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Items: 1 to 50 of 339

1.

eNOS deletion impairs mitochondrial quality control and exacerbates Western diet-induced NASH.

Sheldon RD, Meers GM, Morris EM, Linden MA, Cunningham RP, Ibdah JA, Thyfault JP, Laughlin MH, Rector RS.

Am J Physiol Endocrinol Metab. 2019 Oct 1;317(4):E605-E616. doi: 10.1152/ajpendo.00096.2019. Epub 2019 Jul 30.

PMID:
31361543
2.

Exercise and Vascular Insulin Sensitivity in the Skeletal Muscle and Brain.

Olver TD, Laughlin MH, Padilla J.

Exerc Sport Sci Rev. 2019 Apr;47(2):66-74. doi: 10.1249/JES.0000000000000182. Review.

PMID:
30883470
3.

Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: Effects of PDE5 inhibition.

Aragonez CG, de Beer VJ, Tharp DL, Bowles DK, Laughlin MH, Merkus D, Duncker DJ, Bender SB.

Microcirculation. 2019 Aug;26(6):e12539. doi: 10.1111/micc.12539. Epub 2019 Mar 26.

PMID:
30821858
4.

Endurance exercise training does not limit coronary atherosclerosis in familial hypercholesterolemic swine.

Tharp DL, Masseau I, Ivey J, Laughlin MH, Bowles DK.

Physiol Rep. 2019 Feb;7(4):e14008. doi: 10.14814/phy2.14008.

5.

Nitric oxide-dependent attenuation of noradrenaline-induced vasoconstriction is impaired in the canine model of Duchenne muscular dystrophy.

Kodippili K, Hakim CH, Yang HT, Pan X, Yang NN, Laughlin MH, Terjung RL, Duan D.

J Physiol. 2018 Nov;596(21):5199-5216. doi: 10.1113/JP275672. Epub 2018 Sep 20.

6.

Chronic interval exercise training prevents BKCa channel-mediated coronary vascular dysfunction in aortic-banded miniswine.

Olver TD, Edwards JC, Ferguson BS, Hiemstra JA, Thorne PK, Hill MA, Laughlin MH, Emter CA.

J Appl Physiol (1985). 2018 Jul 1;125(1):86-96. doi: 10.1152/japplphysiol.01138.2017. Epub 2018 Mar 29.

7.

Microvascular insulin resistance in skeletal muscle and brain occurs early in the development of juvenile obesity in pigs.

Olver TD, Grunewald ZI, Jurrissen TJ, MacPherson REK, LeBlanc PJ, Schnurbusch TR, Czajkowski AM, Laughlin MH, Rector RS, Bender SB, Walters EM, Emter CA, Padilla J.

Am J Physiol Regul Integr Comp Physiol. 2018 Feb 1;314(2):R252-R264. doi: 10.1152/ajpregu.00213.2017. Epub 2017 Dec 4.

8.

Loss of Female Sex Hormones Exacerbates Cerebrovascular and Cognitive Dysfunction in Aortic Banded Miniswine Through a Neuropeptide Y-Ca2+-Activated Potassium Channel-Nitric Oxide Mediated Mechanism.

Olver TD, Hiemstra JA, Edwards JC, Schachtman TR, Heesch CM, Fadel PJ, Laughlin MH, Emter CA.

J Am Heart Assoc. 2017 Oct 31;6(11). pii: e007409. doi: 10.1161/JAHA.117.007409.

9.

A chronic physical activity treatment in obese rats normalizes the contributions of ET-1 and NO to insulin-mediated posterior cerebral artery vasodilation.

Olver TD, McDonald MW, Klakotskaia D, Richardson RA, Jasperse JL, Melling CWJ, Schachtman TR, Yang HT, Emter CA, Laughlin MH.

J Appl Physiol (1985). 2017 Apr 1;122(4):1040-1050. doi: 10.1152/japplphysiol.00811.2016. Epub 2017 Feb 9.

10.

Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli.

Green DJ, Hopman MT, Padilla J, Laughlin MH, Thijssen DH.

Physiol Rev. 2017 Apr;97(2):495-528. doi: 10.1152/physrev.00014.2016. Review.

11.

Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats.

Padilla J, Thorne PK, Martin JS, Rector RS, Akter S, Davis JW, Laughlin MH, Jenkins NT.

Exp Biol Med (Maywood). 2017 Mar;242(6):617-624. doi: 10.1177/1535370216689825. Epub 2017 Jan 23.

12.

The protective role of sex hormones in females and exercise prehabilitation in males on sternotomy-induced cranial hypoperfusion in aortic banded mini-swine.

Olver TD, Hiemstra JA, Edwards JC, Ferguson BS, Laughlin MH, Emter CA.

J Appl Physiol (1985). 2017 Mar 1;122(3):423-429. doi: 10.1152/japplphysiol.00817.2016. Epub 2016 Dec 1.

13.

Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees.

Laughlin MH, Yang HT, Tharp DL, Rector RS, Padilla J, Bowles DK.

Microcirculation. 2017 Feb;24(2). doi: 10.1111/micc.12336. Review.

PMID:
27889934
14.

Severe familial hypercholesterolemia impairs the regulation of coronary blood flow and oxygen supply during exercise.

Bender SB, de Beer VJ, Tharp DL, Bowles DK, Laughlin MH, Merkus D, Duncker DJ.

Basic Res Cardiol. 2016 Nov;111(6):61. doi: 10.1007/s00395-016-0579-9. Epub 2016 Sep 13.

PMID:
27624732
15.

A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats.

Linden MA, Fletcher JA, Meers GM, Thyfault JP, Laughlin MH, Rector RS.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G387-95. doi: 10.1152/ajpgi.00089.2016. Epub 2016 Jul 21.

16.

Effects of acute and chronic interval sprint exercise performed on a manually propelled treadmill on upper limb vascular mechanics in healthy young men.

Olver TD, Reid SM, Smith AR, Zamir M, Lemon PW, Laughlin MH, Shoemaker JK.

Physiol Rep. 2016 Jul;4(13). pii: e12861. doi: 10.14814/phy2.12861.

17.

Carotid Artery Vascular Mechanics Serve as Biomarkers of Cognitive Dysfunction in Aortic-Banded Miniature Swine That Can Be Treated With an Exercise Intervention.

Olver TD, Klakotskaia D, Ferguson BS, Hiemstra JA, Schachtman TR, Laughlin MH, Emter CA.

J Am Heart Assoc. 2016 May 20;5(5). pii: e003248. doi: 10.1161/JAHA.116.003248.

18.

Aerobic exercise training in the treatment of non-alcoholic fatty liver disease related fibrosis.

Linden MA, Sheldon RD, Meers GM, Ortinau LC, Morris EM, Booth FW, Kanaley JA, Vieira-Potter VJ, Sowers JR, Ibdah JA, Thyfault JP, Laughlin MH, Rector RS.

J Physiol. 2016 Sep 15;594(18):5271-84. doi: 10.1113/JP272235. Epub 2016 May 27.

19.

Impaired Coronary Endothelial Vasorelaxation in a Preclinical Model of Peripheral Arterial Insufficiency.

Arce-Esquivel AA, Bunker AK, Simmons GH, Yang HT, Laughlin MH, Terjung RL.

J Heart Cardiol. 2015;1(2). doi: 10.15436/2378-6914/15/010. Epub 2015 Jun 29.

20.

Molecular Mechanisms for Exercise Training-Induced Changes in Vascular Structure and Function: Skeletal Muscle, Cardiac Muscle, and the Brain.

Olver TD, Ferguson BS, Laughlin MH.

Prog Mol Biol Transl Sci. 2015;135:227-57. doi: 10.1016/bs.pmbts.2015.07.017. Epub 2015 Sep 5. Review.

PMID:
26477917
21.

Physical activity-induced remodeling of vasculature in skeletal muscle: role in treatment of type 2 diabetes.

Laughlin MH.

J Appl Physiol (1985). 2016 Jan 1;120(1):1-16. doi: 10.1152/japplphysiol.00789.2015. Epub 2015 Oct 15. Review.

22.

Impact of 2-Weeks Continuous Increase in Retrograde Shear Stress on Brachial Artery Vasomotor Function in Young and Older Men.

Thijssen DH, Schreuder TH, Newcomer SW, Laughlin MH, Hopman MT, Green DJ.

J Am Heart Assoc. 2015 Sep 28;4(10):e001968. doi: 10.1161/JAHA.115.001968.

23.

Endurance, interval sprint, and resistance exercise training: impact on microvascular dysfunction in type 2 diabetes.

Olver TD, Laughlin MH.

Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H337-50. doi: 10.1152/ajpheart.00440.2015. Epub 2015 Sep 25. Review.

24.

Combining metformin therapy with caloric restriction for the management of type 2 diabetes and nonalcoholic fatty liver disease in obese rats.

Linden MA, Lopez KT, Fletcher JA, Morris EM, Meers GM, Siddique S, Laughlin MH, Sowers JR, Thyfault JP, Ibdah JA, Rector RS.

Appl Physiol Nutr Metab. 2015 Oct;40(10):1038-47. doi: 10.1139/apnm-2015-0236. Epub 2015 Jun 24.

25.

Divergent role of nitric oxide in insulin-stimulated aortic vasorelaxation between low- and high-intrinsic aerobic capacity rats.

Crissey JM, Padilla J, Vieira-Potter VJ, Thorne PK, Koch LG, Britton SL, Thyfault JP, Laughlin MH.

Physiol Rep. 2015 Jul;3(7). pii: e12459. doi: 10.14814/phy2.12459.

26.

Exercise training causes differential changes in gene expression in diaphragm arteries and 2A arterioles of obese rats.

Laughlin MH, Padilla J, Jenkins NT, Thorne PK, Martin JS, Rector RS, Akter S, Davis JW.

J Appl Physiol (1985). 2015 Sep 15;119(6):604-16. doi: 10.1152/japplphysiol.00317.2015. Epub 2015 Jul 16.

27.

Exercise-induced differential changes in gene expression among arterioles of skeletal muscles of obese rats.

Laughlin MH, Padilla J, Jenkins NT, Thorne PK, Martin JS, Rector RS, Akter S, Davis JW.

J Appl Physiol (1985). 2015 Sep 15;119(6):583-603. doi: 10.1152/japplphysiol.00316.2015. Epub 2015 Jul 16.

28.

Effect of electron radiation on vasomotor function of the left anterior descending coronary artery.

Sanzari JK, Billings PC, Wilson JM, Diffenderfer ES, Arce-Esquivel AA, Thorne PK, Laughlin MH, Kennedy AR.

Life Sci Space Res (Amst). 2015 Jan;4:6-10.

29.

Modulation of endothelial cell phenotype by physical activity: impact on obesity-related endothelial dysfunction.

Bender SB, Laughlin MH.

Am J Physiol Heart Circ Physiol. 2015 Jul 1;309(1):H1-8. doi: 10.1152/ajpheart.00177.2015. Epub 2015 May 1. Review.

30.

Chronic NOS inhibition accelerates NAFLD progression in an obese rat model.

Sheldon RD, Padilla J, Jenkins NT, Laughlin MH, Rector RS.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G540-9. doi: 10.1152/ajpgi.00247.2014. Epub 2015 Jan 8.

31.

Characterizing rapid-onset vasodilation to single muscle contractions in the human leg.

Credeur DP, Holwerda SW, Restaino RM, King PM, Crutcher KL, Laughlin MH, Padilla J, Fadel PJ.

J Appl Physiol (1985). 2015 Feb 15;118(4):455-64. doi: 10.1152/japplphysiol.00785.2014. Epub 2014 Dec 24.

32.

Exercise training in patients with heart disease: review of beneficial effects and clinical recommendations.

Gielen S, Laughlin MH, O'Conner C, Duncker DJ.

Prog Cardiovasc Dis. 2015 Jan-Feb;57(4):347-55. doi: 10.1016/j.pcad.2014.10.001. Epub 2014 Oct 22. Review.

PMID:
25459973
33.

Identification of genes whose expression is altered by obesity throughout the arterial tree.

Padilla J, Jenkins NT, Thorne PK, Martin JS, Rector RS, Davis JW, Laughlin MH.

Physiol Genomics. 2014 Nov 15;46(22):821-32. doi: 10.1152/physiolgenomics.00091.2014. Epub 2014 Sep 30.

34.

Treating NAFLD in OLETF rats with vigorous-intensity interval exercise training.

Linden MA, Fletcher JA, Morris EM, Meers GM, Laughlin MH, Booth FW, Sowers JR, Ibdah JA, Thyfault JP, Rector RS.

Med Sci Sports Exerc. 2015 Mar;47(3):556-67. doi: 10.1249/MSS.0000000000000430.

35.

The effect of purinergic P2 receptor blockade on skeletal muscle exercise hyperemia in miniature swine.

Mortensen SP, McAllister RM, Yang HT, Hellsten Y, Laughlin MH.

Eur J Appl Physiol. 2014 Oct;114(10):2147-55. doi: 10.1007/s00421-014-2932-8. Epub 2014 Jun 25.

PMID:
24962002
36.

Differential regulation of adipose tissue and vascular inflammatory gene expression by chronic systemic inhibition of NOS in lean and obese rats.

Padilla J, Jenkins NT, Thorne PK, Lansford KA, Fleming NJ, Bayless DS, Sheldon RD, Rector RS, Laughlin MH.

Physiol Rep. 2014 Feb 7;2(2):e00225. doi: 10.1002/phy2.225. eCollection 2014 Feb 1.

37.

Reduced hepatic eNOS phosphorylation is associated with NAFLD and type 2 diabetes progression and is prevented by daily exercise in hyperphagic OLETF rats.

Sheldon RD, Laughlin MH, Rector RS.

J Appl Physiol (1985). 2014 May 1;116(9):1156-64. doi: 10.1152/japplphysiol.01275.2013. Epub 2014 Feb 27.

38.

Beneficial paracrine effects of adipocytes from obese rats on cultured endothelial cells.

Jenkins NT, Padilla J, Laughlin MH.

J Clin Transl Endocrinol. 2014 Mar;1(1):e27-e30.

39.

Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats.

Crissey JM, Jenkins NT, Lansford KA, Thorne PK, Bayless DS, Vieira-Potter VJ, Rector RS, Thyfault JP, Laughlin MH, Padilla J.

Am J Physiol Regul Integr Comp Physiol. 2014 Apr 15;306(8):R596-606. doi: 10.1152/ajpregu.00493.2013. Epub 2014 Feb 12.

40.

Phosphodiesterase-5 activity exerts a coronary vasoconstrictor influence in awake swine that is mediated in part via an increase in endothelin production.

Zhou Z, de Beer VJ, Bender SB, Jan Danser AH, Merkus D, Laughlin MH, Duncker DJ.

Am J Physiol Heart Circ Physiol. 2014 Mar;306(6):H918-27. doi: 10.1152/ajpheart.00331.2013. Epub 2014 Jan 24.

41.

Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. I. Impact of obesity.

Jenkins NT, Padilla J, Thorne PK, Martin JS, Rector RS, Davis JW, Laughlin MH.

J Appl Physiol (1985). 2014 Apr 15;116(8):1017-32. doi: 10.1152/japplphysiol.01233.2013. Epub 2014 Jan 16.

42.

Reduced contribution of endothelin to the regulation of systemic and pulmonary vascular tone in severe familial hypercholesterolaemia.

Bender SB, de Beer VJ, Tharp DL, van Deel ED, Bowles DK, Duncker DJ, Laughlin MH, Merkus D.

J Physiol. 2014 Apr 15;592(8):1757-69. doi: 10.1113/jphysiol.2013.267351. Epub 2014 Jan 13.

43.

Pulmonary vasoconstrictor influence of endothelin in exercising swine depends critically on phosphodiesterase 5 activity.

Zhou Z, de Beer VJ, de Wijs-Meijler D, Bender SB, Hoekstra M, Laughlin MH, Duncker DJ, Merkus D.

Am J Physiol Lung Cell Mol Physiol. 2014 Mar 1;306(5):L442-52. doi: 10.1152/ajplung.00057.2013. Epub 2014 Jan 10.

44.

Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. II. Impact of exercise training in obesity.

Padilla J, Jenkins NT, Thorne PK, Martin JS, Rector RS, Davis JW, Laughlin MH.

J Appl Physiol (1985). 2014 Apr 15;116(8):1033-47. doi: 10.1152/japplphysiol.01234.2013. Epub 2014 Jan 9.

45.

Epicardial adipose excision slows the progression of porcine coronary atherosclerosis.

McKenney ML, Schultz KA, Boyd JH, Byrd JP, Alloosh M, Teague SD, Arce-Esquivel AA, Fain JN, Laughlin MH, Sacks HS, Sturek M.

J Cardiothorac Surg. 2014 Jan 3;9:2. doi: 10.1186/1749-8090-9-2.

46.

Combining metformin and aerobic exercise training in the treatment of type 2 diabetes and NAFLD in OLETF rats.

Linden MA, Fletcher JA, Morris EM, Meers GM, Kearney ML, Crissey JM, Laughlin MH, Booth FW, Sowers JR, Ibdah JA, Thyfault JP, Rector RS.

Am J Physiol Endocrinol Metab. 2014 Feb;306(3):E300-10. doi: 10.1152/ajpendo.00427.2013. Epub 2013 Dec 10.

47.

New insights into the physiologic basis for intermittent pneumatic limb compression as a therapeutic strategy for peripheral artery disease.

Sheldon RD, Roseguini BT, Laughlin MH, Newcomer SC.

J Vasc Surg. 2013 Dec;58(6):1688-96. doi: 10.1016/j.jvs.2013.08.094. Review.

48.

Exercise training and vascular cell phenotype in a swine model of familial hypercholesterolaemia: conduit arteries and veins.

Simmons GH, Padilla J, Jenkins NT, Laughlin MH.

Exp Physiol. 2014 Feb;99(2):454-65. doi: 10.1113/expphysiol.2013.075838. Epub 2013 Nov 8.

49.

Familial hypercholesterolemia impairs exercise-induced systemic vasodilation due to reduced NO bioavailability.

de Beer VJ, Merkus D, Bender SB, Tharp DL, Bowles DK, Duncker DJ, Laughlin MH.

J Appl Physiol (1985). 2013 Dec;115(12):1767-76. doi: 10.1152/japplphysiol.00619.2013. Epub 2013 Oct 24.

50.

Differential vasomotor effects of insulin on gastrocnemius and soleus feed arteries in the OLETF rat model: role of endothelin-1.

Jenkins NT, Padilla J, Martin JS, Crissey JM, Thyfault JP, Rector RS, Laughlin MH.

Exp Physiol. 2014 Jan;99(1):262-71. doi: 10.1113/expphysiol.2013.074047. Epub 2013 Aug 30.

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