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Items: 1 to 50 of 225

1.

Blocking inflammasome activation caused by β-amyloid peptide (Aβ) and islet amyloid polypeptide (IAPP) through an IAPP mimic.

Aftabizadeh M, Tatarek-Nossol M, Andreetto E, El Bounkari O, Kipp M, Beyer C, Latz E, Bernhagen J, Kapurniotu A.

ACS Chem Neurosci. 2019 Jul 11. doi: 10.1021/acschemneuro.9b00260. [Epub ahead of print]

PMID:
31295403
2.

NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells.

Li T, Zehner M, He J, Próchnicki T, Horvath G, Latz E, Burgdorf S, Takeoka S.

Int J Nanomedicine. 2019 May 13;14:3503-3516. doi: 10.2147/IJN.S202379. eCollection 2019.

3.

Predator traits determine food-web architecture across ecosystems.

Brose U, Archambault P, Barnes AD, Bersier LF, Boy T, Canning-Clode J, Conti E, Dias M, Digel C, Dissanayake A, Flores AAV, Fussmann K, Gauzens B, Gray C, Häussler J, Hirt MR, Jacob U, Jochum M, Kéfi S, McLaughlin O, MacPherson MM, Latz E, Layer-Dobra K, Legagneux P, Li Y, Madeira C, Martinez ND, Mendonça V, Mulder C, Navarrete SA, O'Gorman EJ, Ott D, Paula J, Perkins D, Piechnik D, Pokrovsky I, Raffaelli D, Rall BC, Rosenbaum B, Ryser R, Silva A, Sohlström EH, Sokolova N, Thompson MSA, Thompson RM, Vermandele F, Vinagre C, Wang S, Wefer JM, Williams RJ, Wieters E, Woodward G, Iles AC.

Nat Ecol Evol. 2019 Jun;3(6):919-927. doi: 10.1038/s41559-019-0899-x. Epub 2019 May 20.

PMID:
31110252
4.

Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency.

He J, Li T, Próchnicki T, Horvath G, Latz E, Takeoka S.

Biochem Biophys Rep. 2019 Apr 12;18:100623. doi: 10.1016/j.bbrep.2019.100623. eCollection 2019 Jul.

5.

The Western lifestyle has lasting effects on metaflammation.

Christ A, Latz E.

Nat Rev Immunol. 2019 May;19(5):267-268. doi: 10.1038/s41577-019-0156-1. No abstract available.

PMID:
30911129
6.

Targeting hormone refractory prostate cancer by in vivo selected DNA libraries in an orthotopic xenograft mouse model.

Civit L, Theodorou I, Frey F, Weber H, Lingnau A, Gröber C, Blank M, Dambrune C, Stunden J, Beyer M, Schultze J, Latz E, Ducongé F, Kubbutat MHG, Mayer G.

Sci Rep. 2019 Mar 21;9(1):4976. doi: 10.1038/s41598-019-41460-2.

7.

Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis.

Alvarez-Silva C, Schierwagen R, Pohlmann A, Magdaleno F, Uschner FE, Ryan P, Vehreschild MJGT, Claria J, Latz E, Lelouvier B, Arumugam M, Trebicka J.

Front Immunol. 2019 Feb 8;10:69. doi: 10.3389/fimmu.2019.00069. eCollection 2019.

8.

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease.

Heneka MT, McManus RM, Latz E.

Nat Rev Neurosci. 2019 Mar;20(3):187. doi: 10.1038/s41583-019-0137-1.

PMID:
30742056
9.

Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells.

Wang L, Schmidt S, Larsen PP, Meyer JH, Roush WR, Latz E, Holz FG, Krohne TU.

J Mol Med (Berl). 2019 Apr;97(4):523-532. doi: 10.1007/s00109-019-01753-5. Epub 2019 Feb 10.

PMID:
30739141
10.

DNA-Mediated Interferon Signature Induction by SLE Serum Occurs in Monocytes Through Two Pathways: A Mechanism to Inhibit Both Pathways.

Porat A, Giat E, Kowal C, He M, Son M, Latz E, Ben-Zvi I, Al-Abed Y, Diamond B.

Front Immunol. 2018 Dec 11;9:2824. doi: 10.3389/fimmu.2018.02824. eCollection 2018.

11.

Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1β Inflammation in Human Macrophages.

Rodríguez-Alcázar JF, Ataide MA, Engels G, Schmitt-Mabmunyo C, Garbi N, Kastenmüller W, Latz E, Franklin BS.

J Immunol. 2019 Jan 15;202(2):550-558. doi: 10.4049/jimmunol.1800107. Epub 2018 Dec 17.

PMID:
30559319
12.

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.

Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, Diep H, Kett MM, Samuel CS, Kemp-Harper BK, Robertson AAB, Cooper MA, Peter K, Latz E, Mansell AS, Sobey CG, Drummond GR, Vinh A.

Cardiovasc Res. 2019 Mar 15;115(4):776-787. doi: 10.1093/cvr/cvy252.

13.

NLRP3 inflammasome activation in inflammaging.

Latz E, Duewell P.

Semin Immunol. 2018 Dec;40:61-73. doi: 10.1016/j.smim.2018.09.001. Epub 2018 Sep 26. Review.

PMID:
30268598
14.

Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity.

Köppert S, Büscher A, Babler A, Ghallab A, Buhl EM, Latz E, Hengstler JG, Smith ER, Jahnen-Dechent W.

Front Immunol. 2018 Sep 4;9:1991. doi: 10.3389/fimmu.2018.01991. eCollection 2018.

15.

Inflammasome signalling in brain function and neurodegenerative disease.

Heneka MT, McManus RM, Latz E.

Nat Rev Neurosci. 2018 Oct;19(10):610-621. doi: 10.1038/s41583-018-0055-7. Review. Erratum in: Nat Rev Neurosci. 2019 Mar;20(3):187.

PMID:
30206330
16.

Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.

Tzeng TC, Hasegawa Y, Iguchi R, Cheung A, Caffrey DR, Thatcher EJ, Mao W, Germain G, Tamburro ND, Okabe S, Heneka MT, Latz E, Futai K, Golenbock DT.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):9002-9007. doi: 10.1073/pnas.1801802115. Epub 2018 Aug 20.

17.

Targeting the NLRP3 inflammasome in inflammatory diseases.

Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E.

Nat Rev Drug Discov. 2018 Sep;17(9):688. doi: 10.1038/nrd.2018.149. Epub 2018 Aug 17.

PMID:
30116046
18.

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling.

De Nardo D, Balka KR, Cardona Gloria Y, Rao VR, Latz E, Masters SL.

J Biol Chem. 2018 Sep 28;293(39):15195-15207. doi: 10.1074/jbc.RA118.003314. Epub 2018 Aug 3.

19.

ASC specks: a biomarker for myelodysplastic syndromes?

Wolf D, Latz E.

Lancet Haematol. 2018 Sep;5(9):e379-e380. doi: 10.1016/S2352-3026(18)30113-3. Epub 2018 Jul 30. No abstract available.

PMID:
30072145
20.

Targeting the NLRP3 inflammasome in inflammatory diseases.

Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E.

Nat Rev Drug Discov. 2018 Aug;17(8):588-606. doi: 10.1038/nrd.2018.97. Epub 2018 Jul 20. Review. Erratum in: Nat Rev Drug Discov. 2018 Sep;17(9):688.

PMID:
30026524
21.

PD-L1 is expressed on human platelets and is affected by immune checkpoint therapy.

Rolfes V, Idel C, Pries R, Plötze-Martin K, Habermann J, Gemoll T, Bohnet S, Latz E, Ribbat-Idel J, Franklin BS, Wollenberg B.

Oncotarget. 2018 Jun 8;9(44):27460-27470. doi: 10.18632/oncotarget.25446. eCollection 2018 Jun 8.

22.

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis.

Grebe A, Hoss F, Latz E.

Circ Res. 2018 Jun 8;122(12):1722-1740. doi: 10.1161/CIRCRESAHA.118.311362. Review.

PMID:
29880500
23.

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.

Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E.

Immunity. 2018 May 15;48(5):911-922.e7. doi: 10.1016/j.immuni.2018.04.011.

24.

Immortalization of Murine Bone Marrow-Derived Macrophages.

De Nardo D, Kalvakolanu DV, Latz E.

Methods Mol Biol. 2018;1784:35-49. doi: 10.1007/978-1-4939-7837-3_4.

PMID:
29761386
25.

Circulating microbiome in blood of different circulatory compartments.

Schierwagen R, Alvarez-Silva C, Madsen MSA, Kolbe CC, Meyer C, Thomas D, Uschner FE, Magdaleno F, Jansen C, Pohlmann A, Praktiknjo M, Hischebeth GT, Molitor E, Latz E, Lelouvier B, Trebicka J, Arumugam M.

Gut. 2018 Mar 26. pii: gutjnl-2018-316227. doi: 10.1136/gutjnl-2018-316227. [Epub ahead of print] No abstract available.

PMID:
29581241
26.

Inhibitory effects of colchicine on inflammasomes.

Hoss F, Latz E.

Atherosclerosis. 2018 Jun;273:153-154. doi: 10.1016/j.atherosclerosis.2018.02.026. Epub 2018 Mar 2. No abstract available.

PMID:
29526464
27.

TAK1ng control: TAK1 restrains NLRP3 activation.

Mangan MS, Latz E.

J Exp Med. 2018 Apr 2;215(4):1007-1008. doi: 10.1084/jem.20180282. Epub 2018 Mar 5.

28.

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E.

Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013.

29.

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease.

Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT.

Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158.

PMID:
29293211
30.

Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.

Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, Günther P, Xue J, Baßler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, Händler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL.

Immunity. 2017 Dec 19;47(6):1051-1066.e12. doi: 10.1016/j.immuni.2017.11.024.

31.

The intra- and extracellular functions of ASC specks.

Franklin BS, Latz E, Schmidt FI.

Immunol Rev. 2018 Jan;281(1):74-87. doi: 10.1111/imr.12611. Review.

PMID:
29247990
32.

Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes.

Steinhagen F, Zillinger T, Peukert K, Fox M, Thudium M, Barchet W, Putensen C, Klinman D, Latz E, Bode C.

Eur J Immunol. 2018 Apr;48(4):605-611. doi: 10.1002/eji.201747338. Epub 2017 Dec 27.

33.

Generation of Innate Immune Reporter Cells Using Retroviral Transduction.

Cardona Gloria Y, Latz E, De Nardo D.

Methods Mol Biol. 2018;1714:97-117. doi: 10.1007/978-1-4939-7519-8_7.

PMID:
29177858
34.

Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells.

Ziauddin SM, Yoshimura A, Montenegro Raudales JL, Ozaki Y, Higuchi K, Ukai T, Kaneko T, Miyazaki T, Latz E, Hara Y.

J Periodontal Res. 2018 Jun;53(3):353-361. doi: 10.1111/jre.12520. Epub 2017 Nov 20.

PMID:
29159877
35.

Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients.

Ahmad F, Mishra N, Ahrenstorf G, Franklin BS, Latz E, Schmidt RE, Bossaller L.

AIDS. 2018 Jan 28;32(3):299-307. doi: 10.1097/QAD.0000000000001693.

PMID:
29135573
36.

Lysine-containing cationic liposomes activate the NLRP3 inflammasome: Effect of a spacer between the head group and the hydrophobic moieties of the lipids.

Li T, He J, Horvath G, Próchnicki T, Latz E, Takeoka S.

Nanomedicine. 2018 Feb;14(2):279-288. doi: 10.1016/j.nano.2017.10.011. Epub 2017 Nov 8.

PMID:
29127038
37.

Innate Immunity and Neurodegeneration.

Labzin LI, Heneka MT, Latz E.

Annu Rev Med. 2018 Jan 29;69:437-449. doi: 10.1146/annurev-med-050715-104343. Epub 2017 Nov 6.

PMID:
29106805
38.

RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo.

Fülle L, Steiner N, Funke M, Gondorf F, Pfeiffer F, Siegl J, Opitz FV, Haßel SK, Erazo AB, Schanz O, Stunden HJ, Blank M, Gröber C, Händler K, Beyer M, Weighardt H, Latz E, Schultze JL, Mayer G, Förster I.

Mol Ther. 2018 Jan 3;26(1):95-104. doi: 10.1016/j.ymthe.2017.10.005. Epub 2017 Oct 13.

39.

Increase in liver stiffness after transjugular intrahepatic portosystemic shunt is associated with inflammation and predicts mortality.

Jansen C, Möller P, Meyer C, Kolbe CC, Bogs C, Pohlmann A, Schierwagen R, Praktiknjo M, Abdullah Z, Lehmann J, Thomas D, Strassburg CP, Latz E, Mueller S, Rössle M, Trebicka J.

Hepatology. 2018 Apr;67(4):1472-1484. doi: 10.1002/hep.29612. Epub 2018 Feb 20.

PMID:
29059466
40.

Systematic evaluation of cell-SELEX enriched aptamers binding to breast cancer cells.

Civit L, Taghdisi SM, Jonczyk A, Haßel SK, Gröber C, Blank M, Stunden HJ, Beyer M, Schultze J, Latz E, Mayer G.

Biochimie. 2018 Feb;145:53-62. doi: 10.1016/j.biochi.2017.10.007. Epub 2017 Oct 18.

PMID:
29054799
41.

CD14-New Tricks of an Old Acquaintance.

Schmidt FI, Latz E.

Immunity. 2017 Oct 17;47(4):606-608. doi: 10.1016/j.immuni.2017.10.003.

42.

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

Gaidt MM, Ebert TS, Chauhan D, Ramshorn K, Pinci F, Zuber S, O'Duill F, Schmid-Burgk JL, Hoss F, Buhmann R, Wittmann G, Latz E, Subklewe M, Hornung V.

Cell. 2017 Nov 16;171(5):1110-1124.e18. doi: 10.1016/j.cell.2017.09.039. Epub 2017 Oct 12.

43.

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH.

Cell Metab. 2017 Oct 3;26(4):620-632.e6. doi: 10.1016/j.cmet.2017.08.023. Epub 2017 Sep 21.

44.

Activation of the NLRP3 inflammasome in microglia: the role of ceramide.

Scheiblich H, Schlütter A, Golenbock DT, Latz E, Martinez-Martinez P, Heneka MT.

J Neurochem. 2017 Dec;143(5):534-550. doi: 10.1111/jnc.14225. Epub 2017 Oct 26.

45.

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K.

PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843. eCollection 2017.

46.

Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.

Bakke SS, Aune MH, Niyonzima N, Pilely K, Ryan L, Skjelland M, Garred P, Aukrust P, Halvorsen B, Latz E, Damås JK, Mollnes TE, Espevik T.

J Immunol. 2017 Oct 15;199(8):2910-2920. doi: 10.4049/jimmunol.1700302. Epub 2017 Aug 30.

47.

A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

48.

Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control.

Próchnicki T, Latz E.

Cell Metab. 2017 Jul 5;26(1):71-93. doi: 10.1016/j.cmet.2017.06.018. Review.

49.

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain.

Stutz A, Kolbe CC, Stahl R, Horvath GL, Franklin BS, van Ray O, Brinkschulte R, Geyer M, Meissner F, Latz E.

J Exp Med. 2017 Jun 5;214(6):1725-1736. doi: 10.1084/jem.20160933. Epub 2017 May 2.

50.

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.

Choo MK, Sano Y, Kim C, Yasuda K, Li XD, Lin X, Stenzel-Poore M, Alexopoulou L, Ghosh S, Latz E, Rifkin IR, Chen ZJ, Stewart GC, Chong H, Park JM.

J Exp Med. 2017 May 1;214(5):1297-1311. doi: 10.1084/jem.20161141. Epub 2017 Apr 11.

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