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Items: 1 to 50 of 518

1.

Biochemical and biophysical characterization of purified native CD20 alone and in complex with rituximab and obinutuzumab.

Agez M, Mandon ED, Iwema T, Gianotti R, Limani F, Herter S, Mössner E, Kusznir EA, Huber S, Lauer M, Ringler P, Ferrara C, Klein C, Jawhari A.

Sci Rep. 2019 Sep 23;9(1):13675. doi: 10.1038/s41598-019-50031-4.

2.

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity.

Sustmann C, Dickopf S, Regula JT, Kettenberger H, Mølhøj M, Gassner C, Weininger D, Fenn S, Manigold T, Kling L, Künkele KP, Schwaiger M, Bossenmaier B, Griese JJ, Hopfner KP, Graff-Meyer A, Stahlberg H, Ringler P, Lauer ME, Brinkmann U, Schaefer W, Klein C.

MAbs. 2019 Sep 17:1-13. doi: 10.1080/19420862.2019.1661736. [Epub ahead of print]

PMID:
31526159
3.

Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies.

Hoffmann E, Jordan G, Lauer M, Ringler P, Kusznir EA, Rufer AC, Huber S, Jochner A, Winter G, Staack RF.

Pharm Res. 2019 Jun 28;36(9):129. doi: 10.1007/s11095-019-2661-0.

4.

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.

Shahmoradian SH, Lewis AJ, Genoud C, Hench J, Moors TE, Navarro PP, Castaño-Díez D, Schweighauser G, Graff-Meyer A, Goldie KN, Sütterlin R, Huisman E, Ingrassia A, Gier Y, Rozemuller AJM, Wang J, Paepe A, Erny J, Staempfli A, Hoernschemeyer J, Großerüschkamp F, Niedieker D, El-Mashtoly SF, Quadri M, Van IJcken WFJ, Bonifati V, Gerwert K, Bohrmann B, Frank S, Britschgi M, Stahlberg H, Van de Berg WDJ, Lauer ME.

Nat Neurosci. 2019 Jul;22(7):1099-1109. doi: 10.1038/s41593-019-0423-2. Epub 2019 Jun 24.

PMID:
31235907
5.

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.

Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, Albrecht R, Herter S, Schlenker R, Hüsser T, Diggelmann S, Challier J, Mössner E, Hosse RJ, Hofer T, Brünker P, Joseph C, Benz J, Ringler P, Stahlberg H, Lauer M, Perro M, Chen S, Küttel C, Bhavani Mohan PL, Nicolini V, Birk MC, Ongaro A, Prince C, Gianotti R, Dugan G, Whitlow CT, Solingapuram Sai KK, Caudell DL, Burgos-Rodriguez AG, Cline JM, Hettich M, Ceppi M, Giusti AM, Crameri F, Driessen W, Morcos PN, Freimoser-Grundschober A, Levitsky V, Amann M, Grau-Richards S, von Hirschheydt T, Tournaviti S, Mølhøj M, Fauti T, Heinzelmann-Schwarz V, Teichgräber V, Colombetti S, Bacac M, Zippelius A, Klein C, Umaña P.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaav5989. doi: 10.1126/scitranslmed.aav5989.

PMID:
31189721
6.

Life-time exposure to waterborne copper III: Effects on the energy metabolism of the killifish Poecilia vivipara.

Abou Anni IS, Zebral YD, Afonso SB, Moreno Abril SI, Lauer MM, Bianchini A.

Chemosphere. 2019 Jul;227:580-588. doi: 10.1016/j.chemosphere.2019.04.080. Epub 2019 Apr 12.

PMID:
31009864
7.

Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging.

Albrecht F, Mueller K, Ballarini T, Lampe L, Diehl-Schmid J, Fassbender K, Fliessbach K, Jahn H, Jech R, Kassubek J, Kornhuber J, Landwehrmeyer B, Lauer M, Ludolph AC, Lyros E, Prudlo J, Schneider A, Synofzik M, Wiltfang J, Danek A, Otto M; FTLD-Consortium, Schroeter ML.

Cortex. 2019 Aug;117:33-40. doi: 10.1016/j.cortex.2019.02.015. Epub 2019 Feb 25.

8.

Response.

Collins FS, Tabak LA, Wolinetz CD, Lauer MS, Gottesman MM.

Science. 2019 Mar 22;363(6433):1292-1294. doi: 10.1126/science.aaw8810. No abstract available.

9.

Highly flexible, IgG-shaped, trivalent antibodies effectively target tumor cells and induce T cell-mediated killing.

Dickopf S, Lauer ME, Ringler P, Spick C, Kern P, Brinkmann U.

Biol Chem. 2019 Jan 9. pii: /j/bchm.ahead-of-print/hsz-2018-0338/hsz-2018-0338.xml. doi: 10.1515/hsz-2018-0338. [Epub ahead of print]

PMID:
30864397
10.

Perceptions and responses of Pacific Island fishers to changing coral reefs.

Rassweiler A, Lauer M, Lester SE, Holbrook SJ, Schmitt RJ, Madi Moussa R, Munsterman KS, Lenihan HS, Brooks AJ, Wencélius J, Claudet J.

Ambio. 2019 Mar 7. doi: 10.1007/s13280-019-01154-5. [Epub ahead of print]

PMID:
30843168
11.

Highly flexible, IgG-shaped, trivalent antibodies effectively target tumor cells and induce T cell-mediated killing.

Dickopf S, Lauer ME, Ringler P, Spick C, Kern P, Brinkmann U.

Biol Chem. 2019 Feb 25;400(3):343-350. doi: 10.1515/hsz-2018-0338.

PMID:
30763031
12.

FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations.

Diehl-Schmid J, Licata A, Goldhardt O, Förstl H, Yakushew I, Otto M, Anderl-Straub S, Beer A, Ludolph AC, Landwehrmeyer GB, Levin J, Danek A, Fliessbach K, Spottke A, Fassbender K, Lyros E, Prudlo J, Krause BJ, Volk A, Edbauer D, Schroeter ML, Drzezga A, Kornhuber J, Lauer M; FTLDc Study Group, Grimmer T.

Transl Psychiatry. 2019 Jan 31;9(1):54. doi: 10.1038/s41398-019-0381-1.

13.

NIH Policies on Experimental Studies with Humans.

Riley WT, Riddle M, Lauer M.

Nat Hum Behav. 2018 Feb;2(2):103-106. doi: 10.1038/s41562-017-0265-4. Epub 2017 Nov 22.

14.

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles.

Navarro PP, Genoud C, Castaño-Díez D, Graff-Meyer A, Lewis AJ, de Gier Y, Lauer ME, Britschgi M, Bohrmann B, Frank S, Hench J, Schweighauser G, Rozemuller AJM, van de Berg WDJ, Stahlberg H, Shahmoradian SH.

Sci Rep. 2018 Dec 21;8(1):18046. doi: 10.1038/s41598-018-36223-4.

15.

The applause sign in frontotemporal lobar degeneration and related conditions.

Schönecker S, Hell F, Bötzel K, Wlasich E, Ackl N, Süßmair C; German FTLD Consortium, Otto M, Anderl-Straub S, Ludolph A, Kassubek J, Huppertz HJ, Diehl-Schmid J, Riedl L, Roßmeier C, Fassbender K, Lyros E, Kornhuber J, Oberstein TJ, Fliessbach K, Schneider A, Schroeter ML, Prudlo J, Lauer M, Jahn H, Levin J, Danek A.

J Neurol. 2019 Feb;266(2):330-338. doi: 10.1007/s00415-018-9134-y. Epub 2018 Dec 1.

PMID:
30506397
16.

Bone Scintigraphy: A Review of Technical Aspects and Applications in Orthopedic Surgery.

Krumme JW, Lauer MF, Stowell JT, Beteselassie NM, Kotwal SY.

Orthopedics. 2019 Jan 1;42(1):e14-e24. doi: 10.3928/01477447-20181120-05. Epub 2018 Nov 28. Review.

PMID:
30484853
17.

Intramedullary Antibiotic Delivery for Emphysematous Osteomyelitis of the Femur.

Lauer MF, Boschert EN, Dubin JR, Bernhardt M.

Orthopedics. 2019 Jan 1;42(1):e128-e130. doi: 10.3928/01477447-20181023-08. Epub 2018 Oct 29.

PMID:
30371923
18.

Inclusion Across the Lifespan: NIH Policy for Clinical Research.

Bernard MA, Clayton JA, Lauer MS.

JAMA. 2018 Oct 16;320(15):1535-1536. doi: 10.1001/jama.2018.12368. No abstract available.

PMID:
30326521
19.

Working Together to Address Women's Health in Research and Drug Development: Summary of the 2017 Women's Health Congress Preconference Symposium.

Feuerstein IM, Jenkins MR, Kornstein SG, Lauer MS, Scott PE, Raju TNK, Johnson T, Devaney S, Lolic M, Henderson M, Clayton JA.

J Womens Health (Larchmt). 2018 Oct;27(10):1195-1203. doi: 10.1089/jwh.2018.29019.pcss.

20.

Researchers, Patients, and Stakeholders Evaluating Comparative-Effectiveness Research: A Mixed-Methods Study of the PCORI Reviewer Experience.

Forsythe LP, Frank LB, Hemphill R, Tafari AT, Szydlowski V, Lauer M, Goertz C, Clauser S.

Value Health. 2018 Oct;21(10):1161-1167. doi: 10.1016/j.jval.2018.03.018. Epub 2018 Jun 12.

21.

Unique Review Criteria and Patient and Stakeholder Reviewers: Analysis of PCORI's Approach to Research Funding.

Forsythe LP, Frank LB, Tafari AT, Cohen SS, Lauer M, Clauser S, Goertz C, Schrandt S.

Value Health. 2018 Oct;21(10):1152-1160. doi: 10.1016/j.jval.2018.03.017. Epub 2018 Jun 8.

22.

Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase.

Oeckl P, Weydt P, Steinacker P, Anderl-Straub S, Nordin F, Volk AE, Diehl-Schmid J, Andersen PM, Kornhuber J, Danek A, Fassbender K, Fliessbach K; German Consortium for Frontotemporal Lobar Degeneration, Jahn H, Lauer M, Müller K, Knehr A, Prudlo J, Schneider A, Thal DR, Yilmazer-Hanke D, Weishaupt JH, Ludolph AC, Otto M.

J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):4-10. doi: 10.1136/jnnp-2018-318868. Epub 2018 Sep 17.

PMID:
30224549
23.

Serum neurofilament light chain in behavioral variant frontotemporal dementia.

Steinacker P, Anderl-Straub S, Diehl-Schmid J, Semler E, Uttner I, von Arnim CAF, Barthel H, Danek A, Fassbender K, Fliessbach K, Foerstl H, Grimmer T, Huppertz HJ, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer B, Lauer M, Maler JM, Mayer B, Oeckl P, Prudlo J, Schneider A, Volk AE, Wiltfang J, Schroeter ML, Ludolph AC, Otto M; FTLDc study group.

Neurology. 2018 Oct 9;91(15):e1390-e1401. doi: 10.1212/WNL.0000000000006318. Epub 2018 Sep 12.

PMID:
30209235
24.

Midgut Laterality Is Driven by Hyaluronan on the Right.

Sivakumar A, Mahadevan A, Lauer ME, Narvaez RJ, Ramesh S, Demler CM, Souchet NR, Hascall VC, Midura RJ, Garantziotis S, Frank DB, Kimata K, Kurpios NA.

Dev Cell. 2018 Sep 10;46(5):533-551.e5. doi: 10.1016/j.devcel.2018.08.002. Epub 2018 Aug 30.

25.

Cryo-EM structure of alpha-synuclein fibrils.

Guerrero-Ferreira R, Taylor NM, Mona D, Ringler P, Lauer ME, Riek R, Britschgi M, Stahlberg H.

Elife. 2018 Jul 3;7. pii: e36402. doi: 10.7554/eLife.36402.

26.

Nitric oxide alters hyaluronan deposition by airway smooth muscle cells.

Majors AK, Chakravarti R, Ruple LM, Leahy R, Stuehr DJ, Lauer M, Erzurum SC, Janocha A, Aronica MA.

PLoS One. 2018 Jul 2;13(7):e0200074. doi: 10.1371/journal.pone.0200074. eCollection 2018.

27.

A Miniaturized Extruder to Prototype Amorphous Solid Dispersions: Selection of Plasticizers for Hot Melt Extrusion.

Lauer ME, Maurer R, Paepe AT, Stillhart C, Jacob L, James R, Kojima Y, Rietmann R, Kissling T, van den Ende JA, Schwarz S, Grassmann O, Page S.

Pharmaceutics. 2018 May 19;10(2). pii: E58. doi: 10.3390/pharmaceutics10020058.

28.

Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls.

Denk J, Oberhauser F, Kornhuber J, Wiltfang J, Fassbender K, Schroeter ML, Volk AE, Diehl-Schmid J, Prudlo J, Danek A, Landwehrmeyer B, Lauer M, Otto M, Jahn H; FTLDc study group.

PLoS One. 2018 May 10;13(5):e0197329. doi: 10.1371/journal.pone.0197329. eCollection 2018.

29.

A language-based sum score for the course and therapeutic intervention in primary progressive aphasia.

Semler E, Anderl-Straub S, Uttner I, Diehl-Schmid J, Danek A, Einsiedler B, Fassbender K, Fliessbach K, Huppertz HJ, Jahn H, Kornhuber J, Landwehrmeyer B, Lauer M, Muche R, Prudlo J, Schneider A, Schroeter ML, Ludolph AC, Otto M; FTLD consortium.

Alzheimers Res Ther. 2018 Apr 25;10(1):41. doi: 10.1186/s13195-018-0345-3.

30.

Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment.

Katzorke A, Zeller JBM, Müller LD, Lauer M, Polak T, Deckert J, Herrmann MJ.

Psychiatry Res Neuroimaging. 2018 Apr 30;274:11-18. doi: 10.1016/j.pscychresns.2018.02.003. Epub 2018 Feb 11.

PMID:
29472145
31.

A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests.

Schroeter ML, Pawelke S, Bisenius S, Kynast J, Schuemberg K, Polyakova M, Anderl-Straub S, Danek A, Fassbender K, Jahn H, Jessen F, Kornhuber J, Lauer M, Prudlo J, Schneider A, Uttner I, Thöne-Otto A, Otto M, Diehl-Schmid J.

Front Aging Neurosci. 2018 Jan 30;10:11. doi: 10.3389/fnagi.2018.00011. eCollection 2018.

32.

Reduced spontaneous low frequency oscillations as measured with functional near-infrared spectroscopy in mild cognitive impairment.

Zeller JBM, Katzorke A, Müller LD, Breunig J, Haeussinger FB, Deckert J, Warrings B, Lauer M, Polak T, Herrmann MJ.

Brain Imaging Behav. 2019 Feb;13(1):283-292. doi: 10.1007/s11682-018-9827-y.

PMID:
29362991
33.

Quantification of hyaluronan (HA) using a simplified fluorophore-assisted carbohydrate electrophoresis (FACE) procedure.

Midura RJ, Cali V, Lauer ME, Calabro A, Hascall VC.

Methods Cell Biol. 2018;143:297-316. doi: 10.1016/bs.mcb.2017.08.017. Epub 2017 Oct 13.

PMID:
29310784
34.

Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.

Steinacker P, Verde F, Fang L, Feneberg E, Oeckl P, Roeber S, Anderl-Straub S, Danek A, Diehl-Schmid J, Fassbender K, Fliessbach K, Foerstl H, Giese A, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer GB, Lauer M, Pinkhardt EH, Prudlo J, Rosenbohm A, Schneider A, Schroeter ML, Tumani H, von Arnim CAF, Weishaupt J, Weydt P, Ludolph AC, Yilmazer Hanke D, Otto M; FTLDc study group.

J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):239-247. doi: 10.1136/jnnp-2017-317138. Epub 2017 Nov 15.

PMID:
29142138
35.

TNF-stimulated gene 6 promotes formation of hyaluronan-inter-α-inhibitor heavy chain complexes necessary for ozone-induced airway hyperresponsiveness.

Stober VP, Johnson CG, Majors A, Lauer ME, Cali V, Midura RJ, Wisniewski HG, Aronica MA, Garantziotis S.

J Biol Chem. 2017 Dec 22;292(51):20845-20858. doi: 10.1074/jbc.M116.756627. Epub 2017 Nov 9.

36.

Opinion: The Next Generation Researchers Initiative at NIH.

Lauer M, Tabak L, Collins F.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11801-11803. doi: 10.1073/pnas.1716941114. No abstract available.

37.

The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity.

Zahreddine HA, Culjkovic-Kraljacic B, Emond A, Pettersson F, Midura R, Lauer M, Del Rincon S, Cali V, Assouline S, Miller WH, Hascall V, Borden KL.

Elife. 2017 Nov 7;6. pii: e29830. doi: 10.7554/eLife.29830.

38.

Near-infrared spectroscopy (NIRS) and vagus somatosensory evoked potentials (VSEP) in the early diagnosis of Alzheimer's disease: rationale, design, methods, and first baseline data of the Vogel study.

Polak T, Herrmann MJ, Müller LD, Zeller JBM, Katzorke A, Fischer M, Spielmann F, Weinmann E, Hommers L, Lauer M, Fallgatter AJ, Deckert J.

J Neural Transm (Vienna). 2017 Nov;124(11):1473-1488. doi: 10.1007/s00702-017-1781-0. Epub 2017 Sep 1.

PMID:
28864837
39.

Chronic asthma and Mesenchymal stem cells: Hyaluronan and airway remodeling.

Goldstein BD, Lauer ME, Caplan AI, Bonfield TL.

J Inflamm (Lond). 2017 Aug 30;14:18. doi: 10.1186/s12950-017-0165-4. eCollection 2017.

40.

Enumeration of circulating endothelial cell frequency as a diagnostic marker in aortic valve surgery - a flow cytometric approach.

Sabashnikov A, Neef K, Chesnokova V, Wegener L, Godthardt K, Scherner M, Kuhn EW, Deppe AC, Lauer M, Eghbalzadeh K, Zeriouh M, Rahmanian PB, Wippermann J, Kuhn-Régnier F, Madershahian N, Wahlers T, Weymann A, Choi YH.

J Cardiothorac Surg. 2017 Aug 9;12(1):68. doi: 10.1186/s13019-017-0631-3.

41.

Asymptomatic Aortic Stenosis: From Flights of Stairs to Exercise Testing to Exercise Echocardiography?

Lauer MS.

JACC Cardiovasc Imaging. 2018 Jun;11(6):796-797. doi: 10.1016/j.jcmg.2017.06.001. Epub 2017 Jul 19. No abstract available.

42.

FDA Device Regulation.

Lauer M, Barker JP, Solano M, Dubin J.

Mo Med. 2017 Jul-Aug;114(4):283-288. Review. No abstract available.

43.

Methyltransferase-directed covalent coupling of fluorophores to DNA.

Lauer MH, Vranken C, Deen J, Frederickx W, Vanderlinden W, Wand N, Leen V, Gehlen MH, Hofkens J, Neely RK.

Chem Sci. 2017 May 1;8(5):3804-3811. doi: 10.1039/c6sc04229e. Epub 2017 Mar 14.

44.

Efficient design of clinical trials and epidemiological research: is it possible?

Lauer MS, Gordon D, Wei G, Pearson G.

Nat Rev Cardiol. 2017 Aug;14(8):493-501. doi: 10.1038/nrcardio.2017.60. Epub 2017 Apr 27. Review.

PMID:
28447664
45.

Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD.

Lehmer C, Oeckl P, Weishaupt JH, Volk AE, Diehl-Schmid J, Schroeter ML, Lauer M, Kornhuber J, Levin J, Fassbender K, Landwehrmeyer B; German Consortium for Frontotemporal Lobar Degeneration, Schludi MH, Arzberger T, Kremmer E, Flatley A, Feederle R, Steinacker P, Weydt P, Ludolph AC, Edbauer D, Otto M.

EMBO Mol Med. 2017 Jul;9(7):859-868. doi: 10.15252/emmm.201607486.

46.

Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task.

Katzorke A, Zeller JB, Müller LD, Lauer M, Polak T, Reif A, Deckert J, Herrmann MJ.

Front Hum Neurosci. 2017 Feb 6;11:46. doi: 10.3389/fnhum.2017.00046. eCollection 2017.

47.

Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias.

Steinacker P, Semler E, Anderl-Straub S, Diehl-Schmid J, Schroeter ML, Uttner I, Foerstl H, Landwehrmeyer B, von Arnim CA, Kassubek J, Oeckl P, Huppertz HJ, Fassbender K, Fliessbach K, Prudlo J, Roßmeier C, Kornhuber J, Schneider A, Volk AE, Lauer M, Danek A, Ludolph AC, Otto M; FTLDc Study Group.

Neurology. 2017 Mar 7;88(10):961-969. doi: 10.1212/WNL.0000000000003688. Epub 2017 Feb 8.

PMID:
28179468
48.

Transforming Evidence Generation to Support Health and Health Care Decisions.

Califf RM, Robb MA, Bindman AB, Briggs JP, Collins FS, Conway PH, Coster TS, Cunningham FE, De Lew N, DeSalvo KB, Dymek C, Dzau VJ, Fleurence RL, Frank RG, Gaziano JM, Kaufmann P, Lauer M, Marks PW, McGinnis JM, Richards C, Selby JV, Shulkin DJ, Shuren J, Slavitt AM, Smith SR, Washington BV, White PJ, Woodcock J, Woodson J, Sherman RE.

N Engl J Med. 2016 Dec 15;375(24):2395-2400. No abstract available.

49.

Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-α, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages.

Dong Y, Arif A, Olsson M, Cali V, Hardman B, Dosanjh M, Lauer M, Midura RJ, Hascall VC, Brown KL, Johnson P.

Sci Rep. 2016 Nov 21;6:36928. doi: 10.1038/srep36928.

50.

Dysregulation of hyaluronan homeostasis during aortic valve disease.

Krishnamurthy VK, Stout AJ, Sapp MC, Matuska B, Lauer ME, Grande-Allen KJ.

Matrix Biol. 2017 Oct;62:40-57. doi: 10.1016/j.matbio.2016.11.003. Epub 2016 Nov 15.

PMID:
27856308

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