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The Role of PTEN in Innate and Adaptive Immunity.

Taylor H, Laurence ADJ, Uhlig HH.

Cold Spring Harb Perspect Med. 2019 Sep 9. pii: a036996. doi: 10.1101/cshperspect.a036996. [Epub ahead of print]


Forensic palynology and the search for geolocation: Factors for analysis and the Baby Doe case.

Laurence AR, Bryant VM.

Forensic Sci Int. 2019 Jul 27;302:109903. doi: 10.1016/j.forsciint.2019.109903. [Epub ahead of print]


TFEB mediates immune evasion and resistance to mTOR inhibition of renal cell carcinoma via induction of PD-L1.

Zhang C, Duan Y, Xia M, Dong Y, Chen Y, Zheng L, Chai S, Zhang Q, Wei Z, Liu N, Wang J, Sun C, Tang Z, Cheng X, Wu J, Wang G, Zheng F, Laurence A, Li B, Yang XP.

Clin Cancer Res. 2019 Aug 5. pii: clincanres.0733.2019. doi: 10.1158/1078-0432.CCR-19-0733. [Epub ahead of print]


Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells.

Mallett G, Laurence A, Amarnath S.

Int J Mol Sci. 2019 Jun 11;20(11). pii: E2836. doi: 10.3390/ijms20112836. Review.


Viral integration drives multifocal HCC during the occult HBV infection.

Chen XP, Long X, Jia WL, Wu HJ, Zhao J, Liang HF, Laurence A, Zhu J, Dong D, Chen Y, Lin L, Xia YD, Li WY, Li GB, Zhao ZK, Wu K, Hou Y, Yu JJ, Xiao W, Wang GP, Zhu PC, Chen W, Bai MZ, Jian YX, Kristiansen K, Chen Q.

J Exp Clin Cancer Res. 2019 Jun 14;38(1):261. doi: 10.1186/s13046-019-1273-1.


ATP6V0d2 mediates leucine-induced mTORC1 activation and polarization of macrophages.

Li P, Deng X, Luo J, Chen Y, Bi G, Gong F, Wei Z, Liu N, Li H, Laurence A, Yang XP.

Protein Cell. 2019 Aug;10(8):615-619. doi: 10.1007/s13238-019-0636-x. No abstract available.


The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.

Xia Y, Liu N, Xie X, Bi G, Ba H, Li L, Zhang J, Deng X, Yao Y, Tang Z, Yin B, Wang J, Jiang K, Li Z, Choi Y, Gong F, Cheng X, O'Shea JJ, Chae JJ, Laurence A, Yang XP.

Autophagy. 2019 Jun;15(6):960-975. doi: 10.1080/15548627.2019.1569916. Epub 2019 Jan 29.


Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.

Schwartz DM, Farley TK, Richoz N, Yao C, Shih HY, Petermann F, Zhang Y, Sun HW, Hayes E, Mikami Y, Jiang K, Davis FP, Kanno Y, Milner JD, Siegel R, Laurence A, Meylan F, O'Shea JJ.

Immunity. 2019 Jan 15;50(1):106-120.e10. doi: 10.1016/j.immuni.2018.12.014.


Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression.

Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, Wei Z, Xie X, Yin B, Chen F, Luo S, Liu H, Wang J, Jiang K, Gong F, Tang ZH, Cheng X, Li H, Li Z, Laurence A, Wang G, Yang XP.

J Clin Invest. 2019 Feb 1;129(2):631-646. doi: 10.1172/JCI123027. Epub 2019 Jan 7.


Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa.

Povoleri GAM, Nova-Lamperti E, Scottà C, Fanelli G, Chen YC, Becker PD, Boardman D, Costantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun HW, Shih HY, Cousins DJ, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B.

Nat Immunol. 2018 Dec;19(12):1403-1414. doi: 10.1038/s41590-018-0230-z. Epub 2018 Nov 5.


Genomic medicine must reduce, not compound, health inequities: the case for hauora-enhancing genomic resources for New Zealand.

Robertson SP, Hindmarsh JH, Berry S, Cameron VA, Cox MP, Dewes O, Doughty RN, Gray G, Jacobsen JC, Laurence A, Matisoo-Smith E, Morton S, Shelling AN, Sika-Paotonu D, Rolleston A, Skinner JR, Snell RG, Sporle A, Print C, Merriman TR, Hudson M, Wilcox P.

N Z Med J. 2018 Aug 17;131(1480):81-89.


PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells.

Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt FA, Liniany LP, Knight D, Samsel LA, Berlinguer-Palmini R, Yim JJ, Felizardo TC, Eckhaus MA, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler DH, van Kasteren SI, Laurence A, Bogyo M, Watts C, Shevach EM, Amarnath S.

Immunity. 2018 Aug 21;49(2):247-263.e7. doi: 10.1016/j.immuni.2018.05.006. Epub 2018 Jul 24.


TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome.

Myles IA, Anderson ED, Earland NJ, Zarember KA, Sastalla I, Williams KW, Gough P, Moore IN, Ganesan S, Fowler CJ, Laurence A, Garofalo M, Kuhns DB, Kieh MD, Saleem A, Welch PA, Darnell DA, Gallin JI, Freeman AF, Holland SM, Datta SK.

J Clin Invest. 2018 Aug 1;128(8):3595-3604. doi: 10.1172/JCI121486. Epub 2018 Jul 23.


Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs.

Gadina M, Johnson C, Schwartz D, Bonelli M, Hasni S, Kanno Y, Changelian P, Laurence A, O'Shea JJ.

J Leukoc Biol. 2018 Sep;104(3):499-514. doi: 10.1002/JLB.5RI0218-084R. Epub 2018 Jul 12. Review.


Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial.

Chen Q, Shu C, Laurence AD, Chen Y, Peng BG, Zhen ZJ, Cai JQ, Ding YT, Li LQ, Zhang YB, Zheng QC, Xu GL, Li B, Zhou WP, Cai SW, Wang XY, Wen H, Peng XY, Zhang XW, Dai CL, Bie P, Xing BC, Fu ZR, Liu LX, Mu Y, Zhang L, Zhang QS, Jiang B, Qian HX, Wang YJ, Liu JF, Qin XH, Li Q, Yin P, Zhang ZW, Chen XP.

Gut. 2018 Nov;67(11):2006-2016. doi: 10.1136/gutjnl-2018-315983. Epub 2018 May 25.


STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection.

St Leger AJ, Hansen AM, Karauzum H, Horai R, Yu CR, Laurence A, Mayer-Barber KD, Silver P, Villasmil R, Egwuagu C, Datta SK, Caspi RR.

J Exp Med. 2018 Apr 2;215(4):1079-1090. doi: 10.1084/jem.20170369. Epub 2018 Feb 28.


Sewage sludge as a soil amendment in a Larix decidua plantation: Effects on tree growth and floristic diversity.

Mohamed B, Olivier G, François G, Laurence AS, Bourgeade P, Badr AS, Lotfi A.

Sci Total Environ. 2018 Apr 15;621:291-301. doi: 10.1016/j.scitotenv.2017.11.283. Epub 2017 Nov 27.


Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation.

Bigley V, Maisuria S, Cytlak U, Jardine L, Care MA, Green K, Gunawan M, Milne P, Dickinson R, Wiscombe S, Parry D, Doffinger R, Laurence A, Fonseca C, Stoevesandt O, Gennery A, Cant A, Tooze R, Simpson AJ, Hambleton S, Savic S, Doody G, Collin M.

J Allergy Clin Immunol. 2018 Jun;141(6):2234-2248. doi: 10.1016/j.jaci.2017.08.044. Epub 2017 Nov 8.


Targeting JAK/STAT signalling in inflammatory skin diseases with small molecule inhibitors.

Welsch K, Holstein J, Laurence A, Ghoreschi K.

Eur J Immunol. 2017 Jul;47(7):1096-1107. doi: 10.1002/eji.201646680. Epub 2017 Jun 21. Review.


BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali B, Grönholm J, Vandrovcova J, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ.

Nat Immunol. 2017 Jul;18(7):813-823. doi: 10.1038/ni.3753. Epub 2017 May 22.


Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease.

Amarnath S, Laurence A, Zhu N, Cunha R, Eckhaus MA, Taylor S, Foley JE, Ghosh M, Felizardo TC, Fowler DH.

Haematologica. 2017 Aug;102(8):1446-1456. doi: 10.3324/haematol.2016.155879. Epub 2017 May 4.


When half a glass of STAT3 is just not enough.

Laurence AD, Uhlig HH.

Blood. 2016 Dec 29;128(26):3020-3021. doi: 10.1182/blood-2016-11-750539. No abstract available.


Raman spectroscopy in microsurgery: impact of operating microscope illumination sources on data quality and tissue classification.

Desroches J, Laurence A, Jermyn M, Pinto M, Tremblay MA, Petrecca K, Leblond F.

Analyst. 2017 Apr 10;142(8):1185-1191. doi: 10.1039/c6an02061e.


Intraoperative video-rate hemodynamic response assessment in human cortex using snapshot hyperspectral optical imaging.

Pichette J, Laurence A, Angulo L, Lesage F, Bouthillier A, Nguyen DK, Leblond F.

Neurophotonics. 2016 Oct;3(4):045003. Epub 2016 Oct 12.


Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

Villarino A, Laurence A, Robinson GW, Bonelli M, Dema B, Afzali B, Shih HY, Sun HW, Brooks SR, Hennighausen L, Kanno Y, O'Shea JJ.

Elife. 2016 Mar 21;5. pii: e08384. doi: 10.7554/eLife.08384.


Land spreading of sewage sludge in forest plantations: effects on the growth of the duckweed Lemna minor and trace metal bioaccumulation in the snail Cantareus aspersus.

Mohamed B, Frédéric G, Laurence AS, Pierre-Marie B, Badr AS, Lotfi A.

Environ Sci Pollut Res Int. 2016 May;23(10):9891-900. doi: 10.1007/s11356-016-6222-3. Epub 2016 Feb 9.


Loss of 11βHSD1 enhances glycolysis, facilitates intrahepatic metastasis, and indicates poor prognosis in hepatocellular carcinoma.

Liu X, Tan XL, Xia M, Wu C, Song J, Wu JJ, Laurence A, Xie QG, Zhang MZ, Liang HF, Zhang BX, Chen XP.

Oncotarget. 2016 Jan 12;7(2):2038-53. doi: 10.18632/oncotarget.6661.


Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach.

Gao F, Liang H, Lu H, Wang J, Xia M, Yuan Z, Yao Y, Wang T, Tan X, Laurence A, Xu H, Yu J, Xiao W, Chen W, Zhou M, Zhang X, Chen Q, Chen X.

Clin Epigenetics. 2015 Aug 21;7:86. doi: 10.1186/s13148-015-0121-1. eCollection 2015.


Influenza and pneumococcal vaccination: do older people know if they have been vaccinated?

Laurence A, Lewis P, Gately C, Dixon A.

Aust N Z J Public Health. 2016 Jun;40(3):279-80. doi: 10.1111/1753-6405.12423. Epub 2015 Aug 10.


EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion.

Yang XP, Jiang K, Hirahara K, Vahedi G, Afzali B, Sciume G, Bonelli M, Sun HW, Jankovic D, Kanno Y, Sartorelli V, O'Shea JJ, Laurence A.

Sci Rep. 2015 Jun 19;5:10643. doi: 10.1038/srep10643.


Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.

Hirahara K, Onodera A, Villarino AV, Bonelli M, Sciumè G, Laurence A, Sun HW, Brooks SR, Vahedi G, Shih HY, Gutierrez-Cruz G, Iwata S, Suzuki R, Mikami Y, Okamoto Y, Nakayama T, Holland SM, Hunter CA, Kanno Y, O'Shea JJ.

Immunity. 2015 May 19;42(5):877-89. doi: 10.1016/j.immuni.2015.04.014.


IL-1 watches the watchmen.

Villarino AV, Laurence A.

Nat Immunol. 2015 Mar;16(3):226-7. doi: 10.1038/ni.3105. No abstract available.


Sub-diffuse interstitial optical tomography to improve the safety of brain needle biopsies: a proof-of-concept study.

Goyette A, Pichette J, Tremblay MA, Laurence A, Jermyn M, Mok K, Paulsen KD, Roberts DW, Petrecca K, Wilson BC, Leblond F.

Opt Lett. 2015 Jan 15;40(2):170-3. doi: 10.1364/OL.40.000170.


Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ.

Astry B, Venkatesha SH, Laurence A, Christensen-Quick A, Garzino-Demo A, Frieman MB, O'Shea JJ, Moudgil KD.

Clin Immunol. 2015 Apr;157(2):228-38. doi: 10.1016/j.clim.2015.01.011. Epub 2015 Feb 7.


The JAK-STAT pathway: impact on human disease and therapeutic intervention.

O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A.

Annu Rev Med. 2015;66:311-28. doi: 10.1146/annurev-med-051113-024537. Review.


Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.

Amarnath S, Foley JE, Farthing DE, Gress RE, Laurence A, Eckhaus MA, Métais JY, Rose JJ, Hakim FT, Felizardo TC, Cheng AV, Robey PG, Stroncek DE, Sabatino M, Battiwalla M, Ito S, Fowler DH, Barrett AJ.

Stem Cells. 2015 Apr;33(4):1200-12. doi: 10.1002/stem.1934.


Environmental enrichment reduces behavioural alterations induced by chronic stress in Japanese quail.

Laurence A, Houdelier C, Calandreau L, Arnould C, Favreau-Peigné A, Leterrier C, Boissy A, Lumineau S.

Animal. 2015 Feb;9(2):331-8. doi: 10.1017/S1751731114002523. Epub 2014 Oct 30.


Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinoma.

Ding ZY, Jin GN, Wang W, Chen WX, Wu YH, Ai X, Chen L, Zhang WG, Liang HF, Laurence A, Zhang MZ, Datta PK, Zhang B, Chen XP.

Hepatology. 2014 Nov;60(5):1620-36. doi: 10.1002/hep.27273. Epub 2014 Sep 25.


Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.

Bonelli M, Shih HY, Hirahara K, Singelton K, Laurence A, Poholek A, Hand T, Mikami Y, Vahedi G, Kanno Y, O'Shea JJ.

Curr Top Microbiol Immunol. 2014;381:279-326. doi: 10.1007/82_2014_371. Review.


Short- and long-term effects of unpredictable repeated negative stimuli on Japanese quail's fear of humans.

Laurence A, Lumineau S, Calandreau L, Arnould C, Leterrier C, Boissy A, Houdelier C.

PLoS One. 2014 Mar 25;9(3):e93259. doi: 10.1371/journal.pone.0093259. eCollection 2014.


A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ.

Blood. 2014 May 8;123(19):2978-87. doi: 10.1182/blood-2013-09-523167. Epub 2014 Mar 14.


Emotionality modulates the effect of chronic stress on feeding behaviour in birds.

Favreau-Peigné A, Calandreau L, Constantin P, Gaultier B, Bertin A, Arnould C, Laurence A, Richard-Yris MA, Houdelier C, Lumineau S, Boissy A, Leterrier C.

PLoS One. 2014 Feb 3;9(2):e87249. doi: 10.1371/journal.pone.0087249. eCollection 2014.


A degrading view of regulatory T cells.

Laurence A, Belkaid Y, O'Shea JJ.

Immunity. 2013 Aug 22;39(2):201-3. doi: 10.1016/j.immuni.2013.08.017.


Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease.

Hirahara K, Poholek A, Vahedi G, Laurence A, Kanno Y, Milner JD, O'Shea JJ.

J Allergy Clin Immunol. 2013 May;131(5):1276-87. doi: 10.1016/j.jaci.2013.03.015. Review.


Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene.

Adamson A, Ghoreschi K, Rittler M, Chen Q, Sun HW, Vahedi G, Kanno Y, Stetler-Stevenson WG, O'Shea JJ, Laurence A.

PLoS One. 2013;8(3):e59367. doi: 10.1371/journal.pone.0059367. Epub 2013 Mar 26.


Janus kinase inhibitors in autoimmune diseases.

O'Shea JJ, Kontzias A, Yamaoka K, Tanaka Y, Laurence A.

Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii111-5. doi: 10.1136/annrheumdis-2012-202576. Review.


Back to the future: oral targeted therapy for RA and other autoimmune diseases.

O'Shea JJ, Laurence A, McInnes IB.

Nat Rev Rheumatol. 2013 Mar;9(3):173-82. doi: 10.1038/nrrheum.2013.7. Epub 2013 Feb 19. Review.


Helper T-cell identity and evolution of differential transcriptomes and epigenomes.

Vahedi G, C Poholek A, Hand TW, Laurence A, Kanno Y, O'Shea JJ, Hirahara K.

Immunol Rev. 2013 Mar;252(1):24-40. doi: 10.1111/imr.12037. Review.


Distinct requirements for T-bet in gut innate lymphoid cells.

Sciumé G, Hirahara K, Takahashi H, Laurence A, Villarino AV, Singleton KL, Spencer SP, Wilhelm C, Poholek AC, Vahedi G, Kanno Y, Belkaid Y, O'Shea JJ.

J Exp Med. 2012 Dec 17;209(13):2331-8. doi: 10.1084/jem.20122097. Epub 2012 Dec 3.


Japanese quail's genetic background modulates effects of chronic stress on emotional reactivity but not spatial learning.

Laurence A, Houdelier C, Petton C, Calandreau L, Arnould C, Favreau-Peigné A, Leterrier C, Boissy A, Richard-Yris MA, Lumineau S.

PLoS One. 2012;7(10):e47475. doi: 10.1371/journal.pone.0047475. Epub 2012 Oct 11.

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