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Mycofactocin Biosynthesis Proceeds through 3-Amino-5-[( p-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone (AHDP); Direct Observation of MftE Specificity toward MftA.

Ayikpoe R, Salazar J, Majestic B, Latham JA.

Biochemistry. 2018 Sep 18;57(37):5379-5383. doi: 10.1021/acs.biochem.8b00816. Epub 2018 Sep 6.


Providing safe and effective pleural medicine services in the UK: an aspirational statement from UK pleural physicians.

Evison M, Blyth KG, Bhatnagar R, Corcoran J, Saba T, Duncan T, Hallifax R, Ahmed L, West A, Pepperell JCT, Roberts M, Sivasothy P, Psallidas I, Clive AO, Latham J, Stanton AE, Maskell N, Rahman N.

BMJ Open Respir Res. 2018 Aug 3;5(1):e000307. doi: 10.1136/bmjresp-2018-000307. eCollection 2018.


Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.

Hinman A, Holst CR, Latham JC, Bruegger JJ, Ulas G, McCusker KP, Amagata A, Davis D, Hoff KG, Kahn-Kirby AH, Kim V, Kosaka Y, Lee E, Malone SA, Mei JJ, Richards SJ, Rivera V, Miller G, Trimmer JK, Shrader WD.

PLoS One. 2018 Aug 15;13(8):e0201369. doi: 10.1371/journal.pone.0201369. eCollection 2018.


X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE.

Barr I, Stich TA, Gizzi AS, Grove TL, Bonanno JB, Latham JA, Chung T, Wilmot CM, Britt RD, Almo SC, Klinman JP.

Biochemistry. 2018 Feb 27;57(8):1306-1315. doi: 10.1021/acs.biochem.7b01097. Epub 2018 Feb 6.


Generation of Conditional Mutants in Borrelia burgdorferi.

Latham JI, Blevins JS.

Methods Mol Biol. 2018;1690:225-239. doi: 10.1007/978-1-4939-7383-5_17.


The distinct properties of natural and GM cry insecticidal proteins.

Latham JR, Love M, Hilbeck A.

Biotechnol Genet Eng Rev. 2017 Apr;33(1):62-96. doi: 10.1080/02648725.2017.1357295. Epub 2017 Sep 13. Review.


At the confluence of ribosomally synthesized peptide modification and radical S-adenosylmethionine (SAM) enzymology.

Latham JA, Barr I, Klinman JP.

J Biol Chem. 2017 Oct 6;292(40):16397-16405. doi: 10.1074/jbc.R117.797399. Epub 2017 Aug 22. Review.


Crystal structures reveal metal-binding plasticity at the metallo-β-lactamase active site of PqqB from Pseudomonas putida.

Tu X, Latham JA, Klema VJ, Evans RL 3rd, Li C, Klinman JP, Wilmot CM.

J Biol Inorg Chem. 2017 Oct;22(7):1089-1097. doi: 10.1007/s00775-017-1486-8. Epub 2017 Aug 19.


Catalytic Mechanism of the Hotdog-Fold Thioesterase PA1618 Revealed by X-ray Structure Determination of a Substrate-Bound Oxygen Ester Analogue Complex.

Latham JA, Ji T, Matthews K, Mariano PS, Allen KN, Dunaway-Mariano D.

Chembiochem. 2017 Oct 5;18(19):1935-1943. doi: 10.1002/cbic.201700322. Epub 2017 Aug 30.


Lower limb arthroplasty: can we produce a tool to predict outcome and failure, and is it cost-effective? An epidemiological study.

Arden N, Altman D, Beard D, Carr A, Clarke N, Collins G, Cooper C, Culliford D, Delmestri A, Garden S, Griffin T, Javaid K, Judge A, Latham J, Mullee M, Murray D, Ogundimu E, Pinedo-Villanueva R, Price A, Prieto-Alhambra D, Raftery J.

Southampton (UK): NIHR Journals Library; 2017 Jun.


Mechanistic elucidation of the mycofactocin-biosynthetic radical S-adenosylmethionine protein, MftC.

Khaliullin B, Ayikpoe R, Tuttle M, Latham JA.

J Biol Chem. 2017 Aug 4;292(31):13022-13033. doi: 10.1074/jbc.M117.795682. Epub 2017 Jun 20.


Nuclear Magnetic Resonance Structure and Binding Studies of PqqD, a Chaperone Required in the Biosynthesis of the Bacterial Dehydrogenase Cofactor Pyrroloquinoline Quinone.

Evans RL 3rd, Latham JA, Xia Y, Klinman JP, Wilmot CM.

Biochemistry. 2017 May 30;56(21):2735-2746. doi: 10.1021/acs.biochem.7b00247. Epub 2017 May 12.


Development of Halogenase Enzymes for Use in Synthesis.

Latham J, Brandenburger E, Shepherd SA, Menon BRK, Micklefield J.

Chem Rev. 2018 Jan 10;118(1):232-269. doi: 10.1021/acs.chemrev.7b00032. Epub 2017 May 3.


Full deflection profile calculation and Young's modulus optimisation for engineered high performance materials.

Farsi A, Pullen AD, Latham JP, Bowen J, Carlsson M, Stitt EH, Marigo M.

Sci Rep. 2017 Apr 11;7:46190. doi: 10.1038/srep46190.


Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms.

Mason BN, Kaiser EA, Kuburas A, Loomis MM, Latham JA, Garcia-Martinez LF, Russo AF.

J Neurosci. 2017 Jan 4;37(1):204-216. doi: 10.1523/JNEUROSCI.2967-16.2016.


An Engineered Tryptophan Synthase Opens New Enzymatic Pathways to β-Methyltryptophan and Derivatives.

Francis D, Winn M, Latham J, Greaney MF, Micklefield J.

Chembiochem. 2017 Feb 16;18(4):382-386. doi: 10.1002/cbic.201600471. Epub 2017 Jan 20.


ALD1613, a Novel Long-Acting Monoclonal Antibody to Control ACTH-Driven Pharmacology.

Feldhaus AL, Anderson K, Dutzar B, Ojala E, McNeill PD, Fan P, Mulligan J, Marzolf S, Karasek C, Scalley-Kim M, Stewart E, Billgren J, Rubin V, Schneider K, Jurchen D, Snow K, Barnett S, Bengtsson B, Baker B, Latham JA, Allison D, Garcia-Martinez LF.

Endocrinology. 2017 Jan 1;158(1):1-8. doi: 10.1210/en.2016-1455.


Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes.

Menon BR, Latham J, Dunstan MS, Brandenburger E, Klemstein U, Leys D, Karthikeyan C, Greaney MF, Shepherd SA, Micklefield J.

Org Biomol Chem. 2016 Oct 4;14(39):9354-9361.


(1)H, (13)C, and (15)N resonance assignments and secondary structure information for Methylobacterium extorquens PqqD and the complex of PqqD with PqqA.

Evans RL 3rd, Latham JA, Klinman JP, Wilmot CM, Xia Y.

Biomol NMR Assign. 2016 Oct;10(2):385-9. doi: 10.1007/s12104-016-9705-8. Epub 2016 Sep 16.


Damage mechanisms at the cement-implant interface of polished cemented femoral stems.

Shearwood-Porter N, Browne M, Milton JA, Cooper MJ, Palmer MR, Latham JM, Wood RJK, Cook RB.

J Biomed Mater Res B Appl Biomater. 2017 Oct;105(7):2027-2033. doi: 10.1002/jbm.b.33739. Epub 2016 Jul 4.


Disinfection Efficacy of Current Regenerative Endodontic Protocols in Simulated Necrotic Immature Permanent Teeth.

Latham J, Fong H, Jewett A, Johnson JD, Paranjpe A.

J Endod. 2016 Aug;42(8):1218-25. doi: 10.1016/j.joen.2016.05.004. Epub 2016 Jun 29.


Mycofactocin biosynthesis: modification of the peptide MftA by the radical S-adenosylmethionine protein MftC.

Khaliullin B, Aggarwal P, Bubas M, Eaton GR, Eaton SS, Latham JA.

FEBS Lett. 2016 Aug;590(16):2538-48. doi: 10.1002/1873-3468.12249. Epub 2016 Jun 29.


Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C-H activation.

Latham J, Henry JM, Sharif HH, Menon BR, Shepherd SA, Greaney MF, Micklefield J.

Nat Commun. 2016 Jun 10;7:11873. doi: 10.1038/ncomms11873.


Novel genotypes of Coxiella burnetii identified in isolates from Australian Q fever patients.

Vincent G, Stenos J, Latham J, Fenwick S, Graves S.

Int J Med Microbiol. 2016 Sep;306(6):463-70. doi: 10.1016/j.ijmm.2016.05.014. Epub 2016 May 25.


Intra-pelvic migration of femoral head trial in total hip arthroplasty, a rare intra-operative complication: a systematic literature review.

Abouel-Enin S, Fraig H, Griffiths J, Latham J.

Musculoskelet Surg. 2016 Aug;100(2):77-81. doi: 10.1007/s12306-016-0403-6. Epub 2016 Apr 19. Review.


Demonstration That the Radical S-Adenosylmethionine (SAM) Enzyme PqqE Catalyzes de Novo Carbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqD.

Barr I, Latham JA, Iavarone AT, Chantarojsiri T, Hwang JD, Klinman JP.

J Biol Chem. 2016 Apr 22;291(17):8877-84. doi: 10.1074/jbc.C115.699918. Epub 2016 Mar 8.


Whole Genome Analysis of Injectional Anthrax Identifies Two Disease Clusters Spanning More Than 13 Years.

Keim P, Grunow R, Vipond R, Grass G, Hoffmaster A, Birdsell DN, Klee SR, Pullan S, Antwerpen M, Bayer BN, Latham J, Wiggins K, Hepp C, Pearson T, Brooks T, Sahl J, Wagner DM.

EBioMedicine. 2015 Oct 6;2(11):1613-8. doi: 10.1016/j.ebiom.2015.10.004. eCollection 2015 Nov.


1,3-Dinitrobenzene neurotoxicity - Passage effect in immortalized astrocytes.

Maurer LL, Latham JD, Landis RW, Song DH, Epstein T, Philbert MA.

Neurotoxicology. 2016 Mar;53:74-84. doi: 10.1016/j.neuro.2015.11.011. Epub 2016 Jan 6.


Whole-genome sequencing investigation of animal-skin-drum-associated UK anthrax cases reveals evidence of mixed populations and relatedness to a US case.

Pullan ST, Pearson TR, Latham J, Mason J, Atkinson B, Silman NJ, Marston CK, Sahl JW, Birdsell D, Hoffmaster AR, Keim P, Vipond R.

Microb Genom. 2015 Nov 7;1(5):e000039. doi: 10.1099/mgen.0.000039. eCollection 2015 Nov.


Understanding the experiences and needs of lesbian, gay, bisexual and trans Australians living with dementia, and their partners.

Barrett C, Crameri P, Lambourne S, Latham JR, Whyte C.

Australas J Ageing. 2015 Oct;34 Suppl 2:34-8. doi: 10.1111/ajag.12271.


It is more than sex and clothes: Culturally safe services for older lesbian, gay, bisexual, transgender and intersex people.

Crameri P, Barrett C, Latham JR, Whyte C.

Australas J Ageing. 2015 Oct;34 Suppl 2:21-5. doi: 10.1111/ajag.12270.


Appropriate bodies and other damn lies: Intersex ageing and aged care.

Latham JR, Barrett C.

Australas J Ageing. 2015 Oct;34 Suppl 2:19-20. doi: 10.1111/ajag.12275. No abstract available.


Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes.

Shepherd SA, Karthikeyan C, Latham J, Struck AW, Thompson ML, Menon BRK, Styles MQ, Levy C, Leys D, Micklefield J.

Chem Sci. 2015 Jun 1;6(6):3454-3460. doi: 10.1039/c5sc00913h. Epub 2015 Apr 10.


A non-fatal case of hantavirus cardiopulmonary syndrome imported into the UK (ex Panama), July 2014.

Atkinson B, Jameson LJ, Bovill BA, Aarons EJ, Clewlow J, Lumley S, Latham J, Jenkins MH, MacGowan AP, Simpson AJ, Ahmed J, Brooks TJ, Hewson R.

J Clin Virol. 2015 Jun;67:52-5. doi: 10.1016/j.jcv.2015.04.007. Epub 2015 Apr 8. No abstract available.


Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma.

Scott HA, Latham JR, Callister R, Pretto JJ, Baines K, Saltos N, Upham JW, Wood LG.

Ann Allergy Asthma Immunol. 2015 Jun;114(6):470-9. doi: 10.1016/j.anai.2015.04.002. Epub 2015 Apr 29.


The effect of frictional torque and bending moment on corrosion at the taper interface : an in vitro study.

Panagiotidou A, Meswania J, Osman K, Bolland B, Latham J, Skinner J, Haddad FS, Hart A, Blunn G.

Bone Joint J. 2015 Apr;97-B(4):463-72. doi: 10.1302/0301-620X.97B4.34800.


PqqD is a novel peptide chaperone that forms a ternary complex with the radical S-adenosylmethionine protein PqqE in the pyrroloquinoline quinone biosynthetic pathway.

Latham JA, Iavarone AT, Barr I, Juthani PV, Klinman JP.

J Biol Chem. 2015 May 15;290(20):12908-18. doi: 10.1074/jbc.M115.646521. Epub 2015 Mar 27.


Marine cloud brightening: regional applications.

Latham J, Gadian A, Fournier J, Parkes B, Wadhams P, Chen J.

Philos Trans A Math Phys Eng Sci. 2014 Dec 28;372(2031). pii: 20140053. doi: 10.1098/rsta.2014.0053.


Climate engineering: exploring nuances and consequences of deliberately altering the Earth's energy budget.

Latham J, Rasch PJ, Launder B.

Philos Trans A Math Phys Eng Sci. 2014 Dec 28;372(2031). pii: 20140050. doi: 10.1098/rsta.2014.0050. No abstract available.


Infiltrative anesthesia in office practice.

Latham JL, Martin SN.

Am Fam Physician. 2014 Jun 15;89(12):956-62.


Diarrhoea in slum children: observation from a large diarrhoeal disease hospital in Dhaka, Bangladesh.

Ferdous F, Das SK, Ahmed S, Farzana FD, Malek MA, Das J, Latham JR, Faruque AS, Chisti MJ.

Trop Med Int Health. 2014 Oct;19(10):1170-6. doi: 10.1111/tmi.12357. Epub 2014 Jul 18.


Structure and catalysis in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB.

Wu R, Latham JA, Chen D, Farelli J, Zhao H, Matthews K, Allen KN, Dunaway-Mariano D.

Biochemistry. 2014 Jul 29;53(29):4788-805. doi: 10.1021/bi500334v. Epub 2014 Jul 18.


Divergence of substrate specificity and function in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB.

Latham JA, Chen D, Allen KN, Dunaway-Mariano D.

Biochemistry. 2014 Jul 29;53(29):4775-87. doi: 10.1021/bi500333m. Epub 2014 Jul 18.


Estrogen-related receptor γ serves a role in blood pressure homeostasis during pregnancy.

Luo Y, Kumar P, Chen CC, Latham J, Wang L, Tudela C, Alexander JM, Shelton JM, McKown L, Mendelson CR.

Mol Endocrinol. 2014 Jun;28(6):965-75. doi: 10.1210/me.2014-1003. Epub 2014 Apr 11.


Geographical diversity in seasonality of major diarrhoeal pathogens in Bangladesh observed between 2010 and 2012.

Das SK, Begum D, Ahmed S, Ferdous F, Farzana FD, Chisti MJ, Latham JR, Talukder KA, Rahman MM, Begum YA, Faruque AS, Malek MA, Qadri F, Ahmed T, Alam N.

Epidemiol Infect. 2014 Dec;142(12):2530-41. doi: 10.1017/S095026881400017X. Epub 2014 Feb 13.


The role and utilisation of public health evaluations in Europe: a case study of national hand hygiene campaigns.

Latham JR, Magiorakos AP, Monnet DL, Alleaume S, Aspevall O, Blacky A, Borg M, Ciurus M; Spanish Hand Hygiene Campaign, Costa AC, Cunney R, Dolinšek M, Dumpis U, Erne S, Gudlaugsson O, Hedlova D, Heisbourg E, Holt J, Kerbo N, Sorknes NK, Lyytikäinen O, Maltezou HC, Michael S, Moro ML, Reichardt C, Stefkovicova M, Szilágyi E, Valinteliene R, Vatcheva-Dobrevska R, Viseur N, Voss A, Woodward S, Cordier L, Jansen A.

BMC Public Health. 2014 Feb 7;14:131. doi: 10.1186/1471-2458-14-131.


Hung jury: testimonies of genital surgery by transsexual men.

Latham JR.

Cult Health Sex. 2014 Jan 16. [Epub ahead of print] No abstract available.


Etiological diversity of diarrhoeal disease in Bangladesh.

Das SK, Ahmed S, Ferdous F, Farzana FD, Chisti MJ, Latham JR, Talukder KA, Rahman M, Begum YA, Qadri F, Faruque AS, Ahmed T.

J Infect Dev Ctries. 2013 Dec 15;7(12):900-9. doi: 10.3855/jidc.3003.

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