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A CRISPR Interference System for Efficient and Rapid Gene Knockdown in Caulobacter crescentus.

Guzzo M, Castro LK, Reisch CR, Guo MS, Laub MT.

mBio. 2020 Jan 14;11(1). pii: e02415-19. doi: 10.1128/mBio.02415-19.


An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp.

Ahmad S, Wang B, Walker MD, Tran HR, Stogios PJ, Savchenko A, Grant RA, McArthur AG, Laub MT, Whitney JC.

Nature. 2019 Nov;575(7784):674-678. doi: 10.1038/s41586-019-1735-9. Epub 2019 Nov 6.


Engineering orthogonal signalling pathways reveals the sparse occupancy of sequence space.

McClune CJ, Alvarez-Buylla A, Voigt CA, Laub MT.

Nature. 2019 Oct;574(7780):702-706. doi: 10.1038/s41586-019-1639-8. Epub 2019 Oct 23.


The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC.

Kraemer JA, Sanderlin AG, Laub MT.

mBio. 2019 Jul 2;10(4). pii: e01330-19. doi: 10.1128/mBio.01330-19.


Concerns about "Stress-Induced MazF-Mediated Proteins in Escherichia coli".

Wade JT, Laub MT.

mBio. 2019 Jun 4;10(3). pii: e00825-19. doi: 10.1128/mBio.00825-19. No abstract available.


Author Correction: Affinity-based capture and identification of protein effectors of the growth regulator ppGpp.

Wang B, Dai P, Ding D, Del Rosario A, Grant RA, Pentelute BL, Laub MT.

Nat Chem Biol. 2019 Jul;15(7):756. doi: 10.1038/s41589-019-0296-4.


The PLOS Biology XV Collection: 15 Years of Exceptional Science Highlighted across 12 Months.

Richardson LA, Schmid SL, Bhandoola A, Harly C, Hedenström A, Laub MT, Mace GM, Sengupta P, Stock AM, Read AF, Malik HS, Estelle M, Lowell S, Kimmelman J.

PLoS Biol. 2019 Feb 27;17(2):e3000180. doi: 10.1371/journal.pbio.3000180. eCollection 2019 Feb. No abstract available.


Unique Patterns and Biogeochemical Relevance of Two-Component Sensing in Marine Bacteria.

Held NA, McIlvin MR, Moran DM, Laub MT, Saito MA.

mSystems. 2019 Feb 5;4(1). pii: e00317-18. doi: 10.1128/mSystems.00317-18. eCollection 2019 Jan-Feb.


Mechanisms of Resistance to the Contact-Dependent Bacteriocin CdzC/D in Caulobacter crescentus.

García-Bayona L, Gozzi K, Laub MT.

J Bacteriol. 2019 Mar 26;201(8). pii: e00538-18. doi: 10.1128/JB.00538-18. Print 2019 Apr 15.


Affinity-based capture and identification of protein effectors of the growth regulator ppGpp.

Wang B, Dai P, Ding D, Del Rosario A, Grant RA, Pentelute BL, Laub MT.

Nat Chem Biol. 2019 Feb;15(2):141-150. doi: 10.1038/s41589-018-0183-4. Epub 2018 Dec 17. Erratum in: Nat Chem Biol. 2019 Jul;15(7):756.


Constriction Rate Modulation Can Drive Cell Size Control and Homeostasis in C. crescentus.

Lambert A, Vanhecke A, Archetti A, Holden S, Schaber F, Pincus Z, Laub MT, Goley E, Manley S.

iScience. 2018 Jun 29;4:180-189. doi: 10.1016/j.isci.2018.05.020. Epub 2018 May 30.


A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication.

Guo MS, Haakonsen DL, Zeng W, Schumacher MA, Laub MT.

Cell. 2018 Oct 4;175(2):583-597.e23. doi: 10.1016/j.cell.2018.08.029. Epub 2018 Sep 13.


Flexibility and constraint: Evolutionary remodeling of the sporulation initiation pathway in Firmicutes.

Davidson P, Eutsey R, Redler B, Hiller NL, Laub MT, Durand D.

PLoS Genet. 2018 Sep 13;14(9):e1007470. doi: 10.1371/journal.pgen.1007470. eCollection 2018 Sep.


Global Analysis of the E. coli Toxin MazF Reveals Widespread Cleavage of mRNA and the Inhibition of rRNA Maturation and Ribosome Biogenesis.

Culviner PH, Laub MT.

Mol Cell. 2018 Jun 7;70(5):868-880.e10. doi: 10.1016/j.molcel.2018.04.026. Epub 2018 May 31.


Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.

Wu X, Haakonsen DL, Sanderlin AG, Liu YJ, Shen L, Zhuang N, Laub MT, Zhang Y.

Nucleic Acids Res. 2018 Apr 6;46(6):3245-3256. doi: 10.1093/nar/gky161.


SMC Progressively Aligns Chromosomal Arms in Caulobacter crescentus but Is Antagonized by Convergent Transcription.

Tran NT, Laub MT, Le TBK.

Cell Rep. 2017 Aug 29;20(9):2057-2071. doi: 10.1016/j.celrep.2017.08.026.


Unsupervised Extraction of Stable Expression Signatures from Public Compendia with an Ensemble of Neural Networks.

Tan J, Doing G, Lewis KA, Price CE, Chen KM, Cady KC, Perchuk B, Laub MT, Hogan DA, Greene CS.

Cell Syst. 2017 Jul 26;5(1):63-71.e6. doi: 10.1016/j.cels.2017.06.003. Epub 2017 Jul 12.


Global analysis of double-strand break processing reveals in vivo properties of the helicase-nuclease complex AddAB.

Badrinarayanan A, Le TBK, Spille JH, Cisse II, Laub MT.

PLoS Genet. 2017 May 10;13(5):e1006783. doi: 10.1371/journal.pgen.1006783. eCollection 2017 May.


Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins.

García-Bayona L, Guo MS, Laub MT.

Elife. 2017 Mar 21;6. pii: e24869. doi: 10.7554/eLife.24869.


Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus.

Wang X, Brandão HB, Le TB, Laub MT, Rudner DZ.

Science. 2017 Feb 3;355(6324):524-527. doi: 10.1126/science.aai8982.


The small membrane protein MgrB regulates PhoQ bifunctionality to control PhoP target gene expression dynamics.

Salazar ME, Podgornaia AI, Laub MT.

Mol Microbiol. 2016 Nov;102(3):430-445. doi: 10.1111/mmi.13471. Epub 2016 Aug 25.


ClpAP is an auxiliary protease for DnaA degradation in Caulobacter crescentus.

Liu J, Francis LI, Jonas K, Laub MT, Chien P.

Mol Microbiol. 2016 Dec;102(6):1075-1085. doi: 10.1111/mmi.13537. Epub 2016 Oct 17.


Keeping Signals Straight: How Cells Process Information and Make Decisions.

Laub MT.

PLoS Biol. 2016 Jul 18;14(7):e1002519. doi: 10.1371/journal.pbio.1002519. eCollection 2016 Jul.


Transcription rate and transcript length drive formation of chromosomal interaction domain boundaries.

Le TB, Laub MT.

EMBO J. 2016 Jul 15;35(14):1582-95. doi: 10.15252/embj.201593561. Epub 2016 Jun 10.


Bacterial chromosome organization and segregation.

Badrinarayanan A, Le TB, Laub MT.

Annu Rev Cell Dev Biol. 2015;31:171-99. doi: 10.1146/annurev-cellbio-100814-125211. Review.


The bacterial cell cycle regulator GcrA is a σ70 cofactor that drives gene expression from a subset of methylated promoters.

Haakonsen DL, Yuan AH, Laub MT.

Genes Dev. 2015 Nov 1;29(21):2272-86. doi: 10.1101/gad.270660.115.


Identification of the PhoB Regulon and Role of PhoU in the Phosphate Starvation Response of Caulobacter crescentus.

Lubin EA, Henry JT, Fiebig A, Crosson S, Laub MT.

J Bacteriol. 2015 Oct 19;198(1):187-200. doi: 10.1128/JB.00658-15. Print 2016 Jan 1.


Evolving new protein-protein interaction specificity through promiscuous intermediates.

Aakre CD, Herrou J, Phung TN, Perchuk BS, Crosson S, Laub MT.

Cell. 2015 Oct 22;163(3):594-606. doi: 10.1016/j.cell.2015.09.055. Epub 2015 Oct 17.


Condensin promotes the juxtaposition of DNA flanking its loading site in Bacillus subtilis.

Wang X, Le TB, Lajoie BR, Dekker J, Laub MT, Rudner DZ.

Genes Dev. 2015 Aug 1;29(15):1661-75. doi: 10.1101/gad.265876.115.


Rapid pairing and resegregation of distant homologous loci enables double-strand break repair in bacteria.

Badrinarayanan A, Le TB, Laub MT.

J Cell Biol. 2015 Aug 3;210(3):385-400. doi: 10.1083/jcb.201505019.


Nutritional Control of DNA Replication Initiation through the Proteolysis and Regulated Translation of DnaA.

Leslie DJ, Heinen C, Schramm FD, Thüring M, Aakre CD, Murray SM, Laub MT, Jonas K.

PLoS Genet. 2015 Jul 2;11(7):e1005342. doi: 10.1371/journal.pgen.1005342. eCollection 2015 Jul.


Protein evolution. Pervasive degeneracy and epistasis in a protein-protein interface.

Podgornaia AI, Laub MT.

Science. 2015 Feb 6;347(6222):673-7. doi: 10.1126/science.1257360.


Temporal and evolutionary dynamics of two-component signaling pathways.

Salazar ME, Laub MT.

Curr Opin Microbiol. 2015 Apr;24:7-14. doi: 10.1016/j.mib.2014.12.003. Epub 2015 Jan 10. Review.


A DNA damage-induced, SOS-independent checkpoint regulates cell division in Caulobacter crescentus.

Modell JW, Kambara TK, Perchuk BS, Laub MT.

PLoS Biol. 2014 Oct 28;12(10):e1001977. doi: 10.1371/journal.pbio.1001977. eCollection 2014 Oct.


Permanent genetic memory with >1-byte capacity.

Yang L, Nielsen AA, Fernandez-Rodriguez J, McClune CJ, Laub MT, Lu TK, Voigt CA.

Nat Methods. 2014 Dec;11(12):1261-6. doi: 10.1038/nmeth.3147. Epub 2014 Oct 26.


New approaches to understanding the spatial organization of bacterial genomes.

Le TB, Laub MT.

Curr Opin Microbiol. 2014 Dec;22:15-21. doi: 10.1016/j.mib.2014.09.014. Epub 2014 Oct 7. Review.


A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp.

Aakre CD, Phung TN, Huang D, Laub MT.

Mol Cell. 2013 Dec 12;52(5):617-28. doi: 10.1016/j.molcel.2013.10.014. Epub 2013 Nov 14.


High-resolution mapping of the spatial organization of a bacterial chromosome.

Le TB, Imakaev MV, Mirny LA, Laub MT.

Science. 2013 Nov 8;342(6159):731-4. doi: 10.1126/science.1242059. Epub 2013 Oct 24.


Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling.

Podgornaia AI, Casino P, Marina A, Laub MT.

Structure. 2013 Sep 3;21(9):1636-47. doi: 10.1016/j.str.2013.07.005. Epub 2013 Aug 15.


Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA.

Jonas K, Liu J, Chien P, Laub MT.

Cell. 2013 Aug 1;154(3):623-36. doi: 10.1016/j.cell.2013.06.034.


Using analyses of amino Acid coevolution to understand protein structure and function.

Ashenberg O, Laub MT.

Methods Enzymol. 2013;523:191-212. doi: 10.1016/B978-0-12-394292-0.00009-6.


Regulated proteolysis of a transcription factor complex is critical to cell cycle progression in Caulobacter crescentus.

Gora KG, Cantin A, Wohlever M, Joshi KK, Perchuk BS, Chien P, Laub MT.

Mol Microbiol. 2013 Mar;87(6):1277-89. doi: 10.1111/mmi.12166. Epub 2013 Feb 25.


Determinants of specificity in two-component signal transduction.

Podgornaia AI, Laub MT.

Curr Opin Microbiol. 2013 Apr;16(2):156-62. doi: 10.1016/j.mib.2013.01.004. Epub 2013 Jan 24. Review.


Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.

Ashenberg O, Keating AE, Laub MT.

J Mol Biol. 2013 Apr 12;425(7):1198-209. doi: 10.1016/j.jmb.2013.01.011. Epub 2013 Jan 16.


Polarity and cell fate asymmetry in Caulobacter crescentus.

Tsokos CG, Laub MT.

Curr Opin Microbiol. 2012 Dec;15(6):744-50. doi: 10.1016/j.mib.2012.10.011. Epub 2012 Nov 9. Review.


Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity.

Capra EJ, Perchuk BS, Ashenberg O, Seid CA, Snow HR, Skerker JM, Laub MT.

Mol Microbiol. 2012 Dec;86(6):1393-403. doi: 10.1111/mmi.12064. Epub 2012 Nov 5.


Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families.

Capra EJ, Perchuk BS, Skerker JM, Laub MT.

Cell. 2012 Jul 6;150(1):222-32. doi: 10.1016/j.cell.2012.05.033.


Evolution of two-component signal transduction systems.

Capra EJ, Laub MT.

Annu Rev Microbiol. 2012;66:325-47. doi: 10.1146/annurev-micro-092611-150039. Epub 2012 Jun 28. Review.


Asymmetric cell division: a persistent issue?

Aakre CD, Laub MT.

Dev Cell. 2012 Feb 14;22(2):235-6. doi: 10.1016/j.devcel.2012.01.016.


Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks.

Abel S, Chien P, Wassmann P, Schirmer T, Kaever V, Laub MT, Baker TA, Jenal U.

Mol Cell. 2011 Aug 19;43(4):550-60. doi: 10.1016/j.molcel.2011.07.018.

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