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Items: 16


Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies.

Slatter DA, Percy CL, Allen-Redpath K, Gajsiewicz JM, Brooks NJ, Clayton A, Tyrrell VJ, Rosas M, Lauder SN, Watson A, Dul M, Garcia-Diaz Y, Aldrovandi M, Heurich M, Hall J, Morrissey JH, Lacroix-Desmazes S, Delignat S, Jenkins PV, Collins PW, O'Donnell VB.

JCI Insight. 2018 Mar 22;3(6). pii: 98459. doi: 10.1172/jci.insight.98459. [Epub ahead of print]


Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.

Lauder SN, Allen-Redpath K, Slatter DA, Aldrovandi M, O'Connor A, Farewell D, Percy CL, Molhoek JE, Rannikko S, Tyrrell VJ, Ferla S, Milne GL, Poole AW, Thomas CP, Obaji S, Taylor PR, Jones SA, de Groot PG, Urbanus RT, Hörkkö S, Uderhardt S, Ackermann J, Vince Jenkins P, Brancale A, Krönke G, Collins PW, O'Donnell VB.

Sci Signal. 2017 Nov 28;10(507). pii: eaan2787. doi: 10.1126/scisignal.aan2787.


Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells.

Zhao J, Minami Y, Etling E, Coleman JM, Lauder SN, Tyrrell V, Aldrovandi M, O'Donnell V, Claesson HE, Kagan V, Wenzel S.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):692-701. doi: 10.1165/rcmb.2017-0031OC.


Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo.

Lauder SN, Tyrrell VJ, Allen-Redpath K, Aldrovandi M, Gray D, Collins P, Jones SA, Taylor PR, O'Donnell V.

Wellcome Open Res. 2017 Jan 4;2:1. doi: 10.12688/wellcomeopenres.10308.1.


DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression.

Aldrovandi M, Hinz C, Lauder SN, Podmore H, Hornshaw M, Slatter DA, Tyrrell VJ, Clark SR, Marnett LJ, Collins PW, Murphy RC, O'Donnell VB.

Redox Biol. 2017 Apr;11:663-672. doi: 10.1016/j.redox.2017.01.001. Epub 2017 Jan 13.


Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid.

Hinz C, Aldrovandi M, Uhlson C, Marnett LJ, Longhurst HJ, Warner TD, Alam S, Slatter DA, Lauder SN, Allen-Redpath K, Collins PW, Murphy RC, Thomas CP, O'Donnell VB.

J Biol Chem. 2016 Jun 24;291(26):13448-64. doi: 10.1074/jbc.M115.700609. Epub 2016 Apr 22.


A distinct chemokine axis does not account for enrichment of Foxp3(+)  CD4(+) T cells in carcinogen-induced fibrosarcomas.

Ondondo B, Colbeck E, Jones E, Smart K, Lauder SN, Hindley J, Godkin A, Moser B, Ager A, Gallimore A.

Immunology. 2015 May;145(1):94-104. doi: 10.1111/imm.12430. Erratum in: Immunology. 2015 Oct;146(2):347.


Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology.

Lauder SN, Jones E, Smart K, Bloom A, Williams AS, Hindley JP, Ondondo B, Taylor PR, Clement M, Fielding C, Godkin AJ, Jones SA, Gallimore AM.

Eur J Immunol. 2013 Oct;43(10):2613-25. doi: 10.1002/eji.201243018. Epub 2013 Aug 12.


Antiviral therapy can reverse the development of immune senescence in elderly mice with latent cytomegalovirus infection.

Beswick M, Pachnio A, Lauder SN, Sweet C, Moss PA.

J Virol. 2013 Jan;87(2):779-89. doi: 10.1128/JVI.02427-12. Epub 2012 Oct 31.


T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion.

Hindley JP, Jones E, Smart K, Bridgeman H, Lauder SN, Ondondo B, Cutting S, Ladell K, Wynn KK, Withers D, Price DA, Ager A, Godkin AJ, Gallimore AM.

Cancer Res. 2012 Nov 1;72(21):5473-82. doi: 10.1158/0008-5472.CAN-12-1912. Epub 2012 Sep 7.


Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.

Clement M, Ladell K, Ekeruche-Makinde J, Miles JJ, Edwards ES, Dolton G, Williams T, Schauenburg AJ, Cole DK, Lauder SN, Gallimore AM, Godkin AJ, Burrows SR, Price DA, Sewell AK, Wooldridge L.

J Immunol. 2011 Jul 15;187(2):654-63. doi: 10.4049/jimmunol.1003941. Epub 2011 Jun 15.


Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity.

Lauder SN, Taylor PR, Clark SR, Evans RL, Hindley JP, Smart K, Leach H, Kidd EJ, Broadley KJ, Jones SA, Wise MP, Godkin AJ, O'Donnell V, Gallimore AM.

Thorax. 2011 May;66(5):368-74. doi: 10.1136/thx.2010.150318. Epub 2011 Feb 10.


Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors.

Hindley JP, Ferreira C, Jones E, Lauder SN, Ladell K, Wynn KK, Betts GJ, Singh Y, Price DA, Godkin AJ, Dyson J, Gallimore A.

Cancer Res. 2011 Feb 1;71(3):736-46. doi: 10.1158/0008-5472.CAN-10-1797. Epub 2010 Dec 13.


Interferon-gamma inhibits interleukin-1beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis.

Page CE, Smale S, Carty SM, Amos N, Lauder SN, Goodfellow RM, Richards PJ, Jones SA, Topley N, Williams AS.

Arthritis Res Ther. 2010;12(2):R49. doi: 10.1186/ar2960. Epub 2010 Mar 22.


Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells.

Longhi MP, Wright K, Lauder SN, Nowell MA, Jones GW, Godkin AJ, Jones SA, Gallimore AM.

PLoS Pathog. 2008 Feb 29;4(2):e1000006. doi: 10.1371/journal.ppat.1000006.


Interleukin-1beta induced activation of nuclear factor-kappab can be inhibited by novel pharmacological agents in osteoarthritis.

Lauder SN, Carty SM, Carpenter CE, Hill RJ, Talamas F, Bondeson J, Brennan P, Williams AS.

Rheumatology (Oxford). 2007 May;46(5):752-8. Epub 2007 Jan 11.


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