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Multicenter Study Demonstrates Standardization Requirements for Mold Identification by MALDI-TOF MS.

Lau AF, Walchak RC, Miller HB, Slechta ES, Kamboj K, Riebe K, Robertson AE, Gilbreath JJ, Mitchell KF, Wallace MA, Bryson AL, Balada-Llasat JM, Bulman A, Buchan BW, Burnham CD, Butler-Wu S, Desai U, Doern CD, Hanson KE, Henderson CM, Kostrzewa M, Ledeboer NA, Maier T, Pancholi P, Schuetz AN, Shi G, Wengenack NL, Zhang SX, Zelazny AM, Frank KM.

Front Microbiol. 2019 Sep 20;10:2098. doi: 10.3389/fmicb.2019.02098. eCollection 2019.


Plasmid Dissemination and Selection of a Multidrug-Resistant Klebsiella pneumoniae Strain during Transplant-Associated Antibiotic Therapy.

Conlan S, Lau AF, Deming C, Spalding CD, Lee-Lin S, Thomas PJ, Park M, Dekker JP, Frank KM, Palmore TN, Segre JA.

MBio. 2019 Oct 8;10(5). pii: e00652-19. doi: 10.1128/mBio.00652-19.


Investigation of a Cluster of Sphingomonas koreensis Infections.

Johnson RC, Deming C, Conlan S, Zellmer CJ, Michelin AV, Lee-Lin S, Thomas PJ, Park M, Weingarten RA, Less J, Dekker JP, Frank KM, Musser KA, McQuiston JR, Henderson DK, Lau AF, Palmore TN, Segre JA.

N Engl J Med. 2018 Dec 27;379(26):2529-2539. doi: 10.1056/NEJMoa1803238.


Comprehensive Evaluation of Compendial USP<71>, BacT/Alert Dual-T, and Bactec FX for Detection of Product Sterility Testing Contaminants.

England MR, Stock F, Gebo JET, Frank KM, Lau AF.

J Clin Microbiol. 2019 Jan 30;57(2). pii: e01548-18. doi: 10.1128/JCM.01548-18. Print 2019 Feb.


Prospective Evaluation of a Practical Guideline for Managing Positive Sterility Test Results in Cell Therapy Products.

Panch SR, Bikkani T, Vargas V, Procter J, Atkins JW, Guptill V, Frank KM, Lau AF, Stroncek DF.

Biol Blood Marrow Transplant. 2019 Jan;25(1):172-178. doi: 10.1016/j.bbmt.2018.08.003. Epub 2018 Aug 9.


Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of Bacterial Plasmids Conferring Carbapenem Resistance.

Weingarten RA, Johnson RC, Conlan S, Ramsburg AM, Dekker JP, Lau AF, Khil P, Odom RT, Deming C, Park M, Thomas PJ; NISC Comparative Sequencing Program, Henderson DK, Palmore TN, Segre JA, Frank KM.

MBio. 2018 Feb 6;9(1). pii: e02011-17. doi: 10.1128/mBio.02011-17.


Diagnostic challenges of prolonged post-treatment clearance of Plasmodium nucleic acids in a pre-transplant autosplenectomized patient with sickle cell disease.

Luethy PM, Murphy SC, Seilie AM, Xie YL, Lau CY, Tisdale JF, Hsieh MM, Reinhardt JL, Lau AF, Fahle GA.

Malar J. 2018 Jan 10;17(1):23. doi: 10.1186/s12936-017-2152-x.


Whole-Genome Sequencing Overrules a Suspected Case of Carbapenem-Resistant Enterobacter cloacae Transmission.

Chen M, Conlan S, Lau AF, Dekker JP, Deming C; NISC Comparative Sequencing Program, Henderson DK, Frank KM, Palmore TN, Segre JA.

J Clin Microbiol. 2017 Sep;55(9):2868-2870. doi: 10.1128/JCM.00915-17. Epub 2017 Jun 28. No abstract available.


Healthcare personnel intestinal colonization with multidrug-resistant organisms.

Decker BK, Lau AF, Dekker JP, Spalding CD, Sinaii N, Conlan S, Henderson DK, Segre JA, Frank KM, Palmore TN.

Clin Microbiol Infect. 2018 Jan;24(1):82.e1-82.e4. doi: 10.1016/j.cmi.2017.05.010. Epub 2017 May 12.


The clinical utility, reliability and validity of the Rivermead Behavioural Memory Test-Third Edition (RBMT-3) in Hong Kong older adults with or without cognitive impairments.

Fong KNK, Lee KKL, Tsang ZPY, Wan JYH, Zhang YY, Lau AFC.

Neuropsychol Rehabil. 2019 Jan;29(1):144-159. doi: 10.1080/09602011.2016.1272467. Epub 2017 Jan 4.


Problematic Dichotomization of Risk for Intensive Care Unit (ICU)-Acquired Invasive Candidiasis: Results Using a Risk-Predictive Model to Categorize 3 Levels of Risk From a Multicenter Prospective Cohort of Australian ICU Patients.

Playford EG, Lipman J, Jones M, Lau AF, Kabir M, Chen SC, Marriott DJ, Seppelt I, Gottlieb T, Cheung W, Iredell JR, McBryde ES, Sorrell TC.

Clin Infect Dis. 2016 Dec 1;63(11):1463-1469. Epub 2016 Sep 6.


Complete Genome Sequence of a Klebsiella pneumoniae Strain Carrying blaNDM-1 on a Multidrug Resistance Plasmid.

Conlan S, Lau AF; NISC Comparative Sequencing Program, Palmore TN, Frank KM, Segre JA.

Genome Announc. 2016 Jul 14;4(4). pii: e00664-16. doi: 10.1128/genomeA.00664-16.


Plasmid Dynamics in KPC-Positive Klebsiella pneumoniae during Long-Term Patient Colonization.

Conlan S, Park M, Deming C, Thomas PJ, Young AC, Coleman H, Sison C; NISC Comparative Sequencing Program, Weingarten RA, Lau AF, Dekker JP, Palmore TN, Frank KM, Segre JA.

MBio. 2016 Jun 28;7(3). pii: e00742-16. doi: 10.1128/mBio.00742-16.


Performance of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Aspergillus, Scedosporium, and Fusarium spp. in the Australian Clinical Setting.

Sleiman S, Halliday CL, Chapman B, Brown M, Nitschke J, Lau AF, Chen SC.

J Clin Microbiol. 2016 Aug;54(8):2182-6. doi: 10.1128/JCM.00906-16. Epub 2016 Jun 1.


An Update on the Streptococcus bovis Group: Classification, Identification, and Disease Associations.

Dekker JP, Lau AF.

J Clin Microbiol. 2016 Jul;54(7):1694-1699. doi: 10.1128/JCM.02977-15. Epub 2016 Feb 24. Review.


Detection and Whole-Genome Sequencing of Carbapenemase-Producing Aeromonas hydrophila Isolates from Routine Perirectal Surveillance Culture.

Hughes HY, Conlan SP, Lau AF, Dekker JP, Michelin AV, Youn JH, Henderson DK, Frank KM, Segre JA, Palmore TN.

J Clin Microbiol. 2016 Apr;54(4):1167-70. doi: 10.1128/JCM.03229-15. Epub 2016 Feb 17.


Clinical Performance of Check-Direct CPE, a Multiplex PCR for Direct Detection of bla(KPC), bla(NDM) and/or bla(VIM), and bla(OXA)-48 from Perirectal Swabs.

Lau AF, Fahle GA, Kemp MA, Jassem AN, Dekker JP, Frank KM.

J Clin Microbiol. 2015 Dec;53(12):3729-37. doi: 10.1128/JCM.01921-15. Epub 2015 Sep 2.


Clinical Performance of a Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Method for Detection of Certain blaKPC-Containing Plasmids.

Youn JH, Drake SK, Weingarten RA, Frank KM, Dekker JP, Lau AF.

J Clin Microbiol. 2016 Jan;54(1):35-42. doi: 10.1128/JCM.01643-15. Epub 2015 Sep 2.


Candida colonization as a risk marker for invasive candidiasis in mixed medical-surgical intensive care units: development and evaluation of a simple, standard protocol.

Lau AF, Kabir M, Chen SC, Playford EG, Marriott DJ, Jones M, Lipman J, McBryde E, Gottlieb T, Cheung W, Seppelt I, Iredell J, Sorrell TC.

J Clin Microbiol. 2015 Apr;53(4):1324-30. doi: 10.1128/JCM.03239-14. Epub 2015 Feb 11.


Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75).

Kopanic JL, Schlingmann B, Koval M, Lau AF, Sorgen PL, Su VF.

Biochem J. 2015 Mar 15;466(3):571-85. doi: 10.1042/BJ20141042.


Complete Genome Sequence of a Klebsiella pneumoniae Isolate with Chromosomally Encoded Carbapenem Resistance and Colibactin Synthesis Loci.

Conlan S, Deming C, Tsai YC, Lau AF, Dekker JP, Korlach J, Segre JA.

Genome Announc. 2014 Dec 24;2(6). pii: e01332-14. doi: 10.1128/genomeA.01332-14.


Reply to "Tn4401 carrying blaKPC is inserted within another insertion in pKpQIL and related plasmids".

Lau AF, Wang H, Weingarten RA, Drake SK, Suffredini AF, Chen Y, Gucek M, Youn JH, Stock F, Tso H, DeLeo J, Cimino JJ, Frank KM, Dekker JP.

J Clin Microbiol. 2014 Dec;52(12):4450. doi: 10.1128/JCM.02614-14. No abstract available.


Single-molecule sequencing to track plasmid diversity of hospital-associated carbapenemase-producing Enterobacteriaceae.

Conlan S, Thomas PJ, Deming C, Park M, Lau AF, Dekker JP, Snitkin ES, Clark TA, Luong K, Song Y, Tsai YC, Boitano M, Dayal J, Brooks SY, Schmidt B, Young AC, Thomas JW, Bouffard GG, Blakesley RW; NISC Comparative Sequencing Program, Mullikin JC, Korlach J, Henderson DK, Frank KM, Palmore TN, Segre JA.

Sci Transl Med. 2014 Sep 17;6(254):254ra126. doi: 10.1126/scitranslmed.3009845.


A rapid matrix-assisted laser desorption ionization-time of flight mass spectrometry-based method for single-plasmid tracking in an outbreak of carbapenem-resistant Enterobacteriaceae.

Lau AF, Wang H, Weingarten RA, Drake SK, Suffredini AF, Garfield MK, Chen Y, Gucek M, Youn JH, Stock F, Tso H, DeLeo J, Cimino JJ, Frank KM, Dekker JP.

J Clin Microbiol. 2014 Aug;52(8):2804-12. doi: 10.1128/JCM.00694-14. Epub 2014 May 21.


Connexins: mechanisms regulating protein levels and intercellular communication.

Su V, Lau AF.

FEBS Lett. 2014 Apr 17;588(8):1212-20. doi: 10.1016/j.febslet.2014.01.013. Epub 2014 Jan 20. Review.


CIP75 (connexin43-interacting protein of 75 kDa) mediates the endoplasmic reticulum dislocation of connexin43.

Su V, Hoang C, Geerts D, Lau AF.

Biochem J. 2014 Feb 15;458(1):57-67. doi: 10.1042/BJ20131247.


The connexin43-interacting protein, CIP85, mediates the internalization of connexin43 from the plasma membrane.

Cochrane K, Su V, Lau AF.

Cell Commun Adhes. 2013 Aug;20(3-4):53-66. doi: 10.3109/15419061.2013.784745. Epub 2013 Apr 16.


Combined effects of sensory cueing and limb activation on unilateral neglect in subacute left hemiplegic stroke patients: a randomized controlled pilot study.

Fong KN, Yang NY, Chan MK, Chan DY, Lau AF, Chan DY, Cheung JT, Cheung HK, Chung RC, Chan CC.

Clin Rehabil. 2013 Jul;27(7):628-37. doi: 10.1177/0269215512471959. Epub 2013 Feb 12.


Development of a clinically comprehensive database and a simple procedure for identification of molds from solid media by matrix-assisted laser desorption ionization-time of flight mass spectrometry.

Lau AF, Drake SK, Calhoun LB, Henderson CM, Zelazny AM.

J Clin Microbiol. 2013 Mar;51(3):828-34. doi: 10.1128/JCM.02852-12. Epub 2012 Dec 26.


Degradation of connexins through the proteasomal, endolysosomal and phagolysosomal pathways.

Su V, Cochrane K, Lau AF.

J Membr Biol. 2012 Jul;245(7):389-400. doi: 10.1007/s00232-012-9461-3. Epub 2012 Jul 8. Review.


Ubiquitination, intracellular trafficking, and degradation of connexins.

Su V, Lau AF.

Arch Biochem Biophys. 2012 Aug 1;524(1):16-22. doi: 10.1016/ Epub 2012 Jan 3. Review.


Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability.

Dunn CA, Su V, Lau AF, Lampe PD.

J Biol Chem. 2012 Jan 20;287(4):2600-7. doi: 10.1074/jbc.M111.276261. Epub 2011 Dec 2.


Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75.

Su V, Nakagawa R, Koval M, Lau AF.

J Biol Chem. 2010 Dec 24;285(52):40979-90. doi: 10.1074/jbc.M110.170753. Epub 2010 Oct 12.


NMR structure note: UBA domain of CIP75.

Kieken F, Spagnol G, Su V, Lau AF, Sorgen PL.

J Biomol NMR. 2010 Mar;46(3):245-50. doi: 10.1007/s10858-010-9397-9. Epub 2010 Feb 3. No abstract available.


Monoclonal antibodies against the connexin43-interacting protein CIP85.

Cochrane K, Berestecky JM, Kitamura C, Lau AF.

Hybridoma (Larchmt). 2009 Oct;28(5):355-61. doi: 10.1089/hyb.2009.0033.


Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation.

Su V, Lau AF.

Cell Mol Life Sci. 2009 Sep;66(17):2819-33. doi: 10.1007/s00018-009-0048-9. Epub 2009 May 26. Review.


Generation and characterization of mouse monoclonal antibodies against CIP75, an UbL-UBA domain-containing protein.

Su V, Knutson A, Lau K, Kurata W, Berestecky J, Lau AF.

Hybridoma (Larchmt). 2009 Apr;28(2):79-84. doi: 10.1089/hyb.2008.0082.


Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3.

Park DJ, Wallick CJ, Martyn KD, Lau AF, Jin C, Warn-Cramer BJ.

Cell Commun Adhes. 2007 Sep-Oct;14(5):211-26.


A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.

Li X, Su V, Kurata WE, Jin C, Lau AF.

J Biol Chem. 2008 Feb 29;283(9):5748-59. Epub 2007 Dec 13.


Gap junction channel gating modulated through protein phosphorylation.

Moreno AP, Lau AF.

Prog Biophys Mol Biol. 2007 May-Jun;94(1-2):107-19. Epub 2007 Mar 15. Review.


v-Src tyrosine phosphorylation of connexin43: regulation of gap junction communication and effects on cell transformation.

Lin R, Martyn KD, Guyette CV, Lau AF, Warn-Cramer BJ.

Cell Commun Adhes. 2006 Jul-Aug;13(4):199-216.


Connexin43 PDZ2 binding domain mutants create functional gap junctions and exhibit altered phosphorylation.

Jin C, Martyn KD, Kurata WE, Warn-Cramer BJ, Lau AF.

Cell Commun Adhes. 2004 Mar-Aug;11(2-4):67-87.


Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation.

Lan Z, Kurata WE, Martyn KD, Jin C, Lau AF.

Biochemistry. 2005 Feb 22;44(7):2385-96.


The effects of connexin phosphorylation on gap junctional communication.

Lampe PD, Lau AF.

Int J Biochem Cell Biol. 2004 Jul;36(7):1171-86. Review.


Regulation of gap junctions by tyrosine protein kinases.

Warn-Cramer BJ, Lau AF.

Biochim Biophys Acta. 2004 Mar 23;1662(1-2):81-95. Review.


Maintaining connexin43 gap junctional communication in v-Src cells does not alter growth properties associated with the transformed phenotype.

Warn-Cramer BJ, Lin R, Martyn K, Guyette CV, Lau AF.

Cell Commun Adhes. 2003 Jul-Dec;10(4-6):299-303.


Prediction of discharge status of persons with brain injury in rehabilitation.

Lau AF, Man DW.

Int J Rehabil Res. 2003 Dec;26(4):251-5.


Mechanism of v-Src- and mitogen-activated protein kinase-induced reduction of gap junction communication.

Cottrell GT, Lin R, Warn-Cramer BJ, Lau AF, Burt JM.

Am J Physiol Cell Physiol. 2003 Feb;284(2):C511-20. Epub 2002 Oct 16.

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