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The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration.

Lu W, Gómez NM, Lim JC, Guha S, O'Brien-Jenkins A, Coffey EE, Campagno KE, McCaughey SA, Laties AM, Carlsson LG, Mitchell CH.

Front Pharmacol. 2018 Apr 19;9:242. doi: 10.3389/fphar.2018.00242. eCollection 2018.


The P2X7 receptor links mechanical strain to cytokine IL-6 up-regulation and release in neurons and astrocytes.

Lu W, Albalawi F, Beckel JM, Lim JC, Laties AM, Mitchell CH.

J Neurochem. 2017 May;141(3):436-448. doi: 10.1111/jnc.13998.


Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye.

Lu W, Hu H, Sévigny J, Gabelt BT, Kaufman PL, Johnson EC, Morrison JC, Zode GS, Sheffield VC, Zhang X, Laties AM, Mitchell CH.

Invest Ophthalmol Vis Sci. 2015 May;56(5):3075-83. doi: 10.1167/iovs.14-15891.


Acute nonarteritic anterior ischemic optic neuropathy and exposure to phosphodiesterase type 5 inhibitors.

Campbell UB, Walker AM, Gaffney M, Petronis KR, Creanga D, Quinn S, Klein BE, Laties AM, Lewis M, Sharlip ID, Kolitsopoulos F, Klee BJ, Mo J, Reynolds RF.

J Sex Med. 2015 Jan;12(1):139-51. doi: 10.1111/jsm.12726. Epub 2014 Oct 31.


Cataractogenic potential of quetiapine versus risperidone in the long-term treatment of patients with schizophrenia or schizoaffective disorder: a randomized, open-label, ophthalmologist-masked, flexible-dose, non-inferiority trial.

Laties AM, Flach AJ, Baldycheva I, Rak I, Earley W, Pathak S.

J Psychopharmacol. 2015 Jan;29(1):69-79. doi: 10.1177/0269881114553253. Epub 2014 Oct 14.


Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations.

Guha S, Coffey EE, Lu W, Lim JC, Beckel JM, Laties AM, Boesze-Battaglia K, Mitchell CH.

Exp Eye Res. 2014 Sep;126:68-76. doi: 10.1016/j.exer.2014.05.013. Review.


Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain.

Beckel JM, Argall AJ, Lim JC, Xia J, Lu W, Coffey EE, Macarak EJ, Shahidullah M, Delamere NA, Zode GS, Sheffield VC, Shestopalov VI, Laties AM, Mitchell CH.

Glia. 2014 Sep;62(9):1486-501. doi: 10.1002/glia.22695. Epub 2014 May 19.


Four Measures of Intraocular Pressure Fluctuation: Which Correlates Most Optimally With Actual Office-hour Readings?

Huang R, Ge J, Chen G, Gao X, Laties AM, Zhang X.

J Glaucoma. 2015 Sep;24(7):550-5. doi: 10.1097/IJG.0000000000000059.


Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells.

Guha S, Liu J, Baltazar G, Laties AM, Mitchell CH.

Adv Exp Med Biol. 2014;801:105-11. doi: 10.1007/978-1-4614-3209-8_14. Review.


Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP.

Coffey EE, Beckel JM, Laties AM, Mitchell CH.

Neuroscience. 2014 Mar 28;263:111-24. doi: 10.1016/j.neuroscience.2014.01.001. Epub 2014 Jan 10.


Collagen: a potential factor involved in the pathogenesis of glaucoma.

Huang W, Fan Q, Wang W, Zhou M, Laties AM, Zhang X.

Med Sci Monit Basic Res. 2013 Sep 4;19:237-40. doi: 10.12659/MSMBR.889061.


Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor.

Guha S, Baltazar GC, Coffey EE, Tu LA, Lim JC, Beckel JM, Patel S, Eysteinsson T, Lu W, O'Brien-Jenkins A, Laties AM, Mitchell CH.

FASEB J. 2013 Nov;27(11):4500-9. doi: 10.1096/fj.13-236166. Epub 2013 Aug 20.


Increased expression of the transient receptor potential cation channel 6 gene in patients with primary open-angle glaucoma.

Chen S, Fan Q, Gao X, Wang X, Huang R, Laties AM, Zhang X.

Clin Exp Ophthalmol. 2013 Nov;41(8):753-60. doi: 10.1111/ceo.12111. Epub 2013 Apr 25.


Dynamic mobilization of PGC-1α mediates mitochondrial biogenesis for the protection of RGC-5 cells by resveratrol during serum deprivation.

Chen S, Fan Q, Li A, Liao D, Ge J, Laties AM, Zhang X.

Apoptosis. 2013 Jul;18(7):786-99. doi: 10.1007/s10495-013-0837-3.


Choroidal thickness in fellow eyes of patients with acute primary angle-closure measured by enhanced depth imaging spectral-domain optical coherence tomography.

Zhou M, Wang W, Ding X, Huang W, Chen S, Laties AM, Zhang X.

Invest Ophthalmol Vis Sci. 2013 Mar 19;54(3):1971-8. doi: 10.1167/iovs.12-11090.


Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells.

Baltazar GC, Guha S, Lu W, Lim J, Boesze-Battaglia K, Laties AM, Tyagi P, Kompella UB, Mitchell CH.

PLoS One. 2012;7(12):e49635. doi: 10.1371/journal.pone.0049635. Epub 2012 Dec 18.


Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.

Guha S, Baltazar GC, Tu LA, Liu J, Lim JC, Lu W, Argall A, Boesze-Battaglia K, Laties AM, Mitchell CH.

J Neurochem. 2012 Aug;122(4):823-33. doi: 10.1111/j.1471-4159.2012.07804.x. Epub 2012 Jun 27.


Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells.

Liu J, Lu W, Guha S, Baltazar GC, Coffey EE, Laties AM, Rubenstein RC, Reenstra WW, Mitchell CH.

Am J Physiol Cell Physiol. 2012 Jul 15;303(2):C160-9. doi: 10.1152/ajpcell.00278.2011. Epub 2012 May 9.


Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors.

Xia J, Lim JC, Lu W, Beckel JM, Macarak EJ, Laties AM, Mitchell CH.

J Physiol. 2012 May 15;590(10):2285-304. doi: 10.1113/jphysiol.2012.227983. Epub 2012 Mar 12.


Regeneration of cone outer segments induced by CNTF.

Wen R, Tao W, Luo L, Huang D, Kauper K, Stabila P, LaVail MM, Laties AM, Li Y.

Adv Exp Med Biol. 2012;723:93-9. doi: 10.1007/978-1-4614-0631-0_13. No abstract available.


Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma.

Li A, Zhang X, Zheng D, Ge J, Laties AM, Mitchell CH.

Exp Eye Res. 2011 Oct;93(4):528-33. doi: 10.1016/j.exer.2011.06.020. Epub 2011 Jul 2.


Long-term visual safety of voriconazole in adult patients with paracoccidioidomycosis.

Laties AM, Fraunfelder FT, Tomaszewski K, Goodrich J, Moreira AT, Sato MT, de Queiroz-Telles F.

Clin Ther. 2010 Dec;32(13):2207-17. doi: 10.1016/S0149-2918(10)80024-4.


Caspase inhibitors protect against NMDA-mediated retinal ganglion cell death.

Schuettauf F, Stein T, Choragiewicz TJ, Rejdak R, Bolz S, Zurakowski D, Varde MA, Laties AM, Thaler S.

Clin Exp Ophthalmol. 2011 Aug;39(6):545-54. doi: 10.1111/j.1442-9071.2010.02486.x. Epub 2011 Feb 23.


Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo.

Hu H, Lu W, Zhang M, Zhang X, Argall AJ, Patel S, Lee GE, Kim YC, Jacobson KA, Laties AM, Mitchell CH.

Exp Eye Res. 2010 Sep;91(3):425-32. doi: 10.1016/j.exer.2010.06.017. Epub 2010 Jul 1.


TRPC6 channel protects retinal ganglion cells in a rat model of retinal ischemia/reperfusion-induced cell death.

Wang X, Teng L, Li A, Ge J, Laties AM, Zhang X.

Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5751-8. doi: 10.1167/iovs.10-5451. Epub 2010 Jun 16.


Clinical assessment of the optic disc at risk of nonarteritic anterior ischaemic optic neuropathy.

Jonas JB, Laties AM.

Acta Ophthalmol. 2011 Jun;89(4):e375-7. doi: 10.1111/j.1755-3768.2010.01868.x. Epub 2010 Mar 19. No abstract available.


CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration.

Li Y, Tao W, Luo L, Huang D, Kauper K, Stabila P, Lavail MM, Laties AM, Wen R.

PLoS One. 2010 Mar 2;5(3):e9495. doi: 10.1371/journal.pone.0009495.


The A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cells.

Zhang M, Hu H, Zhang X, Lu W, Lim J, Eysteinsson T, Jacobson KA, Laties AM, Mitchell CH.

Neurochem Int. 2010 Jan;56(1):35-41. doi: 10.1016/j.neuint.2009.08.011. Epub 2009 Aug 31.


Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date.

Laties AM.

Drug Saf. 2009;32(1):1-18. doi: 10.2165/00002018-200932010-00001. Review.


Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI.

Li Y, Song Y, Zhao L, Gaidosh G, Laties AM, Wen R.

Nat Protoc. 2008;3(11):1703-8. doi: 10.1038/nprot.2008.172.


Stimulation of an alpha1-adrenergic receptor downregulates ecto-5' nucleotidase activity on the apical membrane of RPE cells.

Reigada D, Zhang X, Crespo A, Nguyen J, Liu J, Pendrak K, Stone RA, Laties AM, Mitchell C.

Purinergic Signal. 2006 Sep;2(3):499-507. doi: 10.1007/s11302-005-3980-7. Epub 2006 Aug 11.


Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.

Liu J, Lu W, Reigada D, Nguyen J, Laties AM, Mitchell CH.

Invest Ophthalmol Vis Sci. 2008 Feb;49(2):772-80. doi: 10.1167/iovs.07-0675.


CNTF negatively regulates the phototransduction machinery in rod photoreceptors: implication for light-induced photostasis plasticity.

Wen R, Song Y, Liu Y, Li Y, Zhao L, Laties AM.

Adv Exp Med Biol. 2008;613:407-13. doi: 10.1007/978-0-387-74904-4_48. No abstract available.


Acute increase of intraocular pressure releases ATP into the anterior chamber.

Zhang X, Li A, Ge J, Reigada D, Laties AM, Mitchell CH.

Exp Eye Res. 2007 Nov;85(5):637-43. Epub 2007 Aug 2.


Regulation of rod phototransduction machinery by ciliary neurotrophic factor.

Wen R, Song Y, Kjellstrom S, Tanikawa A, Liu Y, Li Y, Zhao L, Bush RA, Laties AM, Sieving PA.

J Neurosci. 2006 Dec 27;26(52):13523-30.


Time course of age-dependent changes in intraocular pressure and retinal ganglion cell death in DBA/2J mouse.

Zhang X, Zhang M, Avila MY, Ge J, Laties AM.

Yan Ke Xue Bao. 2006 Sep;22(3):184-9, 194.


Identification of the A3 adenosine receptor in rat retinal ganglion cells.

Zhang M, Budak MT, Lu W, Khurana TS, Zhang X, Laties AM, Mitchell CH.

Mol Vis. 2006 Aug 16;12:937-48.


Ultrasound biomicroscopy of Chinese eyes with iridocorneal endothelial syndrome.

Zhang M, Chen J, Liang L, Laties AM, Liu Z.

Br J Ophthalmol. 2006 Jan;90(1):64-9.


Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells.

Zhang X, Zhang M, Laties AM, Mitchell CH.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2183-91.


Degradation of extracellular ATP by the retinal pigment epithelium.

Reigada D, Lu W, Zhang X, Friedman C, Pendrak K, McGlinn A, Stone RA, Laties AM, Mitchell CH.

Am J Physiol Cell Physiol. 2005 Sep;289(3):C617-24. Epub 2005 Apr 27.


Photoreceptor protection by cardiotrophin-1 in transgenic rats with the rhodopsin mutation s334ter.

Song Y, Zhao L, Tao W, Laties AM, Luo Z, Wen R.

Invest Ophthalmol Vis Sci. 2003 Sep;44(9):4069-75.


A 4-year update on the safety of sildenafil citrate (Viagra).

Padma-nathan H, Eardley I, Kloner RA, Laties AM, Montorsi F.

Urology. 2002 Sep;60(2 Suppl 2):67-90. Review.


Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa.

Tao W, Wen R, Goddard MB, Sherman SD, O'Rourke PJ, Stabila PF, Bell WJ, Dean BJ, Kauper KA, Budz VA, Tsiaras WG, Acland GM, Pearce-Kelling S, Laties AM, Aguirre GD.

Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3292-8.


Nerve fiber layer splaying at vascular crossings.

Zhang X, Mitchell C, Wen R, Laties AM.

Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2063-6.


Quetiapine and cataracts.

Laties AM.

Am J Psychiatry. 2002 Feb;159(2):322-3. No abstract available.


Augmented rod bipolar cell function in partial receptor loss: an ERG study in P23H rhodopsin transgenic and aging normal rats.

Aleman TS, LaVail MM, Montemayor R, Ying G, Maguire MM, Laties AM, Jacobson SG, Cideciyan AV.

Vision Res. 2001 Sep;41(21):2779-97.

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