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Items: 1 to 50 of 138

1.

The dystroglycan receptor maintains glioma stem cells in the vascular niche.

Day BW, Lathia JD, Bruce ZC, D'Souza RCJ, Baumgartner U, Ensbey KS, Lim YC, Stringer BW, Akgül S, Offenhäuser C, Li Y, Jamieson PR, Smith FM, Jurd CLR, Robertson T, Inglis PL, Lwin Z, Jeffree RL, Johns TG, Bhat KPL, Rich JN, Campbell KP, Boyd AW.

Acta Neuropathol. 2019 Aug 28. doi: 10.1007/s00401-019-02069-x. [Epub ahead of print]

PMID:
31463571
2.

ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells.

Jimenez-Pascual A, Hale JS, Kordowski A, Pugh J, Silver DJ, Bayik D, Roversi G, Alban TJ, Rao S, Chen R, McIntyre TM, Colombo G, Taraboletti G, Holmberg KO, Forsberg-Nilsson K, Lathia JD, Siebzehnrubl FA.

Cancer Discov. 2019 Aug 21. pii: CD-18-1308. doi: 10.1158/2159-8290.CD-18-1308. [Epub ahead of print]

PMID:
31434712
3.

IL-11 drives postsurgical hepatocellular carcinoma recurrence.

Lauko A, Bayik D, Lathia JD.

EBioMedicine. 2019 Aug 8. pii: S2352-3964(19)30523-7. doi: 10.1016/j.ebiom.2019.08.007. [Epub ahead of print] No abstract available.

4.

Therapeutic strategies to induce ERα in luminal breast cancer to enhance tamoxifen efficacy.

Esakov EL, Hale J, Richards EG, Torre-Healy L, Gullapalli K, Trivedi D, Chumakova A, Wessely O, Jensen J, Lathia JD, Reizes O.

Endocr Relat Cancer. 2019 Jun 1. pii: ERC-19-0042.R1. doi: 10.1530/ERC-19-0042. [Epub ahead of print]

PMID:
31167163
5.

Development of a Cx46 Targeting Strategy for Cancer Stem Cells.

Mulkearns-Hubert EE, Torre-Healy LA, Silver DJ, Eurich JT, Bayik D, Serbinowski E, Hitomi M, Zhou J, Przychodzen B, Zhang R, Sprowls SA, Hale JS, Alban TJ, Berezovsky A, Bell BA, Lockman PR, Jha BK, Lathia JD.

Cell Rep. 2019 Apr 23;27(4):1062-1072.e5. doi: 10.1016/j.celrep.2019.03.079.

6.

Drak, Drak, Goose: A New Signaling Axis in Glioblastoma.

Lathia JD.

Cancer Res. 2019 Mar 15;79(6):1036-1037. doi: 10.1158/0008-5472.CAN-19-0229.

PMID:
30877099
7.

High-Throughput Automated Single-Cell Imaging Analysis Reveals Dynamics of Glioblastoma Stem Cell Population During State Transition.

Chumakova AP, Hitomi M, Sulman EP, Lathia JD.

Cytometry A. 2019 Mar;95(3):290-301. doi: 10.1002/cyto.a.23728. Epub 2019 Feb 6.

PMID:
30729665
8.

Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data.

Yang W, Warrington NM, Taylor SJ, Whitmire P, Carrasco E, Singleton KW, Wu N, Lathia JD, Berens ME, Kim AH, Barnholtz-Sloan JS, Swanson KR, Luo J, Rubin JB.

Sci Transl Med. 2019 Jan 2;11(473). pii: eaao5253. doi: 10.1126/scitranslmed.aao5253.

9.

Targeting Cancer Stemness in the Clinic: From Hype to Hope.

Saygin C, Matei D, Majeti R, Reizes O, Lathia JD.

Cell Stem Cell. 2019 Jan 3;24(1):25-40. doi: 10.1016/j.stem.2018.11.017. Epub 2018 Dec 27. Review.

PMID:
30595497
10.

A non-hierarchical organization of tumorigenic NG2 cells in glioblastoma promoted by EGFR.

Al-Mayhani TF, Heywood RM, Vemireddy V, Lathia JD, Piccirillo SGM, Watts C.

Neuro Oncol. 2019 Jun 10;21(6):719-729. doi: 10.1093/neuonc/noy204.

PMID:
30590711
11.

Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis.

Alban TJ, Alvarado AG, Sorensen MD, Bayik D, Volovetz J, Serbinowski E, Mulkearns-Hubert EE, Sinyuk M, Hale JS, Onzi GR, McGraw M, Huang P, Grabowski MM, Wathen CA, Ahluwalia MS, Radivoyevitch T, Kornblum HI, Kristensen BW, Vogelbaum MA, Lathia JD.

JCI Insight. 2018 Nov 2;3(21). pii: 122264. doi: 10.1172/jci.insight.122264.

12.

Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models.

Liu X, Taftaf R, Kawaguchi M, Chang YF, Chen W, Entenberg D, Zhang Y, Gerratana L, Huang S, Patel DB, Tsui E, Adorno-Cruz V, Chirieleison SM, Cao Y, Harney AS, Patel S, Patsialou A, Shen Y, Avril S, Gilmore HL, Lathia JD, Abbott DW, Cristofanilli M, Condeelis JS, Liu H.

Cancer Discov. 2019 Jan;9(1):96-113. doi: 10.1158/2159-8290.CD-18-0065. Epub 2018 Oct 25.

PMID:
30361447
13.

Sex-specific gene and pathway modeling of inherited glioma risk.

Ostrom QT, Coleman W, Huang W, Rubin JB, Lathia JD, Berens ME, Speyer G, Liao P, Wrensch MR, Eckel-Passow JE, Armstrong G, Rice T, Wiencke JK, McCoy LS, Hansen HM, Amos CI, Bernstein JL, Claus EB, Houlston RS, Il'yasova D, Jenkins RB, Johansen C, Lachance DH, Lai RK, Merrell RT, Olson SH, Sadetzki S, Schildkraut JM, Shete S, Andersson U, Rajaraman P, Chanock SJ, Linet MS, Wang Z, Yeager M; GliomaScan consortium , Melin B, Bondy ML, Barnholtz-Sloan JS.

Neuro Oncol. 2019 Jan 1;21(1):71-82. doi: 10.1093/neuonc/noy135.

PMID:
30124908
14.

Comparing and Contrasting the Effects of Drosophila Condensin II Subunit dCAP-D3 Overexpression and Depletion in Vivo.

Deutschman E, Ward JR, Ho-A-Lim KT, Alban TJ, Zhang D, Willard B, Lemieux ME, Lathia JD, Longworth MS.

Genetics. 2018 Oct;210(2):531-546. doi: 10.1534/genetics.118.301344. Epub 2018 Aug 1.

15.

Five-Part Pentameric Nanocomplex Shows Improved Efficacy of Doxorubicin in CD44+ Cancer Cells.

Beals N, Thiagarajan PS, Soehnlen E, Das A, Reizes O, Lathia JD, Basu S.

ACS Omega. 2017 Nov 30;2(11):7702-7713. doi: 10.1021/acsomega.7b01168. Epub 2017 Nov 9.

16.

An anatomic transcriptional atlas of human glioblastoma.

Puchalski RB, Shah N, Miller J, Dalley R, Nomura SR, Yoon JG, Smith KA, Lankerovich M, Bertagnolli D, Bickley K, Boe AF, Brouner K, Butler S, Caldejon S, Chapin M, Datta S, Dee N, Desta T, Dolbeare T, Dotson N, Ebbert A, Feng D, Feng X, Fisher M, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Hejazinia N, Hohmann J, Hothi P, Howard R, Joines K, Kriedberg A, Kuan L, Lau C, Lee F, Lee H, Lemon T, Long F, Mastan N, Mott E, Murthy C, Ngo K, Olson E, Reding M, Riley Z, Rosen D, Sandman D, Shapovalova N, Slaughterbeck CR, Sodt A, Stockdale G, Szafer A, Wakeman W, Wohnoutka PE, White SJ, Marsh D, Rostomily RC, Ng L, Dang C, Jones A, Keogh B, Gittleman HR, Barnholtz-Sloan JS, Cimino PJ, Uppin MS, Keene CD, Farrokhi FR, Lathia JD, Berens ME, Iavarone A, Bernard A, Lein E, Phillips JW, Rostad SW, Cobbs C, Hawrylycz MJ, Foltz GD.

Science. 2018 May 11;360(6389):660-663. doi: 10.1126/science.aaf2666.

17.

Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.

Ostrom QT, Kinnersley B, Wrensch MR, Eckel-Passow JE, Armstrong G, Rice T, Chen Y, Wiencke JK, McCoy LS, Hansen HM, Amos CI, Bernstein JL, Claus EB, Il'yasova D, Johansen C, Lachance DH, Lai RK, Merrell RT, Olson SH, Sadetzki S, Schildkraut JM, Shete S, Rubin JB, Lathia JD, Berens ME, Andersson U, Rajaraman P, Chanock SJ, Linet MS, Wang Z, Yeager M; GliomaScan consortium, Houlston RS, Jenkins RB, Melin B, Bondy ML, Barnholtz-Sloan JS.

Sci Rep. 2018 May 9;8(1):7352. doi: 10.1038/s41598-018-24580-z.

18.

Therapeutic Injury and Tumor Regrowth: Tumor Resection and Radiation Establish the Recurrent Glioblastoma Microenvironment.

Silver DJ, Lathia JD.

EBioMedicine. 2018 May;31:13-14. doi: 10.1016/j.ebiom.2018.04.016. Epub 2018 Apr 20. No abstract available.

20.

Females have the survival advantage in glioblastoma.

Ostrom QT, Rubin JB, Lathia JD, Berens ME, Barnholtz-Sloan JS.

Neuro Oncol. 2018 Mar 27;20(4):576-577. doi: 10.1093/neuonc/noy002. No abstract available.

21.

Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase.

Thiagarajan PS, Sinyuk M, Turaga SM, Mulkearns-Hubert EE, Hale JS, Rao V, Demelash A, Saygin C, China A, Alban TJ, Hitomi M, Torre-Healy LA, Alvarado AG, Jarrar A, Wiechert A, Adorno-Cruz V, Fox PL, Calhoun BC, Guan JL, Liu H, Reizes O, Lathia JD.

Nat Commun. 2018 Feb 8;9(1):578. doi: 10.1038/s41467-018-02938-1.

22.

Revealing the glioma cancer stem cell interactome, one niche at a time.

Silver DJ, Lathia JD.

J Pathol. 2018 Mar;244(3):260-264. doi: 10.1002/path.5024. Epub 2018 Feb 2.

23.

Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells.

Ma Y, Cheng Z, Liu J, Torre-Healy L, Lathia JD, Nakano I, Guo Y, Thompson RC, Freeman ML, Wang J.

Stem Cell Reports. 2017 Dec 12;9(6):1948-1960. doi: 10.1016/j.stemcr.2017.10.028. Epub 2017 Nov 30.

24.

A 4-miRNA signature to predict survival in glioblastomas.

Hermansen SK, Sørensen MD, Hansen A, Knudsen S, Alvarado AG, Lathia JD, Kristensen BW.

PLoS One. 2017 Nov 14;12(11):e0188090. doi: 10.1371/journal.pone.0188090. eCollection 2017.

25.

New Advances and Challenges of Targeting Cancer Stem Cells.

Dashzeveg NK, Taftaf R, Ramos EK, Torre-Healy L, Chumakova A, Silver DJ, Alban TJ, Sinyuk M, Thiagarajan PS, Jarrar AM, Turaga SM, Saygin C, Mulkearns-Hubert E, Hitomi M, Rich JN, Gerson SL, Lathia JD, Liu H.

Cancer Res. 2017 Oct 1;77(19):5222-5227. doi: 10.1158/0008-5472.CAN-17-0054. Epub 2017 Sep 19.

26.

Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival.

Müller-Greven G, Carlin CR, Burgett ME, Ahluwalia MS, Lauko A, Nowacki AS, Herting CJ, Qadan MA, Bredel M, Toms SA, Lathia JD, Hambardzumyan D, Sarkaria JN, Hamerlik P, Gladson CL.

Clin Cancer Res. 2017 Nov 15;23(22):7059-7071. doi: 10.1158/1078-0432.CCR-17-0249. Epub 2017 Sep 14.

27.

CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors.

Saygin C, Wiechert A, Rao VS, Alluri R, Connor E, Thiagarajan PS, Hale JS, Li Y, Chumakova A, Jarrar A, Parker Y, Lindner DJ, Nagaraj AB, Kim JJ, DiFeo A, Abdul-Karim FW, Michener C, Rose PG, DeBernardo R, Mahdi H, McCrae KR, Lin F, Lathia JD, Reizes O.

J Exp Med. 2017 Sep 4;214(9):2715-2732. doi: 10.1084/jem.20170438. Epub 2017 Aug 24.

28.

Transferrin receptor-1 and ferritin heavy and light chains in astrocytic brain tumors: Expression and prognostic value.

Rosager AM, Sørensen MD, Dahlrot RH, Hansen S, Schonberg DL, Rich JN, Lathia JD, Kristensen BW.

PLoS One. 2017 Aug 24;12(8):e0182954. doi: 10.1371/journal.pone.0182954. eCollection 2017.

29.

STAT3 activation by leptin receptor is essential for TNBC stem cell maintenance.

Thiagarajan PS, Zheng Q, Bhagrath M, Mulkearns-Hubert EE, Myers MG, Lathia JD, Reizes O.

Endocr Relat Cancer. 2017 Aug;24(8):415-426. doi: 10.1530/ERC-16-0349.

30.

RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis.

Karunanithi S, Levi L, DeVecchio J, Karagkounis G, Reizes O, Lathia JD, Kalady MF, Noy N.

Stem Cell Reports. 2017 Aug 8;9(2):438-450. doi: 10.1016/j.stemcr.2017.06.002. Epub 2017 Jul 6.

31.

Expression and prognostic value of JAM-A in gliomas.

Rosager AM, Sørensen MD, Dahlrot RH, Boldt HB, Hansen S, Lathia JD, Kristensen BW.

J Neurooncol. 2017 Oct;135(1):107-117. doi: 10.1007/s11060-017-2555-0. Epub 2017 Jul 4.

32.

Overview of Cancer Stem Cells and Stemness for Community Oncologists.

Lathia JD, Liu H.

Target Oncol. 2017 Aug;12(4):387-399. doi: 10.1007/s11523-017-0508-3. Review.

33.

An update on minding the gap in cancer.

Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC.

Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):237-243. doi: 10.1016/j.bbamem.2017.06.015. Epub 2017 Jun 24. Review.

34.

Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma.

Velpula KK, Guda MR, Sahu K, Tuszynski J, Asuthkar S, Bach SE, Lathia JD, Tsung AJ.

Oncotarget. 2017 May 30;8(22):35639-35655. doi: 10.18632/oncotarget.16767.

35.

Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications.

Abou-Antoun TJ, Hale JS, Lathia JD, Dombrowski SM.

Neurotherapeutics. 2017 Apr;14(2):372-384. doi: 10.1007/s13311-017-0524-0. Review.

36.

Isolation, Characterization, and Expansion of Cancer Stem Cells.

Torre-Healy LA, Berezovsky A, Lathia JD.

Methods Mol Biol. 2017;1553:133-143. doi: 10.1007/978-1-4939-6756-8_10.

PMID:
28229412
37.

Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression.

Alvarado AG, Thiagarajan PS, Mulkearns-Hubert EE, Silver DJ, Hale JS, Alban TJ, Turaga SM, Jarrar A, Reizes O, Longworth MS, Vogelbaum MA, Lathia JD.

Cell Stem Cell. 2017 Apr 6;20(4):450-461.e4. doi: 10.1016/j.stem.2016.12.001. Epub 2017 Jan 12.

38.

Migrating glioma cells express stem cell markers and give rise to new tumors upon xenografting.

Munthe S, Sørensen MD, Thomassen M, Burton M, Kruse TA, Lathia JD, Poulsen FR, Kristensen BW.

J Neurooncol. 2016 Oct;130(1):53-62. Epub 2016 Aug 10.

39.

Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells.

Shi Y, Zhou W, Cheng L, Chen C, Huang Z, Fang X, Wu Q, He Z, Xu S, Lathia JD, Ping Y, Rich JN, Bian XW, Bao S.

Cell Death Differ. 2017 Jan;24(1):167-180. doi: 10.1038/cdd.2016.110. Epub 2016 Oct 14.

40.

Adhering towards tumorigenicity: altered adhesion mechanisms in glioblastoma cancer stem cells.

Turaga SM, Lathia JD.

CNS Oncol. 2016 Oct;5(4):251-9. doi: 10.2217/cns-2016-0015. Epub 2016 Sep 12. Review.

41.

Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation.

Lord CC, Ferguson D, Thomas G, Brown AL, Schugar RC, Burrows A, Gromovsky AD, Betters J, Neumann C, Sacks J, Marshall S, Watts R, Schweiger M, Lee RG, Crooke RM, Graham MJ, Lathia JD, Sakaguchi TF, Lehner R, Haemmerle G, Zechner R, Brown JM.

Cell Rep. 2016 Jul 26;16(4):939-949. doi: 10.1016/j.celrep.2016.06.049. Epub 2016 Jul 7.

42.

Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells.

Burgett ME, Lathia JD, Roth P, Nowacki AS, Galileo DS, Pugacheva E, Huang P, Vasanji A, Li M, Byzova T, Mikkelsen T, Bao S, Rich JN, Weller M, Gladson CL.

Oncotarget. 2016 Jul 12;7(28):43852-43867. doi: 10.18632/oncotarget.9700.

43.

Reporter Systems to Study Cancer Stem Cells.

Saygin C, Samour M, Chumakova A, Jarrar A, Lathia JD, Reizes O.

Methods Mol Biol. 2016;1516:319-333. doi: 10.1007/7651_2016_360.

PMID:
27221339
44.

Taking a Toll on Self-Renewal: TLR-Mediated Innate Immune Signaling in Stem Cells.

Alvarado AG, Lathia JD.

Trends Neurosci. 2016 Jul;39(7):463-471. doi: 10.1016/j.tins.2016.04.005. Epub 2016 May 4. Review.

PMID:
27155992
45.

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion.

Otvos B, Silver DJ, Mulkearns-Hubert EE, Alvarado AG, Turaga SM, Sorensen MD, Rayman P, Flavahan WA, Hale JS, Stoltz K, Sinyuk M, Wu Q, Jarrar A, Kim SH, Fox PL, Nakano I, Rich JN, Ransohoff RM, Finke J, Kristensen BW, Vogelbaum MA, Lathia JD.

Stem Cells. 2016 Aug;34(8):2026-39. doi: 10.1002/stem.2393. Epub 2016 May 27.

46.

Cisplatin induces stemness in ovarian cancer.

Wiechert A, Saygin C, Thiagarajan PS, Rao VS, Hale JS, Gupta N, Hitomi M, Nagaraj AB, DiFeo A, Lathia JD, Reizes O.

Oncotarget. 2016 May 24;7(21):30511-22. doi: 10.18632/oncotarget.8852.

47.

Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury.

Saber M, Kokiko-Cochran O, Puntambekar SS, Lathia JD, Lamb BT.

J Neurotrauma. 2017 Jan 15;34(2):423-435. doi: 10.1089/neu.2016.4401. Epub 2016 May 9.

PMID:
26976047
48.

Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models.

Dermawan JK, Hitomi M, Silver DJ, Wu Q, Sandlesh P, Sloan AE, Purmal AA, Gurova KV, Rich JN, Lathia JD, Stark GR, Venere M.

Cancer Res. 2016 Apr 15;76(8):2432-42. doi: 10.1158/0008-5472.CAN-15-2162. Epub 2016 Feb 26.

49.

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.

Schonberg DL, Miller TE, Wu Q, Flavahan WA, Das NK, Hale JS, Hubert CG, Mack SC, Jarrar AM, Karl RT, Rosager AM, Nixon AM, Tesar PJ, Hamerlik P, Kristensen BW, Horbinski C, Connor JR, Fox PL, Lathia JD, Rich JN.

Cancer Cell. 2015 Oct 12;28(4):441-455. doi: 10.1016/j.ccell.2015.09.002.

50.

Cx25 contributes to leukemia cell communication and chemosensitivity.

Sinyuk M, Alvarado AG, Nesmiyanov P, Shaw J, Mulkearns-Hubert EE, Eurich JT, Hale JS, Bogdanova A, Hitomi M, Maciejewski J, Huang AY, Saunthararajah Y, Lathia JD.

Oncotarget. 2015 Oct 13;6(31):31508-21. doi: 10.18632/oncotarget.5226.

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