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Items: 1 to 50 of 68

1.

Presence of Stromal Cells Enhances Epithelial-to-Mesenchymal Transition (EMT) Induction in Lung Bronchial Epithelium after Protracted Exposure to Oxidative Stress of Gamma Radiation.

Acheva A, Haghdoost S, Sollazzo A, Launonen V, Kämäräinen M.

Oxid Med Cell Longev. 2019 Sep 8;2019:4120379. doi: 10.1155/2019/4120379. eCollection 2019.

2.

Assessment of targeted and non-targeted responses in cells deficient in ATM function following exposure to low and high dose X-rays.

Kiuru A, Kämäräinen M, Heinävaara S, Pylkäs K, Chapman K, Koivistoinen A, Parviainen T, Winqvist R, Kadhim M, Launonen V, Lindholm C.

PLoS One. 2014 Mar 28;9(3):e93211. doi: 10.1371/journal.pone.0093211. eCollection 2014.

3.

A laboratory inter-comparison of the importance of serum serotonin levels in the measurement of a range of radiation-induced bystander effects: overview of study and results presentation.

Mothersill C, Antonelli F, Dahle J, Dini V, Hegyesi H, Iliakis G, Kämäräinen K, Launonen V, Lumniczky K, Lyng F, Safrany G, Salomaa S, Schilling-Tóth B, Tabocchini A, Kadhim MA.

Int J Radiat Biol. 2012 Oct;88(10):763-9.

PMID:
22891994
4.

Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer.

Saarinen S, Vahteristo P, Lehtonen R, Aittomäki K, Launonen V, Kiviluoto T, Aaltonen LA.

Fam Cancer. 2012 Sep;11(3):525-8. doi: 10.1007/s10689-012-9532-8.

PMID:
22638770
5.

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.

Mäkinen N, Mehine M, Tolvanen J, Kaasinen E, Li Y, Lehtonen HJ, Gentile M, Yan J, Enge M, Taipale M, Aavikko M, Katainen R, Virolainen E, Böhling T, Koski TA, Launonen V, Sjöberg J, Taipale J, Vahteristo P, Aaltonen LA.

Science. 2011 Oct 14;334(6053):252-5. doi: 10.1126/science.1208930. Epub 2011 Aug 25.

6.

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.

Bardella C, El-Bahrawy M, Frizzell N, Adam J, Ternette N, Hatipoglu E, Howarth K, O'Flaherty L, Roberts I, Turner G, Taylor J, Giaslakiotis K, Macaulay VM, Harris AL, Chandra A, Lehtonen HJ, Launonen V, Aaltonen LA, Pugh CW, Mihai R, Trudgian D, Kessler B, Baynes JW, Ratcliffe PJ, Tomlinson IP, Pollard PJ.

J Pathol. 2011 Sep;225(1):4-11. doi: 10.1002/path.2932. Epub 2011 Jun 1.

PMID:
21630274
7.

Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma.

Saarinen S, Aavikko M, Aittomäki K, Launonen V, Lehtonen R, Franssila K, Lehtonen HJ, Kaasinen E, Broderick P, Tarkkanen J, Bain BJ, Bauduer F, Ünal A, Swerdlow AJ, Cooke R, Mäkinen MJ, Houlston R, Vahteristo P, Aaltonen LA.

Blood. 2011 Jul 21;118(3):493-8. doi: 10.1182/blood-2011-03-341560. Epub 2011 May 11.

PMID:
21562039
8.

Analysis of KLHDC8B in familial nodular lymphocyte predominant Hodgkin lymphoma.

Saarinen S, Vahteristo P, Launonen V, Franssila K, Kivirikko S, Lehtonen R, Bain BJ, Bauduer F, Ünal A, Aaltonen LA, Aittomäki K.

Br J Haematol. 2011 Aug;154(3):413-5. doi: 10.1111/j.1365-2141.2010.08528.x. Epub 2011 Apr 22. No abstract available.

PMID:
21517803
9.

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.

Ashrafian H, O'Flaherty L, Adam J, Steeples V, Chung YL, East P, Vanharanta S, Lehtonen H, Nye E, Hatipoglu E, Miranda M, Howarth K, Shukla D, Troy H, Griffiths J, Spencer-Dene B, Yusuf M, Volpi E, Maxwell PH, Stamp G, Poulsom R, Pugh CW, Costa B, Bardella C, Di Renzo MF, Kotlikoff MI, Launonen V, Aaltonen L, El-Bahrawy M, Tomlinson I, Pollard PJ.

Cancer Res. 2010 Nov 15;70(22):9153-65. doi: 10.1158/0008-5472.CAN-10-1949. Epub 2010 Oct 26.

10.

Mutations in the circadian gene CLOCK in colorectal cancer.

Alhopuro P, Björklund M, Sammalkorpi H, Turunen M, Tuupanen S, Biström M, Niittymäki I, Lehtonen HJ, Kivioja T, Launonen V, Saharinen J, Nousiainen K, Hautaniemi S, Nuorva K, Mecklin JP, Järvinen H, Orntoft T, Arango D, Lehtonen R, Karhu A, Taipale J, Aaltonen LA.

Mol Cancer Res. 2010 Jul;8(7):952-60. doi: 10.1158/1541-7786.MCR-10-0086. Epub 2010 Jun 15.

11.

No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome.

Vahteristo P, Koski TA, Näätsaari L, Kiuru M, Karhu A, Herva R, Sallinen SL, Vierimaa O, Björck E, Richard S, Gardie B, Bessis D, Van Glabeke E, Blanco I, Houlston R, Senter L, Hietala M, Aittomäki K, Aaltonen LA, Launonen V, Lehtonen R.

Fam Cancer. 2010 Jun;9(2):245-51. doi: 10.1007/s10689-009-9312-2.

PMID:
20091131
12.

The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas.

Heliövaara E, Raitila A, Launonen V, Paetau A, Arola J, Lehtonen H, Sane T, Weil RJ, Vierimaa O, Salmela P, Tuppurainen K, Mäkinen M, Aaltonen LA, Karhu A.

Am J Pathol. 2009 Dec;175(6):2501-7. doi: 10.2353/ajpath.2009.081131. Epub 2009 Oct 22.

13.

Aryl hydrocarbon receptor interacting protein mutations seem not to associate with familial non-medullary thyroid cancer.

Raitila A, Georgitsi M, Bonora E, Vargiolu M, Tuppurainen K, Mäkinen MJ, Vierimaa O, Salmela PI, Launonen V, Vahteristo P, Aaltonen LA, Romeo G, Karhu A.

J Endocrinol Invest. 2009 May;32(5):426-9.

PMID:
19794292
14.

Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer.

Koski TA, Lehtonen HJ, Jee KJ, Ninomiya S, Joosse SA, Vahteristo P, Kiuru M, Karhu A, Sammalkorpi H, Vanharanta S, Lehtonen R, Edgren H, Nederlof PM, Hietala M, Aittomäki K, Herva R, Knuutila S, Aaltonen LA, Launonen V.

Genes Chromosomes Cancer. 2009 Jul;48(7):544-51. doi: 10.1002/gcc.20663.

PMID:
19373782
15.

Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer.

Ahvenainen T, Lehtonen HJ, Lehtonen R, Vahteristo P, Aittomäki K, Baynam G, Dommering C, Eng C, Gruber SB, Grönberg H, Harvima R, Herva R, Hietala M, Kujala M, Kääriäinen H, Sunde L, Vierimaa O, Pollard PJ, Tomlinson IP, Björck E, Aaltonen LA, Launonen V.

Cancer Genet Cytogenet. 2008 Jun;183(2):83-8. doi: 10.1016/j.cancergencyto.2008.01.010.

PMID:
18503824
16.

Unregulated smooth-muscle myosin in human intestinal neoplasia.

Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, Robinson JP, Yang Z, Chen LQ, Orntoft T, Mecklin JP, Järvinen H, Eng C, Moeslein G, Shibata D, Houlston RS, Lucassen A, Tomlinson IP, Launonen V, Ristimäki A, Arango D, Karhu A, Sweeney HL, Aaltonen LA.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5513-8. doi: 10.1073/pnas.0801213105. Epub 2008 Apr 7.

17.
18.

Stress-induced expression of a novel variant of human fumarate hydratase (FH).

Lehtonen HJ, Ylisaukko-Oja SK, Kiuru M, Karhu A, Lehtonen R, Vanharanta S, Jalanko A, Aaltonen LA, Launonen V.

Gene Expr. 2007;14(2):59-69.

19.

No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.

Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Mäkinen MJ, Birkenkamp-Demtröder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA.

Endocr Relat Cancer. 2007 Sep;14(3):901-6.

PMID:
17914118
20.

Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability.

Lehtonen HJ, Mäkinen MJ, Kiuru M, Laiho P, Herva R, van Minderhout I, Hogendoorn PC, Cornelisse C, Devilee P, Launonen V, Aaltonen LA.

Int J Cancer. 2007 Sep 15;121(6):1386-9.

21.

Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia.

Georgitsi M, Raitila A, Karhu A, van der Luijt RB, Aalfs CM, Sane T, Vierimaa O, Mäkinen MJ, Tuppurainen K, Paschke R, Gimm O, Koch CA, Gündogdu S, Lucassen A, Tischkowitz M, Izatt L, Aylwin S, Bano G, Hodgson S, De Menis E, Launonen V, Vahteristo P, Aaltonen LA.

J Clin Endocrinol Metab. 2007 Aug;92(8):3321-5. Epub 2007 May 22.

PMID:
17519308
22.

Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations.

Georgitsi M, Raitila A, Karhu A, Tuppurainen K, Mäkinen MJ, Vierimaa O, Paschke R, Saeger W, van der Luijt RB, Sane T, Robledo M, De Menis E, Weil RJ, Wasik A, Zielinski G, Lucewicz O, Lubinski J, Launonen V, Vahteristo P, Aaltonen LA.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4101-5. Epub 2007 Feb 28.

23.

Conventional renal cancer in a patient with fumarate hydratase mutation.

Lehtonen HJ, Blanco I, Piulats JM, Herva R, Launonen V, Aaltonen LA.

Hum Pathol. 2007 May;38(5):793-6. Epub 2007 Jan 31.

PMID:
17270241
24.

Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers.

Georgitsi M, Karhu A, Winqvist R, Visakorpi T, Waltering K, Vahteristo P, Launonen V, Aaltonen LA.

Br J Cancer. 2007 Jan 29;96(2):352-6.

25.

No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer.

Tuupanen S, Karhu A, Järvinen H, Mecklin JP, Launonen V, Aaltonen LA.

Oncogene. 2007 Apr 12;26(17):2513-7. Epub 2006 Oct 9.

PMID:
17043646
26.

Pituitary adenoma predisposition caused by germline mutations in the AIP gene.

Vierimaa O, Georgitsi M, Lehtonen R, Vahteristo P, Kokko A, Raitila A, Tuppurainen K, Ebeling TM, Salmela PI, Paschke R, Gündogdu S, De Menis E, Mäkinen MJ, Launonen V, Karhu A, Aaltonen LA.

Science. 2006 May 26;312(5777):1228-30.

27.

LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome.

Volikos E, Robinson J, Aittomäki K, Mecklin JP, Järvinen H, Westerman AM, de Rooji FW, Vogel T, Moeslein G, Launonen V, Tomlinson IP, Silver AR, Aaltonen LA.

J Med Genet. 2006 May;43(5):e18.

28.

Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma.

Ylisaukko-oja SK, Cybulski C, Lehtonen R, Kiuru M, Matyjasik J, Szymañska A, Szymañska-Pasternak J, Dyrskjot L, Butzow R, Orntoft TF, Launonen V, Lubiñski J, Aaltonen LA.

Eur J Hum Genet. 2006 Jul;14(7):880-3. Epub 2006 Apr 26.

29.

Analysis of fumarate hydratase mutations in a population-based series of early onset uterine leiomyosarcoma patients.

Ylisaukko-oja SK, Kiuru M, Lehtonen HJ, Lehtonen R, Pukkala E, Arola J, Launonen V, Aaltonen LA.

Int J Cancer. 2006 Jul 15;119(2):283-7.

30.

Increased risk of cancer in patients with fumarate hydratase germline mutation.

Lehtonen HJ, Kiuru M, Ylisaukko-Oja SK, Salovaara R, Herva R, Koivisto PA, Vierimaa O, Aittomäki K, Pukkala E, Launonen V, Aaltonen LA.

J Med Genet. 2006 Jun;43(6):523-6. Epub 2005 Sep 9.

31.

Mutations in the human LKB1/STK11 gene.

Launonen V.

Hum Mutat. 2005 Oct;26(4):291-7. Review.

PMID:
16110486
32.

Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers.

Hienonen T, Sammalkorpi H, Enholm S, Alhopuro P, Barber TD, Lehtonen R, Nupponen NN, Lehtonen H, Salovaara R, Mecklin JP, Järvinen H, Koistinen R, Arango D, Launonen V, Vogelstein B, Karhu A, Aaltonen LA.

Cancer Res. 2005 Jun 1;65(11):4607-13.

33.

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.

Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja SK, Näätsaari L, Karhu A, Westerman AM, Wilson JH, de Rooij FW, Vogel T, Moeslein G, Tomlinson IP, Aaltonen LA, Mäkelä TP, Launonen V.

Br J Cancer. 2005 Mar 28;92(6):1126-9.

34.

Hereditary leiomyomatosis and renal cell cancer (HLRCC).

Kiuru M, Launonen V.

Curr Mol Med. 2004 Dec;4(8):869-75. Review.

PMID:
15579034
35.

No germline FH mutations in familial breast cancer patients.

Kiuru M, Lehtonen R, Eerola H, Aittomäki K, Blomqvist C, Nevanlinna H, Aaltonen LA, Launonen V.

Eur J Hum Genet. 2005 Apr;13(4):506-9.

36.

Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.

Lehtonen R, Kiuru M, Vanharanta S, Sjöberg J, Aaltonen LM, Aittomäki K, Arola J, Butzow R, Eng C, Husgafvel-Pursiainen K, Isola J, Järvinen H, Koivisto P, Mecklin JP, Peltomäki P, Salovaara R, Wasenius VM, Karhu A, Launonen V, Nupponen NN, Aaltonen LA.

Am J Pathol. 2004 Jan;164(1):17-22.

37.

Little evidence for involvement of MLH3 in colorectal cancer predisposition.

Hienonen T, Laiho P, Salovaara R, Mecklin JP, Järvinen H, Sistonen P, Peltomäki P, Lehtonen R, Nupponen NN, Launonen V, Karhu A, Aaltonen LA.

Int J Cancer. 2003 Aug 20;106(2):292-6.

38.

Mutation and LOH analysis of ACO2 in colorectal cancer: no evidence of biallelic genetic inactivation.

Laiho P, Hienonen T, Mecklin JP, Järvinen H, Karhu A, Launonen V, Aaltonen LA.

J Med Genet. 2003 May;40(5):e73. No abstract available.

39.

Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases.

Laiho P, Hienonen T, Karhu A, Lipton L, Aalto Y, Thomas HJ, Birkenkamp-Demtroder K, Hodgson S, Salovaara R, Mecklin JP, Järvinen H, Knuutila S, Halford S, Ørntoft TF, Tomlinson I, Launonen V, Houlston R, Aaltonen LA.

Oncogene. 2003 Apr 10;22(14):2206-14.

PMID:
12687022
40.

EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer.

Jagmohan-Changur S, Poikonen T, Vilkki S, Launonen V, Wikman F, Orntoft TF, Møller P, Vasen H, Tops C, Kolodner RD, Mecklin JP, Järvinen H, Bevan S, Houlston RS, Aaltonen LA, Fodde R, Wijnen J, Karhu A.

Cancer Res. 2003 Jan 1;63(1):154-8.

41.

Screening for microsatellite instability target genes in colorectal cancers.

Vilkki S, Launonen V, Karhu A, Sistonen P, Västrik I, Aaltonen LA.

J Med Genet. 2002 Nov;39(11):785-9.

42.

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.

Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, Henkemeyer M, Ristimaki A, Aaltonen LA, Makela TP.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12327-32. Epub 2002 Sep 6.

43.

Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families.

Kiuru M, Lehtonen R, Arola J, Salovaara R, Järvinen H, Aittomäki K, Sjöberg J, Visakorpi T, Knuutila S, Isola J, Delahunt B, Herva R, Launonen V, Karhu A, Aaltonen LA.

Cancer Res. 2002 Aug 15;62(16):4554-7.

44.

Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylation.

Allinen M, Peri L, Kujala S, Lahti-Domenici J, Outila K, Karppinen SM, Launonen V, Winqvist R.

Genes Chromosomes Cancer. 2002 Aug;34(4):384-9.

PMID:
12112527
45.

Frequent loss of SMAD4/DPC4 protein in colorectal cancers.

Salovaara R, Roth S, Loukola A, Launonen V, Sistonen P, Avizienyte E, Kristo P, Järvinen H, Souchelnytskyi S, Sarlomo-Rikala M, Aaltonen LA.

Gut. 2002 Jul;51(1):56-9.

46.

ATM mutations in Finnish breast cancer patients.

Allinen M, Launonen V, Laake K, Jansen L, Huusko P, Kääriäinen H, Børresen-Dale AL, Winqvist R.

J Med Genet. 2002 Mar;39(3):192-6. No abstract available.

47.

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, Leigh I, Gorman P, Lamlum H, Rahman S, Roylance RR, Olpin S, Bevan S, Barker K, Hearle N, Houlston RS, Kiuru M, Lehtonen R, Karhu A, Vilkki S, Laiho P, Eklund C, Vierimaa O, Aittomäki K, Hietala M, Sistonen P, Paetau A, Salovaara R, Herva R, Launonen V, Aaltonen LA; Multiple Leiomyoma Consortium.

Nat Genet. 2002 Apr;30(4):406-10. Epub 2002 Feb 25.

PMID:
11865300
48.

Low-level microsatellite instability in most colorectal carcinomas.

Laiho P, Launonen V, Lahermo P, Esteller M, Guo M, Herman JG, Mecklin JP, Järvinen H, Sistonen P, Kim KM, Shibata D, Houlston RS, Aaltonen LA.

Cancer Res. 2002 Feb 15;62(4):1166-70.

49.

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.

Esteller M, Fraga MF, Guo M, Garcia-Foncillas J, Hedenfalk I, Godwin AK, Trojan J, Vaurs-Barrière C, Bignon YJ, Ramus S, Benitez J, Caldes T, Akiyama Y, Yuasa Y, Launonen V, Canal MJ, Rodriguez R, Capella G, Peinado MA, Borg A, Aaltonen LA, Ponder BA, Baylin SB, Herman JG.

Hum Mol Genet. 2001 Dec 15;10(26):3001-7.

PMID:
11751682
50.

Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology.

Kiuru M, Launonen V, Hietala M, Aittomäki K, Vierimaa O, Salovaara R, Arola J, Pukkala E, Sistonen P, Herva R, Aaltonen LA.

Am J Pathol. 2001 Sep;159(3):825-9.

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