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Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis.

Cao P, Kim SJ, Xing A, Schenck CA, Liu L, Jiang N, Wang J, Last RL, Brandizzi F.

Elife. 2019 Dec 6;8. pii: e50747. doi: 10.7554/eLife.50747.


Location, location! cellular relocalization primes specialized metabolic diversification.

Schenck CA, Last RL.

FEBS J. 2019 Oct 17. doi: 10.1111/febs.15097. [Epub ahead of print] Review.


Pyrethrin Biosynthesis: The Cytochrome P450 Oxidoreductase CYP82Q3 Converts Jasmolone To Pyrethrolone.

Li W, Lybrand DB, Zhou F, Last RL, Pichersky E.

Plant Physiol. 2019 Nov;181(3):934-944. doi: 10.1104/pp.19.00499. Epub 2019 Aug 26.


A New Light on Photosystem II Maintenance in Oxygenic Photosynthesis.

Liu J, Lu Y, Hua W, Last RL.

Front Plant Sci. 2019 Jul 31;10:975. doi: 10.3389/fpls.2019.00975. eCollection 2019. Review.


Put on Your Sunscreen: The Birth of Arabidopsis Abiotic Stress Genetics.

Last RL.

Plant Cell. 2019 Jul;31(7):1406-1407. doi: 10.1105/tpc.19.00341. Epub 2019 May 8. No abstract available.


Evolution of metabolic novelty: A trichome-expressed invertase creates specialized metabolic diversity in wild tomato.

Leong BJ, Lybrand DB, Lou YR, Fan P, Schilmiller AL, Last RL.

Sci Adv. 2019 Apr 24;5(4):eaaw3754. doi: 10.1126/sciadv.aaw3754. eCollection 2019 Apr.


Tip of the trichome: evolution of acylsugar metabolic diversity in Solanaceae.

Fan P, Leong BJ, Last RL.

Curr Opin Plant Biol. 2019 Jun;49:8-16. doi: 10.1016/j.pbi.2019.03.005. Epub 2019 Apr 19. Review.


Robust predictions of specialized metabolism genes through machine learning.

Moore BM, Wang P, Fan P, Leong B, Schenck CA, Lloyd JP, Lehti-Shiu MD, Last RL, Pichersky E, Shiu SH.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2344-2353. doi: 10.1073/pnas.1817074116. Epub 2019 Jan 23. Erratum in: Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5830.


Production of trans-chrysanthemic acid, the monoterpene acid moiety of natural pyrethrin insecticides, in tomato fruit.

Xu H, Lybrand D, Bennewitz S, Tissier A, Last RL, Pichersky E.

Metab Eng. 2018 May;47:271-278. doi: 10.1016/j.ymben.2018.04.004. Epub 2018 Apr 9.


Evolution of a flipped pathway creates metabolic innovation in tomato trichomes through BAHD enzyme promiscuity.

Fan P, Miller AM, Liu X, Jones AD, Last RL.

Nat Commun. 2017 Dec 12;8(1):2080. doi: 10.1038/s41467-017-02045-7.


Coexpression Analysis Identifies Two Oxidoreductases Involved in the Biosynthesis of the Monoterpene Acid Moiety of Natural Pyrethrin Insecticides in Tanacetum cinerariifolium.

Xu H, Moghe GD, Wiegert-Rininger K, Schilmiller AL, Barry CS, Last RL, Pichersky E.

Plant Physiol. 2018 Jan;176(1):524-537. doi: 10.1104/pp.17.01330. Epub 2017 Nov 9.


A chloroplast thylakoid lumen protein is required for proper photosynthetic acclimation of plants under fluctuating light environments.

Liu J, Last RL.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8110-E8117. doi: 10.1073/pnas.1712206114. Epub 2017 Sep 5.


Evolutionary routes to biochemical innovation revealed by integrative analysis of a plant-defense related specialized metabolic pathway.

Moghe GD, Leong BJ, Hurney SM, Daniel Jones A, Last RL.

Elife. 2017 Aug 30;6. pii: e28468. doi: 10.7554/eLife.28468.


Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism.

Leong BJ, Last RL.

Curr Opin Struct Biol. 2017 Dec;47:105-112. doi: 10.1016/ Epub 2017 Aug 16. Review.


A Regulatory Hierarchy of the Arabidopsis Branched-Chain Amino Acid Metabolic Network.

Xing A, Last RL.

Plant Cell. 2017 Jun;29(6):1480-1499. doi: 10.1105/tpc.17.00186. Epub 2017 May 18.


Utility and Limitations of Using Gene Expression Data to Identify Functional Associations.

Uygun S, Peng C, Lehti-Shiu MD, Last RL, Shiu SH.

PLoS Comput Biol. 2016 Dec 9;12(12):e1005244. doi: 10.1371/journal.pcbi.1005244. eCollection 2016 Dec.


Comparative Biochemistry and In Vitro Pathway Reconstruction as Powerful Partners in Studies of Metabolic Diversity.

Fan P, Moghe GD, Last RL.

Methods Enzymol. 2016;576:1-17. doi: 10.1016/bs.mie.2016.02.023. Epub 2016 Mar 16.


Acylsugar Acylhydrolases: Carboxylesterase-Catalyzed Hydrolysis of Acylsugars in Tomato Trichomes.

Schilmiller AL, Gilgallon K, Ghosh B, Jones AD, Last RL.

Plant Physiol. 2016 Mar;170(3):1331-44. doi: 10.1104/pp.15.01348. Epub 2016 Jan 25.


In vitro reconstruction and analysis of evolutionary variation of the tomato acylsucrose metabolic network.

Fan P, Miller AM, Schilmiller AL, Liu X, Ofner I, Jones AD, Zamir D, Last RL.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E239-48. doi: 10.1073/pnas.1517930113. Epub 2015 Dec 29.


MPH1 is a thylakoid membrane protein involved in protecting photosystem II from photodamage in land plants.

Liu J, Last RL.

Plant Signal Behav. 2015;10(10):e1076602. doi: 10.1080/15592324.2015.1076602.


Something Old, Something New: Conserved Enzymes and the Evolution of Novelty in Plant Specialized Metabolism.

Moghe GD, Last RL.

Plant Physiol. 2015 Nov;169(3):1512-23. doi: 10.1104/pp.15.00994. Epub 2015 Aug 14. Review.


The Impact of the Branched-Chain Ketoacid Dehydrogenase Complex on Amino Acid Homeostasis in Arabidopsis.

Peng C, Uygun S, Shiu SH, Last RL.

Plant Physiol. 2015 Nov;169(3):1807-20. doi: 10.1104/pp.15.00461. Epub 2015 May 18.


A Feedback-Insensitive Isopropylmalate Synthase Affects Acylsugar Composition in Cultivated and Wild Tomato.

Ning J, Moghe GD, Leong B, Kim J, Ofner I, Wang Z, Adams C, Jones AD, Zamir D, Last RL.

Plant Physiol. 2015 Nov;169(3):1821-35. doi: 10.1104/pp.15.00474. Epub 2015 May 18.


Functionally divergent alleles and duplicated Loci encoding an acyltransferase contribute to acylsugar metabolite diversity in Solanum trichomes.

Schilmiller AL, Moghe GD, Fan P, Ghosh B, Ning J, Jones AD, Last RL.

Plant Cell. 2015 Apr;27(4):1002-17. doi: 10.1105/tpc.15.00087. Epub 2015 Apr 10.


A land plant-specific thylakoid membrane protein contributes to photosystem II maintenance in Arabidopsis thaliana.

Liu J, Last RL.

Plant J. 2015 Jun;82(5):731-43. doi: 10.1111/tpj.12845. Epub 2015 Apr 29.


PHOTOSYSTEM II PROTEIN33, a protein conserved in the plastid lineage, is associated with the chloroplast thylakoid membrane and provides stability to photosystem II supercomplexes in Arabidopsis.

Fristedt R, Herdean A, Blaby-Haas CE, Mamedov F, Merchant SS, Last RL, Lundin B.

Plant Physiol. 2015 Feb;167(2):481-92. doi: 10.1104/pp.114.253336. Epub 2014 Dec 15. Erratum in: Plant Physiol. 2017 Apr;173(4):2411.


Analysis of natural and induced variation in tomato glandular trichome flavonoids identifies a gene not present in the reference genome.

Kim J, Matsuba Y, Ning J, Schilmiller AL, Hammar D, Jones AD, Pichersky E, Last RL.

Plant Cell. 2014 Aug;26(8):3272-85. doi: 10.1105/tpc.114.129460. Epub 2014 Aug 15.


Analysis of essential Arabidopsis nuclear genes encoding plastid-targeted proteins.

Savage LJ, Imre KM, Hall DA, Last RL.

PLoS One. 2013 Sep 4;8(9):e73291. doi: 10.1371/journal.pone.0073291. eCollection 2013.


Striking natural diversity in glandular trichome acylsugar composition is shaped by variation at the Acyltransferase2 locus in the wild tomato Solanum habrochaites.

Kim J, Kang K, Gonzales-Vigil E, Shi F, Jones AD, Barry CS, Last RL.

Plant Physiol. 2012 Dec;160(4):1854-70. doi: 10.1104/pp.112.204735. Epub 2012 Oct 9.


Identification of a BAHD acetyltransferase that produces protective acyl sugars in tomato trichomes.

Schilmiller AL, Charbonneau AL, Last RL.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16377-82. doi: 10.1073/pnas.1207906109. Epub 2012 Sep 17.


Achieving diversity in the face of constraints: lessons from metabolism.

Milo R, Last RL.

Science. 2012 Jun 29;336(6089):1663-7. doi: 10.1126/science.1217665. Review.


Evolution of TPS20-related terpene synthases influences chemical diversity in the glandular trichomes of the wild tomato relative Solanum habrochaites.

Gonzales-Vigil E, Hufnagel DE, Kim J, Last RL, Barry CS.

Plant J. 2012 Sep;71(6):921-35. doi: 10.1111/j.1365-313X.2012.05040.x. Epub 2012 Jun 22.


Taming the hydra of specialized metabolism: how systems biology and comparative approaches are revolutionizing plant biochemistry.

Schilmiller AL, Pichersky E, Last RL.

Curr Opin Plant Biol. 2012 Jun;15(3):338-44. doi: 10.1016/j.pbi.2011.12.005. Epub 2012 Jan 12. Review.


MIPHENO: data normalization for high throughput metabolite analysis.

Bell SM, Burgoon LD, Last RL.

BMC Bioinformatics. 2012 Jan 13;13:10. doi: 10.1186/1471-2105-13-10.


Rapid LC-MS/MS profiling of protein amino acids and metabolically related compounds for large-scale assessment of metabolic phenotypes.

Gu L, Jones AD, Last RL.

Methods Mol Biol. 2012;828:1-11. doi: 10.1007/978-1-61779-445-2_1.


A J-like protein influences fatty acid composition of chloroplast lipids in Arabidopsis.

Ajjawi I, Coku A, Froehlich JE, Yang Y, Osteryoung KW, Benning C, Last RL.

PLoS One. 2011;6(10):e25368. doi: 10.1371/journal.pone.0025368. Epub 2011 Oct 18.


Chloroplast phenomics: systematic phenotypic screening of chloroplast protein mutants in Arabidopsis.

Lu Y, Savage LJ, Last RL.

Methods Mol Biol. 2011;775:161-85. doi: 10.1007/978-1-61779-237-3_9.


The tomato terpene synthase gene family.

Falara V, Akhtar TA, Nguyen TT, Spyropoulou EA, Bleeker PM, Schauvinhold I, Matsuba Y, Bonini ME, Schilmiller AL, Last RL, Schuurink RC, Pichersky E.

Plant Physiol. 2011 Oct;157(2):770-89. doi: 10.1104/pp.111.179648. Epub 2011 Aug 3.


A small zinc finger thylakoid protein plays a role in maintenance of photosystem II in Arabidopsis thaliana.

Lu Y, Hall DA, Last RL.

Plant Cell. 2011 May;23(5):1861-75. doi: 10.1105/tpc.111.085456. Epub 2011 May 17.


Chloroplast 2010: a database for large-scale phenotypic screening of Arabidopsis mutants.

Lu Y, Savage LJ, Larson MD, Wilkerson CG, Last RL.

Plant Physiol. 2011 Apr;155(4):1589-600. doi: 10.1104/pp.110.170118. Epub 2011 Jan 11.


Twenty-first century plant biology: impacts of the Arabidopsis genome on plant biology and agriculture.

Buell CR, Last RL.

Plant Physiol. 2010 Oct;154(2):497-500. doi: 10.1104/pp.110.159541. No abstract available.


Studies of a biochemical factory: tomato trichome deep expressed sequence tag sequencing and proteomics.

Schilmiller AL, Miner DP, Larson M, McDowell E, Gang DR, Wilkerson C, Last RL.

Plant Physiol. 2010 Jul;153(3):1212-23. doi: 10.1104/pp.110.157214. Epub 2010 Apr 29.


Shotguns and SNPs: how fast and cheap sequencing is revolutionizing plant biology.

Rounsley SD, Last RL.

Plant J. 2010 Mar;61(6):922-7. doi: 10.1111/j.1365-313X.2009.04030.x. Review.


Mass spectrometry screening reveals widespread diversity in trichome specialized metabolites of tomato chromosomal substitution lines.

Schilmiller A, Shi F, Kim J, Charbonneau AL, Holmes D, Daniel Jones A, Last RL.

Plant J. 2010 May;62(3):391-403. doi: 10.1111/j.1365-313X.2010.04154.x. Epub 2010 Jan 25.


Broad connections in the Arabidopsis seed metabolic network revealed by metabolite profiling of an amino acid catabolism mutant.

Gu L, Jones AD, Last RL.

Plant J. 2010 Feb;61(4):579-90. doi: 10.1111/j.1365-313X.2009.04083.x. Epub 2009 Nov 19.


Large-scale reverse genetics in Arabidopsis: case studies from the Chloroplast 2010 Project.

Ajjawi I, Lu Y, Savage LJ, Bell SM, Last RL.

Plant Physiol. 2010 Feb;152(2):529-40. doi: 10.1104/pp.109.148494. Epub 2009 Nov 11.


FATTY ACID DESATURASE4 of Arabidopsis encodes a protein distinct from characterized fatty acid desaturases.

Gao J, Ajjawi I, Manoli A, Sawin A, Xu C, Froehlich JE, Last RL, Benning C.

Plant J. 2009 Dec;60(5):832-9. doi: 10.1111/j.1365-313X.2009.04001.x. Epub 2009 Aug 13.


Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate.

Schilmiller AL, Schauvinhold I, Larson M, Xu R, Charbonneau AL, Schmidt A, Wilkerson C, Last RL, Pichersky E.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10865-70. doi: 10.1073/pnas.0904113106. Epub 2009 Jun 1.


Harnessing plant trichome biochemistry for the production of useful compounds.

Schilmiller AL, Last RL, Pichersky E.

Plant J. 2008 May;54(4):702-11. doi: 10.1111/j.1365-313X.2008.03432.x.


Genome-enabled approaches shed new light on plant metabolism.

DellaPenna D, Last RL.

Science. 2008 Apr 25;320(5875):479-81. doi: 10.1126/science.1153715.


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