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Recent Adaptive Acquisition by African Rainforest Hunter-Gatherers of the Late Pleistocene Sickle-Cell Mutation Suggests Past Differences in Malaria Exposure.

Laval G, Peyrégne S, Zidane N, Harmant C, Renaud F, Patin E, Prugnolle F, Quintana-Murci L.

Am J Hum Genet. 2019 Mar 7;104(3):553-561. doi: 10.1016/j.ajhg.2019.02.007. Epub 2019 Feb 28.


Gene flow contributes to diversification of the major fungal pathogen Candida albicans.

Ropars J, Maufrais C, Diogo D, Marcet-Houben M, Perin A, Sertour N, Mosca K, Permal E, Laval G, Bouchier C, Ma L, Schwartz K, Voelz K, May RC, Poulain J, Battail C, Wincker P, Borman AM, Chowdhary A, Fan S, Kim SH, Le Pape P, Romeo O, Shin JH, Gabaldon T, Sherlock G, Bougnoux ME, d'Enfert C.

Nat Commun. 2018 Jun 8;9(1):2253. doi: 10.1038/s41467-018-04787-4.


Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation.

Manry J, Nédélec Y, Fava VM, Cobat A, Orlova M, Thuc NV, Thai VH, Laval G, Barreiro LB, Schurr E.

PLoS Genet. 2017 Aug 9;13(8):e1006952. doi: 10.1371/journal.pgen.1006952. eCollection 2017 Aug.


Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America.

Patin E, Lopez M, Grollemund R, Verdu P, Harmant C, Quach H, Laval G, Perry GH, Barreiro LB, Froment A, Heyer E, Massougbodji A, Fortes-Lima C, Migot-Nabias F, Bellis G, Dugoujon JM, Pereira JB, Fernandes V, Pereira L, Van der Veen L, Mouguiama-Daouda P, Bustamante CD, Hombert JM, Quintana-Murci L.

Science. 2017 May 5;356(6337):543-546. doi: 10.1126/science.aal1988.


Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations.

Quach H, Rotival M, Pothlichet J, Loh YE, Dannemann M, Zidane N, Laval G, Patin E, Harmant C, Lopez M, Deschamps M, Naffakh N, Duffy D, Coen A, Leroux-Roels G, Clément F, Boland A, Deleuze JF, Kelso J, Albert ML, Quintana-Murci L.

Cell. 2016 Oct 20;167(3):643-656.e17. doi: 10.1016/j.cell.2016.09.024.


Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.

Deschamps M, Laval G, Fagny M, Itan Y, Abel L, Casanova JL, Patin E, Quintana-Murci L.

Am J Hum Genet. 2016 Jan 7;98(1):5-21. doi: 10.1016/j.ajhg.2015.11.014.


Detecting Genomic Signatures of Natural Selection with Principal Component Analysis: Application to the 1000 Genomes Data.

Duforet-Frebourg N, Luu K, Laval G, Bazin E, Blum MG.

Mol Biol Evol. 2016 Apr;33(4):1082-93. doi: 10.1093/molbev/msv334. Epub 2015 Dec 29.


Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome.

Day FR, Hinds DA, Tung JY, Stolk L, Styrkarsdottir U, Saxena R, Bjonnes A, Broer L, Dunger DB, Halldorsson BV, Lawlor DA, Laval G, Mathieson I, McCardle WL, Louwers Y, Meun C, Ring S, Scott RA, Sulem P, Uitterlinden AG, Wareham NJ, Thorsteinsdottir U, Welt C, Stefansson K, Laven JSE, Ong KK, Perry JRB.

Nat Commun. 2015 Sep 29;6:8464. doi: 10.1038/ncomms9464.


Recommendations for bowel obstruction with peritoneal carcinomatosis.

Laval G, Marcelin-Benazech B, Guirimand F, Chauvenet L, Copel L, Durand A, Francois E, Gabolde M, Mariani P, Rebischung C, Servois V, Terrebonne E, Arvieux C; French Society for Palliative Care; French Society for Digestive Surgery; French Society for Gastroenterology; French Association for Supportive Care in Oncology; French Society for Digestive Cancer.

J Pain Symptom Manage. 2014 Jul;48(1):75-91. doi: 10.1016/j.jpainsymman.2013.08.022. Epub 2014 May 4. Review.


Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets.

Fagny M, Patin E, Enard D, Barreiro LB, Quintana-Murci L, Laval G.

Mol Biol Evol. 2014 Jul;31(7):1850-68. doi: 10.1093/molbev/msu118. Epub 2014 Apr 1.


Heterogeneous pattern of selective pressure for PRRT2 in human populations, but no association with autism spectrum disorders.

Huguet G, Nava C, Lemière N, Patin E, Laval G, Ey E, Brice A, Leboyer M, Szepetowski P, Gillberg C, Depienne C, Delorme R, Bourgeron T.

PLoS One. 2014 Mar 3;9(3):e88600. doi: 10.1371/journal.pone.0088600. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e100607.


The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists.

Patin E, Siddle KJ, Laval G, Quach H, Harmant C, Becker N, Froment A, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Dominy NJ, Perry GH, Barreiro LB, Verdu P, Heyer E, Quintana-Murci L.

Nat Commun. 2014;5:3163. doi: 10.1038/ncomms4163.


A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection.

Siddle KJ, Deschamps M, Tailleux L, Nédélec Y, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Quintana-Murci L.

Genome Res. 2014 May;24(5):850-9. doi: 10.1101/gr.161471.113. Epub 2014 Jan 30.


Human genetic data reveal contrasting demographic patterns between sedentary and nomadic populations that predate the emergence of farming.

Aimé C, Laval G, Patin E, Verdu P, Ségurel L, Chaix R, Hegay T, Quintana-Murci L, Heyer E, Austerlitz F.

Mol Biol Evol. 2013 Dec;30(12):2629-44. doi: 10.1093/molbev/mst156. Epub 2013 Sep 24.


[Use of midazolam in hospitalized patients: analysis of medical practice].

Giroud M, Sellier E, Laval G.

Bull Cancer. 2013 Sep;100(9):811-7. doi: 10.1684/bdc.2013.1795. French.


Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.

Quach H, Wilson D, Laval G, Patin E, Manry J, Guibert J, Barreiro LB, Nerrienet E, Verschoor E, Gessain A, Przeworski M, Quintana-Murci L.

Hum Mol Genet. 2013 Dec 1;22(23):4829-40. doi: 10.1093/hmg/ddt335. Epub 2013 Jul 12.


Somatostatin analogs for malignant bowel obstruction resulting from peritoneal carcinomatosis.

Zelek L, Laval G, Asselain B.

J Clin Oncol. 2013 Jul 1;31(19):2519-20. doi: 10.1200/JCO.2012.48.4634. Epub 2013 Jun 3. No abstract available.


Similarity in recombination rate and linkage disequilibrium at CYP2C and CYP2D cytochrome P450 gene regions among Europeans indicates signs of selection and no advantage of using tagSNPs in population isolates.

Pimenoff VN, Laval G, Comas D, Palo JU, Gut I, Cann H, Excoffier L, Sajantila A.

Pharmacogenet Genomics. 2012 Dec;22(12):846-57. doi: 10.1097/FPC.0b013e32835a3a6d.


The evolutionary landscape of cytosolic microbial sensors in humans.

Vasseur E, Boniotto M, Patin E, Laval G, Quach H, Manry J, Crouau-Roy B, Quintana-Murci L.

Am J Hum Genet. 2012 Jul 13;91(1):27-37. doi: 10.1016/j.ajhg.2012.05.008. Epub 2012 Jun 28.


SALTO: a randomized, multicenter study assessing octreotide LAR in inoperable bowel obstruction.

Laval G, Rousselot H, Toussaint-Martel S, Mayer F, Terrebonne E, François E, Brixi H, Nguyen T, Bourdeix I, Bisot-Locard S, Zelek L; SALTO Study Group.

Bull Cancer. 2012 Feb 1;99(2):E1-9. doi: 10.1684/bdc.2011.1535.


Evolutionary genetic dissection of human interferons.

Manry J, Laval G, Patin E, Fornarino S, Itan Y, Fumagalli M, Sironi M, Tichit M, Bouchier C, Casanova JL, Barreiro LB, Quintana-Murci L.

J Exp Med. 2011 Dec 19;208(13):2747-59. doi: 10.1084/jem.20111680. Epub 2011 Dec 12.


[Effectiveness of a supportive care form for family physicians].

Fouquereau J, Laval G, Labarère J.

Bull Cancer. 2011 Oct;98(10):1165-72. doi: 10.1684/bdc.2011.1451. French.


The selective footprints of viral pressures at the human RIG-I-like receptor family.

Vasseur E, Patin E, Laval G, Pajon S, Fornarino S, Crouau-Roy B, Quintana-Murci L.

Hum Mol Genet. 2011 Nov 15;20(22):4462-74. doi: 10.1093/hmg/ddr377. Epub 2011 Aug 24.


Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.

Fornarino S, Laval G, Barreiro LB, Manry J, Vasseur E, Quintana-Murci L.

Mol Biol Evol. 2011 Nov;28(11):3087-97. doi: 10.1093/molbev/msr137. Epub 2011 Jun 9.


Evolutionary genetics evidence of an essential, nonredundant role of the IFN-γ pathway in protective immunity.

Manry J, Laval G, Patin E, Fornarino S, Tichit M, Bouchier C, Barreiro LB, Quintana-Murci L.

Hum Mutat. 2011 Jun;32(6):633-42. doi: 10.1002/humu.21484. Epub 2011 Mar 29.


Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions.

Laval G, Patin E, Barreiro LB, Quintana-Murci L.

PLoS One. 2010 Apr 22;5(4):e10284. doi: 10.1371/journal.pone.0010284.


[Pain management for adult patients relative to palliative care].

Béziaud N, Laval G, Rostaing S.

Rev Prat. 2009 Jun 20;59(6):799-808. French.


[Symptomatic treatments (pain management excluded) for adults in palliative care].

Laval G, Béziaud N, Villard ML.

Rev Prat. 2009 Jun 20;59(6):785-97. French.


[April 22nd, 2005 law of patients' rights and end of life: not a well-known law due to poor communication].

de Bazelaire C, Laval G, Aubry R.

Rev Prat. 2009 Jun 20;59(6):768-73. French.


Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.

Barreiro LB, Ben-Ali M, Quach H, Laval G, Patin E, Pickrell JK, Bouchier C, Tichit M, Neyrolles O, Gicquel B, Kidd JR, Kidd KK, Alcaïs A, Ragimbeau J, Pellegrini S, Abel L, Casanova JL, Quintana-Murci L.

PLoS Genet. 2009 Jul;5(7):e1000562. doi: 10.1371/journal.pgen.1000562. Epub 2009 Jul 17.


Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set.

Patin E, Laval G, Barreiro LB, Salas A, Semino O, Santachiara-Benerecetti S, Kidd KK, Kidd JR, Van der Veen L, Hombert JM, Gessain A, Froment A, Bahuchet S, Heyer E, Quintana-Murci L.

PLoS Genet. 2009 Apr;5(4):e1000448. doi: 10.1371/journal.pgen.1000448. Epub 2009 Apr 10.


Signatures of purifying and local positive selection in human miRNAs.

Quach H, Barreiro LB, Laval G, Zidane N, Patin E, Kidd KK, Kidd JR, Bouchier C, Veuille M, Antoniewski C, Quintana-Murci L.

Am J Hum Genet. 2009 Mar;84(3):316-27. doi: 10.1016/j.ajhg.2009.01.022. Epub 2009 Feb 19.


[Bacterial infections in palliative care: antibiotics and therapeutic limitations].

Béziaud N, Pavese P, Barnoud D, Laval G.

Presse Med. 2009 Jun;38(6):935-44. doi: 10.1016/j.lpm.2008.10.013. Epub 2008 Dec 30. Review. French.


[Supplemental oxygen for dyspnea for cancer patients in end-of-life palliative care].

Béziaud N, Diab S, Laval G.

Presse Med. 2009 May;38(5):726-33. doi: 10.1016/j.lpm.2008.08.009. Epub 2008 Dec 12. French.


[Methylphenidate in palliative care in cancer patient: a double-blind randomised trial versus placebo].

Laval G, Paris A.

Bull Cancer. 2008 Feb;95(2):241-6. doi: 10.1684/bdc.2008.0581. French.


Natural selection has driven population differentiation in modern humans.

Barreiro LB, Laval G, Quach H, Patin E, Quintana-Murci L.

Nat Genet. 2008 Mar;40(3):340-5. doi: 10.1038/ng.78. Epub 2008 Feb 3.


Dispersion and transport of energetic particles due to the interaction of intense laser pulses with overdense plasmas.

Adam JC, Héron A, Laval G.

Phys Rev Lett. 2006 Nov 17;97(20):205006. Epub 2006 Nov 17.


Protocol for the treatment of malignant inoperable bowel obstruction: a prospective study of 80 cases at Grenoble University Hospital Center.

Laval G, Arvieux C, Stefani L, Villard ML, Mestrallet JP, Cardin N.

J Pain Symptom Manage. 2006 Jun;31(6):502-12.


Genetic diversity in European pigs utilizing amplified fragment length polymorphism markers.

SanCristobal M, Chevalet C, Peleman J, Heuven H, Brugmans B, van Schriek M, Joosten R, Rattink AP, Harlizius B, Groenen MA, Amigues Y, Boscher MY, Russell G, Law A, Davoli R, Russo V, Dèsautés C, Alderson L, Fimland E, Bagga M, Delgado JV, Vega-Pla JL, Martinez AM, Ramos M, Glodek P, Meyer JN, Gandini G, Matassino D, Siggens K, Laval G, Archibald A, Milan D, Hammond K, Cardellino R, Haley C, Plastow G.

Anim Genet. 2006 Jun;37(3):232-8.


Genetic diversity within and between European pig breeds using microsatellite markers.

SanCristobal M, Chevalet C, Haley CS, Joosten R, Rattink AP, Harlizius B, Groenen MA, Amigues Y, Boscher MY, Russell G, Law A, Davoli R, Russo V, Désautés C, Alderson L, Fimland E, Bagga M, Delgado JV, Vega-Pla JL, Martinez AM, Ramos M, Glodek P, Meyer JN, Gandini GC, Matassino D, Plastow GS, Siggens KW, Laval G, Archibald AL, Milan D, Hammond K, Cardellino R.

Anim Genet. 2006 Jun;37(3):189-98.


[Treatment of malignant intestinal obstruction. A prospective study over 80 cases].

Arvieux C, Laval G, Mestrallet JP, Stefani L, Villard ML, Cardin N.

Ann Chir. 2005 Sep;130(8):470-6. French.


Arlequin (version 3.0): an integrated software package for population genetics data analysis.

Excoffier L, Laval G, Schneider S.

Evol Bioinform Online. 2007 Feb 23;1:47-50.


Gametic phase estimation over large genomic regions using an adaptive window approach.

Excoffier L, Laval G, Balding D.

Hum Genomics. 2003 Nov;1(1):7-19.


CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.

Ganapathipillai S, Laval G, Hoffmann IS, Castejon AM, Nicod J, Dick B, Frey FJ, Frey BM, Cubeddu LX, Ferrari P.

J Clin Endocrinol Metab. 2005 Feb;90(2):1220-5. Epub 2004 Oct 26.


Within-herd spread of contagious bovine pleuropneumonia in Ethiopian highlands.

Lesnoff M, Laval G, Bonnet P, Abdicho S, Workalemahu A, Kifle D, Peyraud A, Lancelot R, Thiaucourt F.

Prev Vet Med. 2004 Jun 10;64(1):27-40.


A mathematical model of the effects of chronic carriers on the within-herd spread of contagious bovine pleuropneumonia in an African mixed crop-livestock system.

Lesnoff M, Laval G, Bonnet P, Chalvet-Monfray K, Lancelot R, Thiaucourt F.

Prev Vet Med. 2004 Feb 26;62(2):101-17.


Genetic diversity of eleven European pig breeds.

Laval G, Iannuccelli N, Legault C, Milan D, Groenen MA, Giuffra E, Andersson L, Nissen PH, Jørgensen CB, Beeckmann P, Geldermann H, Foulley JL, Chevalet C, Ollivier L.

Genet Sel Evol. 2000 Mar-Apr;32(2):187-203.


Contagious bovine pleuropneumonia vaccines, historic highlights, present situation and hopes.

Thiaucourt F, Dedieu L, Maillard JC, Bonnet P, Lesnoff M, Laval G, Provost A.

Dev Biol (Basel). 2003;114:147-60. Review.


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