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Population pharmacokinetic and exposure-response analysis of eptinezumab in the treatment of episodic and chronic migraine.

Baker B, Schaeffler B, Beliveau M, Rubets I, Pederson S, Trinh M, Smith J, Latham J.

Pharmacol Res Perspect. 2020 Apr;8(2):e00567. doi: 10.1002/prp2.567.


Maintaining the healthy body: Blood management and hepatitis C prevention among men who inject performance and image-enhancing drugs.

Fomiatti R, Lenton E, Latham JR, Fraser S, Moore D, Seear K, Aitken C.

Int J Drug Policy. 2020 Jan;75:102592. doi: 10.1016/j.drugpo.2019.10.016. Epub 2019 Dec 17.


Vascular safety of erenumab for migraine prevention.

Kudrow D, Pascual J, Winner PK, Dodick DW, Tepper SJ, Reuter U, Hong F, Klatt J, Zhang F, Cheng S, Picard H, Eisele O, Wang J, Latham JN, Mikol DD.

Neurology. 2020 Feb 4;94(5):e497-e510. doi: 10.1212/WNL.0000000000008743. Epub 2019 Dec 18.


Training opportunities in thoracic ultrasound for respiratory trainees: are current guidelines practical?

Stanton AE, Evison M, Roberts M, Latham J, Clive AO, Batalla-Duran E, Bhatnagar R, Asciak R, Diggins B, Bintcliffe OJ, Lees D, Parsonage M, Denny P, Gow K, Avram C, Gautam M, Rahman NM.

BMJ Open Respir Res. 2019 Oct 3;6(1):e000390. doi: 10.1136/bmjresp-2018-000390. eCollection 2019.


Structural insights for vanadium catecholates and iron‑sulfur clusters obtained from multiple data analysis methods applied to electron spin relaxation data.

Ngendahimana T, Ayikpoe R, Latham JA, Eaton GR, Eaton SS.

J Inorg Biochem. 2019 Dec;201:110806. doi: 10.1016/j.jinorgbio.2019.110806. Epub 2019 Sep 2.


Assessing the Contribution of an HtrA Family Serine Protease During Borrelia turicatae Mammalian Infection.

Jackson-Litteken CD, Zalud AK, Ratliff CT, Latham JI, Bourret TJ, Lopez JE, Blevins JS.

Front Cell Infect Microbiol. 2019 Aug 13;9:290. doi: 10.3389/fcimb.2019.00290. eCollection 2019.


A two-component protease in Methylorubrum extorquens with high activity toward the peptide precursor of the redox cofactor pyrroloquinoline quinone.

Martins AM, Latham JA, Martel PJ, Barr I, Iavarone AT, Klinman JP.

J Biol Chem. 2019 Oct 11;294(41):15025-15036. doi: 10.1074/jbc.RA119.009684. Epub 2019 Aug 19.


Scenario-led modelling of broadleaf forest expansion in Wales.

Manzoor SA, Griffiths G, Latham J, Lukac M.

R Soc Open Sci. 2019 May 22;6(5):190026. doi: 10.1098/rsos.190026. eCollection 2019 May.


Effect of scan substrates on accuracy of 7 intraoral digital impression systems using human maxilla model.

Bocklet C, Renne W, Mennito A, Bacro T, Latham J, Evans Z, Ludlow M, Kelly A, Nash J.

Orthod Craniofac Res. 2019 May;22 Suppl 1:168-174. doi: 10.1111/ocr.12273.


Effect of scan pattern on complete-arch scans with 4 digital scanners.

Latham J, Ludlow M, Mennito A, Kelly A, Evans Z, Renne W.

J Prosthet Dent. 2020 Jan;123(1):85-95. doi: 10.1016/j.prosdent.2019.02.008. Epub 2019 Apr 12.


Prevalence of Anterior Femoral Neck Osteophyte in a Total Hip Arthroplasty Population: Analysis of Preoperative Surgical Plans.

Katchky AM, Smith ML, Shimmin AJ, McMahon SJ, Latham J, Baré JV.

Adv Orthop. 2019 Mar 3;2019:5193945. doi: 10.1155/2019/5193945. eCollection 2019.


Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.

Kahn-Kirby AH, Amagata A, Maeder CI, Mei JJ, Sideris S, Kosaka Y, Hinman A, Malone SA, Bruegger JJ, Wang L, Kim V, Shrader WD, Hoff KG, Latham JC, Ashley EA, Wheeler MT, Bertini E, Carrozzo R, Martinelli D, Dionisi-Vici C, Chapman KA, Enns GM, Gahl W, Wolfe L, Saneto RP, Johnson SC, Trimmer JK, Klein MB, Holst CR.

PLoS One. 2019 Mar 28;14(3):e0214250. doi: 10.1371/journal.pone.0214250. eCollection 2019.


Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway.

Koehn EM, Latham JA, Armand T, Evans RL 3rd, Tu X, Wilmot CM, Iavarone AT, Klinman JP.

J Am Chem Soc. 2019 Mar 13;141(10):4398-4405. doi: 10.1021/jacs.8b13453. Epub 2019 Feb 27.


Occurrence, function, and biosynthesis of mycofactocin.

Ayikpoe R, Govindarajan V, Latham JA.

Appl Microbiol Biotechnol. 2019 Apr;103(7):2903-2912. doi: 10.1007/s00253-019-09684-4. Epub 2019 Feb 18. Review.


Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase-Activating Peptide.

Moldovan Loomis C, Dutzar B, Ojala EW, Hendrix L, Karasek C, Scalley-Kim M, Mulligan J, Fan P, Billgren J, Rubin V, Boshaw H, Kwon G, Marzolf S, Stewart E, Jurchen D, Pederson SM, Perrino McCulloch L, Baker B, Cady RK, Latham JA, Allison D, Garcia-Martinez LF.

J Pharmacol Exp Ther. 2019 Apr;369(1):26-36. doi: 10.1124/jpet.118.253443. Epub 2019 Jan 14.


Spectroscopic and Electrochemical Characterization of the Mycofactocin Biosynthetic Protein, MftC, Provides Insight into Its Redox Flipping Mechanism.

Ayikpoe R, Ngendahimana T, Langton M, Bonitatibus S, Walker LM, Eaton SS, Eaton GR, Pandelia ME, Elliott SJ, Latham JA.

Biochemistry. 2019 Feb 19;58(7):940-950. doi: 10.1021/acs.biochem.8b01082. Epub 2019 Jan 25.


The Artificial Pancreas: What School Nurses Need to Know.

Latham J.

NASN Sch Nurse. 2019 Mar;34(2):86-89. doi: 10.1177/1942602X18804491. Epub 2018 Nov 1.


Light regulation of coccolithophore host-virus interactions.

Thamatrakoln K, Talmy D, Haramaty L, Maniscalco C, Latham JR, Knowles B, Natale F, Coolen MJL, Follows MJ, Bidle KD.

New Phytol. 2019 Feb;221(3):1289-1302. doi: 10.1111/nph.15459. Epub 2018 Oct 8.


Mycofactocin Biosynthesis Proceeds through 3-Amino-5-[( p-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone (AHDP); Direct Observation of MftE Specificity toward MftA.

Ayikpoe R, Salazar J, Majestic B, Latham JA.

Biochemistry. 2018 Sep 18;57(37):5379-5383. doi: 10.1021/acs.biochem.8b00816. Epub 2018 Sep 6.


Providing safe and effective pleural medicine services in the UK: an aspirational statement from UK pleural physicians.

Evison M, Blyth KG, Bhatnagar R, Corcoran J, Saba T, Duncan T, Hallifax R, Ahmed L, West A, Pepperell JCT, Roberts M, Sivasothy P, Psallidas I, Clive AO, Latham J, Stanton AE, Maskell N, Rahman N.

BMJ Open Respir Res. 2018 Aug 3;5(1):e000307. doi: 10.1136/bmjresp-2018-000307. eCollection 2018.


Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.

Hinman A, Holst CR, Latham JC, Bruegger JJ, Ulas G, McCusker KP, Amagata A, Davis D, Hoff KG, Kahn-Kirby AH, Kim V, Kosaka Y, Lee E, Malone SA, Mei JJ, Richards SJ, Rivera V, Miller G, Trimmer JK, Shrader WD.

PLoS One. 2018 Aug 15;13(8):e0201369. doi: 10.1371/journal.pone.0201369. eCollection 2018.


X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE.

Barr I, Stich TA, Gizzi AS, Grove TL, Bonanno JB, Latham JA, Chung T, Wilmot CM, Britt RD, Almo SC, Klinman JP.

Biochemistry. 2018 Feb 27;57(8):1306-1315. doi: 10.1021/acs.biochem.7b01097. Epub 2018 Feb 6.


Generation of Conditional Mutants in Borrelia burgdorferi.

Latham JI, Blevins JS.

Methods Mol Biol. 2018;1690:225-239. doi: 10.1007/978-1-4939-7383-5_17.


The distinct properties of natural and GM cry insecticidal proteins.

Latham JR, Love M, Hilbeck A.

Biotechnol Genet Eng Rev. 2017 Apr;33(1):62-96. doi: 10.1080/02648725.2017.1357295. Epub 2017 Sep 13. Review.


At the confluence of ribosomally synthesized peptide modification and radical S-adenosylmethionine (SAM) enzymology.

Latham JA, Barr I, Klinman JP.

J Biol Chem. 2017 Oct 6;292(40):16397-16405. doi: 10.1074/jbc.R117.797399. Epub 2017 Aug 22. Review.


Crystal structures reveal metal-binding plasticity at the metallo-β-lactamase active site of PqqB from Pseudomonas putida.

Tu X, Latham JA, Klema VJ, Evans RL 3rd, Li C, Klinman JP, Wilmot CM.

J Biol Inorg Chem. 2017 Oct;22(7):1089-1097. doi: 10.1007/s00775-017-1486-8. Epub 2017 Aug 19.


Catalytic Mechanism of the Hotdog-Fold Thioesterase PA1618 Revealed by X-ray Structure Determination of a Substrate-Bound Oxygen Ester Analogue Complex.

Latham JA, Ji T, Matthews K, Mariano PS, Allen KN, Dunaway-Mariano D.

Chembiochem. 2017 Oct 5;18(19):1935-1943. doi: 10.1002/cbic.201700322. Epub 2017 Aug 30.


Lower limb arthroplasty: can we produce a tool to predict outcome and failure, and is it cost-effective? An epidemiological study.

Arden N, Altman D, Beard D, Carr A, Clarke N, Collins G, Cooper C, Culliford D, Delmestri A, Garden S, Griffin T, Javaid K, Judge A, Latham J, Mullee M, Murray D, Ogundimu E, Pinedo-Villanueva R, Price A, Prieto-Alhambra D, Raftery J.

Southampton (UK): NIHR Journals Library; 2017 Jun.


Mechanistic elucidation of the mycofactocin-biosynthetic radical S-adenosylmethionine protein, MftC.

Khaliullin B, Ayikpoe R, Tuttle M, Latham JA.

J Biol Chem. 2017 Aug 4;292(31):13022-13033. doi: 10.1074/jbc.M117.795682. Epub 2017 Jun 20.


Nuclear Magnetic Resonance Structure and Binding Studies of PqqD, a Chaperone Required in the Biosynthesis of the Bacterial Dehydrogenase Cofactor Pyrroloquinoline Quinone.

Evans RL 3rd, Latham JA, Xia Y, Klinman JP, Wilmot CM.

Biochemistry. 2017 May 30;56(21):2735-2746. doi: 10.1021/acs.biochem.7b00247. Epub 2017 May 12.


Development of Halogenase Enzymes for Use in Synthesis.

Latham J, Brandenburger E, Shepherd SA, Menon BRK, Micklefield J.

Chem Rev. 2018 Jan 10;118(1):232-269. doi: 10.1021/acs.chemrev.7b00032. Epub 2017 May 3. Review.


Full deflection profile calculation and Young's modulus optimisation for engineered high performance materials.

Farsi A, Pullen AD, Latham JP, Bowen J, Carlsson M, Stitt EH, Marigo M.

Sci Rep. 2017 Apr 11;7:46190. doi: 10.1038/srep46190.


Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms.

Mason BN, Kaiser EA, Kuburas A, Loomis MM, Latham JA, Garcia-Martinez LF, Russo AF.

J Neurosci. 2017 Jan 4;37(1):204-216. doi: 10.1523/JNEUROSCI.2967-16.2016.


Polyaxial stress-dependent permeability of a three-dimensional fractured rock layer.

Lei Q, Wang X, Xiang J, Latham JP.

Hydrogeol J. 2017;25(8):2251-2262. doi: 10.1007/s10040-017-1624-y. Epub 2017 Jul 5.


An Engineered Tryptophan Synthase Opens New Enzymatic Pathways to β-Methyltryptophan and Derivatives.

Francis D, Winn M, Latham J, Greaney MF, Micklefield J.

Chembiochem. 2017 Feb 16;18(4):382-386. doi: 10.1002/cbic.201600471. Epub 2017 Jan 20.


ALD1613, a Novel Long-Acting Monoclonal Antibody to Control ACTH-Driven Pharmacology.

Feldhaus AL, Anderson K, Dutzar B, Ojala E, McNeill PD, Fan P, Mulligan J, Marzolf S, Karasek C, Scalley-Kim M, Stewart E, Billgren J, Rubin V, Schneider K, Jurchen D, Snow K, Barnett S, Bengtsson B, Baker B, Latham JA, Allison D, Garcia-Martinez LF.

Endocrinology. 2017 Jan 1;158(1):1-8. doi: 10.1210/en.2016-1455.


Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes.

Menon BR, Latham J, Dunstan MS, Brandenburger E, Klemstein U, Leys D, Karthikeyan C, Greaney MF, Shepherd SA, Micklefield J.

Org Biomol Chem. 2016 Oct 4;14(39):9354-9361.


(1)H, (13)C, and (15)N resonance assignments and secondary structure information for Methylobacterium extorquens PqqD and the complex of PqqD with PqqA.

Evans RL 3rd, Latham JA, Klinman JP, Wilmot CM, Xia Y.

Biomol NMR Assign. 2016 Oct;10(2):385-9. doi: 10.1007/s12104-016-9705-8. Epub 2016 Sep 16.


Damage mechanisms at the cement-implant interface of polished cemented femoral stems.

Shearwood-Porter N, Browne M, Milton JA, Cooper MJ, Palmer MR, Latham JM, Wood RJK, Cook RB.

J Biomed Mater Res B Appl Biomater. 2017 Oct;105(7):2027-2033. doi: 10.1002/jbm.b.33739. Epub 2016 Jul 4.


Disinfection Efficacy of Current Regenerative Endodontic Protocols in Simulated Necrotic Immature Permanent Teeth.

Latham J, Fong H, Jewett A, Johnson JD, Paranjpe A.

J Endod. 2016 Aug;42(8):1218-25. doi: 10.1016/j.joen.2016.05.004. Epub 2016 Jun 29.


Mycofactocin biosynthesis: modification of the peptide MftA by the radical S-adenosylmethionine protein MftC.

Khaliullin B, Aggarwal P, Bubas M, Eaton GR, Eaton SS, Latham JA.

FEBS Lett. 2016 Aug;590(16):2538-48. doi: 10.1002/1873-3468.12249. Epub 2016 Jun 29.


Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C-H activation.

Latham J, Henry JM, Sharif HH, Menon BR, Shepherd SA, Greaney MF, Micklefield J.

Nat Commun. 2016 Jun 10;7:11873. doi: 10.1038/ncomms11873.


Novel genotypes of Coxiella burnetii identified in isolates from Australian Q fever patients.

Vincent G, Stenos J, Latham J, Fenwick S, Graves S.

Int J Med Microbiol. 2016 Sep;306(6):463-70. doi: 10.1016/j.ijmm.2016.05.014. Epub 2016 May 25.


Intra-pelvic migration of femoral head trial in total hip arthroplasty, a rare intra-operative complication: a systematic literature review.

Abouel-Enin S, Fraig H, Griffiths J, Latham J.

Musculoskelet Surg. 2016 Aug;100(2):77-81. doi: 10.1007/s12306-016-0403-6. Epub 2016 Apr 19. Review.


Demonstration That the Radical S-Adenosylmethionine (SAM) Enzyme PqqE Catalyzes de Novo Carbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqD.

Barr I, Latham JA, Iavarone AT, Chantarojsiri T, Hwang JD, Klinman JP.

J Biol Chem. 2016 Apr 22;291(17):8877-84. doi: 10.1074/jbc.C115.699918. Epub 2016 Mar 8.


Whole Genome Analysis of Injectional Anthrax Identifies Two Disease Clusters Spanning More Than 13 Years.

Keim P, Grunow R, Vipond R, Grass G, Hoffmaster A, Birdsell DN, Klee SR, Pullan S, Antwerpen M, Bayer BN, Latham J, Wiggins K, Hepp C, Pearson T, Brooks T, Sahl J, Wagner DM.

EBioMedicine. 2015 Oct 6;2(11):1613-8. doi: 10.1016/j.ebiom.2015.10.004. eCollection 2015 Nov.


1,3-Dinitrobenzene neurotoxicity - Passage effect in immortalized astrocytes.

Maurer LL, Latham JD, Landis RW, Song DH, Epstein T, Philbert MA.

Neurotoxicology. 2016 Mar;53:74-84. doi: 10.1016/j.neuro.2015.11.011. Epub 2016 Jan 6.


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