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Cryo-EM structure of alpha-synuclein fibrils.

Guerrero-Ferreira R, Taylor NM, Mona D, Ringler P, Lauer ME, Riek R, Britschgi M, Stahlberg H.

Elife. 2018 Jul 3;7. pii: e36402. doi: 10.7554/eLife.36402.


Nitric oxide alters hyaluronan deposition by airway smooth muscle cells.

Majors AK, Chakravarti R, Ruple LM, Leahy R, Stuehr DJ, Lauer M, Erzurum SC, Janocha A, Aronica MA.

PLoS One. 2018 Jul 2;13(7):e0200074. doi: 10.1371/journal.pone.0200074. eCollection 2018.


A Miniaturized Extruder to Prototype Amorphous Solid Dispersions: Selection of Plasticizers for Hot Melt Extrusion.

Lauer ME, Maurer R, Paepe AT, Stillhart C, Jacob L, James R, Kojima Y, Rietmann R, Kissling T, van den Ende JA, Schwarz S, Grassmann O, Page S.

Pharmaceutics. 2018 May 19;10(2). pii: E58. doi: 10.3390/pharmaceutics10020058.


Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls.

Denk J, Oberhauser F, Kornhuber J, Wiltfang J, Fassbender K, Schroeter ML, Volk AE, Diehl-Schmid J, Prudlo J, Danek A, Landwehrmeyer B, Lauer M, Otto M, Jahn H; FTLDc study group.

PLoS One. 2018 May 10;13(5):e0197329. doi: 10.1371/journal.pone.0197329. eCollection 2018.


A language-based sum score for the course and therapeutic intervention in primary progressive aphasia.

Semler E, Anderl-Straub S, Uttner I, Diehl-Schmid J, Danek A, Einsiedler B, Fassbender K, Fliessbach K, Huppertz HJ, Jahn H, Kornhuber J, Landwehrmeyer B, Lauer M, Muche R, Prudlo J, Schneider A, Schroeter ML, Ludolph AC, Otto M; FTLD consortium.

Alzheimers Res Ther. 2018 Apr 25;10(1):41. doi: 10.1186/s13195-018-0345-3.


Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment.

Katzorke A, Zeller JBM, Müller LD, Lauer M, Polak T, Deckert J, Herrmann MJ.

Psychiatry Res Neuroimaging. 2018 Apr 30;274:11-18. doi: 10.1016/j.pscychresns.2018.02.003. Epub 2018 Feb 11.


A Modified Reading the Mind in the Eyes Test Predicts Behavioral Variant Frontotemporal Dementia Better Than Executive Function Tests.

Schroeter ML, Pawelke S, Bisenius S, Kynast J, Schuemberg K, Polyakova M, Anderl-Straub S, Danek A, Fassbender K, Jahn H, Jessen F, Kornhuber J, Lauer M, Prudlo J, Schneider A, Uttner I, Thöne-Otto A, Otto M, Diehl-Schmid J.

Front Aging Neurosci. 2018 Jan 30;10:11. doi: 10.3389/fnagi.2018.00011. eCollection 2018.


Reduced spontaneous low frequency oscillations as measured with functional near-infrared spectroscopy in mild cognitive impairment.

Zeller JBM, Katzorke A, Müller LD, Breunig J, Haeussinger FB, Deckert J, Warrings B, Lauer M, Polak T, Herrmann MJ.

Brain Imaging Behav. 2018 Jan 23. doi: 10.1007/s11682-018-9827-y. [Epub ahead of print]


Quantification of hyaluronan (HA) using a simplified fluorophore-assisted carbohydrate electrophoresis (FACE) procedure.

Midura RJ, Cali V, Lauer ME, Calabro A, Hascall VC.

Methods Cell Biol. 2018;143:297-316. doi: 10.1016/bs.mcb.2017.08.017. Epub 2017 Oct 13.


Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.

Steinacker P, Verde F, Fang L, Feneberg E, Oeckl P, Roeber S, Anderl-Straub S, Danek A, Diehl-Schmid J, Fassbender K, Fliessbach K, Foerstl H, Giese A, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer GB, Lauer M, Pinkhardt EH, Prudlo J, Rosenbohm A, Schneider A, Schroeter ML, Tumani H, von Arnim CAF, Weishaupt J, Weydt P, Ludolph AC, Yilmazer Hanke D, Otto M; FTLDc study group.

J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):239-247. doi: 10.1136/jnnp-2017-317138. Epub 2017 Nov 15.


TNF-stimulated gene 6 promotes formation of hyaluronan-inter-α-inhibitor heavy chain complexes necessary for ozone-induced airway hyperresponsiveness.

Stober VP, Johnson CG, Majors A, Lauer ME, Cali V, Midura RJ, Wisniewski HG, Aronica MA, Garantziotis S.

J Biol Chem. 2017 Dec 22;292(51):20845-20858. doi: 10.1074/jbc.M116.756627. Epub 2017 Nov 9.


Opinion: The Next Generation Researchers Initiative at NIH.

Lauer M, Tabak L, Collins F.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11801-11803. doi: 10.1073/pnas.1716941114. No abstract available.


The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity.

Zahreddine HA, Culjkovic-Kraljacic B, Emond A, Pettersson F, Midura R, Lauer M, Del Rincon S, Cali V, Assouline S, Miller WH, Hascall V, Borden KL.

Elife. 2017 Nov 7;6. pii: e29830. doi: 10.7554/eLife.29830.


Near-infrared spectroscopy (NIRS) and vagus somatosensory evoked potentials (VSEP) in the early diagnosis of Alzheimer's disease: rationale, design, methods, and first baseline data of the Vogel study.

Polak T, Herrmann MJ, Müller LD, Zeller JBM, Katzorke A, Fischer M, Spielmann F, Weinmann E, Hommers L, Lauer M, Fallgatter AJ, Deckert J.

J Neural Transm (Vienna). 2017 Nov;124(11):1473-1488. doi: 10.1007/s00702-017-1781-0. Epub 2017 Sep 1.


Chronic asthma and Mesenchymal stem cells: Hyaluronan and airway remodeling.

Goldstein BD, Lauer ME, Caplan AI, Bonfield TL.

J Inflamm (Lond). 2017 Aug 30;14:18. doi: 10.1186/s12950-017-0165-4. eCollection 2017.


Enumeration of circulating endothelial cell frequency as a diagnostic marker in aortic valve surgery - a flow cytometric approach.

Sabashnikov A, Neef K, Chesnokova V, Wegener L, Godthardt K, Scherner M, Kuhn EW, Deppe AC, Lauer M, Eghbalzadeh K, Zeriouh M, Rahmanian PB, Wippermann J, Kuhn-Régnier F, Madershahian N, Wahlers T, Weymann A, Choi YH.

J Cardiothorac Surg. 2017 Aug 9;12(1):68. doi: 10.1186/s13019-017-0631-3.


Asymptomatic Aortic Stenosis: From Flights of Stairs to Exercise Testing to Exercise Echocardiography?

Lauer MS.

JACC Cardiovasc Imaging. 2018 Jun;11(6):796-797. doi: 10.1016/j.jcmg.2017.06.001. Epub 2017 Jul 19. No abstract available.


Methyltransferase-directed covalent coupling of fluorophores to DNA.

Lauer MH, Vranken C, Deen J, Frederickx W, Vanderlinden W, Wand N, Leen V, Gehlen MH, Hofkens J, Neely RK.

Chem Sci. 2017 May 1;8(5):3804-3811. doi: 10.1039/c6sc04229e. Epub 2017 Mar 14.


Efficient design of clinical trials and epidemiological research: is it possible?

Lauer MS, Gordon D, Wei G, Pearson G.

Nat Rev Cardiol. 2017 Aug;14(8):493-501. doi: 10.1038/nrcardio.2017.60. Epub 2017 Apr 27. Review.


Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD.

Lehmer C, Oeckl P, Weishaupt JH, Volk AE, Diehl-Schmid J, Schroeter ML, Lauer M, Kornhuber J, Levin J, Fassbender K, Landwehrmeyer B; German Consortium for Frontotemporal Lobar Degeneration, Schludi MH, Arzberger T, Kremmer E, Flatley A, Feederle R, Steinacker P, Weydt P, Ludolph AC, Edbauer D, Otto M.

EMBO Mol Med. 2017 Jul;9(7):859-868. doi: 10.15252/emmm.201607486.


Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task.

Katzorke A, Zeller JB, Müller LD, Lauer M, Polak T, Reif A, Deckert J, Herrmann MJ.

Front Hum Neurosci. 2017 Feb 6;11:46. doi: 10.3389/fnhum.2017.00046. eCollection 2017.


Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias.

Steinacker P, Semler E, Anderl-Straub S, Diehl-Schmid J, Schroeter ML, Uttner I, Foerstl H, Landwehrmeyer B, von Arnim CA, Kassubek J, Oeckl P, Huppertz HJ, Fassbender K, Fliessbach K, Prudlo J, Roßmeier C, Kornhuber J, Schneider A, Volk AE, Lauer M, Danek A, Ludolph AC, Otto M; FTLDc Study Group.

Neurology. 2017 Mar 7;88(10):961-969. doi: 10.1212/WNL.0000000000003688. Epub 2017 Feb 8.


Transforming Evidence Generation to Support Health and Health Care Decisions.

Califf RM, Robb MA, Bindman AB, Briggs JP, Collins FS, Conway PH, Coster TS, Cunningham FE, De Lew N, DeSalvo KB, Dymek C, Dzau VJ, Fleurence RL, Frank RG, Gaziano JM, Kaufmann P, Lauer M, Marks PW, McGinnis JM, Richards C, Selby JV, Shulkin DJ, Shuren J, Slavitt AM, Smith SR, Washington BV, White PJ, Woodcock J, Woodson J, Sherman RE.

N Engl J Med. 2016 Dec 15;375(24):2395-2400. No abstract available.


Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-α, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages.

Dong Y, Arif A, Olsson M, Cali V, Hardman B, Dosanjh M, Lauer M, Midura RJ, Hascall VC, Brown KL, Johnson P.

Sci Rep. 2016 Nov 21;6:36928. doi: 10.1038/srep36928.


Dysregulation of hyaluronan homeostasis during aortic valve disease.

Krishnamurthy VK, Stout AJ, Sapp MC, Matuska B, Lauer ME, Grande-Allen KJ.

Matrix Biol. 2017 Oct;62:40-57. doi: 10.1016/j.matbio.2016.11.003. Epub 2016 Nov 15.


Toward a New Era of Trust and Transparency in Clinical Trials.

Hudson KL, Lauer MS, Collins FS.

JAMA. 2016 Oct 4;316(13):1353-1354. doi: 10.1001/jama.2016.14668. No abstract available.


Heart Rate Recovery: Coming Back Full-Circle to the Baroreceptor Reflex.

Lauer MS.

Circ Res. 2016 Aug 19;119(5):582-3. doi: 10.1161/CIRCRESAHA.116.309392. No abstract available.


Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Is Constitutively Expressed in Adult Central Nervous System (CNS) and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury.

Coulson-Thomas VJ, Lauer ME, Soleman S, Zhao C, Hascall VC, Day AJ, Fawcett JW.

J Biol Chem. 2016 Sep 16;291(38):19939-52. doi: 10.1074/jbc.M115.710673. Epub 2016 Jul 19.


Pathological Hyaluronan Matrices in Cystic Fibrosis Airways and Secretions.

Matuska B, Comhair S, Farver C, Chmiel J, Midura RJ, Bonfield T, Lauer ME.

Am J Respir Cell Mol Biol. 2016 Oct;55(4):576-585.


Isolation and analysis of sugar nucleotides using solid phase extraction and fluorophore assisted carbohydrate electrophoresis.

Barnes J, Tian L, Loftis J, Hiznay J, Comhair S, Lauer M, Dweik R.

MethodsX. 2016 Mar 14;3:251-60. doi: 10.1016/j.mex.2016.03.010. eCollection 2016.


Testosterone replacement therapy: intent matters.

Lauer MS.

Lancet Diabetes Endocrinol. 2016 Jun;4(6):471-3. doi: 10.1016/S2213-8587(16)30008-0. Epub 2016 May 7. No abstract available.


The Productivity of NHLBI-Funded Obesity Research, 1983-2013.

Nicastro HL, Belter CW, Lauer MS, Coady SA, Fine LJ, Loria CM.

Obesity (Silver Spring). 2016 Jun;24(6):1356-65. doi: 10.1002/oby.21478. Epub 2016 May 4.


Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs.

Plath F, Ringler P, Graff-Meyer A, Stahlberg H, Lauer ME, Rufer AC, Graewert MA, Svergun D, Gellermann G, Finkler C, Stracke JO, Koulov A, Schnaible V.

MAbs. 2016 Jul;8(5):928-40. doi: 10.1080/19420862.2016.1168960. Epub 2016 Mar 31.


Basic science: Bedrock of progress.

Collins FS, Anderson JM, Austin CP, Battey JF, Birnbaum LS, Briggs JP, Clayton JA, Cuthbert B, Eisinger RW, Fauci AS, Gallin JI, Gibbons GH, Glass RI, Gottesman MM, Gray PA, Green ED, Greider FB, Hodes R, Hudson KL, Humphreys B, Katz SI, Koob GF, Koroshetz WJ, Lauer MS, Lorsch JR, Lowy DR, McGowan JJ, Murray DM, Nakamura R, Norris A, Perez-Stable EJ, Pettigrew RI, Riley WT, Rodgers GP, Sieving PA, Somerman MJ, Spong CY, Tabak LA, Volkow ND, Wilder EL.

Science. 2016 Mar 25;351(6280):1405. doi: 10.1126/science.351.6280.1405-a. No abstract available.


PCSK9 Inhibitors: Lots of Work Done, Lots More to Do.

Lauer MS.

Ann Intern Med. 2016 May 3;164(9):624-5. doi: 10.7326/M16-0422. Epub 2016 Mar 22. No abstract available.


Policy: NIH push to stop sexual harassment.

Lauer M, Valantine H, Collins FS.

Nature. 2016 Mar 3;531(7592):35. doi: 10.1038/531035b. No abstract available.


Cholesteryl ester transfer between lipoproteins does not require a ternary tunnel complex with CETP.

Lauer ME, Graff-Meyer A, Rufer AC, Maugeais C, von der Mark E, Matile H, D'Arcy B, Magg C, Ringler P, Müller SA, Scherer S, Dernick G, Thoma R, Hennig M, Niesor EJ, Stahlberg H.

J Struct Biol. 2016 May;194(2):191-8. doi: 10.1016/j.jsb.2016.02.016. Epub 2016 Feb 12.


Hyaluronidase and Hyaluronan Oligosaccharides Promote Neurological Recovery after Intraventricular Hemorrhage.

Vinukonda G, Dohare P, Arshad A, Zia MT, Panda S, Korumilli R, Kayton R, Hascall VC, Lauer ME, Ballabh P.

J Neurosci. 2016 Jan 20;36(3):872-89. doi: 10.1523/JNEUROSCI.3297-15.2016.


Time for a prepublication culture in clinical research?

Lauer MS, Krumholz HM, Topol EJ.

Lancet. 2015 Dec 19;386(10012):2447-9. doi: 10.1016/S0140-6736(15)01177-0. Epub 2015 Dec 18. No abstract available.


Striking the Right Balance in Heart Failure.

Shah MR, Lauer MS.

Ann Intern Med. 2016 Jan 19;164(2):125-6. doi: 10.7326/M15-2587. Epub 2015 Dec 22. No abstract available.


Toward Independence: Resubmission Rate of Unfunded National Heart, Lung, and Blood Institute R01 Research Grant Applications Among Early Stage Investigators.

Boyington JE, Antman MD, Patel KC, Lauer MS.

Acad Med. 2016 Apr;91(4):556-62. doi: 10.1097/ACM.0000000000001025.


Hyaluronan Rafts on Airway Epithelial Cells.

Abbadi A, Lauer M, Swaidani S, Wang A, Hascall V.

J Biol Chem. 2016 Jan 15;291(3):1448-55. doi: 10.1074/jbc.M115.704288. Epub 2015 Nov 24.


Reviewing Peer Review at the NIH.

Lauer MS, Nakamura R.

N Engl J Med. 2015 Nov 12;373(20):1893-5. doi: 10.1056/NEJMp1507427.


Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015.

Antman EM, Benjamin EJ, Harrington RA, Houser SR, Peterson ED, Bauman MA, Brown N, Bufalino V, Califf RM, Creager MA, Daugherty A, Demets DL, Dennis BP, Ebadollahi S, Jessup M, Lauer MS, Lo B, MacRae CA, McConnell MV, McCray AT, Mello MM, Mueller E, Newburger JW, Okun S, Packer M, Philippakis A, Ping P, Prasoon P, Roger VL, Singer S, Temple R, Turner MB, Vigilante K, Warner J, Wayte P; American Heart Association Data Sharing Summit Attendees.

J Am Heart Assoc. 2015 Nov 5;4(11). pii: e002810. doi: 10.1161/JAHA.115.002810.


The Rise and Fall of Hyaluronan in Respiratory Diseases.

Lauer ME, Dweik RA, Garantziotis S, Aronica MA.

Int J Cell Biol. 2015;2015:712507. doi: 10.1155/2015/712507. Epub 2015 Sep 10. Review.


Impaired regulation of divalent cations with acute copper exposure in the marine clam Mesodesma mactroides.

Jorge MB, Lauer MM, Martins Cde M, Bianchini A.

Comp Biochem Physiol C Toxicol Pharmacol. 2016 Jan;179:79-86. doi: 10.1016/j.cbpc.2015.09.003. Epub 2015 Sep 21.


News from the NIH: potential contributions of the behavioral and social sciences to the precision medicine initiative.

Riley WT, Nilsen WJ, Manolio TA, Masys DR, Lauer M.

Transl Behav Med. 2015 Sep;5(3):243-6. doi: 10.1007/s13142-015-0320-5. No abstract available.


Social Determinants of Risk and Outcomes for Cardiovascular Disease: A Scientific Statement From the American Heart Association.

Havranek EP, Mujahid MS, Barr DA, Blair IV, Cohen MS, Cruz-Flores S, Davey-Smith G, Dennison-Himmelfarb CR, Lauer MS, Lockwood DW, Rosal M, Yancy CW; American Heart Association Council on Quality of Care and Outcomes Research, Council on Epidemiology and Prevention, Council on Cardiovascular and Stroke Nursing, Council on Lifestyle and Cardiometabolic Health, and Stroke Council.

Circulation. 2015 Sep 1;132(9):873-98. doi: 10.1161/CIR.0000000000000228. Epub 2015 Aug 3. No abstract available.


Publication Speed, Reporting Metrics, and Citation Impact of Cardiovascular Trials Supported by the National Heart, Lung, and Blood Institute.

Gordon D, Cooper-Arnold K, Lauer M.

J Am Heart Assoc. 2015 Jul 31;4(8):e002292. doi: 10.1161/JAHA.115.002292.


Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation.

Lauer ME, Majors AK, Comhair S, Ruple LM, Matuska B, Subramanian A, Farver C, Dworski R, Grandon D, Laskowski D, Dweik RA, Erzurum SC, Hascall VC, Aronica MA.

J Biol Chem. 2015 Sep 18;290(38):23124-34. doi: 10.1074/jbc.M115.663823. Epub 2015 Jul 24.

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