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CCN1-Induced Cellular Senescence Promotes Heart Regeneration.

Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau LF, Zhou B, Zhang H.

Circulation. 2019 May 21;139(21):2495-2498. doi: 10.1161/CIRCULATIONAHA.119.039530. No abstract available.


The matricellular protein CCN1 in tissue injury repair.

Kim KH, Won JH, Cheng N, Lau LF.

J Cell Commun Signal. 2018 Mar;12(1):273-279. doi: 10.1007/s12079-018-0450-x. Epub 2018 Jan 22. Review.


Resolution of organ fibrosis.

Jun JI, Lau LF.

J Clin Invest. 2018 Jan 2;128(1):97-107. doi: 10.1172/JCI93563. Epub 2018 Jan 2. Review.


Recombinant CCN1 prevents hyperoxia-induced lung injury in neonatal rats.

Vaidya R, Zambrano R, Hummler JK, Luo S, Duncan MR, Young K, Lau LF, Wu S.

Pediatr Res. 2017 Nov;82(5):863-871. doi: 10.1038/pr.2017.160. Epub 2017 Aug 2.


Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy.

Lee S, Elaskandrany M, Lau LF, Lazzaro D, Grant MB, Chaqour B.

Sci Rep. 2017 May 3;7(1):1405. doi: 10.1038/s41598-017-01585-8.


In Vitro and In Vivo Anticancer Activity of Gimatecan against Hepatocellular Carcinoma

Zhao Y, Lau LF, Dai X, Li B.

Asian Pac J Cancer Prev. 2016 Nov 1;17(11):4853-4856.


Impacts of a documentary on the daily lives of mothers and children with disabilities: an analysis of cine debates.

Cavalcante FG, Lau LF, Barbosa GF, Berlim DL, Menezes NC, Braga DC, Amorim AC, Amorim YC.

Cien Saude Colet. 2016 Oct;21(10):3071-3080. doi: 10.1590/1413-812320152110.18522016. Portuguese, English.


CCN2 induces cellular senescence in fibroblasts.

Jun JI, Lau LF.

J Cell Commun Signal. 2017 Mar;11(1):15-23. doi: 10.1007/s12079-016-0359-1. Epub 2016 Oct 18.


Construction and Analysis of an Allelic Series of Ccn1 Knockin Mice.

Monzon RI, Kim KH, Lau LF.

Methods Mol Biol. 2017;1489:361-376.


Management of gallstone pancreatitis in the vagrant liver.

Lau LF, Knowles B, Fox A, Banting S.

ANZ J Surg. 2018 Oct;88(10):E741-E742. doi: 10.1111/ans.13715. Epub 2016 Aug 25. No abstract available.


Metabolic response evaluation for colorectal liver metastases and correlation to pathologic response and tumour markers.

Lau LF, Murone C, Williams DS, Standish R, Lee ST, Christophi C, Scott AM, Muralidharan V.

ANZ J Surg. 2018 Mar;88(3):E108-E113. doi: 10.1111/ans.13680. Epub 2016 Jul 24.


Cell surface receptors for CCN proteins.

Lau LF.

J Cell Commun Signal. 2016 Jun;10(2):121-7. doi: 10.1007/s12079-016-0324-z. Epub 2016 Apr 20. Review.


CCN1 in hepatobiliary injury repair.

Kim KH, Lau LF.

Oncotarget. 2015 Oct 27;6(33):34053-4. doi: 10.18632/oncotarget.6079. No abstract available.


The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing.

Jun JI, Kim KH, Lau LF.

Nat Commun. 2015 Jun 16;6:7386. doi: 10.1038/ncomms8386.


The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation.

Chen CC, Kim KH, Lau LF.

Oncogene. 2016 Mar 10;35(10):1314-23. doi: 10.1038/onc.2015.190. Epub 2015 Jun 1.


A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury.

Li TT, Fan ML, Hou SX, Li XY, Barry DM, Jin H, Luo SY, Kong F, Lau LF, Dai XR, Zhang GH, Zhou LL.

Br J Pharmacol. 2015 Aug;172(15):3904-16. doi: 10.1111/bph.13178. Epub 2015 Jun 12.


CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB.

Kim KH, Chen CC, Alpini G, Lau LF.

J Clin Invest. 2015 May;125(5):1886-900. doi: 10.1172/JCI79327. Epub 2015 Mar 30.


The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6.

Choi JS, Kim KH, Lau LF.

Mucosal Immunol. 2015 Nov;8(6):1285-96. doi: 10.1038/mi.2015.19. Epub 2015 Mar 25.


Estrogen-induced CCN1 is critical for establishment of endometriosis-like lesions in mice.

Zhao Y, Li Q, Katzenellenbogen BS, Lau LF, Taylor RN, Bagchi IC, Bagchi MK.

Mol Endocrinol. 2014 Dec;28(12):1934-47. doi: 10.1210/me.2014-1080.


Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection.

Zhao X, Ding EY, Yu OM, Xiang SY, Tan-Sah VP, Yung BS, Hedgpeth J, Neubig RR, Lau LF, Brown JH, Miyamoto S.

J Mol Cell Cardiol. 2014 Oct;75:152-61. doi: 10.1016/j.yjmcc.2014.07.017. Epub 2014 Aug 8.


Metabolic response to preoperative chemotherapy predicts prognosis for patients undergoing surgical resection of colorectal cancer metastatic to the liver.

Lau LF, Williams DS, Lee ST, Scott AM, Christophi C, Muralidharan V.

Ann Surg Oncol. 2014 Jul;21(7):2420-8. doi: 10.1245/s10434-014-3590-0. Epub 2014 Mar 5.


Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina.

Choi J, Lin A, Shrier E, Lau LF, Grant MB, Chaqour B.

J Biol Chem. 2013 Aug 9;288(32):23075-89. doi: 10.1074/jbc.M113.475418. Epub 2013 Jun 24.


Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

Kim KH, Chen CC, Monzon RI, Lau LF.

Mol Cell Biol. 2013 May;33(10):2078-90. doi: 10.1128/MCB.00049-13. Epub 2013 Mar 18.


Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo.

Huang Y, Li T, Eatherton A, Mitchell WL, Rong N, Ye L, Yang XJ, Jin S, Ding Y, Zhang J, Li Y, Wu Y, Jin Y, Sang Y, Cheng Z, Browne ER, Harrison DC, Hussain I, Wan Z, Hall A, Lau LF, Matsuoka Y.

Neuropharmacology. 2013 Jul;70:278-86. doi: 10.1016/j.neuropharm.2013.02.003. Epub 2013 Feb 26.


Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury.

Zemans RL, McClendon J, Aschner Y, Briones N, Young SK, Lau LF, Kahn M, Downey GP.

Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15;304(6):L415-27. doi: 10.1152/ajplung.00180.2012. Epub 2013 Jan 11.


CCN1 and CCN2: blood brothers in angiogenic action.

Lau LF.

J Cell Commun Signal. 2012 Aug;6(3):121-3. doi: 10.1007/s12079-012-0169-z. Epub 2012 Jul 26.


TNFα-induced apoptosis enabled by CCN1/CYR61: pathways of reactive oxygen species generation and cytochrome c release.

Juric V, Chen CC, Lau LF.

PLoS One. 2012;7(2):e31303. doi: 10.1371/journal.pone.0031303. Epub 2012 Feb 17.


Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets.

Jun JI, Lau LF.

Nat Rev Drug Discov. 2011 Dec 1;10(12):945-63. doi: 10.1038/nrd3599. Review.


Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment.

Li T, Huang Y, Jin S, Ye L, Rong N, Yang X, Ding Y, Cheng Z, Zhang J, Wan Z, Harrison DC, Hussain I, Hall A, Lee DH, Lau LF, Matsuoka Y.

J Neurochem. 2012 Apr;121(2):277-86. doi: 10.1111/j.1471-4159.2011.07560.x. Epub 2012 Mar 13.


CCN1/CYR61: the very model of a modern matricellular protein.

Lau LF.

Cell Mol Life Sci. 2011 Oct;68(19):3149-63. doi: 10.1007/s00018-011-0778-3. Epub 2011 Jul 31. Review.


Pyridine-derived γ-secretase modulators.

Wan Z, Hall A, Sang Y, Xiang JN, Yang E, Smith B, Harrison DC, Yang G, Yu H, Price HS, Wang J, Hawkins J, Lau LF, Johnson MR, Li T, Zhao W, Mitchell WL, Su X, Zhang X, Zhou Y, Jin Y, Tong Z, Cheng Z, Hussain I, Elliott JD, Matsuoka Y.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4832-5. doi: 10.1016/j.bmcl.2011.06.042. Epub 2011 Jun 17.


Pyridazine-derived γ-secretase modulators.

Wan Z, Hall A, Jin Y, Xiang JN, Yang E, Eatherton A, Smith B, Yang G, Yu H, Wang J, Ye L, Lau LF, Yang T, Mitchell W, Cai W, Zhang X, Sang Y, Wang Y, Tong Z, Cheng Z, Hussain I, Elliott JD, Matsuoka Y.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4016-9. doi: 10.1016/j.bmcl.2011.04.143. Epub 2011 May 13.


Deregulation of FoxM1b leads to tumour metastasis.

Park HJ, Gusarova G, Wang Z, Carr JR, Li J, Kim KH, Qiu J, Park YD, Williamson PR, Hay N, Tyner AL, Lau LF, Costa RH, Raychaudhuri P.

EMBO Mol Med. 2011 Jan;3(1):21-34. doi: 10.1002/emmm.201000107. Epub 2010 Dec 17.


The extracellular matrix protein CCN1 dictates TNFα and FasL cytotoxicity in vivo.

Chen CC, Juric V, Lau LF.

Adv Exp Med Biol. 2011;691:595-603. doi: 10.1007/978-1-4419-6612-4_63. No abstract available.


Cellular senescence controls fibrosis in wound healing.

Jun JI, Lau LF.

Aging (Albany NY). 2010 Sep;2(9):627-31.


The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing.

Jun JI, Lau LF.

Nat Cell Biol. 2010 Jul;12(7):676-85. doi: 10.1038/ncb2070. Epub 2010 Jun 6. Erratum in: Nat Cell Biol. 2010 Dec;12(12):1249.


Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.

Petrovic V, Costa RH, Lau LF, Raychaudhuri P, Tyner AL.

Cancer Biol Ther. 2010 Jun 15;9(12):1008-16. Epub 2010 Jun 6.


Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages.

Bai T, Chen CC, Lau LF.

J Immunol. 2010 Mar 15;184(6):3223-32. doi: 10.4049/jimmunol.0902792. Epub 2010 Feb 17.


Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines.

Chen CC, Lau LF.

J Cell Commun Signal. 2010 Mar;4(1):63-9. doi: 10.1007/s12079-009-0080-4. Epub 2009 Nov 7.


A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1.

Chen YJ, Dominguez-Brauer C, Wang Z, Asara JM, Costa RH, Tyner AL, Lau LF, Raychaudhuri P.

J Biol Chem. 2009 Oct 30;284(44):30695-707. doi: 10.1074/jbc.M109.007997. Epub 2009 Sep 8.


FoxM1, a critical regulator of oxidative stress during oncogenesis.

Park HJ, Carr JR, Wang Z, Nogueira V, Hay N, Tyner AL, Lau LF, Costa RH, Raychaudhuri P.

EMBO J. 2009 Oct 7;28(19):2908-18. doi: 10.1038/emboj.2009.239. Epub 2009 Aug 20.


CCN3 and bone marrow cells.

Katsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M, Lau LF, Tamamura Y, Takeda S, Umezawa A, Sakamoto K, Yamaguchi A.

J Cell Commun Signal. 2009 Jun;3(2):135-45. doi: 10.1007/s12079-009-0059-1. Epub 2009 Jul 23.


Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis.

Franzen CA, Chen CC, Todorović V, Juric V, Monzon RI, Lau LF.

Mol Cancer Res. 2009 Jul;7(7):1045-55. doi: 10.1158/1541-7786.MCR-09-0017. Epub 2009 Jul 7.


Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.

Hanna M, Liu H, Amir J, Sun Y, Morris SW, Siddiqui MA, Lau LF, Chaqour B.

J Biol Chem. 2009 Aug 21;284(34):23125-36. doi: 10.1074/jbc.M109.019059. Epub 2009 Jun 20.


Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo.

Juric V, Chen CC, Lau LF.

Mol Cell Biol. 2009 Jun;29(12):3266-79. doi: 10.1128/MCB.00064-09. Epub 2009 Apr 13.


Functions and mechanisms of action of CCN matricellular proteins.

Chen CC, Lau LF.

Int J Biochem Cell Biol. 2009 Apr;41(4):771-83. doi: 10.1016/j.biocel.2008.07.025. Epub 2008 Aug 15. Review.


Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase.

Park HJ, Costa RH, Lau LF, Tyner AL, Raychaudhuri P.

Mol Cell Biol. 2008 Sep;28(17):5162-71. doi: 10.1128/MCB.00387-08. Epub 2008 Jun 23.


Assays for ribosomal RNA processing and ribosome assembly.

Pestov DG, Lapik YR, Lau LF.

Curr Protoc Cell Biol. 2008 Jun;Chapter 22:Unit 22.11. doi: 10.1002/0471143030.cb2211s39.


FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness.

Wang IC, Chen YJ, Hughes DE, Ackerson T, Major ML, Kalinichenko VV, Costa RH, Raychaudhuri P, Tyner AL, Lau LF.

J Biol Chem. 2008 Jul 25;283(30):20770-8. doi: 10.1074/jbc.M709892200. Epub 2008 Jun 4.


Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.

Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marié I, Maurin T, Wang L, Figueroa H, Herman M, Krishnamurthy P, Liu L, Planel E, Lau LF, Lahiri DK, Duff K.

Neuron. 2008 Mar 13;57(5):680-90. doi: 10.1016/j.neuron.2008.02.024.

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