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Items: 28

1.

Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.

Khor B, Conway KL, Omar AS, Biton M, Haber AL, Rogel N, Baxt LA, Begun J, Kuballa P, Gagnon JD, Lassen KG, Regev A, Xavier RJ.

J Immunol. 2019 Oct 1;203(7):1820-1829. doi: 10.4049/jimmunol.1800419. Epub 2019 Aug 26.

PMID:
31451676
2.

Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.

Ferder IC, Fung L, Ohguchi Y, Zhang X, Lassen KG, Capen D, Brown D, Xavier RJ, Wang N.

PLoS Genet. 2019 May 6;15(5):e1008084. doi: 10.1371/journal.pgen.1008084. eCollection 2019 May.

3.

Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans.

Tam JM, Reedy JL, Lukason DP, Kuna SG, Acharya M, Khan NS, Negoro PE, Xu S, Ward RA, Feldman MB, Dutko RA, Jeffery JB, Sokolovska A, Wivagg CN, Lassen KG, Le Naour F, Matzaraki V, Garner EC, Xavier RJ, Kumar V, van de Veerdonk FL, Netea MG, Miranti CK, Mansour MK, Vyas JM.

J Immunol. 2019 Jun 1;202(11):3256-3266. doi: 10.4049/jimmunol.1801384. Epub 2019 Apr 22.

PMID:
31010852
4.

The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response.

Lavoie S, Conway KL, Lassen KG, Jijon HB, Pan H, Chun E, Michaud M, Lang JK, Gallini Comeau CA, Dreyfuss JM, Glickman JN, Vlamakis H, Ananthakrishnan A, Kostic A, Garrett WS, Xavier RJ.

Elife. 2019 Jan 22;8. pii: e39982. doi: 10.7554/eLife.39982.

5.

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.

Mohanan V, Nakata T, Desch AN, Lévesque C, Boroughs A, Guzman G, Cao Z, Creasey E, Yao J, Boucher G, Charron G, Bhan AK, Schenone M, Carr SA, Reinecker HC, Daly MJ, Rioux JD, Lassen KG, Xavier RJ.

Science. 2018 Mar 9;359(6380):1161-1166. doi: 10.1126/science.aan0814. Epub 2018 Feb 1.

6.

Mechanisms and function of autophagy in intestinal disease.

Lassen KG, Xavier RJ.

Autophagy. 2018;14(2):216-220. doi: 10.1080/15548627.2017.1389358. Epub 2018 Jan 29. Review.

7.

Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo.

Murano T, Najibi M, Paulus GLC, Adiliaghdam F, Valencia-Guerrero A, Selig M, Wang X, Jeffrey K, Xavier RJ, Lassen KG, Irazoqui JE.

Sci Rep. 2017 Oct 24;7(1):13938. doi: 10.1038/s41598-017-14370-4.

8.

Genetic control of autophagy underlies pathogenesis of inflammatory bowel disease.

Lassen KG, Xavier RJ.

Mucosal Immunol. 2017 May;10(3):589-597. doi: 10.1038/mi.2017.18. Epub 2017 Mar 22. Review.

9.

RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.

Heath RJ, Goel G, Baxt LA, Rush JS, Mohanan V, Paulus GLC, Jani V, Lassen KG, Xavier RJ.

Cell Rep. 2016 Nov 22;17(9):2183-2194. doi: 10.1016/j.celrep.2016.11.005.

10.

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.

Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ.

Immunity. 2016 Jun 21;44(6):1392-405. doi: 10.1016/j.immuni.2016.05.007. Epub 2016 Jun 7.

11.

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.

Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD.

MBio. 2015 Sep 8;6(5):e01157-15. doi: 10.1128/mBio.01157-15.

12.

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Kuo SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G, Dančík V, Kuballa P, Latorre I, Conway KL, Sarkar S, Maetzel D, Jaenisch R, Clemons PA, Schreiber SL, Shamji AF, Xavier RJ.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4281-7. doi: 10.1073/pnas.1512289112. Epub 2015 Jul 20.

13.

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ.

Cell Rep. 2015 Jun 30;11(12):1905-18. doi: 10.1016/j.celrep.2015.05.045. Epub 2015 Jun 18.

14.

An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse.

Liao J, Jijon HB, Kim IR, Goel G, Doan A, Sokol H, Bauer H, Herrmann BG, Lassen KG, Xavier RJ.

PLoS One. 2014 Sep 30;9(9):e108777. doi: 10.1371/journal.pone.0108777. eCollection 2014.

15.

An alteration in ATG16L1 stability in Crohn disease.

Lassen KG, Xavier RJ.

Autophagy. 2014 Oct 1;10(10):1858-60. doi: 10.4161/auto.29963. Epub 2014 Aug 12.

16.

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6. doi: 10.1073/pnas.1407001111. Epub 2014 May 12.

17.

Calcium/calcineurin synergizes with prostratin to promote NF-κB dependent activation of latent HIV.

Chan JK, Bhattacharyya D, Lassen KG, Ruelas D, Greene WC.

PLoS One. 2013 Oct 30;8(10):e77749. doi: 10.1371/journal.pone.0077749. eCollection 2013.

18.

Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.

Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ.

ACS Chem Biol. 2013 Dec 20;8(12):2724-2733. doi: 10.1021/cb400352d. Epub 2013 Oct 29.

19.

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome.

Knights D, Lassen KG, Xavier RJ.

Gut. 2013 Oct;62(10):1505-10. doi: 10.1136/gutjnl-2012-303954. Review.

20.

A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs.

Lassen KG, Hebbeler AM, Bhattacharyya D, Lobritz MA, Greene WC.

PLoS One. 2012;7(1):e30176. doi: 10.1371/journal.pone.0030176. Epub 2012 Jan 24.

21.

Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).

Sakane N, Kwon HS, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M.

PLoS Pathog. 2011 Aug;7(8):e1002184. doi: 10.1371/journal.ppat.1002184. Epub 2011 Aug 18.

22.

HIV-1 replicative fitness in elite controllers.

Lobritz MA, Lassen KG, Arts EJ.

Curr Opin HIV AIDS. 2011 May;6(3):214-20. doi: 10.1097/COH.0b013e3283454cf5. Review.

23.

Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue.

Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WC.

Cell. 2010 Nov 24;143(5):789-801. doi: 10.1016/j.cell.2010.11.001. Erratum in: Cell. 2014 Feb 27;156(5):1112-3.

24.

Identification of two APOBEC3F splice variants displaying HIV-1 antiviral activity and contrasting sensitivity to Vif.

Lassen KG, Wissing S, Lobritz MA, Santiago M, Greene WC.

J Biol Chem. 2010 Sep 17;285(38):29326-35. doi: 10.1074/jbc.M110.154054. Epub 2010 Jul 12.

25.

Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics.

Lassen KG, Lobritz MA, Bailey JR, Johnston S, Nguyen S, Lee B, Chou T, Siliciano RF, Markowitz M, Arts EJ.

PLoS Pathog. 2009 Apr;5(4):e1000377. doi: 10.1371/journal.ppat.1000377. Epub 2009 Apr 10.

26.

Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells.

Lassen KG, Ramyar KX, Bailey JR, Zhou Y, Siliciano RF.

PLoS Pathog. 2006 Jul;2(7):e68.

28.

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