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Items: 36

1.

Activation of the Constitutive Androstane Receptor by Monophthalates.

Laurenzana EM, Coslo DM, Vigilar MV, Roman AM, Omiecinski CJ.

Chem Res Toxicol. 2016 Oct 17;29(10):1651-1661. Epub 2016 Sep 13.

2.

Pharmacological effects of two anti-methamphetamine monoclonal antibodies. Supporting data for lead candidate selection for clinical development.

Laurenzana EM, Stevens MW, Frank JC, Hambuchen MD, Hendrickson HP, White SJ, Williams DK, Owens SM, Gentry WB.

Hum Vaccin Immunother. 2014;10(9):2638-47. doi: 10.4161/hv.29707. Epub 2014 Nov 1.

3.

Treatment with a monoclonal antibody against methamphetamine and amphetamine reduces maternal and fetal rat brain concentrations in late pregnancy.

White SJ, Hendrickson HP, Atchley WT, Laurenzana EM, Gentry WB, Williams DK, Owens SM.

Drug Metab Dispos. 2014 Aug;42(8):1285-91. doi: 10.1124/dmd.114.056879. Epub 2014 May 19.

4.

Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.

Chen T, Laurenzana EM, Coslo DM, Chen F, Omiecinski CJ.

Biochem J. 2014 Feb 15;458(1):95-107. doi: 10.1042/BJ20130685.

5.

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).

Laurenzana EM, Chen T, Kannuswamy M, Sell BE, Strom SC, Li Y, Omiecinski CJ.

Mol Pharmacol. 2012 Nov;82(5):918-28. doi: 10.1124/mol.112.080721. Epub 2012 Aug 15.

6.

Chronic anti-phencyclidine monoclonal antibody therapy decreases phencyclidine-induced in utero fetal mortality in pregnant rats.

Hubbard JJ, Laurenzana EM, Williams DK, Gentry WB, Owens SM.

Int Immunopharmacol. 2011 Dec;11(12):2181-7. doi: 10.1016/j.intimp.2011.09.016. Epub 2011 Oct 12.

7.

Multi-species analyses of direct activators of the constitutive androstane receptor.

Omiecinski CJ, Coslo DM, Chen T, Laurenzana EM, Peffer RC.

Toxicol Sci. 2011 Oct;123(2):550-62. doi: 10.1093/toxsci/kfr191. Epub 2011 Jul 21.

8.

Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor.

DeKeyser JG, Laurenzana EM, Peterson EC, Chen T, Omiecinski CJ.

Toxicol Sci. 2011 Apr;120(2):381-91. doi: 10.1093/toxsci/kfq394. Epub 2011 Jan 12.

9.

The fate and function of therapeutic antiaddiction monoclonal antibodies across the reproductive cycle of rats.

Hubbard JJ, Laurenzana EM, Williams DK, Gentry WB, Owens SM.

J Pharmacol Exp Ther. 2011 Feb;336(2):414-22. doi: 10.1124/jpet.110.175083. Epub 2010 Oct 20.

10.

Hepatocyte differentiation.

Olsavsky Goyak KM, Laurenzana EM, Omiecinski CJ.

Methods Mol Biol. 2010;640:115-38. doi: 10.1007/978-1-60761-688-7_6.

11.

Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling.

DiNatale BC, Murray IA, Schroeder JC, Flaveny CA, Lahoti TS, Laurenzana EM, Omiecinski CJ, Perdew GH.

Toxicol Sci. 2010 May;115(1):89-97. doi: 10.1093/toxsci/kfq024. Epub 2010 Jan 27.

12.

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.

Schroeder JC, Dinatale BC, Murray IA, Flaveny CA, Liu Q, Laurenzana EM, Lin JM, Strom SC, Omiecinski CJ, Amin S, Perdew GH.

Biochemistry. 2010 Jan 19;49(2):393-400. doi: 10.1021/bi901786x.

13.

Functional and biological determinants affecting the duration of action and efficacy of anti-(+)-methamphetamine monoclonal antibodies in rats.

Laurenzana EM, Hendrickson HP, Carpenter D, Peterson EC, Gentry WB, West M, Che Y, Carroll FI, Owens SM.

Vaccine. 2009 Nov 23;27(50):7011-20. doi: 10.1016/j.vaccine.2009.09.072. Epub 2009 Oct 1.

14.

Vulnerability to (+)-methamphetamine effects and the relationship to drug disposition in pregnant rats during chronic infusion.

White SJ, Laurenzana EM, Gentry WB, Hendrickson HP, Williams DK, Ward KW, Owens SM.

Toxicol Sci. 2009 Sep;111(1):27-36. doi: 10.1093/toxsci/kfp127. Epub 2009 Jun 10.

15.

Development and preclinical testing of a high-affinity single-chain antibody against (+)-methamphetamine.

Peterson EC, Laurenzana EM, Atchley WT, Hendrickson HP, Owens SM.

J Pharmacol Exp Ther. 2008 Apr;325(1):124-33. doi: 10.1124/jpet.107.134395. Epub 2008 Jan 11.

16.

Engineering and characterization of a mouse/human chimeric anti-phencyclidine monoclonal antibody.

Lacy HM, Gunnell MG, Laurenzana EM, Owens SM.

Int Immunopharmacol. 2008 Jan;8(1):1-11. Epub 2007 Oct 23.

17.

Sex differences in (+)-amphetamine- and (+)-methamphetamine-induced behavioral response in male and female Sprague-Dawley rats.

Milesi-Hallé A, McMillan DE, Laurenzana EM, Byrnes-Blake KA, Owens SM.

Pharmacol Biochem Behav. 2007 Jan;86(1):140-9. Epub 2007 Jan 9.

18.

Safety and efficiency of an anti-(+)-methamphetamine monoclonal antibody in the protection against cardiovascular and central nervous system effects of (+)-methamphetamine in rats.

Gentry WB, Laurenzana EM, Williams DK, West JR, Berg RJ, Terlea T, Owens SM.

Int Immunopharmacol. 2006 Jun;6(6):968-77. Epub 2006 Feb 9.

PMID:
16644483
19.

Anti-phencyclidine monoclonal antibody binding capacity is not the only determinant of effectiveness, disproving the concept that antibody capacity is easily surmounted.

Pitas G, Laurenzana EM, Williams DK, Owens SM, Gentry WB.

Drug Metab Dispos. 2006 Jun;34(6):906-12. Epub 2006 Feb 28.

PMID:
16507651
20.

Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats.

Byrnes-Blake KA, Laurenzana EM, Landes RD, Gentry WB, Owens SM.

Eur J Pharmacol. 2005 Oct 3;521(1-3):86-94. Epub 2005 Sep 21.

PMID:
16182279
21.

Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats.

Milesi-Hallé A, Hendrickson HP, Laurenzana EM, Gentry WB, Owens SM.

Toxicol Appl Pharmacol. 2005 Dec 15;209(3):203-13.

PMID:
15916788
22.

(+)-Methamphetamine-induced spontaneous behavior in rats depends on route of (+)METH administration.

Gentry WB, Ghafoor AU, Wessinger WD, Laurenzana EM, Hendrickson HP, Owens SM.

Pharmacol Biochem Behav. 2004 Dec;79(4):751-60.

PMID:
15582684
23.

Development of a liquid chromatography-tandem mass spectrometric method for the determination of methamphetamine and amphetamine using small volumes of rat serum.

Hendrickson HP, Milesi-Hallé A, Laurenzana EM, Owens SM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jul 5;806(2):81-7.

PMID:
15171915
24.

Use of anti-(+)-methamphetamine monoclonal antibody to significantly alter (+)-methamphetamine and (+)-amphetamine disposition in rats.

Laurenzana EM, Byrnes-Blake KA, Milesi-Hallé A, Gentry WB, Williams DK, Owens SM.

Drug Metab Dispos. 2003 Nov;31(11):1320-6.

PMID:
14570763
25.

Treatment of adverse effects of excessive phencyclidine exposure in rats with a minimal dose of monoclonal antibody.

Laurenzana EM, Gunnell MG, Gentry WB, Owens SM.

J Pharmacol Exp Ther. 2003 Sep;306(3):1092-8. Epub 2003 Jun 26.

PMID:
12829731
26.

Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats.

Byrnes-Blake KA, Laurenzana EM, Carroll FI, Abraham P, Gentry WB, Landes RD, Owens SM.

Eur J Pharmacol. 2003 Feb 14;461(2-3):119-28.

PMID:
12586207
27.

A single dose of monoclonal anti-phencyclidine IgG offers long-term reductions in phencyclidine behavioral effects in rats.

Hardin JS, Wessinger WD, Wenger GR, Proksch JW, Laurenzana EM, Owens SM.

J Pharmacol Exp Ther. 2002 Jul;302(1):119-26.

PMID:
12065708
28.

Effect of nonylphenol on serum testosterone levels and testicular steroidogenic enzyme activity in neonatal, pubertal, and adult rats.

Laurenzana EM, Balasubramanian G, Weis C, Blaydes B, Newbold RR, Delclos KB.

Chem Biol Interact. 2002 Jan 22;139(1):23-41.

PMID:
11803027
29.
30.

Post-transcriptional regulation of human microsomal epoxide hydrolase.

Laurenzana EM, Hassett C, Omiecinski CJ.

Pharmacogenetics. 1998 Apr;8(2):157-67.

PMID:
10022753
31.

Effects of chemical inducers on human microsomal epoxide hydrolase in primary hepatocyte cultures.

Hassett C, Laurenzana EM, Sidhu JS, Omiecinski CJ.

Biochem Pharmacol. 1998 Apr 1;55(7):1059-69.

PMID:
9605429
32.

Brain microsomal metabolism of phencyclidine in male and female rats.

Laurenzana EM, Owens SM.

Brain Res. 1997 May 9;756(1-2):256-65.

PMID:
9187340
33.

Metabolism of phencyclidine by human liver microsomes.

Laurenzana EM, Owens SM.

Drug Metab Dispos. 1997 May;25(5):557-63.

PMID:
9152594
34.

Human hepatic microsomal epoxide hydrolase: comparative analysis of polymorphic expression.

Hassett C, Lin J, Carty CL, Laurenzana EM, Omiecinski CJ.

Arch Biochem Biophys. 1997 Jan 15;337(2):275-83.

PMID:
9016823
35.

Antipeptide antibodies targeted against specific regions of rat CYP2D1 and human CYP2D6.

Laurenzana EM, Sorrels SL, Owens SM.

Drug Metab Dispos. 1995 Feb;23(2):271-8.

PMID:
7736924
36.

Dose- and time-dependent changes in phencyclidine metabolite covalent binding in rats and the possible role of CYP2D1.

Owens SM, Gunnell M, Laurenzana EM, Valentine JL.

J Pharmacol Exp Ther. 1993 Jun;265(3):1261-6.

PMID:
8510006

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