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Items: 1 to 50 of 164

1.

Human relevance of follicular thyroid tumors in rodents caused by non-genotoxic substances.

Bartsch R, Brinkmann B, Jahnke G, Laube B, Lohmann R, Michaelsen S, Neumann I, Greim H.

Regul Toxicol Pharmacol. 2018 Aug 1;98:199-208. doi: 10.1016/j.yrtph.2018.07.025. [Epub ahead of print] Review.

PMID:
30076866
2.

Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.

Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Müller UC.

EMBO J. 2018 Jun 1;37(11). pii: e98335. doi: 10.15252/embj.201798335. Epub 2018 Apr 16.

PMID:
29661886
3.

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.

Ravichandran M, Priebe S, Grigolon G, Rozanov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M.

Cell Metab. 2018 Apr 3;27(4):914-925.e5. doi: 10.1016/j.cmet.2018.02.004. Epub 2018 Mar 15.

PMID:
29551589
4.

Hypertonic saline has a prolonged effect on mucociliary clearance in adults with cystic fibrosis.

Trimble AT, Whitney Brown A, Laube BL, Lechtzin N, Zeman KL, Wu J, Ceppe A, Waltz D, Bennett WD, Donaldson SH.

J Cyst Fibros. 2018 Sep;17(5):650-656. doi: 10.1016/j.jcf.2018.01.001. Epub 2018 Jan 20.

PMID:
29371133
5.

Homogeneity of Aerosol Deposition and Mucociliary Clearance are Improved Following Ivacaftor Treatment in Cystic Fibrosis.

Bennett WD, Zeman KL, Laube BL, Wu J, Sharpless G, Mogayzel PJ Jr, Donaldson SH.

J Aerosol Med Pulm Drug Deliv. 2018 Aug;31(4):204-211. doi: 10.1089/jamp.2017.1388. Epub 2017 Oct 16.

PMID:
29035122
6.

Acute and chronic in vivo effects of exposure to nicotine and propylene glycol from an E-cigarette on mucociliary clearance in a murine model.

Laube BL, Afshar-Mohajer N, Koehler K, Chen G, Lazarus P, Collaco JM, McGrath-Morrow SA.

Inhal Toxicol. 2017 Apr;29(5):197-205. doi: 10.1080/08958378.2017.1336585. Epub 2017 Jun 26.

7.

Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.

Merry TL, Kuhlow D, Laube B, Pöhlmann D, Pfeiffer AFH, Kahn CR, Ristow M, Zarse K.

Aging Cell. 2017 Aug;16(4):761-772. doi: 10.1111/acel.12610. Epub 2017 May 22.

8.

Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity.

Bledsoe D, Tamer C, Mesic I, Madry C, Klein BG, Laube B, Costa BM.

Front Pharmacol. 2017 May 9;8:229. doi: 10.3389/fphar.2017.00229. eCollection 2017.

9.

ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests.

Coates AL, Wanger J, Cockcroft DW, Culver BH; Bronchoprovocation Testing Task Force: Kai-Håkon Carlsen, Diamant Z, Gauvreau G, Hall GL, Hallstrand TS, Horvath I, de Jongh FHC, Joos G, Kaminsky DA, Laube BL, Leuppi JD, Sterk PJ.

Eur Respir J. 2017 May 1;49(5). pii: 1601526. doi: 10.1183/13993003.01526-2016. Print 2017 May.

PMID:
28461290
10.

GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects.

Platzer K, Yuan H, Schütz H, Winschel A, Chen W, Hu C, Kusumoto H, Heyne HO, Helbig KL, Tang S, Willing MC, Tinkle BT, Adams DJ, Depienne C, Keren B, Mignot C, Frengen E, Strømme P, Biskup S, Döcker D, Strom TM, Mefford HC, Myers CT, Muir AM, LaCroix A, Sadleir L, Scheffer IE, Brilstra E, van Haelst MM, van der Smagt JJ, Bok LA, Møller RS, Jensen UB, Millichap JJ, Berg AT, Goldberg EM, De Bie I, Fox S, Major P, Jones JR, Zackai EH, Abou Jamra R, Rolfs A, Leventer RJ, Lawson JA, Roscioli T, Jansen FE, Ranza E, Korff CM, Lehesjoki AE, Courage C, Linnankivi T, Smith DR, Stanley C, Mintz M, McKnight D, Decker A, Tan WH, Tarnopolsky MA, Brady LI, Wolff M, Dondit L, Pedro HF, Parisotto SE, Jones KL, Patel AD, Franz DN, Vanzo R, Marco E, Ranells JD, Di Donato N, Dobyns WB, Laube B, Traynelis SF, Lemke JR.

J Med Genet. 2017 Jul;54(7):460-470. doi: 10.1136/jmedgenet-2016-104509. Epub 2017 Apr 4.

11.

Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy.

Lemke JR, Geider K, Helbig KL, Heyne HO, Schütz H, Hentschel J, Courage C, Depienne C, Nava C, Heron D, Møller RS, Hjalgrim H, Lal D, Neubauer BA, Nürnberg P, Thiele H, Kurlemann G, Arnold GL, Bhambhani V, Bartholdi D, Pedurupillay CR, Misceo D, Frengen E, Strømme P, Dlugos DJ, Doherty ES, Bijlsma EK, Ruivenkamp CA, Hoffer MJ, Goldstein A, Rajan DS, Narayanan V, Ramsey K, Belnap N, Schrauwen I, Richholt R, Koeleman BP, Sá J, Mendonça C, de Kovel CG, Weckhuysen S, Hardies K, De Jonghe P, De Meirleir L, Milh M, Badens C, Lebrun M, Busa T, Francannet C, Piton A, Riesch E, Biskup S, Vogt H, Dorn T, Helbig I, Michaud JL, Laube B, Syrbe S.

Neurology. 2016 Jun 7;86(23):2171-8. doi: 10.1212/WNL.0000000000002740. Epub 2016 May 6.

12.

The N-terminal domain of the GluN3A subunit determines the efficacy of glycine-activated NMDA receptors.

Mesic I, Madry C, Geider K, Bernhard M, Betz H, Laube B.

Neuropharmacology. 2016 Jun;105:133-141. doi: 10.1016/j.neuropharm.2016.01.014. Epub 2016 Jan 9.

PMID:
26777280
13.

Aerosolized Medications for Gene and Peptide Therapy.

Laube BL.

Respir Care. 2015 Jun;60(6):806-21; discussion 821-4. doi: 10.4187/respcare.03554. Review.

14.

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.

Lynagh T, Beech RN, Lalande MJ, Keller K, Cromer BA, Wolstenholme AJ, Laube B.

Sci Rep. 2015 Feb 24;5:8558. doi: 10.1038/srep08558.

15.

Intranasal Deposition of Accuspray™ Aerosol in Anatomically Correct Models of 2-, 5-, and 12-Year-Old Children.

Laube BL, Sharpless G, Vikani AR, Harrand V, Zinreich SJ, Sedberry K, Knaus D, Barry J, Papania M.

J Aerosol Med Pulm Drug Deliv. 2015 Oct;28(5):320-33. doi: 10.1089/jamp.2014.1174. Epub 2015 Feb 13.

PMID:
25679810
16.

Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics.

Lynagh T, Cromer BA, Dufour V, Laube B.

Int J Parasitol Drugs Drug Resist. 2014 Aug 10;4(3):244-55. doi: 10.1016/j.ijpddr.2014.07.004. eCollection 2014 Dec.

17.

The expanding role of aerosols in systemic drug delivery, gene therapy and vaccination: an update.

Laube BL.

Transl Respir Med. 2014 Jan 13;2:3. doi: 10.1186/2213-0802-2-3. eCollection 2014. Review.

18.

Using your metered dose inhaler (MDI).

Garvey C, Fahy B, Lareau S, Braman S, Laube B.

Am J Respir Crit Care Med. 2014 Oct 15;190(8):P5-6. doi: 10.1164/rccm.1908P5. No abstract available.

PMID:
25317475
19.

Vaccine-induced measles virus-specific T cells do not prevent infection or disease but facilitate subsequent clearance of viral RNA.

Lin WH, Pan CH, Adams RJ, Laube BL, Griffin DE.

MBio. 2014 Apr 15;5(2):e01047. doi: 10.1128/mBio.01047-14.

20.

D-Glucosamine supplementation extends life span of nematodes and of ageing mice.

Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M.

Nat Commun. 2014 Apr 8;5:3563. doi: 10.1038/ncomms4563.

21.

Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site.

Lynagh T, Laube B.

J Neurosci. 2014 Feb 5;34(6):2155-9. doi: 10.1523/JNEUROSCI.4307-13.2014.

22.

Mucus removal is impaired in children with cystic fibrosis who have been infected by Pseudomonas aeruginosa.

Laube BL, Sharpless G, Benson J, Carson KA, Mogayzel PJ Jr.

J Pediatr. 2014 Apr;164(4):839-45. doi: 10.1016/j.jpeds.2013.11.031. Epub 2013 Dec 24.

PMID:
24373575
23.

GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy.

Lemke JR, Hendrickx R, Geider K, Laube B, Schwake M, Harvey RJ, James VM, Pepler A, Steiner I, Hörtnagel K, Neidhardt J, Ruf S, Wolff M, Bartholdi D, Caraballo R, Platzer K, Suls A, De Jonghe P, Biskup S, Weckhuysen S.

Ann Neurol. 2014 Jan;75(1):147-54. doi: 10.1002/ana.24073. Epub 2014 Jan 2.

24.

Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation.

Lynagh T, Kunz A, Laube B.

ACS Chem Neurosci. 2013 Nov 20;4(11):1469-78. doi: 10.1021/cn400134p. Epub 2013 Sep 17.

25.

Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.

Lemke JR, Lal D, Reinthaler EM, Steiner I, Nothnagel M, Alber M, Geider K, Laube B, Schwake M, Finsterwalder K, Franke A, Schilhabel M, Jähn JA, Muhle H, Boor R, Van Paesschen W, Caraballo R, Fejerman N, Weckhuysen S, De Jonghe P, Larsen J, Møller RS, Hjalgrim H, Addis L, Tang S, Hughes E, Pal DK, Veri K, Vaher U, Talvik T, Dimova P, Guerrero López R, Serratosa JM, Linnankivi T, Lehesjoki AE, Ruf S, Wolff M, Buerki S, Wohlrab G, Kroell J, Datta AN, Fiedler B, Kurlemann G, Kluger G, Hahn A, Haberlandt DE, Kutzer C, Sperner J, Becker F, Weber YG, Feucht M, Steinböck H, Neophythou B, Ronen GM, Gruber-Sedlmayr U, Geldner J, Harvey RJ, Hoffmann P, Herms S, Altmüller J, Toliat MR, Thiele H, Nürnberg P, Wilhelm C, Stephani U, Helbig I, Lerche H, Zimprich F, Neubauer BA, Biskup S, von Spiczak S.

Nat Genet. 2013 Sep;45(9):1067-72. doi: 10.1038/ng.2728. Epub 2013 Aug 11.

PMID:
23933819
26.

The common structural architecture of Shigella flexneri and Salmonella typhimurium type three secretion needles.

Demers JP, Sgourakis NG, Gupta R, Loquet A, Giller K, Riedel D, Laube B, Kolbe M, Baker D, Becker S, Lange A.

PLoS Pathog. 2013 Mar;9(3):e1003245. doi: 10.1371/journal.ppat.1003245. Epub 2013 Mar 21.

27.

Multisite comparison of mucociliary and cough clearance measures using standardized methods.

Bennett WD, Laube BL, Corcoran T, Zeman K, Sharpless G, Thomas K, Wu J, Mogayzel PJ Jr, Pilewski J, Donaldson S.

J Aerosol Med Pulm Drug Deliv. 2013 Jun;26(3):157-64. doi: 10.1089/jamp.2011.0909. Epub 2013 Mar 21.

PMID:
23517172
28.

Standardization of techniques for using single-photon emission computed tomography (SPECT) for aerosol deposition assessment of orally inhaled products.

Fleming J, Bailey DL, Chan HK, Conway J, Kuehl PJ, Laube BL, Newman S.

J Aerosol Med Pulm Drug Deliv. 2012 Dec;25 Suppl 1:S29-51. doi: 10.1089/jamp.2012.1Su5.

PMID:
23215845
29.

Standardization of techniques for using planar (2D) imaging for aerosol deposition assessment of orally inhaled products.

Newman S, Bennett WD, Biddiscombe M, Devadason SG, Dolovich MB, Fleming J, Haeussermann S, Kietzig C, Kuehl PJ, Laube BL, Sommerer K, Taylor G, Usmani OS, Zeman KL.

J Aerosol Med Pulm Drug Deliv. 2012 Dec;25 Suppl 1:S10-28. doi: 10.1089/jamp.2012.1Su4.

PMID:
23215844
30.

Editorial: Standards for lung imaging techniques.

Laube BL, Corcoran TE, Devadason SG, Dolovich MB, Fleming J, Newman S.

J Aerosol Med Pulm Drug Deliv. 2012 Dec;25 Suppl 1:S1-2. doi: 10.1089/jamp.2012.1Su1. No abstract available.

PMID:
23215843
31.

Pulmonary delivery of an aerosolized recombinant human butyrylcholinesterase pretreatment protects against aerosolized paraoxon in macaques.

Rosenberg YJ, Laube B, Mao L, Jiang X, Hernandez-Abanto S, Lee KD, Adams R.

Chem Biol Interact. 2013 Mar 25;203(1):167-71. doi: 10.1016/j.cbi.2012.11.004. Epub 2012 Nov 21.

32.

A pilot study to examine the effect of chronic treatment with immunosuppressive drugs on mucociliary clearance in a vagotomized murine model.

Bhashyam AR, Mogayzel PJ Jr, McGrath-Morrow S, Neptune E, Malinina A, Fox J, Laube BL.

PLoS One. 2012;7(9):e45312. doi: 10.1371/journal.pone.0045312. Epub 2012 Sep 20.

33.

Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation.

Mak TN, Fischer N, Laube B, Brinkmann V, Metruccio MM, Sfanos KS, Mollenkopf HJ, Meyer TF, Brüggemann H.

Cell Microbiol. 2012 Nov;14(11):1720-33. doi: 10.1111/j.1462-5822.2012.01833.x. Epub 2012 Jul 22.

PMID:
22759266
34.

Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site.

Dutertre S, Drwal M, Laube B, Betz H.

J Neurochem. 2012 Jul;122(1):38-47. doi: 10.1111/j.1471-4159.2012.07755.x. Epub 2012 Apr 27.

35.

Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.

Amos-Landgraf JM, Irving AA, Hartman C, Hunter A, Laube B, Chen X, Clipson L, Newton MA, Dove WF.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2060-5. doi: 10.1073/pnas.1120753109. Epub 2012 Jan 23.

36.

Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid.

Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Laube B, Jane DE, Monaghan DT.

Neuropharmacology. 2012 Mar;62(4):1730-6. doi: 10.1016/j.neuropharm.2011.11.019. Epub 2011 Dec 6.

37.

Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2.

Kallenborn-Gerhardt W, Lu R, Lorenz J, Gao W, Weiland J, Del Turco D, Deller T, Laube B, Betz H, Geisslinger G, Schmidtko A.

Behav Brain Res. 2012 Jan 1;226(1):106-11. doi: 10.1016/j.bbr.2011.09.002. Epub 2011 Sep 8.

PMID:
21924294
38.

Acute inhalation of hypertonic saline does not improve mucociliary clearance in all children with cystic fibrosis.

Laube BL, Sharpless G, Carson KA, Kelly A, Mogayzel PJ Jr.

BMC Pulm Med. 2011 Sep 6;11:45. doi: 10.1186/1471-2466-11-45.

39.

What the pulmonary specialist should know about the new inhalation therapies.

Laube BL, Janssens HM, de Jongh FH, Devadason SG, Dhand R, Diot P, Everard ML, Horvath I, Navalesi P, Voshaar T, Chrystyn H; European Respiratory Society; International Society for Aerosols in Medicine.

Eur Respir J. 2011 Jun;37(6):1308-31. doi: 10.1183/09031936.00166410. Epub 2011 Feb 10.

40.

Robust post-translocational N-glycosylation at the extreme C-terminus of membrane and secreted proteins in Xenopus laevis oocytes and HEK293 cells.

Pult F, Fallah G, Braam U, Detro-Dassen S, Niculescu C, Laube B, Schmalzing G.

Glycobiology. 2011 Sep;21(9):1147-60. doi: 10.1093/glycob/cwr013. Epub 2011 Feb 8.

PMID:
21303814
41.

Activation of mitochondrial energy metabolism protects against cardiac failure.

Schulz TJ, Westermann D, Isken F, Voigt A, Laube B, Thierbach R, Kuhlow D, Zarse K, Schomburg L, Pfeiffer AF, Tschöpe C, Ristow M.

Aging (Albany NY). 2010 Nov;2(11):843-53.

42.

Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells.

Fassi Fehri L, Mak TN, Laube B, Brinkmann V, Ogilvie LA, Mollenkopf H, Lein M, Schmidt T, Meyer TF, Brüggemann H.

Int J Med Microbiol. 2011 Jan;301(1):69-78. doi: 10.1016/j.ijmm.2010.08.014. Epub 2010 Oct 12.

PMID:
20943438
43.

Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.

Endele S, Rosenberger G, Geider K, Popp B, Tamer C, Stefanova I, Milh M, Kortüm F, Fritsch A, Pientka FK, Hellenbroich Y, Kalscheuer VM, Kohlhase J, Moog U, Rappold G, Rauch A, Ropers HH, von Spiczak S, Tönnies H, Villeneuve N, Villard L, Zabel B, Zenker M, Laube B, Reis A, Wieczorek D, Van Maldergem L, Kutsche K.

Nat Genet. 2010 Nov;42(11):1021-6. doi: 10.1038/ng.677. Epub 2010 Oct 3.

PMID:
20890276
44.

Protein refolding is required for assembly of the type three secretion needle.

Poyraz O, Schmidt H, Seidel K, Delissen F, Ader C, Tenenboim H, Goosmann C, Laube B, Thünemann AF, Zychlinsky A, Baldus M, Lange A, Griesinger C, Kolbe M.

Nat Struct Mol Biol. 2010 Jul;17(7):788-92. doi: 10.1038/nsmb.1822. Epub 2010 Jun 13.

PMID:
20543831
45.

Deposition of albuterol aerosol generated by pneumatic nebulizer in the Sophia Anatomical Infant Nose-Throat (SAINT) model.

Laube BL, Sharpless G, Shermer C, Nasir O, Sullivan V, Powell K.

Pharm Res. 2010 Aug;27(8):1722-9. doi: 10.1007/s11095-010-0171-1. Epub 2010 May 22.

PMID:
20496045
46.

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.

Hakkim A, Fürnrohr BG, Amann K, Laube B, Abed UA, Brinkmann V, Herrmann M, Voll RE, Zychlinsky A.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9813-8. doi: 10.1073/pnas.0909927107. Epub 2010 May 3.

47.

Potentiation of Glycine-Gated NR1/NR3A NMDA Receptors Relieves Ca-Dependent Outward Rectification.

Madry C, Betz H, Geiger JR, Laube B.

Front Mol Neurosci. 2010 Mar 23;3:6. doi: 10.3389/fnmol.2010.00006. eCollection 2010.

48.

Neutrophil extracellular traps: how to generate and visualize them.

Brinkmann V, Laube B, Abu Abed U, Goosmann C, Zychlinsky A.

J Vis Exp. 2010 Feb 24;(36). pii: 1724. doi: 10.3791/1724.

49.

Demonstrating Bioequivalence of Locally Acting Orally Inhaled Drug Products (OIPs): Workshop Summary Report.

Adams WP, Ahrens RC, Chen ML, Christopher D, Chowdhury BA, Conner DP, Dalby R, Fitzgerald K, Hendeles L, Hickey AJ, Hochhaus G, Laube BL, Lucas P, Lee SL, Lyapustina S, Li B, O'Connor D, Parikh N, Parkins DA, Peri P, Pitcairn GR, Riebe M, Roy P, Shah T, Singh GJ, Sharp SS, Suman JD, Weda M, Woodcock J, Yu L.

J Aerosol Med Pulm Drug Deliv. 2010 Feb;23(1):1-29. doi: 10.1089/jamp.2009.0803.

PMID:
20131983
50.

Vagal control of mucociliary clearance in murine lungs: a study in a chronic preparation.

Bhashyam AR, Mogayzel PJ Jr, Cleary JC, Undem BJ, Kollarik M, Fox J, Laube BL.

Auton Neurosci. 2010 Apr 19;154(1-2):74-8. doi: 10.1016/j.autneu.2009.12.002. Epub 2010 Jan 3.

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