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Altered exocrine function can drive adipose wasting in early pancreatic cancer.

Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, Prado CM, Petersen GM, Takahashi N, Sugimoto M, Yeh JJ, Lopez N, Bardeesy N, Fernandez-Del Castillo C, Liss AS, Koong AC, Bui J, Yuan C, Welch MW, Brais LK, Kulke MH, Dennis C, Clish CB, Wolpin BM, Vander Heiden MG.

Nature. 2018 Jun 20. doi: 10.1038/s41586-018-0235-7. [Epub ahead of print]


A phase 2 study of ofatumumab (Arzerra®) in combination with a pan-AKT inhibitor (afuresertib) in previously treated patients with chronic lymphocytic leukemia (CLL).

Chen CI, Paul H, Le LW, Wei EN, Snitzler S, Wang T, Levina O, Kakar S, Lau A, Queau M, Johnston JB, Smith DA, Trudel S.

Leuk Lymphoma. 2018 Jun 19:1-9. doi: 10.1080/10428194.2018.1468892. [Epub ahead of print]


Probing the flexibility of an iterative modular polyketide synthase with non-native substrates in vitro.

Curran SC, Hagen A, Poust S, Chan LJG, Garabedian BM, de Rond T, Baluyot MJ, Vu JT, Lau AK, Yuzawa S, Petzold CJ, Katz L, Keasling JD.

ACS Chem Biol. 2018 Jun 18. doi: 10.1021/acschembio.8b00422. [Epub ahead of print]


Shorter sleep duration is associated with reduced cognitive development at two years of age.

Smithson L, Baird T, Tamana SK, Lau A, Mariasine J, Chikuma J, Lefebvre DL, Subbarao P, Becker AB, Turvey SE, Sears MR; CHILD Study Investigators, Beal DS, Pei J, Mandhane PJ.

Sleep Med. 2018 Apr 30;48:131-139. doi: 10.1016/j.sleep.2018.04.005. [Epub ahead of print]


The ATR inhibitor AZD6738 synergizes with gemcitabine in vitro and in vivo to induce pancreatic ductal adenocarcinoma regression.

Wallez Y, Dunlop CR, Johnson TI, Koh SB, Fornari C, Yates JW, Bernaldo de Quirós Fernández S, Lau A, Richards FM, Jodrell DI.

Mol Cancer Ther. 2018 Jun 11. pii: molcanther.0010.2018. doi: 10.1158/1535-7163.MCT-18-0010. [Epub ahead of print]


The roles of scientific research and stakeholder engagement for evidence-based policy formulation on shipping emissions control in Hong Kong.

Zhang Y, Loh C, Louie PKK, Liu H, Lau AKH.

J Environ Manage. 2018 Jun 8;223:49-56. doi: 10.1016/j.jenvman.2018.06.008. [Epub ahead of print]


Glutamate and Glycine Binding to the NMDA Receptor.

Yu A, Lau AY.

Structure. 2018 May 23. pii: S0969-2126(18)30168-0. doi: 10.1016/j.str.2018.05.004. [Epub ahead of print]


Binding-Induced Molecular Amplifier as a Universal Detection Platform for Biomolecules and Biomolecular Interaction.

Li F, Lin Y, Lau A, Tang Y, Chen J, Le XC.

Anal Chem. 2018 Jun 21. doi: 10.1021/acs.analchem.8b01985. [Epub ahead of print]


Effect of preoperative warming on intraoperative hypothermia: a randomized-controlled trial.

Lau A, Lowlaavar N, Cooke EM, West N, German A, Morse DJ, Görges M, Merchant RN.

Can J Anaesth. 2018 Jun 5. doi: 10.1007/s12630-018-1161-8. [Epub ahead of print]


Phenotypes of sleep-disordered breathing symptoms to two years of age based on age of onset and duration of symptoms.

Kamal M, Tamana SK, Smithson L, Ding L, Lau A, Chikuma J, Mariasine J, Lefebvre DL, Subbarao P, Becker AB, Turvey SE, Sears MR; Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators, Pei J, Mandhane PJ.

Sleep Med. 2018 May 3;48:93-100. doi: 10.1016/j.sleep.2018.04.008. [Epub ahead of print]


Preventing chronic disease in patients with low health literacy using eHealth and teamwork in primary healthcare: protocol for a cluster randomised controlled trial.

Parker SM, Stocks N, Nutbeam D, Thomas L, Denney-Wilson E, Zwar N, Karnon J, Lloyd J, Noakes M, Liaw ST, Lau A, Osborne R, Harris MF.

BMJ Open. 2018 Jun 4;8(6):e023239. doi: 10.1136/bmjopen-2018-023239.


Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.

Lau A, Chung H, Komada T, Platnich JM, Sandall CF, Choudhury SR, Chun J, Naumenko V, Surewaard BG, Nelson MC, Ulke-Lemée A, Beck PL, Benediktsson H, Jevnikar AM, Snelgrove SL, Hickey MJ, Senger DL, James MT, Macdonald JA, Kubes P, Jenne CN, Muruve DA.

J Clin Invest. 2018 Jun 4. pii: 96640. doi: 10.1172/JCI96640. [Epub ahead of print]


BRCA1 Mutation Status and Follicular Fluid Exposure Alters NFκB Signaling and ISGylation in Human Fallopian Tube Epithelial Cells.

Hollingsworth J, Lau A, Tone A, Kollara A, Allen L, Colgan TJ, Dube V, Rosen B, Murphy KJ, Greenblatt EM, Feigenberg T, Virtanen C, Brown TJ.

Neoplasia. 2018 May 28;20(7):697-709. doi: 10.1016/j.neo.2018.05.005. [Epub ahead of print]


Safety and Efficacy of Vesatolimod (GS-9620) in Patients with Chronic Hepatitis B Who Are Not Currently on Antiviral Treatment.

Agarwal K, Ahn SH, Elkhashab M, Lau AH, Gaggar A, Bulusu A, Tian X, Cathcart AL, Woo J, Subramanian GM, Andreone P, Kim HJ, Chuang WL, Nguyen MH.

J Viral Hepat. 2018 May 31. doi: 10.1111/jvh.12942. [Epub ahead of print]


Qualitative, multimethod study of behavioural and attitudinal responses to cochlear implantation from the patient and healthcare professional perspective in Australia and the UK: study protocol.

Rapport F, Bierbaum M, McMahon C, Boisvert I, Lau A, Braithwaite J, Hughes S.

BMJ Open. 2018 May 29;8(5):e019623. doi: 10.1136/bmjopen-2017-019623.


Gender and Sexual Orientation Differences in Human Papillomavirus (HPV) Vaccine Uptake among Chinese Young Adults.

Choi EPH, Wong JYH, Lau AYY, Fong DYT.

Int J Environ Res Public Health. 2018 May 28;15(6). pii: E1099. doi: 10.3390/ijerph15061099.


Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.

Franich NR, Basso M, André EA, Ochaba J, Kumar A, Thein S, Fote G, Kachemov M, Lau AL, Yeung SY, Osmand A, Zeitlin SO, Ratan RR, Thompson LM, Steffan JS.

J Huntingtons Dis. 2018;7(2):137-150. doi: 10.3233/JHD-170274.


Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity.

Edwards ESJ, Bier J, Cole TS, Wong M, Hsu P, Berglund LJ, Boztug K, Lau A, Gostick E, Price DA, O'Sullivan M, Meyts I, Choo S, Gray P, Holland SM, Deenick EK, Uzel G, Tangye SG.

J Allergy Clin Immunol. 2018 May 22. pii: S0091-6749(18)30702-4. doi: 10.1016/j.jaci.2018.04.030. [Epub ahead of print]


Validity and reliability of two alternate versions of the Montreal Cognitive Assessment (Hong Kong version) for screening of Mild Neurocognitive Disorder.

Wong A, Yiu S, Nasreddine Z, Leung KT, Lau A, Soo YOY, Wong LK, Mok V.

PLoS One. 2018 May 23;13(5):e0196344. doi: 10.1371/journal.pone.0196344. eCollection 2018.


The effects of an expanded cognitive stimulation therapy model on the improvement of cognitive ability of elderly with mild stage Dementia living in a community - a randomized waitlist controlled trial.

Young DK, Ng PY, Kwok T, Ho F, Cheng D, Mak V, Lau A.

Aging Ment Health. 2018 May 21:1-8. doi: 10.1080/13607863.2018.1471586. [Epub ahead of print]


Ethnicity moderates the benefits of perceived support and emotional expressivity on stress reactivity for Asian Americans and Euro Americans.

Wang SW, Lau AS.

Cultur Divers Ethnic Minor Psychol. 2018 May 21. doi: 10.1037/cdp0000197. [Epub ahead of print]


Orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice.

Karlin J, Allen J, Ahmad SF, Hughes G, Sheridan V, Odedra R, Farrington P, Cadogan EB, Riches LC, Garcia-Trinidad A, Thomason AG, Patel B, Vincent J, Lau A, Pike KG, Hunt TA, Sule A, Valerie NCK, Biddlestone-Thorpe L, Kahn J, Beckta JM, Mukhopadhyay N, Barlaam B, Degorce SL, Kettle J, Colclough N, Wilson J, Smith A, Barrett IP, Zheng L, Zhang T, Wang Y, Chen K, Pass M, Durant ST, Valerie K.

Mol Cancer Ther. 2018 May 16. pii: molcanther.0975.2017. doi: 10.1158/1535-7163.MCT-17-0975. [Epub ahead of print]


Concentrations, fluxes and field calibration of passive water samplers for pesticides and hazard-based risk assessment.

Ahrens L, Daneshvar A, Lau AE, Kreuger J.

Sci Total Environ. 2018 Oct 1;637-638:835-843. doi: 10.1016/j.scitotenv.2018.05.039. Epub 2018 May 12.


96 weeks treatment of tenofovir alafenamide vs. tenofovir disoproxil fumarate for hepatitis B virus infection.

Agarwal K, Brunetto M, Seto WK, Lim YS, Fung S, Marcellin P, Ahn SH, Izumi N, Chuang WL, Bae H, Sharma M, Janssen HLA, Pan CQ, Çelen MK, Furusyo N, Shalimar D, Yoon KT, Trinh H, Flaherty JF, Gaggar A, Lau AH, Cathcart AL, Lin L, Bhardwaj N, Suri V, Mani Subramanian G, Gane EJ, Buti M, Chan HLY; GS-US-320-0110; GS-US-320-0108 Investigators.

J Hepatol. 2018 Apr;68(4):672-681. doi: 10.1016/j.jhep.2017.11.039. Epub 2018 Jan 17.


Long-term exposure to ambient particulate matter (PM2.5) is associated with platelet counts in adults.

Zhang Z, Chan TC, Guo C, Chang LY, Lin C, Chuang YC, Jiang WK, Ho KF, Tam T, Woo KS, Lau AKH, Lao XQ.

Environ Pollut. 2018 May 9;240:432-439. doi: 10.1016/j.envpol.2018.04.123. [Epub ahead of print]


Towards the elimination of paediatric tuberculosis in high-income, immigrant-receiving countries: a 25-year conventional and molecular epidemiological case study.

Dhawan V, Bown J, Lau A, Langlois-Klassen D, Kunimoto D, Bhargava R, Chui L, Collin SM, Long R.

ERJ Open Res. 2018 May 8;4(2). pii: 00131-2017. doi: 10.1183/23120541.00131-2017. eCollection 2018 Apr.


Similar radiological results with accelerometer-based navigation versus conventional technique in total knee arthroplasty.

Moo IH, Chen JYQ, Chau DHH, Tan SW, Lau ACK, Teo YS.

J Orthop Surg (Hong Kong). 2018 May-Aug;26(2):2309499018772374. doi: 10.1177/2309499018772374.


Discriminating Strains of Self-Propagating Protein Aggregates Using a Conformational Stability Assay.

Lau HHC, Lau A, Watts JC.

Methods Mol Biol. 2018;1777:339-354. doi: 10.1007/978-1-4939-7811-3_22.


Self-Assembled N-Heterocyclic Carbene-Based Carboxymethylated Dextran Monolayers on Gold as a Tunable Platform for Designing Affinity-Capture Biosensor Surfaces.

Li Z, Munro K, Narouz MR, Lau A, Hao H, Crudden CM, Horton JH.

ACS Appl Mater Interfaces. 2018 May 30;10(21):17560-17570. doi: 10.1021/acsami.8b02595. Epub 2018 May 15.


Sorption, mobility, and bioavailability of PBDEs in the agricultural soils: Roles of co-existing metals, dissolved organic matter, and fertilizers.

Zhu X, Beiyuan J, Lau AYT, Chen SS, Tsang DCW, Graham NJD, Lin D, Sun J, Pan Y, Yang X, Li XD.

Sci Total Environ. 2018 Apr 1;619-620:1153-1162. doi: 10.1016/j.scitotenv.2017.11.159. Epub 2017 Nov 29.


Applications of low-cost sensing technologies for air quality monitoring and exposure assessment: How far have they gone?

Morawska L, Thai PK, Liu X, Asumadu-Sakyi A, Ayoko G, Bartonova A, Bedini A, Chai F, Christensen B, Dunbabin M, Gao J, Hagler GSW, Jayaratne R, Kumar P, Lau AKH, Louie PKK, Mazaheri M, Ning Z, Motta N, Mullins B, Rahman MM, Ristovski Z, Shafiei M, Tjondronegoro D, Westerdahl D, Williams R.

Environ Int. 2018 Jul;116:286-299. doi: 10.1016/j.envint.2018.04.018. Epub 2018 Apr 26. Review.


Sinew acupuncture for knee osteoarthritis: study protocol for a randomized sham-controlled trial.

Au KY, Chen H, Lam WC, Chong CO, Lau A, Vardhanabhuti V, Mak KC, Jiang F, Lam WY, Wu FM, Chan HN, Ng YW, Ng BF, Ziea ET, Lao L.

BMC Complement Altern Med. 2018 Apr 23;18(1):133. doi: 10.1186/s12906-018-2195-8.


Structural Lipids Enable the Formation of Functional Oligomers of the Eukaryotic Purine Symporter UapA.

Pyle E, Kalli AC, Amillis S, Hall Z, Lau AM, Hanyaloglu AC, Diallinas G, Byrne B, Politis A.

Cell Chem Biol. 2018 Apr 10. pii: S2451-9456(18)30113-2. doi: 10.1016/j.chembiol.2018.03.011. [Epub ahead of print]


Low Incidence of Esophageal Toxicity After Lung Stereotactic Body Radiation Therapy: Are Current Esophageal Dose Constraints Too Conservative?

Yau V, Lindsay P, Le L, Lau A, Wong O, Glick D, Bezjak A, Cho BCJ, Hope A, Sun A, Giuliani M.

Int J Radiat Oncol Biol Phys. 2018 Jul 1;101(3):574-580. doi: 10.1016/j.ijrobp.2018.02.025. Epub 2018 Mar 2.


Mapping the contribution and strategic distribution patterns of neuroimaging features of small vessel disease in poststroke cognitive impairment.

Shi L, Zhao L, Yeung FK, Wong SY, Chan RKT, Tse MF, Chan SC, Kwong YC, Li KC, Liu K, Abrigo JM, Lau AYL, Wong A, Lam BYK, Leung TWH, Fu J, Chu WCW, Mok VCT.

J Neurol Neurosurg Psychiatry. 2018 Apr 17. pii: jnnp-2017-317817. doi: 10.1136/jnnp-2017-317817. [Epub ahead of print]


Enhanced sampling of glutamate receptor ligand-binding domains.

Lau AY.

Neurosci Lett. 2018 Apr 14. pii: S0304-3940(18)30281-7. doi: 10.1016/j.neulet.2018.04.018. [Epub ahead of print] Review.


A Randomized Trial Evaluating School-Based Mindfulness Intervention for Ethnic Minority Youth: Exploring Mediators and Moderators of Intervention Effects.

Fung J, Kim JJ, Jin J, Chen G, Bear L, Lau AS.

J Abnorm Child Psychol. 2018 Apr 13. doi: 10.1007/s10802-018-0425-7. [Epub ahead of print]


Hyperpolarized ketone body metabolism in the rat heart.

Miller JJ, Ball DR, Lau AZ, Tyler DJ.

NMR Biomed. 2018 Jun;31(6):e3912. doi: 10.1002/nbm.3912. Epub 2018 Apr 10.


BRD4 facilitates replication stress-induced DNA damage response.

Zhang J, Dulak AM, Hattersley MM, Willis BS, Nikkilä J, Wang A, Lau A, Reimer C, Zinda M, Fawell SE, Mills GB, Chen H.

Oncogene. 2018 Apr 11. doi: 10.1038/s41388-018-0194-3. [Epub ahead of print]


Effect of long-term exposure to fine particulate matter on lung function decline and risk of chronic obstructive pulmonary disease in Taiwan: a longitudinal, cohort study.

Guo C, Zhang Z, Lau AKH, Lin CQ, Chuang YC, Chan J, Jiang WK, Tam T, Yeoh EK, Chan TC, Chang LY, Lao XQ.

Lancet Planet Health. 2018 Mar;2(3):e114-e125. doi: 10.1016/S2542-5196(18)30028-7. Epub 2018 Mar 2.


The Impact of Sex on Alloimmunity.

Lau A, West L, Tullius SG.

Trends Immunol. 2018 May;39(5):407-418. doi: 10.1016/ Epub 2018 Mar 22. Review.


Evaluation of three rapid oral fluid test devices on the screening of multiple drugs of abuse including ketamine.

Tang MHY, Ching CK, Poon S, Chan SSS, Ng WY, Lam M, Wong CK, Pao R, Lau A, Mak TWL.

Forensic Sci Int. 2018 May;286:113-120. doi: 10.1016/j.forsciint.2018.03.004. Epub 2018 Mar 12.


Targeting of embryonic annexin A2 expressed on ovarian and breast cancer by the novel monoclonal antibody 2448.

Cua S, Tan HL, Fong WJ, Chin A, Lau A, Ding V, Song Z, Yang Y, Choo A.

Oncotarget. 2018 Jan 10;9(17):13206-13221. doi: 10.18632/oncotarget.24152. eCollection 2018 Mar 2.


Tobacco Smoking and Antisocial Deviance among Vietnamese, Vietnamese-American, and European-American Adolescents.

Weiss B, Nguyen T, Trung L, Ngo V, Lau A.

J Abnorm Child Psychol. 2018 Mar 21. doi: 10.1007/s10802-018-0416-8. [Epub ahead of print]


Proteomic profiling of barley spent grains guides enzymatic solubilization of the remaining proteins.

Bi X, Ye L, Lau A, Kok YJ, Zheng L, Ng D, Tan K, Ow D, Ananta E, Vafiadi C, Muller J.

Appl Microbiol Biotechnol. 2018 May;102(9):4159-4170. doi: 10.1007/s00253-018-8886-8. Epub 2018 Mar 17.


CC16 levels correlate with cigarette smoke exposure in bronchial epithelial cells and with lung function decline in smokers.

Lam DC, Kwok HH, Yu WC, Ko FW, Tam CY, Lau AC, Fong DY, Ip MS.

BMC Pulm Med. 2018 Mar 16;18(1):47. doi: 10.1186/s12890-018-0607-7.


Using Survival Analysis to Understand Patterns of Sustainment within a System-Driven Implementation of Multiple Evidence-Based Practices for Children's Mental Health Services.

Brookman-Frazee L, Zhan C, Stadnick N, Sommerfeld D, Roesch S, Aarons GA, Innes-Gomberg D, Bando L, Lau AS.

Front Public Health. 2018 Mar 1;6:54. doi: 10.3389/fpubh.2018.00054. eCollection 2018.


Mixed-method analysis of program leader perspectives on the sustainment of multiple child evidence-based practices in a system-driven implementation.

Rodriguez A, Lau AS, Wright B, Regan J, Brookman-Frazee L.

Implement Sci. 2018 Mar 13;13(1):44. doi: 10.1186/s13012-018-0737-6.


Spherical Body Protein 2 truncated copy 11 as a specific Babesia bovis attenuation marker.

Gallego-Lopez GM, Lau AOT, Brown WC, Johnson WC, Ueti MW, Suarez CE.

Parasit Vectors. 2018 Mar 12;11(1):169. doi: 10.1186/s13071-018-2782-z. No abstract available.


MPS-IIIA mice acquire autistic behaviours with age.

Lau AA, Tamang SJ, Hemsley KM.

J Inherit Metab Dis. 2018 Mar 8. doi: 10.1007/s10545-018-0160-9. [Epub ahead of print]


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