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Items: 1 to 50 of 72

1.

Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment.

Madjene LC, Danelli L, Dahdah A, Vibhushan S, Bex-Coudrat J, Pacreau E, Vaugier C, Claver J, Rolas L, Pons M, Madera-Salcedo IK, Beghdadi W, El Ghoneimi A, Benhamou M, Launay P, Abrink M, Pejler G, Moura IC, Charles N, Daugas E, Perianin A, Blank U.

Kidney Int. 2019 Oct 10. pii: S0085-2538(19)30993-7. doi: 10.1016/j.kint.2019.08.037. [Epub ahead of print]

PMID:
31866111
2.

Overexpression of GILZ in macrophages limits systemic inflammation while increasing bacterial clearance in sepsis in mice.

Ellouze M, Vigouroux L, Tcherakian C, Woerther PL, Guguin A, Robert O, Surenaud M, Tran T, Calmette J, Barbin T, Perlemuter G, Cassard AM, Launay P, Maxime V, Annane D, Levy Y, Godot V.

Eur J Immunol. 2019 Dec 16. doi: 10.1002/eji.201948278. [Epub ahead of print]

PMID:
31840802
3.

Small AntiMicrobial Peptide With in Vivo Activity Against Sepsis.

Boullet H, Bentot F, Hequet A, Ganem-Elbaz C, Bechara C, Pacreau E, Launay P, Sagan S, Jolivalt C, Lacombe C, Moumné R, Karoyan P.

Molecules. 2019 May 1;24(9). pii: E1702. doi: 10.3390/molecules24091702.

4.

Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment.

Ngo Nyekel F, Pacreau E, Benadda S, Msallam R, Åbrink M, Pejler G, Davoust J, Benhamou M, Charles N, Launay P, Blank U, Gautier G.

Front Immunol. 2018 Nov 20;9:2690. doi: 10.3389/fimmu.2018.02690. eCollection 2018.

5.

Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells.

Gentek R, Ghigo C, Hoeffel G, Bulle MJ, Msallam R, Gautier G, Launay P, Chen J, Ginhoux F, Bajénoff M.

Immunity. 2018 Jun 19;48(6):1160-1171.e5. doi: 10.1016/j.immuni.2018.04.025. Epub 2018 May 29.

6.

TREM-1 multimerization is essential for its activation on monocytes and neutrophils.

Carrasco K, Boufenzer A, Jolly L, Le Cordier H, Wang G, Heck AJ, Cerwenka A, Vinolo E, Nazabal A, Kriznik A, Launay P, Gibot S, Derive M.

Cell Mol Immunol. 2019 May;16(5):460-472. doi: 10.1038/s41423-018-0003-5. Epub 2018 Mar 22.

PMID:
29568119
7.

Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis.

Martin KR, Pederzoli-Ribeil M, Pacreau E, Burgener SS, Dahdah A, Candalh C, Lauret E, Foretz M, Mouthon L, Lucas B, Thieblemont N, Benarafa C, Launay P, Witko-Sarsat V.

J Immunol. 2017 Dec 1;199(11):3914-3924. doi: 10.4049/jimmunol.1601522. Epub 2017 Oct 27.

8.

Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation.

Mkaddem SB, Murua A, Flament H, Titeca-Beauport D, Bounaix C, Danelli L, Launay P, Benhamou M, Blank U, Daugas E, Charles N, Monteiro RC.

Nat Commun. 2017 Aug 15;8(1):246. doi: 10.1038/s41467-017-00294-0.

9.

Phospholipid scramblase 1 amplifies anaphylactic reactions in vivo.

Kassas-Guediri A, Coudrat J, Pacreau E, Launay P, Monteiro RC, Blank U, Charles N, Benhamou M.

PLoS One. 2017 Mar 10;12(3):e0173815. doi: 10.1371/journal.pone.0173815. eCollection 2017.

10.

The TRPM4 channel is functionally important for the beneficial cardiac remodeling induced by endurance training.

Gueffier M, Zintz J, Lambert K, Finan A, Aimond F, Chakouri N, Hédon C, Granier M, Launay P, Thireau J, Richard S, Demion M.

J Muscle Res Cell Motil. 2017 Feb;38(1):3-16. doi: 10.1007/s10974-017-9466-8. Epub 2017 Feb 21.

PMID:
28224334
11.

Early Phase Mast Cell Activation Determines the Chronic Outcome of Renal Ischemia-Reperfusion Injury.

Danelli L, Madjene LC, Madera-Salcedo I, Gautier G, Pacreau E, Ben Mkaddem S, Charles N, Daugas E, Launay P, Blank U.

J Immunol. 2017 Mar 15;198(6):2374-2382. doi: 10.4049/jimmunol.1601282. Epub 2017 Feb 6.

12.

Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction.

Ngkelo A, Richart A, Kirk JA, Bonnin P, Vilar J, Lemitre M, Marck P, Branchereau M, Le Gall S, Renault N, Guerin C, Ranek MJ, Kervadec A, Danelli L, Gautier G, Blank U, Launay P, Camerer E, Bruneval P, Menasche P, Heymes C, Luche E, Casteilla L, Cousin B, Rodewald HR, Kass DA, Silvestre JS.

J Exp Med. 2016 Jun 27;213(7):1353-74. doi: 10.1084/jem.20160081.

13.

Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile.

van der Velden D, Lagraauw HM, Wezel A, Launay P, Kuiper J, Huizinga TW, Toes RE, Bot I, Stoop JN.

Arthritis Res Ther. 2016 Jun 13;18(1):138. doi: 10.1186/s13075-016-1036-8.

14.

Ocular inflammation induces trigeminal pain, peripheral and central neuroinflammatory mechanisms.

Launay PS, Reboussin E, Liang H, Kessal K, Godefroy D, Rostene W, Sahel JA, Baudouin C, Melik Parsadaniantz S, Reaux Le Goazigo A.

Neurobiol Dis. 2016 Apr;88:16-28. doi: 10.1016/j.nbd.2015.12.017. Epub 2015 Dec 30.

PMID:
26747211
15.

Combined 3DISCO clearing method, retrograde tracer and ultramicroscopy to map corneal neurons in a whole adult mouse trigeminal ganglion.

Launay PS, Godefroy D, Khabou H, Rostene W, Sahel JA, Baudouin C, Melik Parsadaniantz S, Reaux-Le Goazigo A.

Exp Eye Res. 2015 Oct;139:136-43. doi: 10.1016/j.exer.2015.06.008. Epub 2015 Jun 11.

16.

[Mast cells aggravate sepsis in mice by inhibiting peritoneal macrophage phagocytosis].

Gautier G, Launay P.

Med Sci (Paris). 2015 Feb;31(2):127-8. doi: 10.1051/medsci/20153102004. Epub 2015 Mar 4. French. No abstract available.

17.

CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans.

Martinez-Torres AC, Quiney C, Attout T, Boullet H, Herbi L, Vela L, Barbier S, Chateau D, Chapiro E, Nguyen-Khac F, Davi F, Le Garff-Tavernier M, Moumné R, Sarfati M, Karoyan P, Merle-Béral H, Launay P, Susin SA.

PLoS Med. 2015 Mar 3;12(3):e1001796. doi: 10.1371/journal.pmed.1001796. eCollection 2015 Mar.

18.

Space exploration by dendritic cells requires maintenance of myosin II activity by IP3 receptor 1.

Solanes P, Heuzé ML, Maurin M, Bretou M, Lautenschlaeger F, Maiuri P, Terriac E, Thoulouze MI, Launay P, Piel M, Vargas P, Lennon-Duménil AM.

EMBO J. 2015 Mar 12;34(6):798-810. doi: 10.15252/embj.201489056. Epub 2015 Jan 30.

19.

Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations.

Demion M, Thireau J, Gueffier M, Finan A, Khoueiry Z, Cassan C, Serafini N, Aimond F, Granier M, Pasquié JL, Launay P, Richard S.

PLoS One. 2014 Dec 22;9(12):e115256. doi: 10.1371/journal.pone.0115256. eCollection 2014.

20.

Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons.

Lei YT, Thuault SJ, Launay P, Margolskee RF, Kandel ER, Siegelbaum SA.

Front Cell Neurosci. 2014 Sep 4;8:267. doi: 10.3389/fncel.2014.00267. eCollection 2014.

21.

Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

Dahdah A, Gautier G, Attout T, Fiore F, Lebourdais E, Msallam R, Daëron M, Monteiro RC, Benhamou M, Charles N, Davoust J, Blank U, Malissen B, Launay P.

J Clin Invest. 2014 Oct;124(10):4577-89. doi: 10.1172/JCI75212. Epub 2014 Sep 2.

22.

Calcium channels in Fc receptor signaling.

Attout T, Floto A, Launay P.

Curr Top Microbiol Immunol. 2014;382:95-110. doi: 10.1007/978-3-319-07911-0_5. Review.

PMID:
25116097
23.

Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

Ben Mkaddem S, Hayem G, Jönsson F, Rossato E, Boedec E, Boussetta T, El Benna J, Launay P, Goujon JM, Benhamou M, Bruhns P, Monteiro RC.

J Clin Invest. 2014 Sep;124(9):3945-59. doi: 10.1172/JCI74572. Epub 2014 Jul 25.

24.

Mast cells in renal inflammation and fibrosis: lessons learnt from animal studies.

Madjene LC, Pons M, Danelli L, Claver J, Ali L, Madera-Salcedo IK, Kassas A, Pellefigues C, Marquet F, Dadah A, Attout T, El-Ghoneimi A, Gautier G, Benhamou M, Charles N, Daugas E, Launay P, Blank U.

Mol Immunol. 2015 Jan;63(1):86-93. doi: 10.1016/j.molimm.2014.03.002. Epub 2014 May 3. Review.

PMID:
24793464
25.

Substitution p.A350V in Na⁺/Mg²⁺ exchanger SLC41A1, potentially associated with Parkinson's disease, is a gain-of-function mutation.

Kolisek M, Sponder G, Mastrototaro L, Smorodchenko A, Launay P, Vormann J, Schweigel-Röntgen M.

PLoS One. 2013 Aug 15;8(8):e71096. doi: 10.1371/journal.pone.0071096. eCollection 2013.

26.

Adenosine receptor antagonists including caffeine alter fetal brain development in mice.

Silva CG, Métin C, Fazeli W, Machado NJ, Darmopil S, Launay PS, Ghestem A, Nesa MP, Bassot E, Szabó E, Baqi Y, Müller CE, Tomé AR, Ivanov A, Isbrandt D, Zilberter Y, Cunha RA, Esclapez M, Bernard C.

Sci Transl Med. 2013 Aug 7;5(197):197ra104. doi: 10.1126/scitranslmed.3006258.

27.

The TRPM4 non-selective cation channel contributes to the mammalian atrial action potential.

Simard C, Hof T, Keddache Z, Launay P, Guinamard R.

J Mol Cell Cardiol. 2013 Jun;59:11-9. doi: 10.1016/j.yjmcc.2013.01.019. Epub 2013 Feb 13.

PMID:
23416167
28.

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R.

Gaujoux S, Hantel C, Launay P, Bonnet S, Perlemoine K, Lefèvre L, Guillaud-Bataille M, Beuschlein F, Tissier F, Bertherat J, Rizk-Rabin M, Ragazzon B.

PLoS One. 2013;8(2):e55743. doi: 10.1371/journal.pone.0055743. Epub 2013 Feb 7.

29.

Tangentially migrating neurons assemble a primary cilium that promotes their reorientation to the cortical plate.

Baudoin JP, Viou L, Launay PS, Luccardini C, Espeso Gil S, Kiyasova V, Irinopoulou T, Alvarez C, Rio JP, Boudier T, Lechaire JP, Kessaris N, Spassky N, Métin C.

Neuron. 2012 Dec 20;76(6):1108-22. doi: 10.1016/j.neuron.2012.10.027.

30.

Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells.

Kim YS, Kang E, Makino Y, Park S, Shin JH, Song H, Launay P, Linden DJ.

J Neurophysiol. 2013 Feb;109(4):1174-81. doi: 10.1152/jn.01168.2011. Epub 2012 Nov 28.

31.

The TRPM4 channel controls monocyte and macrophage, but not neutrophil, function for survival in sepsis.

Serafini N, Dahdah A, Barbet G, Demion M, Attout T, Gautier G, Arcos-Fajardo M, Souchet H, Jouvin MH, Vrtovsnik F, Kinet JP, Benhamou M, Monteiro RC, Launay P.

J Immunol. 2012 Oct 1;189(7):3689-99. Epub 2012 Aug 29.

32.

IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses.

Aloulou M, Ben Mkaddem S, Biarnes-Pelicot M, Boussetta T, Souchet H, Rossato E, Benhamou M, Crestani B, Zhu Z, Blank U, Launay P, Monteiro RC.

Blood. 2012 Mar 29;119(13):3084-96. doi: 10.1182/blood-2011-08-376046. Epub 2012 Feb 14.

PMID:
22337713
33.

Inhibitory ITAM signaling traps activating receptors with the phosphatase SHP-1 to form polarized "inhibisome" clusters.

Pfirsch-Maisonnas S, Aloulou M, Xu T, Claver J, Kanamaru Y, Tiwari M, Launay P, Monteiro RC, Blank U.

Sci Signal. 2011 Apr 19;4(169):ra24. doi: 10.1126/scisignal.2001309.

34.

Mast cells as cellular sensors in inflammation and immunity.

Beghdadi W, Madjene LC, Benhamou M, Charles N, Gautier G, Launay P, Blank U.

Front Immunol. 2011 Sep 6;2:37. doi: 10.3389/fimmu.2011.00037. eCollection 2011.

35.

β-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma.

Gaujoux S, Grabar S, Fassnacht M, Ragazzon B, Launay P, Libé R, Chokri I, Audebourg A, Royer B, Sbiera S, Vacher-Lavenu MC, Dousset B, Bertagna X, Allolio B, Bertherat J, Tissier F.

Clin Cancer Res. 2011 Jan 15;17(2):328-36. doi: 10.1158/1078-0432.CCR-10-2006. Epub 2010 Nov 18.

36.

Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors.

Bonnet S, Gaujoux S, Launay P, Baudry C, Chokri I, Ragazzon B, Libé R, René-Corail F, Audebourg A, Vacher-Lavenu MC, Groussin L, Bertagna X, Dousset B, Bertherat J, Tissier F.

J Clin Endocrinol Metab. 2011 Feb;96(2):E419-26. doi: 10.1210/jc.2010-1885. Epub 2010 Nov 17.

PMID:
21084400
37.

Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers.

Gaujoux S, Pinson S, Gimenez-Roqueplo AP, Amar L, Ragazzon B, Launay P, Meatchi T, Libé R, Bertagna X, Audebourg A, Zucman-Rossi J, Tissier F, Bertherat J.

Clin Cancer Res. 2010 Nov 1;16(21):5133-41. doi: 10.1158/1078-0432.CCR-10-1497. Epub 2010 Oct 26.

38.

Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers.

Ragazzon B, Libé R, Gaujoux S, Assié G, Fratticci A, Launay P, Clauser E, Bertagna X, Tissier F, de Reyniès A, Bertherat J.

Cancer Res. 2010 Nov 1;70(21):8276-81. doi: 10.1158/0008-5472.CAN-10-2014. Epub 2010 Oct 19.

39.

Physiological roles of the TRPM4 channel extracted from background currents.

Guinamard R, Demion M, Launay P.

Physiology (Bethesda). 2010 Jun;25(3):155-64. doi: 10.1152/physiol.00004.2010. Review.

40.

Inhibitory ITAMs as novel regulators of immunity.

Blank U, Launay P, Benhamou M, Monteiro RC.

Immunol Rev. 2009 Nov;232(1):59-71. doi: 10.1111/j.1600-065X.2009.00832.x. Review.

PMID:
19909356
41.

Chronic hemolytic anemia due to novel alpha-globin chain variants: critical location of the mutation within the gene sequence for a dominant effect.

Préhu C, Moradkhani K, Riou J, Bahuau M, Launay P, Martin N, Wajcman H, Goossens M, Galactéros F.

Haematologica. 2009 Nov;94(11):1624-5. doi: 10.3324/haematol.2009.012971. Epub 2009 Oct 8. No abstract available.

42.

The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells.

Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P.

Nat Immunol. 2008 Oct;9(10):1148-56. doi: 10.1038/ni.1648. Epub 2008 Aug 31.

43.

Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors.

Gaujoux S, Tissier F, Groussin L, Libé R, Ragazzon B, Launay P, Audebourg A, Dousset B, Bertagna X, Bertherat J.

J Clin Endocrinol Metab. 2008 Oct;93(10):4135-40. doi: 10.1210/jc.2008-0631. Epub 2008 Jul 22.

PMID:
18647815
44.

Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway.

Amir-Moazami O, Alexia C, Charles N, Launay P, Monteiro RC, Benhamou M.

J Biol Chem. 2008 Sep 12;283(37):25514-23. doi: 10.1074/jbc.M705320200. Epub 2008 Jun 25.

45.

SLC41A1 is a novel mammalian Mg2+ carrier.

Kolisek M, Launay P, Beck A, Sponder G, Serafini N, Brenkus M, Froschauer EM, Martens H, Fleig A, Schweigel M.

J Biol Chem. 2008 Jun 6;283(23):16235-47. doi: 10.1074/jbc.M707276200. Epub 2008 Mar 25.

46.

9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.

Grand T, Demion M, Norez C, Mettey Y, Launay P, Becq F, Bois P, Guinamard R.

Br J Pharmacol. 2008 Apr;153(8):1697-705. doi: 10.1038/bjp.2008.38. Epub 2008 Feb 25.

47.

The glomerular response to IgA deposition in IgA nephropathy.

Moura IC, Benhamou M, Launay P, Vrtovsnik F, Blank U, Monteiro RC.

Semin Nephrol. 2008 Jan;28(1):88-95. doi: 10.1016/j.semnephrol.2007.10.010. Review.

PMID:
18222350
48.

CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation.

Pinheiro da Silva F, Aloulou M, Skurnik D, Benhamou M, Andremont A, Velasco IT, Chiamolera M, Verbeek JS, Launay P, Monteiro RC.

Nat Med. 2007 Nov;13(11):1368-74. Epub 2007 Oct 14.

PMID:
17934470
49.

Fc alpha receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcR gamma adaptor.

Kanamaru Y, Arcos-Fajardo M, Moura IC, Tsuge T, Cohen H, Essig M, Vrtovsnik F, Loirat C, Peuchmaur M, Beaudoin L, Launay P, Lehuen A, Blank U, Monteiro RC.

Eur J Immunol. 2007 Apr;37(4):1116-28.

50.

TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells.

Demion M, Bois P, Launay P, Guinamard R.

Cardiovasc Res. 2007 Feb 1;73(3):531-8. Epub 2006 Nov 22.

PMID:
17188667

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