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Items: 1 to 50 of 56

1.

A Potent and Effective Suicidal Listeria Vaccine Platform.

Hanson WG, Benanti EL, Lemmens EE, Liu W, Skoble J, Leong ML, Rae CS, Fassò M, Brockstedt DG, Chen C, Portnoy DA, Dubensky TW Jr, Lauer P.

Infect Immun. 2019 Jul 23;87(8). pii: e00144-19. doi: 10.1128/IAI.00144-19. Print 2019 Aug.

2.

TOX is a critical regulator of tumour-specific T cell differentiation.

Scott AC, Dündar F, Zumbo P, Chandran SS, Klebanoff CA, Shakiba M, Trivedi P, Menocal L, Appleby H, Camara S, Zamarin D, Walther T, Snyder A, Femia MR, Comen EA, Wen HY, Hellmann MD, Anandasabapathy N, Liu Y, Altorki NK, Lauer P, Levy O, Glickman MS, Kaye J, Betel D, Philip M, Schietinger A.

Nature. 2019 Jul;571(7764):270-274. doi: 10.1038/s41586-019-1324-y. Epub 2019 Jun 17.

PMID:
31207604
3.

Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies.

Kim VM, Blair AB, Lauer P, Foley K, Che X, Soares K, Xia T, Muth ST, Kleponis J, Armstrong TD, Wolfgang CL, Jaffee EM, Brockstedt D, Zheng L.

J Immunother Cancer. 2019 May 22;7(1):132. doi: 10.1186/s40425-019-0601-5.

4.

Primary or Secondary Subtalar Arthrodesis and Revision of Calcaneal Nonunion with Minimally Invasive Rigid Internal Nail Fixation for Treatment of Displaced Intra-Articular Calcaneal Fractures.

Fuentes-Viejo D, Cellarier G, Lauer P, Simon P, Mittlmeier T.

Clin Podiatr Med Surg. 2019 Apr;36(2):295-306. doi: 10.1016/j.cpm.2018.10.010. Epub 2019 Jan 24. Review.

PMID:
30784538
5.

A microbial-based cancer vaccine for induction of EGFRvIII-specific CD8+ T cells and anti-tumor immunity.

Zebertavage L, Bambina S, Shugart J, Alice A, Zens KD, Lauer P, Hanson B, Gough MJ, Crittenden MR, Bahjat KS.

PLoS One. 2019 Jan 2;14(1):e0209153. doi: 10.1371/journal.pone.0209153. eCollection 2019.

6.

Heterologous vaccination targeting prostatic acid phosphatase (PAP) using DNA and Listeria vaccines elicits superior anti-tumor immunity dependent on CD4+ T cells elicited by DNA priming.

Johnson LE, Brockstedt D, Leong M, Lauer P, Theisen E, Sauer JD, McNeel DG.

Oncoimmunology. 2018 May 7;7(8):e1456603. doi: 10.1080/2162402X.2018.1456603. eCollection 2018.

7.

Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment.

Deng W, Lira V, Hudson TE, Lemmens EE, Hanson WG, Flores R, Barajas G, Katibah GE, Desbien AL, Lauer P, Leong ML, Portnoy DA, Dubensky TW Jr.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8179-8184. doi: 10.1073/pnas.1801910115. Epub 2018 Jul 23.

8.

The VirAB ABC Transporter Is Required for VirR Regulation of Listeria monocytogenes Virulence and Resistance to Nisin.

Grubaugh D, Regeimbal JM, Ghosh P, Zhou Y, Lauer P, Dubensky TW Jr.,, Higgins DE.

Infect Immun. 2018 Feb 20;86(3). pii: e00901-17. doi: 10.1128/IAI.00901-17. Print 2018 Mar.

9.

Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells.

Ortega FE, Rengarajan M, Chavez N, Radhakrishnan P, Gloerich M, Bianchini J, Siemers K, Luckett WS, Lauer P, Nelson WJ, Theriot JA.

Mol Biol Cell. 2017 Nov 1;28(22):2945-2957. doi: 10.1091/mbc.E16-12-0851. Epub 2017 Sep 6.

10.

Chromatin states define tumour-specific T cell dysfunction and reprogramming.

Philip M, Fairchild L, Sun L, Horste EL, Camara S, Shakiba M, Scott AC, Viale A, Lauer P, Merghoub T, Hellmann MD, Wolchok JD, Leslie CS, Schietinger A.

Nature. 2017 May 25;545(7655):452-456. doi: 10.1038/nature22367. Epub 2017 May 17.

11.

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis.

Schietinger A, Philip M, Krisnawan VE, Chiu EY, Delrow JJ, Basom RS, Lauer P, Brockstedt DG, Knoblaugh SE, Hämmerling GJ, Schell TD, Garbi N, Greenberg PD.

Immunity. 2016 Aug 16;45(2):389-401. doi: 10.1016/j.immuni.2016.07.011. Epub 2016 Aug 9.

12.

Systemic Tolerance Mediated by Melanoma Brain Tumors Is Reversible by Radiotherapy and Vaccination.

Jackson CM, Kochel CM, Nirschl CJ, Durham NM, Ruzevick J, Alme A, Francica BJ, Elias J, Daniels A, Dubensky TW Jr, Lauer P, Brockstedt DG, Baxi EG, Calabresi PA, Taube JM, Pardo CA, Brem H, Pardoll DM, Lim M, Drake CG.

Clin Cancer Res. 2016 Mar 1;22(5):1161-72. doi: 10.1158/1078-0432.CCR-15-1516. Epub 2015 Oct 21.

13.

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.

Fu J, Kanne DB, Leong M, Glickman LH, McWhirter SM, Lemmens E, Mechette K, Leong JJ, Lauer P, Liu W, Sivick KE, Zeng Q, Soares KC, Zheng L, Portnoy DA, Woodward JJ, Pardoll DM, Dubensky TW Jr, Kim Y.

Sci Transl Med. 2015 Apr 15;7(283):283ra52. doi: 10.1126/scitranslmed.aaa4306.

14.

Glutathione activates virulence gene expression of an intracellular pathogen.

Reniere ML, Whiteley AT, Hamilton KL, John SM, Lauer P, Brennan RG, Portnoy DA.

Nature. 2015 Jan 8;517(7533):170-3. doi: 10.1038/nature14029.

15.

Attenuated Listeria monocytogenes vectors overcome suppressive plasma factors during HIV infection to stimulate myeloid dendritic cells to promote adaptive immunity and reactivation of latent virus.

Miller EA, Spadaccia MR, Norton T, Demmler M, Gopal R, O'Brien M, Landau N, Dubensky TW Jr, Lauer P, Brockstedt DG, Bhardwaj N.

AIDS Res Hum Retroviruses. 2015 Jan;31(1):127-36. doi: 10.1089/AID.2014.0138.

16.

Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis.

Lizotte PH, Baird JR, Stevens CA, Lauer P, Green WR, Brockstedt DG, Fiering SN.

Oncoimmunology. 2014 May 23;3:e28926. eCollection 2014.

17.

A Listeria vaccine and depletion of T-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice.

Keenan BP, Saenger Y, Kafrouni MI, Leubner A, Lauer P, Maitra A, Rucki AA, Gunderson AJ, Coussens LM, Brockstedt DG, Dubensky TW Jr, Hassan R, Armstrong TD, Jaffee EM.

Gastroenterology. 2014 Jun;146(7):1784-94.e6. doi: 10.1053/j.gastro.2014.02.055. Epub 2014 Mar 6.

18.

Enhanced virus-specific CD8+ T cell responses by Listeria monocytogenes-infected dendritic cells in the context of Tim-3 blockade.

Ma CJ, Ren JP, Li GY, Wu XY, Brockstedt DG, Lauer P, Moorman JP, Yao ZQ.

PLoS One. 2014 Jan 31;9(1):e87821. doi: 10.1371/journal.pone.0087821. eCollection 2014.

19.

Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation.

Cohn L, Chatterjee B, Esselborn F, Smed-Sörensen A, Nakamura N, Chalouni C, Lee BC, Vandlen R, Keler T, Lauer P, Brockstedt D, Mellman I, Delamarre L.

J Exp Med. 2013 May 6;210(5):1049-63. doi: 10.1084/jem.20121251. Epub 2013 Apr 8.

20.

Cutting edge: rapid boosting of cross-reactive memory CD8 T cells broadens the protective capacity of the Flumist vaccine.

Slütter B, Pewe LL, Lauer P, Harty JT.

J Immunol. 2013 Apr 15;190(8):3854-8. doi: 10.4049/jimmunol.1202790. Epub 2013 Mar 6.

21.

Killed but metabolically active vaccines.

Dubensky TW Jr, Skoble J, Lauer P, Brockstedt DG.

Curr Opin Biotechnol. 2012 Dec;23(6):917-23. doi: 10.1016/j.copbio.2012.04.005. Epub 2012 May 18. Review.

PMID:
22608846
22.

Operation of marine diesel engines on biogenic fuels: modification of emissions and resulting climate effects.

Petzold A, Lauer P, Fritsche U, Hasselbach J, Lichtenstern M, Schlager H, Fleischer F.

Environ Sci Technol. 2011 Dec 15;45(24):10394-400. doi: 10.1021/es2021439. Epub 2011 Nov 17.

PMID:
22044020
23.

Tumor-associated antigen expressing Listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases.

Olino K, Wada S, Edil BH, Pan X, Meckel K, Weber W, Slansky J, Tamada K, Lauer P, Brockstedt D, Pardoll D, Schulick R, Yoshimura K.

Ann Surg Oncol. 2012 Jul;19 Suppl 3:S597-607. doi: 10.1245/s10434-011-2037-0. Epub 2011 Oct 7.

24.

The impact of pre-existing memory on differentiation of newly recruited naive CD8 T cells.

Martin MD, Wirth TC, Lauer P, Harty JT, Badovinac VP.

J Immunol. 2011 Sep 15;187(6):2923-31. doi: 10.4049/jimmunol.1100698. Epub 2011 Aug 10.

25.

Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity.

Sauer JD, Pereyre S, Archer KA, Burke TP, Hanson B, Lauer P, Portnoy DA.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12419-24. doi: 10.1073/pnas.1019041108. Epub 2011 Jul 11.

26.

Dynamic imaging of the effector immune response to listeria infection in vivo.

Waite JC, Leiner I, Lauer P, Rae CS, Barbet G, Zheng H, Portnoy DA, Pamer EG, Dustin ML.

PLoS Pathog. 2011 Mar;7(3):e1001326. doi: 10.1371/journal.ppat.1001326. Epub 2011 Mar 24.

27.

Invasive extravillous trophoblasts restrict intracellular growth and spread of Listeria monocytogenes.

Zeldovich VB, Robbins JR, Kapidzic M, Lauer P, Bakardjiev AI.

PLoS Pathog. 2011 Mar;7(3):e1002005. doi: 10.1371/journal.ppat.1002005. Epub 2011 Mar 3.

28.

Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol.

Sauer JD, Witte CE, Zemansky J, Hanson B, Lauer P, Portnoy DA.

Cell Host Microbe. 2010 May 20;7(5):412-9. doi: 10.1016/j.chom.2010.04.004. Epub 2010 Apr 22.

29.

Physical properties, chemical composition, and cloud forming potential of particulate emissions from a marine diesel engine at various load conditions.

Petzold A, Weingartner E, Hasselbach J, Lauer P, Kurok C, Fleischer F.

Environ Sci Technol. 2010 May 15;44(10):3800-5. doi: 10.1021/es903681z.

PMID:
20402501
30.

Priming and activation of human ovarian and breast cancer-specific CD8+ T cells by polyvalent Listeria monocytogenes-based vaccines.

Sinnathamby G, Lauer P, Zerfass J, Hanson B, Karabudak A, Krakover J, Secord AA, Clay TM, Morse MA, Dubensky TW Jr, Brockstedt DG, Philip R, Giedlin M.

J Immunother. 2009 Oct;32(8):856-69. doi: 10.1097/CJI.0b013e3181b0b125.

PMID:
19752748
31.

KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity.

Skoberne M, Yewdall A, Bahjat KS, Godefroy E, Lauer P, Lemmens E, Liu W, Luckett W, Leong M, Dubensky TW, Brockstedt DG, Bhardwaj N.

J Clin Invest. 2008 Dec;118(12):3990-4001. doi: 10.1172/JCI31350. Epub 2008 Nov 6.

32.

Increased EEG power density in alpha and theta bands in adult ADHD patients.

Koehler S, Lauer P, Schreppel T, Jacob C, Heine M, Boreatti-Hümmer A, Fallgatter AJ, Herrmann MJ.

J Neural Transm (Vienna). 2009 Jan;116(1):97-104. doi: 10.1007/s00702-008-0157-x. Epub 2008 Nov 22.

PMID:
19030776
33.

Short-term genome evolution of Listeria monocytogenes in a non-controlled environment.

Orsi RH, Borowsky ML, Lauer P, Young SK, Nusbaum C, Galagan JE, Birren BW, Ivy RA, Sun Q, Graves LM, Swaminathan B, Wiedmann M.

BMC Genomics. 2008 Nov 13;9:539. doi: 10.1186/1471-2164-9-539.

34.

Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria.

Schmidt NW, Podyminogin RL, Butler NS, Badovinac VP, Tucker BJ, Bahjat KS, Lauer P, Reyes-Sandoval A, Hutchings CL, Moore AC, Gilbert SC, Hill AV, Bartholomay LC, Harty JT.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14017-22. doi: 10.1073/pnas.0805452105. Epub 2008 Sep 9.

35.

Pilus backbone contributes to group B Streptococcus paracellular translocation through epithelial cells.

Pezzicoli A, Santi I, Lauer P, Rosini R, Rinaudo D, Grandi G, Telford JL, Soriani M.

J Infect Dis. 2008 Sep 15;198(6):890-8. doi: 10.1086/591182.

PMID:
18694342
36.

Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity.

Crimmins GT, Herskovits AA, Rehder K, Sivick KE, Lauer P, Dubensky TW Jr, Portnoy DA.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10191-6. doi: 10.1073/pnas.0804170105. Epub 2008 Jul 16.

37.

Constitutive Activation of the PrfA regulon enhances the potency of vaccines based on live-attenuated and killed but metabolically active Listeria monocytogenes strains.

Lauer P, Hanson B, Lemmens EE, Liu W, Luckett WS, Leong ML, Allen HE, Skoble J, Bahjat KS, Freitag NE, Brockstedt DG, Dubensky TW Jr.

Infect Immun. 2008 Aug;76(8):3742-53. doi: 10.1128/IAI.00390-08. Epub 2008 Jun 9.

38.

Preliminary model of nitrogen loads from southern bluefin tuna aquaculture.

Fernandes M, Lauer P, Cheshire A, Angove M.

Mar Pollut Bull. 2007 Sep;54(9):1321-32. Epub 2007 Jul 31.

PMID:
17669437
39.

Identification of novel genomic islands coding for antigenic pilus-like structures in Streptococcus agalactiae.

Rosini R, Rinaudo CD, Soriani M, Lauer P, Mora M, Maione D, Taddei A, Santi I, Ghezzo C, Brettoni C, Buccato S, Margarit I, Grandi G, Telford JL.

Mol Microbiol. 2006 Jul;61(1):126-41.

40.

Genome analysis reveals pili in Group B Streptococcus.

Lauer P, Rinaudo CD, Soriani M, Margarit I, Maione D, Rosini R, Taddei AR, Mora M, Rappuoli R, Grandi G, Telford JL.

Science. 2005 Jul 1;309(5731):105.

41.

Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit.

Lauer P, Metzner HJ, Zettlmeissl G, Li M, Smith AG, Lathe R, Dickneite G.

Thromb Haemost. 2002 Dec;88(6):967-74.

PMID:
12529747
42.

Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors.

Lauer P, Chow MY, Loessner MJ, Portnoy DA, Calendar R.

J Bacteriol. 2002 Aug;184(15):4177-86. Erratum in: J Bacteriol. 2003 Feb;185(4):1484.

43.
44.

Prevalence of suicide programs in schools and roadblocks to implementation.

Hayden DC, Lauer P.

Suicide Life Threat Behav. 2000 Fall;30(3):239-51.

PMID:
11079637
46.
47.
48.

Clone-contig and STS maps of the hereditary hemochromatosis region on human chromosome 6p21.3-p22.

Lauer P, Meyer NC, Prass CE, Starnes SM, Wolff RK, Gnirke A.

Genome Res. 1997 May;7(5):457-70.

49.

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis.

Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R Jr, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Prass CE, Quintana L, Starnes SM, Schatzman RC, Brunke KJ, Drayna DT, Risch NJ, Bacon BR, Wolff RK.

Nat Genet. 1996 Aug;13(4):399-408.

PMID:
8696333
50.

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