona F, Zalaquett R, Chiong M, Lavandero S, Castro PF.

Echocardiography. 2017 Jan;34(1):53-60. doi: 10.1111/echo.13401. Epub 2016 Oct 14.

PMID:
27739097

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