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Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.

Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G.

Diabetes. 2020 Apr 3. pii: db190721. doi: 10.2337/db19-0721. [Epub ahead of print]


Combined Use of Common Fecal and Blood Markers for Detection of Endoscopically Active Inflammatory Bowel Disease.

Mak LY, Tong TSM, Cheung KS, Chen LJ, Lui KL, Lau KS, Leung WK.

Clin Transl Gastroenterol. 2020 Mar;11(3):e00138. doi: 10.14309/ctg.0000000000000138.


Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach.

Min J, Vega PN, Engevik AC, Williams JA, Yang Q, Patterson LM, Simmons AJ, Bliton RJ, Betts JW, Lau KS, Magness ST, Goldenring JR, Choi E.

Nat Commun. 2019 Dec 5;10(1):5549. doi: 10.1038/s41467-019-13479-6.


Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population.

Lam KO, Fu MC, Lau KS, Lam KM, Choi CW, Chiu WH, Yuen CM, Kwok LH, Tam FK, Chan WL, Chan SY, Ho PY, Leung TW, Lee HF.

World J Gastrointest Oncol. 2019 Nov 15;11(11):1031-1042. doi: 10.4251/wjgo.v11.i11.1031.


Clinical outcome and toxicity for immunotherapy treatment in metastatic cancer patients.

Lau KS, Liu R, Wong CC, Siu WKS, Yuen KK.

Ann Palliat Med. 2019 Nov 12. pii: apm.2019.10.03. doi: 10.21037/apm.2019.10.03. [Epub ahead of print]


Differences Between the East and the West in Managing Advanced-Stage Non-small Cell Lung Cancer.

Lee VHF, Mok TSK, Goto Y, Hsue VCC, Yang L, Jiang Y, Leung DKC, Lau KS, Tse PY.

Clin Oncol (R Coll Radiol). 2020 Jan;32(1):e1-e9. doi: 10.1016/j.clon.2019.07.014. Epub 2019 Jul 30.


scRNABatchQC: multi-samples quality control for single cell RNA-seq data.

Liu Q, Sheng Q, Ping J, Ramirez MA, Lau KS, Coffey RJ, Shyr Y.

Bioinformatics. 2019 Dec 15;35(24):5306-5308. doi: 10.1093/bioinformatics/btz601.


Methylated Septin 9 and Carcinoembryonic Antigen for Serological Diagnosis and Monitoring of Patients with Colorectal Cancer After Surgery.

Ma ZY, Law WL, Ng EKO, Chan CSY, Lau KS, Cheng YY, Shin VY, Kwong A, Leung WK.

Sci Rep. 2019 Jul 17;9(1):10326. doi: 10.1038/s41598-019-46876-4.


Controlled Synthesis of Well-Aligned and Highly Ordered TiO₂ Nanotubes Without Bundling for Enhanced Solar-Powered Photoelectrochemical Responses.

Lai CW, Lau KS, Chou PM.

J Nanosci Nanotechnol. 2019 Dec 1;19(12):7934-7942. doi: 10.1166/jnn.2019.16777.


Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities.

Vasaikar S, Huang C, Wang X, Petyuk VA, Savage SR, Wen B, Dou Y, Zhang Y, Shi Z, Arshad OA, Gritsenko MA, Zimmerman LJ, McDermott JE, Clauss TR, Moore RJ, Zhao R, Monroe ME, Wang YT, Chambers MC, Slebos RJC, Lau KS, Mo Q, Ding L, Ellis M, Thiagarajan M, Kinsinger CR, Rodriguez H, Smith RD, Rodland KD, Liebler DC, Liu T, Zhang B; Clinical Proteomic Tumor Analysis Consortium.

Cell. 2019 May 2;177(4):1035-1049.e19. doi: 10.1016/j.cell.2019.03.030. Epub 2019 Apr 25.


Real-world treatment patterns and outcomes in refractory metastatic colorectal cancer.

Chiang CL, Choi HC, Lam KO, Chan BY, Lee SF, Yeung SY, Lau KS, Chan SY, Choy TS, Yuen KK.

Asia Pac J Clin Oncol. 2019 Mar;15 Suppl 2:5-13. doi: 10.1111/ajco.13114. Epub 2019 Mar 19.


DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking.

Howard AM, LaFever KS, Fenix AM, Scurrah CR, Lau KS, Burnette DT, Bhave G, Ferrell N, Page-McCaw A.

J Cell Sci. 2019 Apr 8;132(7). pii: jcs226860. doi: 10.1242/jcs.226860.


Gene-environment interaction impacts on heart development and embryo survival.

Moreau JLM, Kesteven S, Martin EMMA, Lau KS, Yam MX, O'Reilly VC, Del Monte-Nieto G, Baldini A, Feneley MP, Moon AM, Harvey RP, Sparrow DB, Chapman G, Dunwoodie SL.

Development. 2019 Feb 20;146(4). pii: dev172957. doi: 10.1242/dev.172957.


Novel kidney dissociation protocol and image-based flow cytometry facilitate improved analysis of injured proximal tubules.

Manolopoulou M, Matlock BK, Nlandu-Khodo S, Simmons AJ, Lau KS, Phillips-Mignemi M, Ivanova A, Alford CE, Flaherty DK, Gewin LS.

Am J Physiol Renal Physiol. 2019 May 1;316(5):F847-F855. doi: 10.1152/ajprenal.00354.2018. Epub 2019 Feb 13.


Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability.

Foegeding NJ, Raghunathan K, Campbell AM, Kim SW, Lau KS, Kenworthy AK, Cover TL, Ohi MD.

Infect Immun. 2019 Mar 25;87(4). pii: e00783-18. doi: 10.1128/IAI.00783-18. Print 2019 Apr.


Not All Insults Are Created Equal for Awakening Dormant Stem Cell Abilities.

Vega PN, Lau KS, Goldenring JR.

Cell Mol Gastroenterol Hepatol. 2019;7(3):619-621. doi: 10.1016/j.jcmgh.2018.12.003. Epub 2019 Jan 7. No abstract available.


Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity.

Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G.

Dev Cell. 2019 Jan 7;48(1):49-63.e7. doi: 10.1016/j.devcel.2018.11.048.


mPGES-1-Mediated Production of PGE2 and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation.

Maseda D, Banerjee A, Johnson EM, Washington MK, Kim H, Lau KS, Crofford LJ.

Front Immunol. 2018 Dec 14;9:2954. doi: 10.3389/fimmu.2018.02954. eCollection 2018.


Bacterio- and Isobacteriodilactones by Stepwise or Direct Oxidations of meso-Tetrakis(pentafluorophenyl)porphyrin.

Hewage N, Daddario P, Lau KSF, Guberman-Pfeffer MJ, Gascón JA, Zeller M, Lee CO, Khalil GE, Gouterman M, Brückner C.

J Org Chem. 2019 Jan 4;84(1):239-256. doi: 10.1021/acs.joc.8b02628. Epub 2018 Dec 18.


Single-Cell Mass Cytometry of Archived Human Epithelial Tissue for Decoding Cancer Signaling Pathways.

Scurrah CR, Simmons AJ, Lau KS.

Methods Mol Biol. 2019;1884:215-229. doi: 10.1007/978-1-4939-8885-3_15.


pyNVR: investigating factors affecting feature selection from scRNA-seq data for lineage reconstruction.

Chen B, Herring CA, Lau KS.

Bioinformatics. 2019 Jul 1;35(13):2335-2337. doi: 10.1093/bioinformatics/bty950.


Quantitative assessment of cell population diversity in single-cell landscapes.

Liu Q, Herring CA, Sheng Q, Ping J, Simmons AJ, Chen B, Banerjee A, Li W, Gu G, Coffey RJ, Shyr Y, Lau KS.

PLoS Biol. 2018 Oct 22;16(10):e2006687. doi: 10.1371/journal.pbio.2006687. eCollection 2018 Oct.


Outcomes of community-based and home-based pulmonary rehabilitation for pneumoconiosis patients: a retrospective study.

Tsang EW, Kwok H, Chan AKY, Choo KL, Chan KS, Lau KS, Chan CCH.

BMC Pulm Med. 2018 Aug 9;18(1):133. doi: 10.1186/s12890-018-0692-7.


Delayed diagnosis of tuberculosis: risk factors and effect on mortality among older adults in Hong Kong.

Leung EC, Leung CC, Chang KC, Chan CK, Mok TY, Chan KS, Lau KS, Chau CH, Yee WK, Law WS, Lee SN, Au KF, Tai LB, Leung WM.

Hong Kong Med J. 2018 Aug;24(4):361-368. doi: 10.12809/hkmj177081. Epub 2018 Jul 30.


Interpreting heterogeneity in intestinal tuft cell structure and function.

Banerjee A, McKinley ET, von Moltke J, Coffey RJ, Lau KS.

J Clin Invest. 2018 May 1;128(5):1711-1719. doi: 10.1172/JCI120330. Epub 2018 May 1. Review.


Single-Cell Computational Strategies for Lineage Reconstruction in Tissue Systems.

Herring CA, Chen B, McKinley ET, Lau KS.

Cell Mol Gastroenterol Hepatol. 2018 Feb 13;5(4):539-548. doi: 10.1016/j.jcmgh.2018.01.023. eCollection 2018. Review.


A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability.

Jheng JR, Lau KS, Lan YW, Horng JT.

J Biomed Sci. 2018 Jan 31;25(1):9. doi: 10.1186/s12929-018-0412-x.


Race/Ethnicity, and Behavioral Health Status: First Arrest and Outcomes in a Large Sample of Juvenile Offenders.

Lau KSL, Rosenman MB, Wiehe SE, Tu W, Aalsma MC.

J Behav Health Serv Res. 2018 Apr;45(2):237-251. doi: 10.1007/s11414-017-9578-3.


Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut.

Herring CA, Banerjee A, McKinley ET, Simmons AJ, Ping J, Roland JT, Franklin JL, Liu Q, Gerdes MJ, Coffey RJ, Lau KS.

Cell Syst. 2018 Jan 24;6(1):37-51.e9. doi: 10.1016/j.cels.2017.10.012. Epub 2017 Nov 15.


Shear stress induces noncanonical autophagy in intestinal epithelial monolayers.

Kim SW, Ehrman J, Ahn MR, Kondo J, Lopez AAM, Oh YS, Kim XH, Crawley SW, Goldenring JR, Tyska MJ, Rericha EC, Lau KS.

Mol Biol Cell. 2017 Nov 1;28(22):3043-3056. doi: 10.1091/mbc.E17-01-0021. Epub 2017 Aug 30.


Perceived Police Injustice, Moral Disengagement, and Aggression Among Juvenile Offenders: Utilizing the General Strain Theory Model.

Zapolski TCB, Banks DE, Lau KSL, Aalsma MC.

Child Psychiatry Hum Dev. 2018 Apr;49(2):290-297. doi: 10.1007/s10578-017-0750-z.


Efficient Solar-Induced Photoelectrochemical Response Using Coupling Semiconductor TiO₂-ZnO Nanorod Film.

Abd Samad NA, Lai CW, Lau KS, Abd Hamid SB.

Materials (Basel). 2016 Nov 22;9(11). pii: E937. doi: 10.3390/ma9110937.


dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication.

Chang YH, Lau KS, Kuo RL, Horng JT.

Front Cell Infect Microbiol. 2017 Jun 28;7:284. doi: 10.3389/fcimb.2017.00284. eCollection 2017.


Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity.

McKinley ET, Sui Y, Al-Kofahi Y, Millis BA, Tyska MJ, Roland JT, Santamaria-Pang A, Ohland CL, Jobin C, Franklin JL, Lau KS, Gerdes MJ, Coffey RJ.

JCI Insight. 2017 Jun 2;2(11). pii: 93487. doi: 10.1172/jci.insight.93487. eCollection 2017 Jun 2.


Ileostomy creation in colorectal cancer surgery: risk of acute kidney injury and chronic kidney disease.

Li L, Lau KS, Ramanathan V, Orcutt ST, Sansgiry S, Albo D, Berger DH, Anaya DA.

J Surg Res. 2017 Apr;210:204-212. doi: 10.1016/j.jss.2016.11.039. Epub 2016 Nov 29.


Alterations in Gastric Microbiota After H. Pylori Eradication and in Different Histological Stages of Gastric Carcinogenesis.

Li TH, Qin Y, Sham PC, Lau KS, Chu KM, Leung WK.

Sci Rep. 2017 Mar 21;7:44935. doi: 10.1038/srep44935.


The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.

Almohazey D, Lo YH, Vossler CV, Simmons AJ, Hsieh JJ, Bucar EB, Schumacher MA, Hamilton KE, Lau KS, Shroyer NF, Frey MR.

Cell Death Differ. 2017 May;24(5):855-865. doi: 10.1038/cdd.2017.27. Epub 2017 Mar 17.


Effects of diabetes mellitus on the clinical presentation and treatment response in tuberculosis.

Leung CC, Yew WW, Mok TYW, Lau KS, Wong CF, Chau CH, Chan CK, Chang KC, Tam G, Tam CM.

Respirology. 2017 Aug;22(6):1225-1232. doi: 10.1111/resp.13017. Epub 2017 Feb 28.


Deciphering tumor heterogeneity from FFPE tissues: Its promise and challenges.

Simmons AJ, Lau KS.

Mol Cell Oncol. 2016 Nov 18;4(1):e1260191. doi: 10.1080/23723556.2016.1260191. eCollection 2017.


Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks.

Simmons AJ, Scurrah CR, McKinley ET, Herring CA, Irish JM, Washington MK, Coffey RJ, Lau KS.

Sci Signal. 2016 Oct 11;9(449):rs11.


Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo.

Simmons AJ, Banerjee A, McKinley ET, Scurrah CR, Herring CA, Gewin LS, Masuzaki R, Karp SJ, Franklin JL, Gerdes MJ, Irish JM, Coffey RJ, Lau KS.

Mol Syst Biol. 2016 Aug 29;12(8):881. doi: 10.15252/msb.20167270. No abstract available.


Elemental concentrations and bioaccessibilities in beached plastic foam litter, with particular reference to lead in polyurethane.

Turner A, Lau KS.

Mar Pollut Bull. 2016 Nov 15;112(1-2):265-270. doi: 10.1016/j.marpolbul.2016.08.005. Epub 2016 Aug 15.


Examining the Influence of Ethnic/Racial Socialization on Aggressive Behaviors Among Juvenile Offenders.

Zapolski TC, Garcia CA, Jarjoura GR, Lau KS, Aalsma MC.

J Juv Justice. 2016 Spring;5(1):65-79.


Detained Adolescents: Mental Health Needs, Treatment Use, and Recidivism.

White LM, Lau KS, Aalsma MC.

J Am Acad Psychiatry Law. 2016 Jun;44(2):200-12.


Impact of Death Work on Self: Existential and Emotional Challenges and Coping of Palliative Care Professionals.

Chan WC, Tin AF, Wong KL, Tse DM, Lau KS, Chan LN.

Health Soc Work. 2016 Feb;41(1):33-41. Erratum in: Health Soc Work. 2016 May;41(2):73. Fong, Agnes [corrected to Tin, Agnes Fong].


Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium.

Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM.

Sci Signal. 2015 Dec 15;8(407):ra129. doi: 10.1126/scisignal.aac7235.


Mortality of Youth Offenders Along a Continuum of Justice System Involvement.

Aalsma MC, Lau KSL, Perkins AJ, Schwartz K, Tu W, Wiehe SE, Monahan P, Rosenman MB.

Am J Prev Med. 2016 Mar;50(3):303-310. doi: 10.1016/j.amepre.2015.08.030. Epub 2015 Nov 12.


Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein.

Tang WF, Huang RT, Chien KY, Huang JY, Lau KS, Jheng JR, Chiu CH, Wu TY, Chen CY, Horng JT.

J Virol. 2015 Nov 18;90(3):1424-38. doi: 10.1128/JVI.02143-15. Print 2016 Feb 1.


Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo.

Simmons AJ, Banerjee A, McKinley ET, Scurrah CR, Herring CA, Gewin LS, Masuzaki R, Karp SJ, Franklin JL, Gerdes MJ, Irish JM, Coffey RJ, Lau KS.

Mol Syst Biol. 2015 Oct 30;11(10):835. doi: 10.15252/msb.20156282. Erratum in: Mol Syst Biol. 2016 Aug 29;12(8):881.


The effects of racial heterogeneity on mental health: A study of detained youth across multiple counties.

Lau KS, Aalsma MC, Holloway ED, Wiehe SE, Vachon DD.

Am J Orthopsychiatry. 2015 Sep;85(5):421-30. doi: 10.1037/ort0000100.

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