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miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders.

Du Y, Wang X, Li LY, Hao W, Zhang H, Li Y, Qin Y, Nie S, Christopher T, Lopez B, Wang Y, Lau WB, Wei YX, Ma XL.

Circ Res. 2019 Nov 7. doi: 10.1161/CIRCRESAHA.119.315067. [Epub ahead of print]


Surgical stress and cancer progression: the twisted tango.

Chen Z, Zhang P, Xu Y, Yan J, Liu Z, Lau WB, Lau B, Li Y, Zhao X, Wei Y, Zhou S.

Mol Cancer. 2019 Sep 2;18(1):132. doi: 10.1186/s12943-019-1058-3. Review.


Withaferin A Prevents Myocardial Ischemia/Reperfusion Injury by Upregulating AMP-Activated Protein Kinase-Dependent B-Cell Lymphoma2 Signaling.

Guo R, Gan L, Lau WB, Yan Z, Xie D, Gao E, Christopher TA, Lopez BL, Ma X, Wang Y.

Circ J. 2019 Jul 25;83(8):1726-1736. doi: 10.1253/circj.CJ-18-1391. Epub 2019 Jun 20.


Activation of T Lymphocytes as a Novel Mechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling.

Du Y, Li X, Yu H, Yan L, Lau WB, Zhang S, Qin Y, Wang W, Ma X, Liu H, Fu M.

Cardiovasc Drugs Ther. 2019 Apr;33(2):149-161. doi: 10.1007/s10557-019-06856-2.


Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress.

Yan Z, Guo R, Gan L, Lau WB, Cao X, Zhao J, Ma X, Christopher TA, Lopez BL, Wang Y.

Life Sci. 2018 Oct 15;211:91-101. doi: 10.1016/j.lfs.2018.09.020. Epub 2018 Sep 10.


Epigenetics in ovarian cancer: premise, properties, and perspectives.

Yang Q, Yang Y, Zhou N, Tang K, Lau WB, Lau B, Wang W, Xu L, Yang Z, Huang S, Wang X, Yi T, Zhao X, Wei Y, Wang H, Zhao L, Zhou S.

Mol Cancer. 2018 Jul 31;17(1):109. doi: 10.1186/s12943-018-0855-4. Review.


Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis.

Zhao D, Feng P, Sun Y, Qin Z, Zhang Z, Tan Y, Gao E, Lau WB, Ma X, Yang J, Yu S, Xu X, Yi D, Yi W.

Cell Death Dis. 2018 Jun 20;9(7):723. doi: 10.1038/s41419-018-0726-3.


Clinical characteristics of patients with pulmonary infarction - A retrospective review.

Chengsupanimit T, Sundaram B, Lau WB, Keith SW, Kane GC.

Respir Med. 2018 Jun;139:13-18. doi: 10.1016/j.rmed.2018.04.008. Epub 2018 Apr 17.


Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis.

Zhao L, Huang S, Mei S, Yang Z, Xu L, Zhou N, Yang Q, Shen Q, Wang W, Le X, Lau WB, Lau B, Wang X, Yi T, Zhao X, Wei Y, Warner M, Gustafsson JÅ, Zhou S.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681. doi: 10.1073/pnas.1803291115. Epub 2018 Mar 28.


The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts.

Zhao L, Wang W, Huang S, Yang Z, Xu L, Yang Q, Zhou X, Wang J, Shen Q, Wang C, Le X, Feng M, Zhou N, Lau WB, Lau B, Yao S, Yi T, Wang X, Zhao X, Wei Y, Zhou S.

Genome Biol. 2018 Mar 16;19(1):35. doi: 10.1186/s13059-018-1412-6.


Endothelial Cell-Derived Microparticles from Patients with Obstructive Sleep Apnea Hypoxia Syndrome and Coronary Artery Disease Increase Aortic Endothelial Cell Dysfunction.

Jia L, Fan J, Cui W, Liu S, Li N, Lau WB, Ma X, Du J, Nie S, Wei Y.

Cell Physiol Biochem. 2017;43(6):2562-2570. doi: 10.1159/000484508. Epub 2017 Nov 1.


C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways.

Yan W, Guo Y, Tao L, Lau WB, Gan L, Yan Z, Guo R, Gao E, Wong GW, Koch WL, Wang Y, Ma XL.

Circulation. 2017 Nov 28;136(22):2162-2177. doi: 10.1161/CIRCULATIONAHA.117.029557. Epub 2017 Oct 4.


Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling.

Wang Y, Liang B, Lau WB, Du Y, Guo R, Yan Z, Gan L, Yan W, Zhao J, Gao E, Koch W, Ma XL.

Autophagy. 2017;13(11):1855-1869. doi: 10.1080/15548627.2017.1358848. Epub 2017 Sep 1.


CTRP3 is a novel biomarker for diabetic retinopathy and inhibits HGHL-induced VCAM-1 expression in an AMPK-dependent manner.

Yan Z, Zhao J, Gan L, Zhang Y, Guo R, Cao X, Lau WB, Ma X, Wang Y.

PLoS One. 2017 Jun 20;12(6):e0178253. doi: 10.1371/journal.pone.0178253. eCollection 2017.


Role of Adipokines in Cardiovascular Disease.

Lau WB, Ohashi K, Wang Y, Ogawa H, Murohara T, Ma XL, Ouchi N.

Circ J. 2017 Jun 23;81(7):920-928. doi: 10.1253/circj.CJ-17-0458. Epub 2017 Jun 10. Review.


Cardiovascular Adiponectin Resistance: The Critical Role of Adiponectin Receptor Modification.

Wang Y, Ma XL, Lau WB.

Trends Endocrinol Metab. 2017 Jul;28(7):519-530. doi: 10.1016/j.tem.2017.03.004. Epub 2017 May 1. Review.


An integrated analysis identifies STAT4 as a key regulator of ovarian cancer metastasis.

Zhao L, Ji G, Le X, Luo Z, Wang C, Feng M, Xu L, Zhang Y, Lau WB, Lau B, Yang Y, Lei L, Yang H, Xuan Y, Chen Y, Deng X, Yi T, Yao S, Zhao X, Wei Y, Zhou S.

Oncogene. 2017 Jun 15;36(24):3384-3396. doi: 10.1038/onc.2016.487. Epub 2017 Jan 23.


T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity.

Wang H, Tao L, Ambrosio A, Yan W, Summer R, Lau WB, Wang Y, Ma X.

Cardiovasc Diabetol. 2017 Jan 19;16(1):12. doi: 10.1186/s12933-016-0488-0.


Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer.

Zhao L, Ji G, Le X, Wang C, Xu L, Feng M, Zhang Y, Yang H, Xuan Y, Yang Y, Lei L, Yang Q, Lau WB, Lau B, Chen Y, Deng X, Yao S, Yi T, Zhao X, Wei Y, Zhou S.

Cancer Res. 2017 Mar 15;77(6):1369-1382. doi: 10.1158/0008-5472.CAN-16-1615. Epub 2017 Jan 13.


Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction.

Wang K, Yuan Y, Liu X, Lau WB, Zuo L, Wang X, Ma L, Jiao K, Shang J, Wang W, Ma X, Liu H.

Sci Rep. 2016 Dec 7;6:37927. doi: 10.1038/srep37927.


LncRNAs: the bridge linking RNA and colorectal cancer.

Yang Y, Zhao L, Lei L, Lau WB, Lau B, Yang Q, Le X, Yang H, Wang C, Luo Z, Xuan Y, Chen Y, Deng X, Xu L, Feng M, Yi T, Zhao X, Wei Y, Zhou S.

Oncotarget. 2017 Feb 14;8(7):12517-12532. doi: 10.18632/oncotarget.13573. Review.


Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy.

Zhang F, Zhao S, Yan W, Xia Y, Chen X, Wang W, Zhang J, Gao C, Peng C, Yan F, Zhao H, Lian K, Lee Y, Zhang L, Lau WB, Ma X, Tao L.

EBioMedicine. 2016 Nov;13:157-167. doi: 10.1016/j.ebiom.2016.10.013. Epub 2016 Oct 11.


Adiponectin ameliorates the apoptotic effects of paraquat on alveolar type Ⅱ cells via improvements in mitochondrial function.

He Y, Zou L, Zhou Y, Hu H, Yao R, Jiang Y, Lau WB, Yuan T, Huang W, Zeng Z, Cao Y.

Mol Med Rep. 2016 Jul;14(1):746-52. doi: 10.3892/mmr.2016.5328. Epub 2016 May 23.


Tumor microenvironment: The culprit for ovarian cancer metastasis?

Luo Z, Wang Q, Lau WB, Lau B, Xu L, Zhao L, Yang H, Feng M, Xuan Y, Yang Y, Lei L, Wang C, Yi T, Zhao X, Wei Y, Zhou S.

Cancer Lett. 2016 Jul 28;377(2):174-82. doi: 10.1016/j.canlet.2016.04.038. Epub 2016 Apr 27. Review.


Adiponectin at Physiologically Relevant Concentrations Enhances the Vasorelaxative Effect of Acetylcholine via Cav-1/AdipoR-1 Signaling.

Du Y, Li R, Lau WB, Zhao J, Lopez B, Christopher TA, Ma XL, Wang Y.

PLoS One. 2016 Mar 29;11(3):e0152247. doi: 10.1371/journal.pone.0152247. eCollection 2016.


Reduction of CTRP9, a novel anti-platelet adipokine, contributes to abnormal platelet activity in diabetic animals.

Wang W, Lau WB, Wang Y, Ma X, Li R.

Cardiovasc Diabetol. 2016 Jan 11;15:6. doi: 10.1186/s12933-015-0321-1.


Low-Dose Versus Standard-Dose Tissue Plasminogen Activator in Acute Ischemic Stroke in Asian Populations: A Meta-Analysis.

Liu MD, Ning WD, Wang RC, Chen W, Yang Y, Lin Y, Hu DH, Lau WB, Qu Y.

Medicine (Baltimore). 2015 Dec;94(52):e2412. doi: 10.1097/MD.0000000000002412.


A mass spectrometric insight into the origins of benign gynecological disorders.

Yang H, Lau WB, Lau B, Xuan Y, Zhou S, Zhao L, Luo Z, Lin Q, Ren N, Zhao X, Wei Y.

Mass Spectrom Rev. 2017 May;36(3):450-470. doi: 10.1002/mas.21484. Epub 2015 Dec 3. Review.


Epigenetic repression of PDZ-LIM domain-containing protein 2 promotes ovarian cancer via NOS2-derived nitric oxide signaling.

Zhao L, Yu C, Zhou S, Lau WB, Lau B, Luo Z, Lin Q, Yang H, Xuan Y, Yi T, Zhao X, Wei Y.

Oncotarget. 2016 Jan 12;7(2):1408-20. doi: 10.18632/oncotarget.6368.


High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation.

Liu GZ, Liang B, Lau WB, Wang Y, Zhao J, Li R, Wang X, Yuan Y, Lopez BL, Christopher TA, Xiao C, Ma XL, Wang Y.

Free Radic Biol Med. 2015 Dec;89:473-85. doi: 10.1016/j.freeradbiomed.2015.09.005. Epub 2015 Oct 8.


Concomitant Retrograde Coronary Venous Infusion of Basic Fibroblast Growth Factor Enhances Engraftment and Differentiation of Bone Marrow Mesenchymal Stem Cells for Cardiac Repair after Myocardial Infarction.

Wang X, Zhen L, Miao H, Sun Q, Yang Y, Que B, Lopes Lao EP, Wu X, Ren H, Shi S, Lau WB, Ma X, Ma C, Nie S.

Theranostics. 2015 Jun 8;5(9):995-1006. doi: 10.7150/thno.11607. eCollection 2015.


An evaluation model of surgery capability of tertiary hospital in disasters: a cross-sectional survey in China.

Liu B, Hu H, He YR, Lau WB, Cao Y, Li ZM, Zhang L.

Public Health. 2015 Sep;129(9):1301-3. doi: 10.1016/j.puhe.2015.05.020. Epub 2015 Jul 3. No abstract available.


A Curious Case of Cold Ludwig's Angina.

Yalamanchili S, Lau WB.

J Emerg Med. 2015 Oct;49(4):e121-2. doi: 10.1016/j.jemermed.2015.04.025. Epub 2015 Jul 3. No abstract available.


The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases.

Yang Y, Hu W, Jiang S, Wang B, Li Y, Fan C, Di S, Ma Z, Lau WB, Qu Y.

Biochim Biophys Acta. 2015 Sep;1852(9):1887-94. doi: 10.1016/j.bbadis.2015.06.019. Epub 2015 Jun 26. Review.


AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings.

Zhang Y, Zhao J, Li R, Lau WB, Yuan YX, Liang B, Li R, Gao EH, Koch WJ, Ma XL, Wang YJ.

Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82. doi: 10.1152/ajpendo.00577.2014. Epub 2015 Jun 2.


Adiponectin attenuates lung fibroblasts activation and pulmonary fibrosis induced by paraquat.

Yao R, Cao Y, He YR, Lau WB, Zeng Z, Liang ZA.

PLoS One. 2015 May 6;10(5):e0125169. doi: 10.1371/journal.pone.0125169. eCollection 2015.


C1q-TNF-related protein-9, a novel cardioprotetcive cardiokine, requires proteolytic cleavage to generate a biologically active globular domain isoform.

Yuan Y, Lau WB, Su H, Sun Y, Yi W, Du Y, Christopher T, Lopez B, Wang Y, Ma XL.

Am J Physiol Endocrinol Metab. 2015 May 15;308(10):E891-8. doi: 10.1152/ajpendo.00450.2014. Epub 2015 Mar 17.


G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart.

Wang Y, Gao E, Lau WB, Wang Y, Liu G, Li JJ, Wang X, Yuan Y, Koch WJ, Ma XL.

Circulation. 2015 Apr 21;131(16):1392-404. doi: 10.1161/CIRCULATIONAHA.114.015248. Epub 2015 Feb 18.


Angiotensin II type 1 receptor autoantibody as a novel regulator of aldosterone independent of preeclampsia.

Yang J, Li L, Shang JY, Cai L, Song L, Zhang SL, Li H, Li X, Lau WB, Ma XL, Liu HR.

J Hypertens. 2015 May;33(5):1046-56. doi: 10.1097/HJH.0000000000000521.


MicroRNAs in colorectal cancer: small molecules with big functions.

Xuan Y, Yang H, Zhao L, Lau WB, Lau B, Ren N, Hu Y, Yi T, Zhao X, Zhou S, Wei Y.

Cancer Lett. 2015 May 1;360(2):89-105. doi: 10.1016/j.canlet.2014.11.051. Epub 2014 Dec 15. Review.


Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress.

Yao R, Zhou Y, He Y, Jiang Y, Liu P, Ye L, Zheng Z, Lau WB, Cao Y, Zeng Z.

Exp Ther Med. 2015 Jan;9(1):131-136. Epub 2014 Nov 17.


Activation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury.

He Q, Pu J, Yuan A, Lau WB, Gao E, Koch WJ, Ma XL, He B.

Circ Heart Fail. 2014 Nov;7(6):1032-41. doi: 10.1161/CIRCHEARTFAILURE.114.001260. Epub 2014 Oct 2.


Effective glycaemic control critically determines insulin cardioprotection against ischaemia/reperfusion injury in anaesthetized dogs.

Yu Q, Zhou N, Nan Y, Zhang L, Li Y, Hao X, Xiong L, Lau WB, Ma XL, Wang H, Gao F.

Cardiovasc Res. 2014 Jul 15;103(2):238-47. doi: 10.1093/cvr/cvu132. Epub 2014 May 20.


Aging aggravates nitrate-mediated ROS/RNS changes.

Fan Q, Chen L, Cheng S, Li F, Lau WB, Wang le F, Liu JH.

Oxid Med Cell Longev. 2014;2014:376515. doi: 10.1155/2014/376515. Epub 2014 Mar 23.


BMP-2 overexpression augments vascular smooth muscle cell motility by upregulating myosin Va via Erk signaling.

Zhang M, Yang M, Liu LP, Lau WB, Gao H, Xin MK, Su LX, Wang J, Cheng SJ, Fan Q, Liu JH.

Oxid Med Cell Longev. 2014;2014:294150. doi: 10.1155/2014/294150. Epub 2014 Mar 20.


Characteristics of patients who leave the emergency department without being seen: the first report in China.

Liu S, Nie H, Huang W, Liu X, Luo L, Lau WB, Cao Y.

Emerg Med Australas. 2014 Jun;26(3):243-8. doi: 10.1111/1742-6723.12167. Epub 2014 Apr 8.


Severe lactic acidosis and acute hepatic and renal insufficiency due to fenaminosulf poisoning.

Wei W, Lau WB, Chen Y, Hu X, Nie H.

Clin Toxicol (Phila). 2014 Apr;52(4):446-7. doi: 10.3109/15563650.2014.900181. Epub 2014 Mar 20. No abstract available.


Dickkopf-3 attenuates pressure overload-induced cardiac remodelling.

Zhang Y, Liu Y, Zhu XH, Zhang XD, Jiang DS, Bian ZY, Zhang XF, Chen K, Wei X, Gao L, Zhu LH, Yang Q, Fan GC, Lau WB, Ma X, Li H.

Cardiovasc Res. 2014 Apr 1;102(1):35-45. doi: 10.1093/cvr/cvu004. Epub 2014 Jan 9.


Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.

Wang Y, Wang X, Lau WB, Yuan Y, Booth D, Li JJ, Scalia R, Preston K, Gao E, Koch W, Ma XL.

Circ Res. 2014 Feb 28;114(5):792-805. doi: 10.1161/CIRCRESAHA.114.302439. Epub 2014 Jan 7.


Adiponectin inhibits oxidative/nitrative stress during myocardial ischemia and reperfusion via PKA signaling.

Zhang Y, Wang XL, Zhao J, Wang YJ, Lau WB, Yuan YX, Gao EH, Koch WJ, Ma XL.

Am J Physiol Endocrinol Metab. 2013 Dec;305(12):E1436-43. doi: 10.1152/ajpendo.00445.2013. Epub 2013 Oct 15.

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