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Extended RAS analysis and correlation with overall survival in advanced pancreatic cancer.

Haas M, Ormanns S, Baechmann S, Remold A, Kruger S, Westphalen CB, Siveke JT, Wenzel P, Schlitter AM, Esposito I, Quietzsch D, Clemens MR, Kettner E, Laubender RP, Jung A, Kirchner T, Boeck S, Heinemann V.

Br J Cancer. 2017 May 23;116(11):1462-1469. doi: 10.1038/bjc.2017.115. Epub 2017 Apr 27.


Multicenter evaluation of analytical characteristics of the Elecsys® Periostin immunoassay.

Palme S, Christenson RH, Jortani SA, Ostlund RE, Kolm R, Kopal G, Laubender RP.

Clin Biochem. 2017 Feb;50(3):139-144. doi: 10.1016/j.clinbiochem.2016.10.002. Epub 2016 Oct 8.


Early repolarization pattern is the strongest predictor of arrhythmia recurrence in patients with idiopathic ventricular fibrillation: results from a single centre long-term follow-up over 20 years.

Siebermair J, Sinner MF, Beckmann BM, Laubender RP, Martens E, Sattler S, Fichtner S, Estner HL, Kääb S, Wakili R.

Europace. 2016 May;18(5):718-25. doi: 10.1093/europace/euv301. Epub 2016 Jan 11.


KRAS exon 2 mutations influence activity of regorafenib in an SW48-based disease model of colorectal cancer.

Camaj P, Primo S, Wang Y, Heinemann V, Zhao Y, Laubender RP, Stintzing S, Giessen-Jung C, Jung A, Gamba S, Bruns CJ, Modest DP.

Future Oncol. 2015;11(13):1919-29. doi: 10.2217/fon.15.97.


Brain Metastasis in Colorectal Cancer Patients: Survival and Analysis of Prognostic Factors.

Michl M, Thurmaier J, Schubert-Fritschle G, Wiedemann M, Laubender RP, Nüssler NC, Ruppert R, Kleeff J, Schepp W, Reuter C, Löhe F, Karthaus M, Neumann J, Kirchner T, Engel J, Heinemann V.

Clin Colorectal Cancer. 2015 Dec;14(4):281-90. doi: 10.1016/j.clcc.2015.05.009. Epub 2015 Jun 6.


Impact of hand-foot skin reaction on treatment outcome in patients receiving capecitabine plus erlotinib for advanced pancreatic cancer: a subgroup analysis from AIO-PK0104.

Kruger S, Boeck S, Heinemann V, Laubender RP, Vehling-Kaiser U, Waldschmidt D, Kettner E, Märten A, Winkelmann C, Klein S, Kojouharoff G, Gauler TC, Fischer von Weikersthal L, Clemens MR, Geissler M, Greten TF, Hegewisch-Becker S, Modest DP, Stintzing S, Haas M.

Acta Oncol. 2015 Jul;54(7):993-1000. doi: 10.3109/0284186X.2015.1034877. Epub 2015 Apr 30.


Effect of KRAS exon 2 mutations on antitumor activity of afatinib and gefitinib.

Gamba S, Camaj P, Heinemann V, Laubender RP, Wang Y, Zhao Y, Stintzing S, Giessen C, Boeck S, Haertl C, Bruns CJ, Modest DP.

Anticancer Drugs. 2015 Apr;26(4):371-8. doi: 10.1097/CAD.0000000000000196.


Assessing novel prognostic serum biomarkers in advanced pancreatic cancer: the role of CYFRA 21-1, serum amyloid A, haptoglobin, and 25-OH vitamin D3.

Haas M, Kern C, Kruger S, Michl M, Modest DP, Giessen C, Schulz C, von Einem JC, Ormanns S, Laubender RP, Holdenrieder S, Heinemann V, Boeck S.

Tumour Biol. 2015 Apr;36(4):2631-40. doi: 10.1007/s13277-014-2885-x. Epub 2014 Dec 4.


An algorithm that predicts the viability and the yield of human hepatocytes isolated from remnant liver pieces obtained from liver resections.

Lee SM, Schelcher C, Laubender RP, Fröse N, Thasler RM, Schiergens TS, Mansmann U, Thasler WE.

PLoS One. 2014 Oct 14;9(10):e107567. doi: 10.1371/journal.pone.0107567. eCollection 2014.


High-resolution computed tomography-based length assessments of the cochlea--an accuracy evaluation.

Kisser U, Ertl-Wagner B, Hempel JM, Müller J, D'Anastasi M, Schrötzlmair F, Adderson-Kisser C, Laubender RP, Stelter K, Braun C, Pomschar A.

Acta Otolaryngol. 2014 Oct;134(10):1011-5. doi: 10.3109/00016489.2014.913313.


Gustatory and olfactory function in patients with granulomatosis with polyangiitis (Wegener's).

Proft F, Steinbach S, Dechant C, Witt M, Reindl C, Schulz S, Vielhauer V, Hilge R, Laubender RP, Manger K, Nüsslein H, Wendler J, Schuch F, Schulze-Koops H, Grunke M.

Scand J Rheumatol. 2014;43(6):512-8. doi: 10.3109/03009742.2014.915056. Epub 2014 Sep 10.


pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cancer: a translational subgroup analysis from AIO-PK0104.

Ormanns S, Siveke JT, Heinemann V, Haas M, Sipos B, Schlitter AM, Esposito I, Jung A, Laubender RP, Kruger S, Vehling-Kaiser U, Winkelmann C, Fischer von Weikersthal L, Clemens MR, Gauler TC, Märten A, Geissler M, Greten TF, Kirchner T, Boeck S.

BMC Cancer. 2014 Aug 28;14:624. doi: 10.1186/1471-2407-14-624.


Tumor markers CEA and CA 19-9 correlate with radiological imaging in metastatic colorectal cancer patients receiving first-line chemotherapy.

Michl M, Koch J, Laubender RP, Modest DP, Giessen C, Schulz Ch, Heinemann V.

Tumour Biol. 2014 Oct;35(10):10121-7. doi: 10.1007/s13277-014-2280-7. Epub 2014 Jul 15.


Surrogate endpoints in second-line treatment for mCRC: a systematic literature-based analysis from 23 randomised trials.

Giessen C, Laubender RP, Ankerst DP, Stintzing S, Modest DP, Schulz C, Mansmann U, Heinemann V.

Acta Oncol. 2015 Feb;54(2):187-93. doi: 10.3109/0284186X.2014.938830. Epub 2014 Jul 14. Review.


MRI evidence for preserved regulation of intracranial pressure in patients with cerebral arteriovenous malformations.

Meinel FG, Fischer J, Pomschar A, Wöhrle N, Koerte IK, Steffinger D, Laubender RP, Muacevic A, Reiser MF, Alperin N, Ertl-Wagner B.

Eur J Radiol. 2014 Aug;83(8):1442-7. doi: 10.1016/j.ejrad.2014.05.011. Epub 2014 May 16.


Early assessment of minimal residual disease in AML by flow cytometry during aplasia identifies patients at increased risk of relapse.

Köhnke T, Sauter D, Ringel K, Hoster E, Laubender RP, Hubmann M, Bohlander SK, Kakadia PM, Schneider S, Dufour A, Sauerland MC, Berdel WE, Büchner T, Wörmann B, Braess J, Hiddemann W, Spiekermann K, Subklewe M.

Leukemia. 2015 Feb;29(2):377-86. doi: 10.1038/leu.2014.186. Epub 2014 Jun 10.


Human equilibrative nucleoside transporter 1 is not predictive for gemcitabine efficacy in advanced pancreatic cancer: translational results from the AIO-PK0104 phase III study with the clone SP120 rabbit antibody.

Ormanns S, Heinemann V, Raponi M, Isaacson J, Laubender RP, Haas M, Kruger S, Kleespies A, Mann E, Bartosiewicz M, Kirchner T, Boeck S.

Eur J Cancer. 2014 Jul;50(11):1891-9. doi: 10.1016/j.ejca.2014.04.023. Epub 2014 May 20.


Evaluating the agreement between tumour volumetry and the estimated volumes of tumour lesions using an algorithm.

Laubender RP, Lynghjem J, D'Anastasi M, Heinemann V, Modest DP, Mansmann UR, Sartorius U, Schlichting M, Graser A.

Eur Radiol. 2014 Jul;24(7):1521-8. doi: 10.1007/s00330-014-3195-9. Epub 2014 May 10.


Risk of malignancies in patients with inflammatory bowel disease treated with thiopurines or anti-TNF alpha antibodies.

Beigel F, Steinborn A, Schnitzler F, Tillack C, Breiteneicher S, John JM, Van Steen K, Laubender RP, Göke B, Seiderer J, Brand S, Ochsenkühn T.

Pharmacoepidemiol Drug Saf. 2014 Jul;23(7):735-44. doi: 10.1002/pds.3621. Epub 2014 Apr 30.


Ascaris lumbricoides infection and its relation to environmental factors in the Mbeya region of Tanzania, a cross-sectional, population-based study.

Schüle SA, Clowes P, Kroidl I, Kowuor DO, Nsojo A, Mangu C, Riess H, Geldmacher C, Laubender RP, Mhina S, Maboko L, Löscher T, Hoelscher M, Saathoff E.

PLoS One. 2014 Mar 18;9(3):e92032. doi: 10.1371/journal.pone.0092032. eCollection 2014.


Reduction of pacemaker implantation rates after CoreValve® implantation by moderate predilatation.

Lange P, Greif M, Vogel A, Thaumann A, Helbig S, Schwarz F, Schmitz C, Becker C, D'Anastasi M, Boekstegers P, Pohl T, Laubender RP, Steinbeck G, Kupatt C.

EuroIntervention. 2014 Feb;9(10):1151-7. doi: 10.4244/EIJV9I10A195.


Quantification of anandamide and 2-arachidonoylglycerol plasma levels to examine potential influences of tetrahydrocannabinol application on the endocannabinoid system in humans.

Thieme U, Schelling G, Hauer D, Greif R, Dame T, Laubender RP, Bernhard W, Thieme D, Campolongo P, Theiler L.

Drug Test Anal. 2014 Jan-Feb;6(1-2):17-23. doi: 10.1002/dta.1561. Epub 2013 Oct 28.


Radioembolization with Yttrium-90 microspheres (SIRT) in pancreatic cancer patients with liver metastases: efficacy, safety and prognostic factors.

Michl M, Haug AR, Jakobs TF, Paprottka P, Hoffmann RT, Bartenstein P, Boeck S, Haas M, Laubender RP, Heinemann V.

Oncology. 2014;86(1):24-32. doi: 10.1159/000355821. Epub 2013 Dec 21.


Translational research in pancreatic cancer: KRAS and beyond.

Boeck S, Ormanns S, Haas M, Bächmann S, Laubender RP, Siveke JT, Jung A, Kirchner T, Heinemann V.

Pancreas. 2014 Jan;43(1):150-2. doi: 10.1097/MPA.0b013e31829629f6. No abstract available.


Outcome of patients with metastatic colorectal cancer depends on the primary tumor site (midgut vs. hindgut): analysis of the FIRE1-trial (FuFIRI or mIROX as first-line treatment).

Modest DP, Schulz C, von Weikersthal LF, Quietzsch D, von Einem JC, Schalhorn A, Vehling-Kaiser U, Laubender RP, Giessen C, Stintzing S, Heinemann V.

Anticancer Drugs. 2014 Feb;25(2):212-8. doi: 10.1097/CAD.0000000000000041.


Methodologic diligence is needed to define and validate tumor-size response metrics to predict overall survival in first-line metastatic colorectal cancer.

Mansmann UR, Laubender RP.

J Clin Oncol. 2013 Dec 1;31(34):4373-4. doi: 10.1200/JCO.2013.51.2954. Epub 2013 Oct 28. No abstract available.


Prognostic factors for 60-day mortality in first-line treatment of metastatic colorectal cancer (mCRC): individual patient analysis of four randomised, controlled trials by the AIO colorectal cancer study group.

Giessen C, Graeven U, Laubender RP, Modest DP, Schulz C, Porschen R, Schmiegel W, Reinacher-Schick A, Hegewisch-Becker S, Stintzing S, Heinemann V.

Ann Oncol. 2013 Dec;24(12):3051-5. doi: 10.1093/annonc/mdt402. Epub 2013 Oct 14.


Pharmacological challenge with naloxone and cue exposure in alcohol dependence: results of a randomized, double-blind placebo-controlled trial.

Lieb M, Palm U, Chiang S, Laubender RP, Nothdurfter C, Sarubin N, Mokhtari-Nejad R, Koller G, Soyka M.

World J Biol Psychiatry. 2013 Sep;14(7):539-46. doi: 10.3109/15622975.2013.812239.


Evaluation of prognostic factors in liver-limited metastatic colorectal cancer: a preplanned analysis of the FIRE-1 trial.

Giessen C, Fischer von Weikersthal L, Laubender RP, Stintzing S, Modest DP, Schalhorn A, Schulz C, Heinemann V.

Br J Cancer. 2013 Sep 17;109(6):1428-36. doi: 10.1038/bjc.2013.475. Epub 2013 Aug 20.


Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans.

Piotrowski K, Becker M, Zugwurst J, Biller-Friedmann I, Spoettl G, Greif M, Leber AW, Becker A, Laubender RP, Lebherz C, Goeke B, Marx N, Parhofer KG, Lehrke M.

Cardiovasc Diabetol. 2013 Aug 16;12:117. doi: 10.1186/1475-2840-12-117.


A note on calculating asymptotic confidence intervals for the adjusted risk difference and number needed to treat in the Cox regression model.

Laubender RP, Bender R.

Stat Med. 2014 Feb 28;33(5):798-810. doi: 10.1002/sim.5913. Epub 2013 Jul 30. Erratum in: Stat Med. 2014 Feb 28;33(5):810-1.


Joint line reconstruction in medial unicompartmental knee arthroplasty: development and validation of a measurement method.

Weber P, Schröder C, Laubender RP, Baur-Melnyk A, von Schulze Pellengahr C, Jansson V, Müller PE.

Knee Surg Sports Traumatol Arthrosc. 2013 Nov;21(11):2468-73. doi: 10.1007/s00167-013-2617-6. Epub 2013 Jul 24.


Clinical relevance and utility of cetuximab-related changes in magnesium and calcium serum levels.

Stintzing S, Fischhaber D, Mook C, Modest DP, Giessen C, Schulz C, Haas M, Boeck S, Michl M, Stemmler J, Laubender RP, Heinemann V.

Anticancer Drugs. 2013 Oct;24(9):969-74. doi: 10.1097/CAD.0b013e32836411bc.


The amount of dysfunctional but viable myocardium predicts long-term survival in patients with ischemic cardiomyopathy and left ventricular dysfunction.

Uebleis C, Hellweger S, Laubender RP, Becker A, Sohn HY, Lehner S, Haug A, Bartenstein P, Cumming P, Van Kriekinge SD, Slomka PJ, Hacker M.

Int J Cardiovasc Imaging. 2013 Oct;29(7):1645-53. doi: 10.1007/s10554-013-0254-2. Epub 2013 Jun 7.


Magnetic resonance-based estimation of intracranial pressure correlates with ventriculoperitoneal shunt valve opening pressure setting in children with hydrocephalus.

Muehlmann M, Koerte IK, Laubender RP, Steffinger D, Lehner M, Peraud A, Heinen F, Kiefer M, Reiser M, Ertl-Wagner B.

Invest Radiol. 2013 Jul;48(7):543-7. doi: 10.1097/RLI.0b013e31828ad504.


Increased pericardial adipose tissue is correlated with atrial fibrillation and left atrial dilatation.

Greif M, von Ziegler F, Wakili R, Tittus J, Becker C, Helbig S, Laubender RP, Schwarz W, D'Anastasi M, Schenzle J, Leber AW, Becker A.

Clin Res Cardiol. 2013 Aug;102(8):555-62. doi: 10.1007/s00392-013-0566-1. Epub 2013 Apr 13.


A genotype-specific, randomized controlled behavioral intervention to improve the neuroemotional outcome of cardiac surgery: study protocol for a randomized controlled trial.

Hauer D, Kolassa IT, Laubender RP, Mansmann U, Hagl C, Roozendaal B, de Quervain DJ, Schelling G.

Trials. 2013 Apr 1;14:89. doi: 10.1186/1745-6215-14-89.


Early tumor shrinkage in metastatic colorectal cancer: retrospective analysis from an irinotecan-based randomized first-line trial.

Giessen C, Laubender RP, Fischer von Weikersthal L, Schalhorn A, Modest DP, Stintzing S, Haas M, Mansmann UR, Heinemann V.

Cancer Sci. 2013 Jun;104(6):718-24. doi: 10.1111/cas.12148. Epub 2013 Apr 15.


Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment.

Tillack C, Ehmann LM, Friedrich M, Laubender RP, Papay P, Vogelsang H, Stallhofer J, Beigel F, Bedynek A, Wetzke M, Maier H, Koburger M, Wagner J, Glas J, Diegelmann J, Koglin S, Dombrowski Y, Schauber J, Wollenberg A, Brand S.

Gut. 2014 Apr;63(4):567-77. doi: 10.1136/gutjnl-2012-302853. Epub 2013 Mar 6.


KRAS allel-specific activity of sunitinib in an isogenic disease model of colorectal cancer.

Modest DP, Camaj P, Heinemann V, Schwarz B, Jung A, Laubender RP, Gamba S, Haertl C, Stintzing S, Primo S, Bruns CJ.

J Cancer Res Clin Oncol. 2013 Jun;139(6):953-61. doi: 10.1007/s00432-013-1401-9. Epub 2013 Mar 2.


KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer.

Boeck S, Jung A, Laubender RP, Neumann J, Egg R, Goritschan C, Ormanns S, Haas M, Modest DP, Kirchner T, Heinemann V.

J Gastroenterol. 2013 Apr;48(4):544-8. doi: 10.1007/s00535-013-0767-4. Epub 2013 Feb 23.


MRI evidence for altered venous drainage and intracranial compliance in mild traumatic brain injury.

Pomschar A, Koerte I, Lee S, Laubender RP, Straube A, Heinen F, Ertl-Wagner B, Alperin N.

PLoS One. 2013;8(2):e55447. doi: 10.1371/journal.pone.0055447. Epub 2013 Feb 6. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/bb7d0e00-ae4b-4ddc-af11-020d75a45a8e.


CD133 is a predictor of poor survival in head and neck squamous cell carcinomas.

Canis M, Lechner A, Mack B, Zengel P, Laubender RP, Koehler U, Heissmeyer V, Gires O.

Cancer Biomark. 2012;12(2):97-105. doi: 10.3233/CBM-130297.


Association between left ventricular mechanical dyssynchrony with myocardial perfusion and functional parameters in patients with left bundle branch block.

Uebleis C, Hoyer X, Van Kriekinge SD, Schuessler F, Laubender RP, Becker A, Lehner S, Todica A, Haug A, Bartenstein P, Cumming P, Germano G, Hacker M.

J Nucl Cardiol. 2013 Apr;20(2):253-61. doi: 10.1007/s12350-013-9673-7. Epub 2013 Jan 25.


Spirometry reference equations for central European populations from school age to old age.

Rochat MK, Laubender RP, Kuster D, Braendli O, Moeller A, Mansmann U, von Mutius E, Wildhaber J.

PLoS One. 2013;8(1):e52619. doi: 10.1371/journal.pone.0052619. Epub 2013 Jan 8.


Prognostic value of CA 19-9, CEA, CRP, LDH and bilirubin levels in locally advanced and metastatic pancreatic cancer: results from a multicenter, pooled analysis of patients receiving palliative chemotherapy.

Haas M, Heinemann V, Kullmann F, Laubender RP, Klose C, Bruns CJ, Holdenrieder S, Modest DP, Schulz C, Boeck S.

J Cancer Res Clin Oncol. 2013 Apr;139(4):681-9. doi: 10.1007/s00432-012-1371-3. Epub 2013 Jan 13.


Glucose and lipid metabolism in patients with advanced pancreatic cancer receiving palliative chemotherapy.

Zeiss K, Parhofer KG, Heinemann V, Haas M, Laubender RP, Holdenrieder S, Schulz C, Boeck S.

Anticancer Res. 2013 Jan;33(1):287-92.


Early tumor shrinkage in patients with metastatic colorectal cancer receiving first-line treatment with cetuximab combined with either CAPIRI or CAPOX: an analysis of the German AIO KRK 0104 trial.

Modest DP, Laubender RP, Stintzing S, Giessen C, Schulz C, Haas M, Mansmann U, Heinemann V.

Acta Oncol. 2013 Jun;52(5):956-62. doi: 10.3109/0284186X.2012.752580. Epub 2012 Dec 18.


Diagnostic biomarkers of pro-inflammatory immune-mediated preterm birth.

Weissenbacher T, Laubender RP, Witkin SS, Gingelmaier A, Schiessl B, Kainer F, Friese K, Jeschke U, Dian D, Karl K.

Arch Gynecol Obstet. 2013 Apr;287(4):673-85. doi: 10.1007/s00404-012-2629-3. Epub 2012 Nov 29.


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