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Hyperbaric oxygenation improves redox control and reduces mortality in the acute phase of myocardial infarction in a rat model.

Oliveira MS, Tanaka LY, Antonio EL, Brandizzi LI, Serra AJ, Dos Santos L, Krieger JE, Laurindo FRM, Tucci PJF.

Mol Med Rep. 2020 Mar;21(3):1431-1438. doi: 10.3892/mmr.2020.10968. Epub 2020 Jan 29.


Peri/Epicellular Thiol Oxidoreductases as Mediators of Extracellular Redox Signaling.

Tanaka LY, Oliveira PVS, Laurindo FRM.

Antioxid Redox Signal. 2020 Feb 4. doi: 10.1089/ars.2019.8012. [Epub ahead of print]


Urate hydroperoxide oxidizes endothelial cell surface protein disulfide isomerase-A1 and impairs adherence.

Mineiro MF, Patricio ES, Peixoto ÁS, Araujo TLS, da Silva RP, Moretti AIS, Lima FS, Laurindo FRM, Meotti FC.

Biochim Biophys Acta Gen Subj. 2020 Mar;1864(3):129481. doi: 10.1016/j.bbagen.2019.129481. Epub 2019 Nov 14.


Impaired vascular smooth muscle cell force-generating capacity and phenotypic deregulation in Marfan Syndrome mice.

Nolasco P, Fernandes CG, Ribeiro-Silva JC, Oliveira PVS, Sacrini M, de Brito IV, De Bessa TC, Pereira LV, Tanaka LY, Alencar A, Laurindo FRM.

Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165587. doi: 10.1016/j.bbadis.2019.165587. Epub 2019 Oct 31.


A Secreted Phospholipase A2 Induces Formation of Smooth Muscle Foam Cells Which Transdifferentiate to Macrophage-Like State.

Giannotti KC, Weinert S, Viana MN, Leiguez E, Araujo TLS, Laurindo FRM, Lomonte B, Braun-Dullaeus R, Teixeira C.

Molecules. 2019 Sep 6;24(18). pii: E3244. doi: 10.3390/molecules24183244.


Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis.

Kowaltowski AJ, Menezes-Filho SL, Assali EA, Gonçalves IG, Cabral-Costa JV, Abreu P, Miller N, Nolasco P, Laurindo FRM, Bruni-Cardoso A, Shirihai OS.

FASEB J. 2019 Dec;33(12):13176-13188. doi: 10.1096/fj.201901136R. Epub 2019 Sep 5.


Unfolded Protein Response: Cause or Consequence of Lipid and Lipoprotein Metabolism Disturbances?

Pinto BAS, França LM, Laurindo FRM, Paes AMA.

Adv Exp Med Biol. 2019;1127:67-82. doi: 10.1007/978-3-030-11488-6_5. Review.


Integrated proteomics and metabolomics analysis reveals differential lipid metabolism in human umbilical vein endothelial cells under high and low shear stress.

Venturini G, Malagrino PA, Padilha K, Tanaka LY, Laurindo FR, Dariolli R, Carvalho VM, Cardozo KHM, Krieger JE, Pereira ADC.

Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C326-C338. doi: 10.1152/ajpcell.00128.2018. Epub 2019 May 8.


Syzygium cumini Leaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats.

França LM, Coêlho CFF, Freitas LNC, Souza ILS, Chagas VT, Debbas V, de Lima TM, de Souza HP, Laurindo FRM, Paes AMA.

Oxid Med Cell Longev. 2019 Mar 21;2019:9417498. doi: 10.1155/2019/9417498. eCollection 2019.


Chemotherapy acutely impairs neurovascular and hemodynamic responses in women with breast cancer.

Sales ARK, Negrão MV, Testa L, Ferreira-Santos L, Groehs RVR, Carvalho B, Toschi-Dias E, Rocha NG, Laurindo FRM, Debbas V, Rondon MUPB, Mano MS, Hajjar LA, Hoff PMG, Filho RK, Negrão CE.

Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(7):H1-H12. doi: 10.1152/ajpheart.00756.2018. Epub 2019 Apr 19.


Protein disulfide isomerase plasma levels in healthy humans reveal proteomic signatures involved in contrasting endothelial phenotypes.

Oliveira PVS, Garcia-Rosa S, Sachetto ATA, Moretti AIS, Debbas V, De Bessa TC, Silva NT, Pereira ADC, Martins-de-Souza D, Santoro ML, Laurindo FRM.

Redox Biol. 2019 Apr;22:101142. doi: 10.1016/j.redox.2019.101142. Epub 2019 Feb 19.


Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas.

De Bessa TC, Pagano A, Moretti AIS, Oliveira PVS, Mendonça SA, Kovacic H, Laurindo FRM.

Cell Death Dis. 2019 Feb 13;10(2):143. doi: 10.1038/s41419-019-1402-y.


Protein Disulfide Isomerase Modulates the Activation of Thyroid Hormone Receptors.

Campos JLO, Doratioto TR, Videira NB, Ribeiro Filho HV, Batista FAH, Fattori J, Indolfo NC, Nakahira M, Bajgelman MC, Cvoro A, Laurindo FRM, Webb P, Figueira ACM.

Front Endocrinol (Lausanne). 2019 Jan 8;9:784. doi: 10.3389/fendo.2018.00784. eCollection 2018.


Cell-surface HSP70 associates with thrombomodulin in endothelial cells.

Araujo TLS, Venturini G, Moretti AIS, Tanaka LY, Pereira AC, Laurindo FRM.

Cell Stress Chaperones. 2019 Jan;24(1):273-282. doi: 10.1007/s12192-018-00964-y. Epub 2019 Jan 15.


Red wine consumption, coronary calcification, and long-term clinical evolution.

da Luz PL, Favarato D, Moriguchi EH, de Carli W, Bruscato N, Mochiduky RI, Schwartzman P, Rochitte CE, Laurindo FR.

Braz J Med Biol Res. 2018 Nov 29;51(12):e7703. doi: 10.1590/1414-431X20187703.


Peri/epicellular protein disulfide isomerase-A1 acts as an upstream organizer of cytoskeletal mechanoadaptation in vascular smooth muscle cells.

Tanaka LY, Araujo TLS, Rodriguez AI, Ferraz MS, Pelegati VB, Morais MCC, Santos AMD, Cesar CL, Ramos AF, Alencar AM, Laurindo FRM.

Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H566-H579. doi: 10.1152/ajpheart.00379.2018. Epub 2018 Nov 30.


Internationalization is Necessary, But is it Enough?

Oliveira GMM, Lorenzo A, Colombo FMC, Sternick EB, Brandão AA, Kaiser SE, Quadros AS, Kalil RAK, Scaramello CBV, Laurindo FRM, Hajjar LA.

Arq Bras Cardiol. 2018 Oct;111(4):626-628. doi: 10.5935/abc.20180212. English, Portuguese. No abstract available.


Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice.

Flister KFT, Pinto BAS, França LM, Coêlho CFF, Dos Santos PC, Vale CC, Kajihara D, Debbas V, Laurindo FRM, Paes AMA.

J Nutr Biochem. 2018 Dec;62:155-166. doi: 10.1016/j.jnutbio.2018.09.007. Epub 2018 Sep 19.


Implications of plasma thiol redox in disease.

Oliveira PVS, Laurindo FRM.

Clin Sci (Lond). 2018 Jun 21;132(12):1257-1280. doi: 10.1042/CS20180157. Print 2018 Jun 29. Review.


Leflunomide counter akt s cardiac hypertrophy.

Pescatore LA, Laurindo FRM.

Clin Sci (Lond). 2018 May 25;132(10):1069-1073. doi: 10.1042/CS20180228. Print 2018 May 31.


Effect of the Antioxidant Lipoic Acid in Aortic Phenotype in a Marfan Syndrome Mouse Model.

Guido MC, Debbas V, Salemi VM, Tavares ER, Meirelles T, Araujo TLS, Nolasco P, Ferreira-Filho JCA, Takimura CK, Pereira LV, Laurindo FR.

Oxid Med Cell Longev. 2018 Mar 25;2018:3967213. doi: 10.1155/2018/3967213. eCollection 2018.


Cardioprotective Effects of Melatonin in Reperfusion Injury.

Laurindo FRM.

Arq Bras Cardiol. 2018 Jan;110(1):5-6. doi: 10.5935/abc.20180011. English, Portuguese. No abstract available.


Influence of apocynin on cardiac remodeling in rats with streptozotocin-induced diabetes mellitus.

Gimenes R, Gimenes C, Rosa CM, Xavier NP, Campos DHS, Fernandes AAH, Cezar MDM, Guirado GN, Pagan LU, Chaer ID, Fernandes DC, Laurindo FR, Cicogna AC, Okoshi MP, Okoshi K.

Cardiovasc Diabetol. 2018 Jan 17;17(1):15. doi: 10.1186/s12933-017-0657-9.


The Eye of the Needle: Redox Mechanisms of Acupuncture Effects in Hypertension.

Tanaka LY, Laurindo FRM.

Hypertension. 2018 Feb;71(2):224-226. doi: 10.1161/HYPERTENSIONAHA.117.09821. Epub 2017 Dec 11. No abstract available.


Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families.

Moretti AIS, Pavanelli JC, Nolasco P, Leisegang MS, Tanaka LY, Fernandes CG, Wosniak J Jr, Kajihara D, Dias MH, Fernandes DC, Jo H, Tran NV, Ebersberger I, Brandes RP, Bonatto D, Laurindo FRM.

Sci Rep. 2017 Dec 8;7(1):17262. doi: 10.1038/s41598-017-16947-5.


Peroxynitrite preferentially oxidizes the dithiol redox motifs of protein-disulfide isomerase.

Peixoto ÁS, Geyer RR, Iqbal A, Truzzi DR, Soares Moretti AI, Laurindo FRM, Augusto O.

J Biol Chem. 2018 Jan 26;293(4):1450-1465. doi: 10.1074/jbc.M117.807016. Epub 2017 Nov 30.


Golgi-independent routes support protein disulfide isomerase externalization in vascular smooth muscle cells.

Araujo TLS, Fernandes CG, Laurindo FRM.

Redox Biol. 2017 Aug;12:1004-1010. doi: 10.1016/j.redox.2017.04.034. Epub 2017 May 3.


Induction of Oxidants Distinguishes Susceptibility of Prostate Carcinoma Cell Lines to p53 Gene Transfer Mediated by an Improved Adenoviral Vector.

Tamura RE, Hunger A, Fernandes DC, Laurindo FR, Costanzi-Strauss E, Strauss BE.

Hum Gene Ther. 2017 Aug;28(8):639-653. doi: 10.1089/hum.2016.139. Epub 2017 Feb 6.


Measurement of Superoxide Production and NADPH Oxidase Activity by HPLC Analysis of Dihydroethidium Oxidation.

Fernandes DC, Gonçalves RC, Laurindo FR.

Methods Mol Biol. 2017;1527:233-249. doi: 10.1007/978-1-4939-6625-7_19.


Vascular remodeling: A redox-modulated mechanism of vessel caliber regulation.

Tanaka LY, Laurindo FRM.

Free Radic Biol Med. 2017 Aug;109:11-21. doi: 10.1016/j.freeradbiomed.2017.01.025. Epub 2017 Jan 18. Review.


Novel antiplatelet role for a protein disulfide isomerase-targeted peptide: evidence of covalent binding to the C-terminal CGHC redox motif.

Sousa HR, Gaspar RS, Sena EM, da Silva SA, Fontelles JL, AraUjo TL, Mastrogiovanni M, Fries DM, Azevedo-Santos AP, Laurindo FR, Trostchansky A, Paes AM.

J Thromb Haemost. 2017 Apr;15(4):774-784. doi: 10.1111/jth.13633. Epub 2017 Feb 28.


Protein disulfide isomerase externalization in endothelial cells follows classical and unconventional routes.

Araujo TLS, Zeidler JD, Oliveira PVS, Dias MH, Armelin HA, Laurindo FRM.

Free Radic Biol Med. 2017 Feb;103:199-208. doi: 10.1016/j.freeradbiomed.2016.12.021. Epub 2016 Dec 27.


Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state.

Trevelin SC, Dos Santos CX, Ferreira RG, de Sá Lima L, Silva RL, Scavone C, Curi R, Alves-Filho JC, Cunha TM, Roxo-Júnior P, Cervi MC, Laurindo FR, Hothersall JS, Cobb AM, Zhang M, Ivetic A, Shah AM, Lopes LR, Cunha FQ.

Sci Rep. 2016 Oct 4;6:34581. doi: 10.1038/srep34581.


Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus.

Rosa CM, Gimenes R, Campos DH, Guirado GN, Gimenes C, Fernandes AA, Cicogna AC, Queiroz RM, Falcão-Pires I, Miranda-Silva D, Rodrigues P, Laurindo FR, Fernandes DC, Correa CR, Okoshi MP, Okoshi K.

Cardiovasc Diabetol. 2016 Sep 1;15(1):126. doi: 10.1186/s12933-016-0442-1.


Modulation of MAPK and NF-954;B Signaling Pathways by Antioxidant Therapy in Skeletal Muscle of Heart Failure Rats.

Martinez PF, Bonomo C, Guizoni DM, Junior SA, Damatto RL, Cezar MD, Lima AR, Pagan LU, Seiva FR, Bueno RT, Fernandes DC, Laurindo FR, Zornoff LA, Okoshi K, Okoshi MP.

Cell Physiol Biochem. 2016;39(1):371-84. doi: 10.1159/000445631. Epub 2016 Jun 29.


Early and sustained exposure to high-sucrose diet triggers hippocampal ER stress in young rats.

Pinto BA, Melo TM, Flister KF, França LM, Kajihara D, Tanaka LY, Laurindo FR, Paes AM.

Metab Brain Dis. 2016 Aug;31(4):917-27. doi: 10.1007/s11011-016-9830-1. Epub 2016 May 7.


Amino acids trigger down-regulation of superoxide via TORC pathway in the midgut of Rhodnius prolixus.

Gandara AC, Oliveira JH, Nunes RD, Goncalves RL, Dias FA, Hecht F, Fernandes DC, Genta FA, Laurindo FR, Oliveira MF, Oliveira PL.

Biosci Rep. 2016 Apr 15;36(2). pii: e00321. doi: 10.1042/BSR20160061. Print 2016.


Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure.

Gomes MJ, Martinez PF, Campos DH, Pagan LU, Bonomo C, Lima AR, Damatto RL, Cezar MD, Damatto FC, Rosa CM, Garcia CM, Reyes DR, Fernandes AA, Fernandes DC, Laurindo FR, Okoshi K, Okoshi MP.

Oxid Med Cell Longev. 2016;2016:8695716. doi: 10.1155/2016/8695716. Epub 2016 Jan 20.


Peri/Epicellular Protein Disulfide Isomerase Sustains Vascular Lumen Caliber Through an Anticonstrictive Remodeling Effect.

Tanaka LY, Araújo HA, Hironaka GK, Araujo TL, Takimura CK, Rodriguez AI, Casagrande AS, Gutierrez PS, Lemos-Neto PA, Laurindo FR.

Hypertension. 2016 Mar;67(3):613-22. doi: 10.1161/HYPERTENSIONAHA.115.06177. Epub 2016 Jan 18.


Fibrillin-1 mgΔ(lpn) Marfan syndrome mutation associates with preserved proteostasis and bypass of a protein disulfide isomerase-dependent quality checkpoint.

Meirelles T, Araujo TLS, Nolasco P, Moretti AIS, Guido MC, Debbas V, Pereira LV, Laurindo FR.

Int J Biochem Cell Biol. 2016 Feb;71:81-91. doi: 10.1016/j.biocel.2015.12.009. Epub 2015 Dec 21.


Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout.

Pagano PJ, Griendling KK, Miller FJ, Laurindo FR, Touyz RM.

Antioxid Redox Signal. 2015 Nov 20;23(15):1246-7. doi: 10.1089/ars.2015.6382. Epub 2015 Jul 14. No abstract available.


The flavo-oxidase QSOX1 supports vascular smooth muscle cell migration and proliferation: Evidence for a role in neointima growth.

Borges BE, Appel MH, Cofré AR, Prado ML, Steclan CA, Esnard F, Zanata SM, Laurindo FR, Nakao LS.

Biochim Biophys Acta. 2015 Jul;1852(7):1334-46. doi: 10.1016/j.bbadis.2015.03.002. Epub 2015 Mar 10.


Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms.

Chignalia AZ, Oliveira MA, Debbas V, Dull RO, Laurindo FR, Touyz RM, Carvalho MH, Fortes ZB, Tostes RC.

Clin Sci (Lond). 2015 Jul;129(1):39-48. doi: 10.1042/CS20140548.


Exercise improves endothelial function: a local analysis of production of nitric oxide and reactive oxygen species.

Tanaka LY, Bechara LR, dos Santos AM, Jordão CP, de Sousa LG, Bartholomeu T, Ventura LI, Laurindo FR, Ramires PR.

Nitric Oxide. 2015 Feb 15;45:7-14. doi: 10.1016/j.niox.2015.01.003. Epub 2015 Jan 22.


Influence of N- acetylcysteine on oxidative stress in slow-twitch soleus muscle of heart failure rats.

Martinez PF, Bonomo C, Guizoni DM, Junior SA, Damatto RL, Cezar MD, Lima AR, Pagan LU, Seiva FR, Fernandes DC, Laurindo FR, Novelli EL, Matsubara LS, Zornoff LA, Okoshi K, Okoshi MP.

Cell Physiol Biochem. 2015;35(1):148-59. doi: 10.1159/000369683. Epub 2015 Jan 2.


An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies.

Ceravolo GS, Montezano AC, Jordão MT, Akamine EH, Costa TJ, Takano AP, Fernandes DC, Barreto-Chaves ML, Laurindo FR, Tostes RC, Fortes ZB, Chopard RP, Touyz RM, Carvalho MH.

PLoS One. 2014 Nov 4;9(11):e111117. doi: 10.1371/journal.pone.0111117. eCollection 2014.


Methods of measuring protein disulfide isomerase activity: a critical overview.

Watanabe MM, Laurindo FR, Fernandes DC.

Front Chem. 2014 Sep 3;2:73. doi: 10.3389/fchem.2014.00073. eCollection 2014. Review.


Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence.

Luz PL, Coimbra S, Favarato D, Albuquerque C, Mochiduky RI, Rochitte CE, Hojaij E, Gonsalves CR, Laurindo FR.

Braz J Med Biol Res. 2014 Aug;47(8):697-705. Epub 2014 Jul 4.


Oxidation, inactivation and aggregation of protein disulfide isomerase promoted by the bicarbonate-dependent peroxidase activity of human superoxide dismutase.

Iqbal A, Paviani V, Moretti AI, Laurindo FR, Augusto O.

Arch Biochem Biophys. 2014 Sep 1;557:72-81. doi: 10.1016/ Epub 2014 Jun 20.


Redox modulation of FAK controls melanoma survival--role of NOX4.

Ribeiro-Pereira C, Moraes JA, Souza Mde J, Laurindo FR, Arruda MA, Barja-Fidalgo C.

PLoS One. 2014 Jun 9;9(6):e99481. doi: 10.1371/journal.pone.0099481. eCollection 2014.

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